65 research outputs found

    Light interception principally drives the understory response to boxelder invasion in riparian forests

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    Since several decades, American boxelder (Acer negundo) is replacing white willow (Salix alba) riparian forests along southern European rivers. This study aims to evaluate the consequences of boxelder invasion on understory community in riparian areas. We determined the understory species richness, composition and biomass in boxelder and white willow stands located in three riparian forests, representative of three rivers with distinct hydrological regimes. We investigated correlation of these variables to soil moisture and particle size, main soil nutrient stocks, potential nitrification and denitrification, tree canopy cover and photosynthetic active radiation (PAR) at the ground level. A greenhouse experiment was then conducted to identify the causal factors responsible for changes in the understory. The effect of soil type, PAR level and water level on the growth and the biomass production of Urtica dioica were examined. A lower plant species richness and biomass, and a modification of community composition were observed for boxelder understory in all sites, regardless of their environmental characteristics. The strongest modification that follows boxelder invasion was the decline in U. dioica, the dominant species of the white willow forest understory. These differences were mainly correlated with a lower incident PAR under boxelder canopy. The greenhouse experiment identified PAR level as the main factor responsible for the changes in U. dioica stem number and biomass. Our results indicate that adult boxelder acts as an ecosystem engineer that decreases light availability. The opportunistic invasion by boxelder leads to important understory changes, which could alter riparian ecosystem functioning

    Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis

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    10.1260/2040-2295.4.1.23Journal of Healthcare Engineering4123-4

    A comprehensive overview of radioguided surgery using gamma detection probe technology

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    The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology

    Fabrication and characterization of 15Cr-15Ni austenitic steel cladding tubes for sodium fast reactors

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    International audienceTwo fabrication routes requiring industrial facilities are being conducted to produce several hundred 15Cr-15Ni claddingtubes. The processing methods involve varying degrees of cold work and different heat treatment conditions. In order to ensure that the specifications are fulfilled, both batches of tubes are fully characterized regarding several aspects. The microstructure isobserved using optical and electron microscopy. A refinement of the grain size is detected in the inner diameter of one batch, which is caused by a nitrogen contamination revealed by glow discharge mass spectrometry analysis. The precipitates are also carefully analyzed. Selective dissolutions are performed on both batches to determine their mass fractions. The precipitates (TiC, TiN and Ti2_2CS) are identified using X-ray diffraction. The titanium content in solid solution is measured and the resulting values are analyzed to assess the quality of the last solution annealing. The tensile properties measured at room temperature comply with those expected for this steel grade. On the basis of our results and considering past experience with cladding irradiated in Phenix reactor a good behavior in pile can be foreseen for these tubes

    Singularities of tensile behavior of advanced austenitic steels obtained by different cold processes

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    International audienceWork-hardened titanium stabilized austenitic steels have been chosen as cladding material for ASTRID (Advanced Sodium Technological Reactor for Industrial Demonstration). The cold-worked level and the stabilization by titanium allow delaying the beginning of the swelling under irradiation and make 15Cr-15Ni steel suitable for use up to 110 dpa at least which is the required target for ASTRID first core. Several fabrication routes involving three cold processes (i.e. drawing, pilgering or swaging) are conducted to produce 15Cr-15Ni cladding tubes. This study investigates the effects of processing paths using various heat treatments and amount of cold work (from 17% to 37%) on the final microstructure and the tensile properties. The microstructure is characterized by examinations in the optical and electron microscopes. Tensile tests are carried out on both longitudinal and circumferential directions by means of respectively tile and ring tensile specimens for temperatures between 20°C and 700°C. The stress-strain curves show strong temperature dependencies of strength and ductility. Both yield strength and ultimate tensile strength decrease linearly from 600-800 MPa below to 450-550 MPa as test temperature increases from 20°C to 700°C. But, on contrary to most metals, the effect of temperature on ductility is not monotonous, with uniform elongation decreasing between 20°C and 200°C, increasing up to 500-600°C and finally decreasing above 600°C (see Figure 1). Very low uniform elongation is thus measured in both directions at 200°C. For the same cold worked state, no effect of the different processes could be highlighted. However, the higher the amount of cold work ( ~ 37%), the higher the yield strength and the ultimate strength and the lower the uniform elongation. In the circumferential direction, the levels of strength are slightly higher and the uniform elongations are weaker than those measured in the longitudinal direction, suggesting a low degree of anisotropy. Figure 1: Uniform elongations measured as a function of the temperature and comparison with an interpolated law proposed for 20-25% cold worked 15Cr-15Ni titanium stabilized stee

    Comprehension des mecanismes de deformation de tubes de gaine en acier austenitique 15-15Ti AIM1

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    International audienceLes reacteurs nucleaires de IVeme Generation sont en phase de developpement dans de nombreux pays. Ils doivent repondre a de nouvelles exigences en matiere de surete, d'efficacite energetique, et de recyclage du combustible nucleaire.La France, par l'intermediaire du CEA, etudie de nouveaux concepts de reacteurs a neutrons rapides refroidis au sodium (RNR-Na), pour lesquels les tubes de gaine des assemblages combustibles seront en acier 15-15Ti AIM1 (Austenitic Improved Material 1).Il s'agit d'un acier inoxydable austenitique avance stabilise au titane, dont la composition est optimisee en elements mineurs (rapport Ti/C, Si, P) pour ameliorer sa resistance au gonflement. Cet acier presente une singularite de comportement plastique, visible en traction une chute importante des allongements homogene et total entre 20 et 200°C. Cette singularite, presente a l'etat hypertrempe, s'accentue a l'etat ecroui correspondant a l'etat metallurgique d'utilisation des tubes de gaine. Le but de cette etude est de determiner les mecanismes de deformation impliques dans cette evolution de comportement.La demarche suivie repose sur une approche multi-echelle basee sur la realisation d'essais de traction dont certains sont couples a des examens au MEB/MET in-situ. Des examens au MEB-EBSD permettent une etude microstructurale globale a l'echelle de plusieurs grains, completee par des observations au MET plus locales au sein d'un grain. L'analyse des cartographies EBSD, apres deformation en traction ex-situ, montrent une evolution des mecanismes de deformation entre 20 et 200°C A 20°C, on met en evidence du glissement, du stockage des dislocations et du maclage mecanique alors qu'a 200°C, le maclage mecanique n'est plus present. Plus precisement, pour les essais realises en traction MEB in-situ a 20°C, on observe que le maclage mecanique s'active uniquement a partir d'une contrainte critique d'activation dont la valeur se situe en dessous de Rm (Rm ~ 580 MPa). Les essais de traction couples a des observations au MET in-situ a 20°C mettent en evidence le role de la dissociation des dislocations parfaites dans la formation des macles mecaniques.En conclusion, le maclage mecanique present a 20°C permet une consolidation importante. Cette consolidation retarde la localisation de la deformation et explique l'allongement plus important obtenu a 20°C par rapport a 200°C

    Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers.

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    International audienceCancer cells frequently express genes normally active in male germ cells. ATAD2 is one of them encoding a conserved factor harbouring an AAA type ATPase domain and a bromodomain. We show here that ATAD2 is highly expressed in testis as well as in many cancers of different origins and that its high expression is a strong predictor of rapid mortality in lung and breast cancers. These observations suggest that ATAD2 acts on upstream and basic cellular processes to enhance oncogenesis in a variety of unrelated cell types. Accordingly, our functional studies show that ATAD2 controls chromatin dynamics, genome transcriptional activities and apoptotic cell response. We could also highlight some of the important intrinsic properties of its two regulatory domains, including a functional cross-talk between the AAA ATPase domain and the bromodomain. Altogether, these data indicate that ATAD2 overexpression in somatic cells, by acting on basic properties of chromatin, may contribute to malignant transformation
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