The Platte as a Prairie River: A Response to Johnson and Boettcher

Johnson and Boettcher (2000) question the status of the presettlement Platte River as a prairie river, and they argue that it was a wooded river traversing a prairie landscape. Here we review evidence in support of the prairie river concept, suggesting the channels of the Platte were predominantly open and largely absent of trees. Direct support for a prairie river is found in the detailed map drawn by Lieutenant Woodbury in locating the site for Fort Kearny in 1847. Woodbury showed a thin strip of timber, located in an area that appeared to be elevated above the influence of active river flows. Woodbury also illustrated the main channel as having vegetated islands only in one location, with only a scattering [of] trees along the banks. Historical accounts, an examination of historical perspectives, the distribution of land survey witness trees, a lack of regeneration of trees following supposed deforestation, and population changes in bird distributions over the past 100 years also support the prairie river concept. We argue woodland development is not true restoration in this area. Given current conditions, we suggest that long term management should be for a mosaic of habitats for migratory birds and other species including 10% open river channel in the Big Bend reach of the Platte River in central Nebraska

Supporting Treatment Adherence Readiness through Training (START) for patients with HIV on antiretroviral therapy: study protocol for a randomized controlled trial.

BackgroundFew HIV antiretroviral adherence interventions target patients before they start treatment, assess adherence readiness to determine the timing of treatment initiation, or tailor the amount of adherence support. The Supporting Treatment Adherence Readiness through Training (START) intervention, based on the information-motivation-behavioral skills model of behavior change, is designed to address these gaps with the inclusion of (1) brief pill-taking practice trials for enhancing pretreatment adherence counseling and providing a behavioral criterion for determining adherence readiness and the timing of treatment initiation and (2) a performance-driven dose regulation mechanism to tailor the amount of counseling to the individual needs of the patient and conserve resources. The primary aim of this randomized controlled trial is to examine the effects of START on antiretroviral adherence and HIV virologic suppression.Methods/designA sample of 240 patients will be randomized to receive START or usual care at one of two HIV clinics. Primary outcomes will be optimal dose-taking adherence (>85 % prescribed doses taken), as measured with electronic monitoring caps, and undetectable HIV viral load. Secondary outcomes will include dose-timing adherence (>85 % prescribed doses taken on time) and CD4 count. Primary endpoints will be month 6 (short-term effect) and month 24 (to test durability of effect), though electronic monitoring will be continuous and a fully battery of assessments will be administered every 6 months for 24 months.DiscussionIf efficacious and cost-effective, START will provide clinicians with a model for assessing patient adherence readiness and helping patients to achieve and sustain readiness and optimal treatment benefits.Trial registrationClinicalTrials.gov identifier NCT02329782 . Registered on 22 December 2014

Predicting peak load of the femoral neck using structural parameters

The current clinical standard for diagnosing osteoporosis uses measurements of bone mineral density (BMD) by dual energy X-ray absorptiometry (DXA). This measurement only partially explains the strength of bones and fails to incorporate other factors that alter bone quality. The aim of this study was to investigate how micro and macro cortical bone structures along the length of the femoral neck relate to the peak load of the proximal femur. Structural measurements were taken from microCT images of ten murine right femurs at ten locations along the femoral neck. These specimens were then tested to failure. The major diameter, minor diameter, cortical thickness, cross sectional area, cortical area, and cortical fraction were measured and correlated to the peak compressive load. The highest significant correlation was found using major diameter (R2 = 0.6) or cross sectional area (R2 = 0.59). Significant correlations for the major diameter were found between 40% - 60% along the femoral neck, while cross sectional area had significant correlations between 40% - 80% of the femoral neck. By combining major diameter and cortical area in a multivariable regression, R2 improved to 0.66. Understanding the contribution of cortical structure to peak load will allow for improved characterization of bone properties in both healthy and diseased bone, and provide indices for targeted imaging to better diagnosis osteoporosis

1861-12-10 W. J. Currier requests a pass to the 2nd Regiment

https://digitalmaine.com/cw_me_2nd_regiment_corr/1218/thumbnail.jp

The value of electrical stimulation as an exercise training modality

Voluntary exercise is the traditional way of improving performance of the human body in both the healthy and unhealthy states. Physiological responses to voluntary exercise are well documented. It benefits the functions of bone, joints, connective tissue, and muscle. In recent years, research has shown that neuromuscular electrical stimulation (NMES) simulates voluntary exercise in many ways. Generically, NMES can perform three major functions: suppression of pain, improve healing of soft tissues, and produce muscle contractions. Low frequency NMES may gate or disrupt the sensory input to the central nervous system which results in masking or control of pain. At the same time NMES may contribute to the activation of endorphins, serotonin, vasoactive intestinal polypeptides, and ACTH which control pain and may even cause improved athletic performances. Soft tissue conditions such as wounds and inflammations have responded very favorably to NMES. NMES of various amplitudes can induce muscle contractions ranging from weak to intense levels. NMES seems to have made its greatest gains in rehabilitation where directed muscle contractions may improve joint ranges of motion correct joint contractures that result from shortening muscles; control abnormal movements through facilitating recruitment or excitation into the alpha motoneuron in orthopedically, neurologically, or healthy subjects with intense sensory, kinesthetic, and proprioceptive information; provide a conservative approach to management of spasticity in neurological patients; by stimulation of the antagonist muscle to a spastic muscle stimulation of the agonist muscle, and sensory habituation; serve as an orthotic substitute to conventional bracing used with stroke patients in lieu of dorsiflexor muscles in preventing step page gait and for shoulder muscles to maintain glenohumeral alignment to prevent subluxation; and of course NMES is used in maintaining or improving the performance or torque producing capability of muscle. NMES in exercise training is our major concern

Subclinical myocardial disease by cardiac magnetic resonance imaging and spectroscopy in healthy HIV/Hepatitis C virus-coinfected persons.

Objective The contribution of hepatitis C virus (HCV) infection to the risk of heart failure in human immunodeficiency virus (HIV)-coinfected persons is unknown. The objective was to characterize cardiac function and morphology in HIV-treated coinfected persons. Methods In a cross-sectional study, HIV-infected patients virologically suppressed on antiretroviral therapy without known cardiovascular disease or diabetes mellitus underwent cardiac magnetic resonance imaging and spectroscopy for measures of cardiac function, myocardial fibrosis, and steatosis. Results The study included 18 male patients with a median age of 44 years. Of these, 10 had untreated HCV coinfection and eight had HIV monoinfection. Global systolic and diastolic function in the cohort were normal, and median myocardial fat content was 0.48% (interquartile range 0.35-1.54). Left ventricular (LV) mass index and LV mass/volume ratio were significantly greater in the HIV/HCV-coinfected group compared with the HIV-monoinfected group. In the HIV-monoinfected group, there was more myocardial fibrosis as measured by extracellular volume fraction. Conclusions There were differences between HIV/HCV-coinfected and HIV-monoinfected patients in cardiac structure and morphology. Larger studies are needed to examine whether HIV and HCV independently contribute to mechanisms of heart failure

Dengue virus downregulates TNFR1- and TLR3-stimulated NF-kB activation by targeting RIPK1

Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a productive infection. Here we report that the DENV NS3 protein targets RIPK1 (Receptor Interacting Protein Kinase I), a central mediator of inflammation and cell death, and decreases intracellular RIPK1 levels during DENV infection. The interaction of NS3 with RIPK1 results in the inhibition of NF-κB activation in response to TNFR or TLR3 stimulation. Also, we observed that the effects of NS3 on RIPK1 were independent of NS3 protease activity. Our data demonstrate a novel mechanism by which DENV suppresses normal cellular functions to evade host innate immune response

Effect of Pivot Point on Aerodynamic Force and Vortical Structure of Pitching Flat Plate Wings

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106512/1/AIAA2013-792.pd