223 research outputs found
Gender Differences in the Mediation Between Childhood Abuse/Neglect and Trauma
Childhood abuse/neglect is a consistent concern in the United States and is related to future physical and mental health concerns. Studies have shown that childhood abuse/neglect can result in negative trauma appraisal, difficulties in emotion regulation, and lower levels of self-compassion. However, less is known about how gender impacts the relationship between negative trauma appraisal, difficulties in emotion regulation, and self-compassion with trauma symptoms in those with a history of childhood abuse/neglect. The purpose of this quantitative cross-sectional correlational study was to measure the impact of gender on the mediating variables (negative trauma appraisal, difficulties in emotion regulation, and self-compassion) and the outcome variable of trauma symptoms with a predictor variable of childhood abuse/neglect. Fairbairnian object-relations theory provided the framework for the study. Data were collected from 176 participants who completed an online survey. Data analyses included conditional process analyses with PROCESS-Macro Model 15. The results indicated that gender did not impact the relationships between the mediating variables and trauma symptoms. Although the null hypotheses could not be rejected, noteworthy findings are presented and discussed. The similarities for males and females in this model may have implications for future interventions. Research into trauma symptoms lead to positive social change by assisting in the improvement of interventions, education, and mitigation of future childhood abuse/neglect
Inhibitory effects associated with use of modified Photinus pyralis and Renilla reniformis luciferase vectors in dual reporter assays and implications for analysis of ISGs
Luciferase reporter constructs are widely used for analysis of gene regulation when characterizing promoter and enhancer elements. We report that the recently developed codon-modified Renilla luciferase construct included as an internal standard for cotransfection must be used with great caution with respect to the amount of DNA transfected. Also, the dual-luciferase reporter vectors encoding Photinus pyralis firefly or Renilla reniformis luciferase showed a linear increase in dose-response with increasing amounts of transfected DNA, but at higher levels of transfected DNA, a reduction in expressed levels of luciferase activity resulted. In addition, treatment with type I interferon (IFN) was found to significantly reduce levels of P. pyralis firefly and Renilla luciferase activity. In contrast, cells transfected with a green fluorescent protein (GFP) reporter construct showed no significant IFN-associated change. The reduction in luciferase activity resulting from IFN treatment was not due to IFN-mediated cytotoxicity, as no change in cellular propidium iodide (PI) staining was observed by flow cytometry. IFN treatment did not alter the levels of firefly luciferase activity in cell culture supernatants or the luciferase mRNA levels determined by quantitative real-time RT-PCR analysis. Based on these results, it is probable that the IFN-induced reduction in levels of luciferase activity detected in reporter assays occurs via a posttranscriptional mechanism. Thus, it is important to be aware of these complications when using luciferase reporter systems in general or for analyzing cytokine-mediated responsive regulation of target genes, particularly by the type I IFNs.No Full Tex
Observational constraints on the neutron star mass distribution
Radio observations of neutron star binary pulsar systems have constrained
strongly the masses of eight neutron stars. Assuming neutron star masses are
uniformly distributed between lower and upper bounds and , the
observations determine with 95\% confidence that and . These limits give observational
support to neutron star formation scenarios that suggest that masses should
fall predominantly in the range , and will also be
important in the interpretation of binary inspiral observations by the Laser
Interferometer Gravitational-wave Observatory.Comment: Postscript, 4 pages, NU-GR-
Binary inspiral, gravitational radiation, and cosmology
Observations of binary inspiral in a single interferometric gravitational
wave detector can be cataloged according to signal-to-noise ratio and
chirp mass . The distribution of events in a catalog composed of
observations with greater than a threshold depends on the
Hubble expansion, deceleration parameter, and cosmological constant, as well as
the distribution of component masses in binary systems and evolutionary
effects. In this paper I find general expressions, valid in any homogeneous and
isotropic cosmological model, for the distribution with and of
cataloged events; I also evaluate these distributions explicitly for relevant
matter-dominated Friedmann-Robertson-Walker models and simple models of the
neutron star mass distribution. In matter dominated Friedmann-Robertson-Walker
cosmological models advanced LIGO detectors will observe binary neutron star
inspiral events with from distances not exceeding approximately
, corresponding to redshifts of (0.26) for
(), at an estimated rate of 1 per week. As the binary system mass
increases so does the distance it can be seen, up to a limit: in a matter
dominated Einstein-deSitter cosmological model with () that limit
is approximately (1.7) for binaries consisting of two
black holes. Cosmological tests based on catalogs of the
kind discussed here depend on the distribution of cataloged events with
and . The distributions found here will play a pivotal role in testing
cosmological models against our own universe and in constructing templates for
the detection of cosmological inspiraling binary neutron stars and black holes.Comment: REVTeX, 38 pages, 9 (encapsulated) postscript figures, uses epsf.st
1994-95 Advisory Council on Social Security Technical Panel on Assumptions and Methods Final Report
The Panel\u27s major conclusions are: The intermediate projection of the Trustees Report for the Old-Age. Survivors. and Disability Insurance (OASDI) program provide a reasonable evaluation of the financial status. Although the Panel suggests that modifications be considered in various specific assumptions, the overall effect of those suggestions would not significantly change the financial status evaluation. There should be evolutionary implementation of procedures to indicate more adequately the uncertainties involved in the projections. Even though such uncertainties are unavoidable, stochastic analysis should be used to examine more explicitly the probabilities of alternative projections. It is emphasized that there should be an extended period during which the new procedures would supplement, rather than replace, the current methods of considering high-cost and low-cost projections and individual assumption sensitivity analysis. Evaluation of the long-range financial status should put less emphasis on the 75-year actuarial balance and the test of long-range close actuarial balance. Prior to enactment of legislation reforming the program, primary emphasis should be on the projected date the Trust Fund Ratio would fall below 100 percent; when definitive legislative revisions are adopted, subsequent long-range evaluation should compare up-dated projections with the intended results of the legislation. There should be a substantial expansion of SSA\u27s resources and its interaction with experts in related areas: increased recognition should be given to the interrelationships between OASDI and many public and private programs as well as other aspects of the economy. Social Security Administration (SSA) staff does high quality work, but is relatively small and works with inadequate resources. In addition to internal expansion, there should be greater use of outside consultants and contractual research; periodic comprehensive review by technical panels should be supplemented by ongoing arrangements for advice on specific matters
Exploring the âactive mechanismsâ for engaging rural-dwelling older men with dementia in a community technological initiative
Research has suggested ecopsychosocial initiatives can promote a sense of well-being and inclusion in people with dementia. However, few studies have elucidated the âactive mechanismsâ whereby such initiatives can achieve these outcomes, so hindering their generalisability. This is particularly pertinent when seeking to support community-dwelling older men with dementia who are reluctant to engage with traditional health and social care initiatives. This paper reports on a study that drew from the principles of Participatory Action Research to explore the âactive mechanismsâ of a technological initiative for older men (65+ years) with dementia in rural England. An individually-tailored, male-only initiative, using off-the-shelf computer game technology (e.g. iPad, Nintendo Wii and Microsoft Kinect) was delivered over a nine week period. Multiple qualitative methods were employed including; focus groups, open interviews and extensive reflexive field-notes, to gather data from the perspective of twenty-two men, fifteen care partners and five community volunteers. The data were analysed thematically and interpreted using a masculinity lens. Three mechanisms contributed to the initiativeâs success: the use of the technology; the male-only environment; and the empowering approach adopted. The paper argues that initiatives aimed at community-dwelling older men with dementia would be advised to consider these gendered experiences and ensure participants can maximise their masculine capital when participating in them, by providing enabling activities, non-threatening environments and empowering approaches of delivery
Aperture synthesis for gravitational-wave data analysis: Deterministic Sources
Gravitational wave detectors now under construction are sensitive to the
phase of the incident gravitational waves. Correspondingly, the signals from
the different detectors can be combined, in the analysis, to simulate a single
detector of greater amplitude and directional sensitivity: in short, aperture
synthesis. Here we consider the problem of aperture synthesis in the special
case of a search for a source whose waveform is known in detail: \textit{e.g.,}
compact binary inspiral. We derive the likelihood function for joint output of
several detectors as a function of the parameters that describe the signal and
find the optimal matched filter for the detection of the known signal. Our
results allow for the presence of noise that is correlated between the several
detectors. While their derivation is specialized to the case of Gaussian noise
we show that the results obtained are, in fact, appropriate in a well-defined,
information-theoretic sense even when the noise is non-Gaussian in character.
The analysis described here stands in distinction to ``coincidence
analyses'', wherein the data from each of several detectors is studied in
isolation to produce a list of candidate events, which are then compared to
search for coincidences that might indicate common origin in a gravitational
wave signal. We compare these two analyses --- optimal filtering and
coincidence --- in a series of numerical examples, showing that the optimal
filtering analysis always yields a greater detection efficiency for given false
alarm rate, even when the detector noise is strongly non-Gaussian.Comment: 39 pages, 4 figures, submitted to Phys. Rev.
Care home practitionersâ perceptions of the barriers and facilitators for using off-the-shelf gaming technology with people with dementia
Off-the-shelf digital gaming technology has been shown to support the well-being of people with dementia. Yet, to date, it is rarely adopted within dementia care practice, particularly within care homes. Drawing on a descriptive, qualitative approach, this is the first study that has sought to explore care home practitionersâ perceptions of the barriers and facilitators for using gaming technology within their workplace. Data were collected across eight focus groups in the south of England with a total of 39 care home workers. These were analysed inductively following the 6-stage thematic process as outlined by Braun and Clarke (2006). Three themes, constructed from the data suggested, the care environment, staff knowledge and skills for inclusive gaming, and staff perceptions about capabilities (their own and those of people with dementia) inhibited or facilitated the use of gaming technology in care homes. The findings were interpreted through a combination of the Capability, Opportunity, Motivation and Behaviour model and the Theoretical Domains Framework to provide theory-based insights into the mechanisms for supporting behaviour change and implementation within the care home context. We argue for the need to target wider institutional barriers alongside providing inclusive training for care staff on incorporating gaming technology within their person-centred care approaches. Through these mechanisms, they can be provided with the capabilities, opportunities and motivation to integrate gaming technology within their practice, and thus facilitate the process of culture change within care homes
Gravitational Waves from a Compact Star in a Circular, Inspiral Orbit, in the Equatorial Plane of a Massive, Spinning Black Hole, as Observed by LISA
Results are presented from high-precision computations of the orbital
evolution and emitted gravitational waves for a stellar-mass object spiraling
into a massive black hole in a slowly shrinking, circular, equatorial orbit.
The focus of these computations is inspiral near the innermost stable circular
orbit (isco)---more particularly, on orbits for which the angular velocity
Omega is 0.03 < Omega/Omega_{isco} < 1. The computations are based on the
Teukolsky-Sasaki-Nakamura formalism, and the results are tabulated in a set of
functions that are of order unity and represent relativistic corrections to
low-orbital-velocity formulas. These tables can form a foundation for future
design studies for the LISA space-based gravitational-wave mission. A first
survey of applications to LISA is presented: Signal to noise ratios S/N are
computed and graphed as functions of the time-evolving gravitational-wave
frequency for representative values of the hole's mass M and spin a and the
inspiraling object's mass \mu, with the distance to Earth chosen to be r_o = 1
Gpc. These S/N's show a very strong dependence on the black-hole spin, as well
as on M and \mu. A comparison with predicted event rates shows strong promise
for detecting these waves, but not beyond about 1Gpc if the inspiraling object
is a white dwarf or neutron star. This argues for a modest lowering of LISA's
noise floor. A brief discussion is given of the prospects for extracting
information from the observed wavesComment: Physical Review D, in press; 21 pages, 9 figures, 10 tables it is
present in the RevTeX fil
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Care home practitionersâ perceptions of the barriers and facilitators for using off-the-shelf digital gaming technology with people with dementia
Off-the-shelf digital gaming technology has been shown to support the well-being of people with dementia. Yet, to date, it is rarely adopted within dementia care practice, particularly within care homes. Drawing on a descriptive, qualitative approach, this is the first study that has sought to explore care home practitionersâ perceptions of the barriers and facilitators for using gaming technology within their workplace. Data were collected across eight focus groups in the south of England with a total of 39 care home workers. These were analysed inductively following the 6-stage thematic process as outlined by Braun and Clarke (2006). Three themes, constructed from the data suggested, the care environment, staff knowledge and skills for inclusive gaming, and staff perceptions about capabilities (their own and those of people with dementia) inhibited or facilitated the use of gaming technology in care homes. The findings were interpreted through a combination of the Capability, Opportunity, Motivation and Behaviour model and the Theoretical Domains Framework to provide theory-based insights into the mechanisms for supporting behaviour change and implementation within the care home context. We argue for the need to target wider institutional barriers alongside providing inclusive training for care staff on incorporating gaming technology within their person-centred care approaches. Through these mechanisms, they can be provided with the capabilities, opportunities and motivation to integrate gaming technology within their practice, and thus facilitate the process of culture change within care homes
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