Clinical Practice Guidelines for Recall and Maintenance of Patients with Tooth-Borne and Implant-Borne Dental Restorations

Purpose To provide guidelines for patient recall regimen, professional maintenance regimen, and at-home maintenance regimen for patients with tooth-borne and implant-borne removable and fixed restorations. Materials and Methods The American College of Prosthodontists (ACP) convened a scientific panel of experts appointed by the ACP, American Dental Association (ADA), Academy of General Dentistry (AGD), and American Dental Hygienists Association (ADHA) who critically evaluated and debated recently published findings from two systematic reviews on this topic. The major outcomes and consequences considered during formulation of the clinical practice guidelines (CPGs) were risk for failure of tooth- and implant-borne restorations. The panel conducted a round table discussion of the proposed guidelines, which were debated in detail. Feedback was used to supplement and refine the proposed guidelines, and consensus was attained. Results A set of CPGs was developed for tooth-borne restorations and implant-borne restorations. Each CPG comprised (1) patient recall, (2) professional maintenance, and (3) at-home maintenance. For tooth-borne restorations, the professional maintenance and at-home maintenance CPGs were subdivided for removable and fixed restorations. For implant-borne restorations, the professional maintenance CPGs were subdivided for removable and fixed restorations and further divided into biological maintenance and mechanical maintenance for each type of restoration. The at-home maintenance CPGs were subdivided for removable and fixed restorations. Conclusions The clinical practice guidelines presented in this document were initially developed using the two systematic reviews. Additional guidelines were developed using expert opinion and consensus, which included discussion of the best clinical practices, clinical feasibility, and risk-benefit ratio to the patient. To the authors’ knowledge, these are the first CPGs addressing patient recall regimen, professional maintenance regimen, and at-home maintenance regimen for patients with tooth-borne and implant-borne restorations. This document serves as a baseline with the expectation of future modifications when additional evidence becomes available

A Systematic Review of Recall Regimen and Maintenance Regimen of Patients with Dental Restorations. Part 2: Implant-Borne Restorations

Purpose To evaluate the current scientific evidence on patient recall and maintenance of implant-supported restorations, to standardize patient care regimens and improve maintenance of oral health. An additional purpose was to examine areas of deficiency in the current scientific literature and provide recommendations for future studies. Materials and Methods An electronic search for articles in the English language literature from the past 10 years was performed independently by multiple investigators using a systematic search process. After application of predetermined inclusion and exclusion criteria, the final list of articles was reviewed to meet the objectives of this review. Results The initial electronic search resulted in 2816 titles. The systematic application of inclusion and exclusion criteria resulted in 14 articles that satisfied the study objectives. An additional 6 articles were added through a supplemental search process for a total of 20 studies. Of these, 11 were randomized controlled clinical trials, and 9 were observational studies. The majority of the studies (15 out of 20) were conducted in the past 5 years and most studies were conducted in Europe (15), followed by Asia (2), South America (1), the United States (1), and the Middle East (1). Results from the qualitative data on a combined 1088 patients indicated that outcome improvements in recall and maintenance regimen were related to (1) patient/treatment characteristic (type of prosthesis, type of prosthetic components, and type of restorative materials); (2) specific oral topical agents or oral hygiene aids (electric toothbrush, interdental brush, chlorhexidine, triclosan, water flossers) and (3) professional intervention (oral hygiene maintenance, and maintenance of the prosthesis). Conclusions There is minimal evidence related to recall regimens in patients with implant-borne removable and fixed restorations; however, a considerable body of evidence indicates that patients with implant-borne removable and fixed restorations require lifelong professional recall regimens to provide biological and mechanical maintenance, customized for each patient. Current evidence also demonstrates that the use of specific oral topical agents and oral hygiene aids can improve professional and at-home maintenance of implant-borne restorations. There is evidence to demonstrate differences in mechanical and biological maintenance needs due to differences in prosthetic materials and designs. Deficiencies in existing evidence compel the forethought of creating clinical practice guidelines for recall and maintenance of patients with implant-borne dental restorations

The Photovoltaic Array Space Power plus Diagnostics (PASP Plus) Flight Experiment

An overview of the Photovoltaic Array Space Power Plus Diagnostics (PASP Plus) flight experiment is presented in outline and graphic form. The goal of the experiment is to test a variety of photovoltaic cell and array technologies under various space environmental conditions. Experiment objectives, flight hardware, experiment control and diagnostic instrumentation, and illuminated thermal vacuum testing are addressed

Effect of 0.2% peracetic acid disinfection on the horizontal dimension of implant framework indexed with two autopolymerized acrylic resins.

BackgroundTo minimize misfit between prosthesis and implant, the welding of the implant fixed partial denture (IFPD) framework is recommended and autopolymerized acrylic resin (AR) is the material of choice for the indexing process. As for any prosthetic device that comes into contact with saliva and blood in the oral cavity, IFPD indexed with AR must be disinfected before sending to the laboratory. However, disinfection procedures are often neglected for fear of shrinkage or distortion caused by a dimensional change of the acrylic resin. Peracetic acid is a high-level disinfectant agent at low concentrations and immersion time, with no reported toxic residues, and it is not inactivated in the presence of organic matter when compared to other disinfectants. This study aimed to evaluate the influence of 0.2% peracetic acid disinfectant solution after different storage media and times on the horizontal dimension of IFPD frameworks indexed with AR.Material and methodsIFPD frameworks were indexed with two AR: group 1 Duralay and group 2 Pattern Resin LS. Each group was further divided into five subgroups according to disinfection procedure and storage medium: no disinfection and dry storage, no disinfection and water storage, 0.2% peracetic acid disinfection and water storage, 0.2% peracetic acid disinfection and peracetic acid storage, and 0.2% peracetic acid disinfection and dry storage. The horizontal dimension of the specimens and an average was established for analysis. Measurements were performed at four different storage times (hours): T0, T24, T48, T168.ResultsNo statistical differences were found when T0 was compared to T168 for Pattern resin groups submitted to disinfection and storage in water (group 2b, p = 1.000) or peracetic acid solution (group 2c, p = 0.352). For Duralay groups, the use of peracetic acid solution did not affect the horizontal dimension of the specimens when T0 was compared to T168 only with water as a storage medium (group 1b, p = 1.000). Additionally, T0 did not differ from T24 for groups 1c (p = 0.553), 2b (p = 1.000), 2d (p = 0.234), and 2e (p = 1.000) and from T48 for groups 1d (p = 0.118) and 2b (p = 1.000).ConclusionWithin the studied conditions, the use of 0.2% peracetic acid can be safely used as a disinfectant solution regarding dimensional stability of AR-indexed IFPD until 7 days of storage. Horizontal discrepancies are dependent on acrylic resin type, time, and medium of storage

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences.

Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral vectors has proven challenging. In this study, we deploy LV-MPRA (lentiviral vector-based, massively parallel reporter assay), an approach that simultaneously analyzes thousands of synthetic DNA fragments in parallel to identify sequence-intrinsic and lineage-specific enhancer function at near-base-pair resolution. We demonstrate the power of LV-MPRA in elucidating the boundaries of previously unknown intrinsic enhancer sequences of the human β-globin locus control region. Our approach facilitated the rapid assembly of novel therapeutic βAS3-globin lentiviral vectors harboring strong lineage-specific recombinant control elements capable of correcting a mouse model of sickle cell disease. LV-MPRA can be used to map any genomic locus for enhancer activity and facilitates the rapid development of therapeutic vectors for treating disorders of the hematopoietic system or other specific tissues and cell types

The significance of surgically modifying soft tissue phenotype around fixed dental prostheses: An American Academy of Periodontology best evidence review

BackgroundThis systematic review endeavored to investigate the effect of soft tissue phenotype modification therapy (PhMT- s) at sites with a tooth or an implant supported fixed dental prosthesis.MethodsA comprehensive literature search was conducted by two independent examiners to identify relevant studies reporting differences in clinical, esthetic, or radiographic outcomes of interest between sites underwent PhMT- s and sites that remained untreated. Risk of bias assessment was calculated for all included studies. Meta- analyses involving endpoints of interest were performed when feasible.ResultsNo controlled studies pertaining to tooth sites were identified. A total of six articles reporting on the outcomes of buccal soft tissue phenotype modification around implants were selected, of which, five were included in the meta- analyses. Quantitative analyses showed a weighted mean difference (WMD) of 0.98 mm (95% CI = 0.25 to 1.72 mm, P = 0.009) for change of tissue thickness; a WMD of - 4.87% (95% CI = - 34.27 to 24.53%, P = 0.75) for bleeding on probing (BOP); a WMD of 0.36 mm (95% CI = 0.12 to 0.59 mm, P = 0.003) for mucosal recession (MR); a WMD of 0.13 mm (95% CI = - 0.11 to 0.36 mm, P = 0.30 for probing depth (PD); a WMD of 1.08 (95% CI = - 0.39 to 2.55, P = 0.15) for pink esthetic score (PES), and a WMD of 0.40 mm (95% CI = - 0.34 to 1.14 mm, P = 0.28) for marginal bone loss (MBL).ConclusionsSurgical modification of peri- implant soft tissue phenotype via PhMT- s may decrease the amount of MR. Future clinical trials are needed to warrant the clinical benefits of modifying soft tissue phenotype around tooth- supported restorations.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/1/jper10458-sup-0006-figureS1F.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/2/jper10458_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/3/jper10458-sup-0001-figureS1A.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/4/jper10458-sup-0005-figureS1E.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/5/jper10458-sup-0004-figureS1D.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/6/jper10458-sup-0003-figureS1C.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/7/jper10458-sup-0002-figureS1B.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154660/8/jper10458.pd

Stability of bulk Ba2YCu3O(7-x) in a variety of environments

Small bars of ceramic Ba2YCu3O(7-x) were fabricated and subjected to environments similar to those that might be encountered during some NASA missions. These conditions include ambient conditions, high humidity, vacuum, and high fluences of electrons and protrons. The normal state resistivity or critical current density (J sub c) were monitored during these tests to assess the stability of the material. When normal state resistivity is used as a criterion, the ambient stability of these samples was relatively good, exhibiting only a 2 percent degradation over a 3 month period. The humidity stability was shown to be very poor, and to be a steep function of temperature. Samples stored at 50 C for 40 min increased in normal state resistivity by four orders of magnitude. Kinetic analysis indicates that the degradation reaction is second order with water vapor concentration. It is suspected that humidity degradation also accounts for the ambient instability. The samples were stable to vacuum over a period of at least 3 months. Degradation of J sub c in a 1 MeV electron fluence of 9.7 x 10 to the 14th e(-)/sq cm was determined to be no more than about 2 percent. Degradation of J sub c in a 8.7 x 10 to the 14th p(+)/sq cm of 42 MeV protons was found to be grain size dependent. Samples with smaller grain size and initial J sub c of about 240 A/sq cm showed no degradation. while that with larger grain size and an initial J sub c of about 30 A/sq cm degraded to 37 percent of its original value

Sensory traits, color, and shelf life of low-dose irradiated, raw, ground beef patties

Irradiation of raw ground beef patties had minimal effects on flavor and aroma of patties after cooking. Oxidative rancidity increased when patties were irradiated in aerobic but not in vacuum packages. Irradiation of vacuum-packaged ground beef patties produced a more stable color. In both packaging types, irradiation significantly reduced microbial growth during storage

Sensory traits, color, and shelf life of low-dose irradiated, precooked, ground beef patties

Irradiation did not influence bitter, bloody, burnt, chemical, fat-like, juiciness, liver-like, beef identity, metallic, rancid, sour, sweet, and toughness flavor/textural attributes, beef aroma, or off-odor in precooked ground beef patties. Irradiation slightly increased the animal hair flavor note, but intensity levels were <1 on the 15-point sensory scale. Except for 10% fat non-irradiated controls, reheated precooked patties had a slight sour, ammonia-like, top note. Irradiation at 3.5 kilograys (kGy) increased external redness in vacuum-packaged patties, but not in aerobic packages. Aerobic packaging with or without irradiation decreased external precooked redness. Oxidative rancidity increased when patties were irradiated in aerobic but not in vacuum packages. Reduction of oxygen in vacuum bags extended the shelf life of the precooked ground beef patties, at least in terms of oxidative rancidity. Precooking ground beef patties, irrespective of irradiation or packaging type, posed sensory disadvantages, and improvements to the precooking process are needed before irradiating at low-dose levels is appropriate

Survey form and methods for second CASC survey of academic research computing and data center usage

Full analysis paper is in the ACM PEARC'21 Proceedings: ACM ISBN 978-1-4503-8292-2/21/07. https://doi.org/10.1145/3437359.3465589Availability of cloud-based resource delivery modes is transforming many areas of computing. Many academic institutions that support research computing facilities are considering and changing their mix of on-premise and remote facilities (including in particular use of commercial cloud facilities). A working group of the Coalition for Academic Scientific Computation (an educational nonprofit 501(c)(3) organization) has conducted an annual survey of higher education institutions now for two years running, with intentions of continuing. This survey asks a number of questions of academic institutions regarding their investments in research and data-oriented computing facilities, the extent of those facilities, and institutional activities. This technical report includes the full text of the survey instrument itself and describes the methods and survey population.http://deepblue.lib.umich.edu/bitstream/2027.42/167731/1/CASC 2021 Survey Methods and Form.pdfDescription of CASC 2021 Survey Methods and Form.pdf : Survey form and methods to accompany the full publication in the ACM PEARC'21 Proceedings, ACM ISBN 978-1-4503-8292-2/21/07. https://doi.org/10.1145/3437359.3465589SEL