Statistical analysis of the trigger algorithm for the NEMO project

We discuss the performances of a trigger implemented for the planned neutrino telescope NEMO. This trigger seems capable to discriminate between the signal and the strong background introduced by atmospheric muons and by the beta decay of the K-40 nuclei present in the water. The performances of the trigger, as evaluated on simulated data are analyzed in detail.Comment: Published in the Proceedings of the "I Workshop of Astronomy and Astrophysics for Students", Eds. N.R. Napolitano & M. Paolillo, Naples, 19-20 April 2006 (astro-ph/0701577

Implementation of the trigger algorithm for the NEMO project

We describe the implementation of trigger algorithm specifically tailored on the characteristics of the neutrino telescope NEMO. Extensive testing against realistic simulations shows that, by making use of the uncorrelated nature of the noise produced mainly by the decay of K-40 beta-decay, this trigger is capable to discriminate among different types of muonic events.Comment: Published in the Proceedings of the "I Workshop of Astronomy and Astrophysics for Students", Eds. N.R. Napolitano & M. Paolillo, Naples, 19-20 April 2006 (astro-ph/0701577

Multi-objective design of robust flight control systems

A multi–objective evolutionary algorithm is used in the framework of H1 control theory to find the controller gains that minimize a weighted combination of the infinite–norm of the sensitivity function (for disturbance attenuation requirements) and complementary sensitivity function (for robust stability requirements). After considering a single operating point for a level flight trim condition of a F-16 fighter aircraft model, two different approaches will then be considered to extend the domain of validity of the control law: 1) the controller is designed for different operating points and gain scheduling is adopted; 2) a single control law is designed for all the considered operating points by multiobjective minimisation. The two approaches are analyzed and compared in terms of effectiveness of the design method and resulting closed loop performance of the system

Migration and Accretion of Protoplanets in 2D and 3D Global Hydrodynamical Simulations

Planet evolution is tightly connected to the dynamics of both distant and close disk material. Hence, an appropriate description of disk-planet interaction requires global and high resolution computations, which we accomplish by applying a Nested-Grid method. Through simulations in two and three dimensions, we investigate how migration and accretion are affected by long and short range interactions. For small mass objects, 3D models provide longer growth and migration time scales than 2D ones do, whereas time lengths are comparable for large mass planets.Comment: 4 pages, 4 figures; to appear in the Conference Proceedings of "Scientific Frontiers in Research on Extrasolar Planets

Follow-up after curative resection for gastric cancer. Is it time to tailor it?

There is still no consensus on the follow-up frequency and regimen after curative resection for gastric cancer. Moreover, controversy exists regarding the utility of follow-up in improving survival, and the recommendations of experts and societies vary considerably. The main reason to establish surveillance programs is to diagnose tumor recurrence or metachronous cancers early and to thereby provide prompt treatment and prolong survival. In the setting of gastric malignancies, other reasons have been put forth: (1) the detection of adverse effects of a previous surgery, such as malnutrition or digestive sequelae; (2) the collection of data; and (3) the identification of psychological and/or social problems and provision of appropriate support to the patients. No randomized controlled trials on the role of follow-up after curative resection of gastric carcinoma have been published. Herein, the primary retrospective series and systematic reviews on this subject are analyzed and discussed. Furthermore, the guidelines from international and national scientific societies are discussed. Follow-up is recommended by the majority of institutions; however, there is no real evidence that follow-up can improve long-term survival rates. Several studies have demonstrated that it is possible to stratify patients submitted to curative gastrectomy into different classes according to the risk of recurrence. Furthermore, promising studies have identified several molecular markers that are related to the risk of relapse and to prognosis. Based on these premises, a promising strategy will be to tailor follow-up in relation to the patient and tumor characteristics, molecular marker status, and individual risk of recurrence

Closed-loop approach to thermodynamics

We present the closed loop approach to linear nonequilibrium thermodynamics considering a generic heat engine dissipatively connected to two temperature baths. The system is usually quite generally characterized by two parameters: the output power $P$ and the conversion efficiency $\eta$, to which we add a third one, the working frequency $\omega$. We establish that a detailed understanding of the effects of the dissipative coupling on the energy conversion process, necessitates the knowledge of only two quantities: the system's feedback factor $\beta$ and its open-loop gain $A_{0}$, the product of which, $A_{0}\beta$, characterizes the interplay between the efficiency, the output power and the operating rate of the system. By placing thermodynamics analysis on a higher level of abstraction, the feedback loop approach provides a versatile and economical, hence a very efficient, tool for the study of \emph{any} conversion engine operation for which a feedback factor may be defined

Contribution to diffuse gamma-ray emission coming from self-confined CRs around their Galactic sources

Recent observations of the diffuse Galactic gamma-ray emission by the Fermi-LAT satellite have shown significant deviations from models which assume the same diffusion properties for cosmic rays (CR) throughout the Galaxy. We explore the possibility that a fraction of this diffuse Galactic emission could be due to hadronic interactions of CRs self-confined in the region around their sources. In fact, freshly accelerated CRs that diffuse away from the acceleration region can trigger the streaming instability able to amplify magnetic disturbance and to reduce the particle diffusion. When this happen, CRs are trapped in the near source region for a time longer than expected and an extended gamma-ray halo is produces around each source. Here we calculate the contribution to the diffuse gamma-ray background due to the overlap along lines of sight of several of these extended halos. We find that if the density of neutrals is low, the halos can account for a substantial fraction of the diffuse emission observed by Fermi-LAT, depending on the orientation of the line of sight with respect to the direction of the galactic center.Comment: 8 pages, 2 figs. Proceeding the 35th International Cosmic Ray Conference (ICRC2017), Bexco, Busan, Kore

Astrophysics in S.Co.P.E

S.Co.P.E. is one of the four projects funded by the Italian Government in order to provide Southern Italy with a distributed computing infrastructure for fundamental science. Beside being aimed at building the infrastructure, S.Co.P.E. is also actively pursuing research in several areas among which astrophysics and observational cosmology. We shortly summarize the most significant results obtained in the first two years of the project and related to the development of middleware and Data Mining tools for the Virtual Observatory

Regulation of ISWI chromatin remodelling activity

The packaging of the eukaryotic genome into chromatin facilitates the storage of the genetic information within the nucleus, but prevents the access to the underlying DNA sequences. Structural changes in chromatin are mediated by several mechanisms. Among them, ATP-dependent remodelling complexes belonging to ISWI family provides one of the best examples that eukaryotic cells evolved to finely regulate these changes. ISWI-containing complexes use the energy derived from ATP hydrolysis to rearrange nucleosomes on chromatin in order to favour specific nuclear reactions. The combination of regulatory nuclear factors associated with the ATPase subunit as well as its modulation by specific histone modifications, specializes the nuclear function of each ISWI-containing complex. Here we review the different ways by which ISWI enzymatic activity can be modulated and regulated in the nucleus of eukaryotic cells

Role of the flat-designed surface in improving the cyclic fatigue resistance of endodontic NiTi rotary instruments

The aim of this study was to investigate the role of the flat-designed surface in improving the resistance to cyclic fatigue by comparing heat-treated F-One (Fanta Dental, Shanghai, China) nickel-titanium (NiTi) rotary instruments and similar prototypes, differing only by the absence of the flat side. The null hypothesis was that there were no differences between the two tested instruments in terms of cyclic fatigue lifespan. A total of 40 new NiTi instruments (20 F-One and 20 prototypes) were tested in the present study. The instruments were rotated with the same speed (500 rpm) and torque (2 N) using an endodontic motor (Elements Motor, Kerr, Orange, CA, USA) in the same stainless steel, artificial canal (90° angle of curvature and 5 mm radius). A Wilcoxon-Mann-Whitney test was performed to assess the differences in terms of time to fracture and the length of the fractured segment between the flat- and non-flat-sided instruments. Significance was set at p = 0.05. The differences in terms of time to fracture between non-flat and flat were statistically significant (p < 0.001). In addition, the differences in terms of fractured segment length were statistically significant (p = 0.034). The results of this study highlight the importance of flat-sided design in increasing the cyclic fatigue lifespan of NiTi rotary instruments