Daughters of Single Fathers: Working as a Team

In this paper, we consider the perspectives of daughters of single fathers as they reflect on their experiences and relationships with their fathers. The paper provides an opportunity to consider an under-represented group in the literature on single parent families. Three themes emerge from the qualitative research design: parental expectations and involvement, household tasks, and family relationships. We consider these themes in light of the work done by Bronte-Tinkew et al (2010) and Risman (1986) regarding the involvement and support of single fathers in the lives of their children. We conclude by providing suggestions for teachers and other professionals regarding single fathers and their daughters

Systematic review of micro-RNA expression in pre-eclampsia identifies a number of common pathways associated with the disease

Background: Pre-eclampsia (PE) is a complex, multi-systemic condition of pregnancy which greatly impacts maternal and perinatal morbidity and mortality. MicroRNAs (miRs) are differentially expressed in PE and may be important in helping to understand the condition and its pathogenesis. Methods: Case-control studies investigating expression of miRs in PE were collected through a systematic literature search. Data was extracted and compared from 58 studies to identify the most promising miRs associated with PE pathogenesis and identify areas of methodology which could account for often conflicting results. Results: Some of the most frequently differentially expressed miRs in PE include miR-210, miR-223 and miR-126/126* which associate strongly with the etiological domains of hypoxia, immunology and angiogenesis. Members of the miR-515 family belonging to the imprinted chromosome 19 miR cluster with putative roles in trophoblast invasion were also found to be differentially expressed. Certain miRs appear to associate with more severe forms of PE such as miR-210 and the immune-related miR-181a and miR-15 families. Patterns of miR expression may help pinpoint key pathways (e.g. IL-6/miR-223/STAT3) and aid in untangling the heterogeneous nature of PE. The detectable presence of many PE-associated miRs in antenatal circulatory samples suggests their usefulness as predictive biomarkers. Further progress in ascertaining the clinical value of miRs and in understanding how they might contribute to pathogenesis is predicated upon resolving current methodological challenges in studies. These include differences in diagnostic criteria, cohort characteristics, sampling technique, RNA isolation and platform-dependent variation in miR profiling. Conclusion: Reviewing studies of PE-associated miRs has revealed their potential as informants of underlying target genes and pathways relating to PE pathogenesis. However, the incongruity in results across current studies hampers their capacity to be useful biomarkers of the condition

Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System

Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups. Although we have a relatively detailed understanding of the genetics and evolution of the innate immune system of animals, we know little about social immunity. Addressing this knowledge gap is crucial for understanding how life-history traits influence immunity, and identifying if trade-offs exist between innate and social immunity. Hygienic behavior in the Western honey bee, Apis mellifera, provides an excellent model for investigating the genetics and evolution of social immunity in animals. This heritable, colony-level behavior is performed by nurse bees when they detect and remove infected or dead brood from the colony. We sequenced 125 haploid genomes from two artificially selected highly hygienic populations and a baseline unselected population. Genomic contrasts allowed us to identify a minimum of 73 genes tentatively associated with hygienic behavior. Many genes were within previously discovered QTLs associated with hygienic behavior and were predictive of hygienic behavior within the unselected population. These genes were often involved in neuronal development and sensory perception in solitary insects. We found that genes associated with hygienic behavior have evidence of positive selection within honey bees (Apis), supporting the hypothesis that social immunity contributes to fitness. Our results indicate that genes influencing developmental neurobiology and behavior in solitary insects may have been co-opted to give rise to a novel and adaptive social immune phenotype in honey bees.York University Librarie

Testing correlates of lifetime exposure to print fiction following a multi-method approach: Evidence from young and older readers

Two pre-registered studies investigated associations of lifetime exposure to fiction, applying a battery of self-report, explicit and implicit indicators. Study 1 (N=150 university students) tested the relationships between exposure to fiction and social and moral cognitive abilities in a lab setting, using a correlational design. Results failed to reveal evidence for enhanced social or moral cognition with increasing lifetime exposure to narrative fiction. Study 2 followed a cross-sectional design and compared 50-80 year-old fiction experts (N=66), non-fiction experts (N=53), and infrequent readers (N=77) regarding social cognition, general knowledge, imaginability, and creativity in an online setting. Fiction experts outperformed the remaining groups regarding creativity, but not regarding social cognition or imaginability. In addition, both fiction and non-fiction experts demonstrated higher general knowledge than infrequent readers. Taken together, the present results do not support theories postulating benefits of narrative fiction for social cognition, but suggest that reading fiction may be associated with a specific gain in creativity, and that print (fiction or non-fiction) exposure has a general enhancement effect on world knowledge

Reading fictional narratives to improve social and moral cognition: the influence of narrative perspective, transportation, and Identification

There is a long tradition in philosophy and literary criticism of belief in the social and moral benefits of exposure to fiction, and recent empirical work has examined some of these claims. However, little of this research has addressed the textual features responsible for the hypothesized cognitive effects. We present two experiments examining whether readers’ social and moral cognition are influenced by the perspective from which a narrative is told (voice and focalization), and whether potential effects of perspective are mediated by transportation into the story or by identification with the protagonist. Both experiments employed a between-subjects design in which participants read a short story, either in the first-person voice using internal focalization, third-person voice using internal focalization, or third-person voice using external focalization. Social and moral cognition was assessed using a battery of tasks. Experiment 1 (N=258) failed to detect any effects of perspective or any mediating roles of transportation or identification. Implementing a more rigorous adaptation of the third-person story using external focalization, Experiment 2 (N=262) largely replicated this pattern. Taken together, the evidence reported here suggests that perspective does not have a significant impact on the extent to which narratives modulate social and moral cognition, either directly or indirectly via transportation and identification

Learning from Fiction

The idea that fictions may educate us is an old one, as is the view that they distort the truth and mislead us. While there is a long tradition of passionate assertion in this debate, systematic arguments are a recent development, and the idea of empirically testing is particularly novel. Our aim in this chapter is to provide clarity about what is at stake in this debate, what the options are, and how empirical work does or might bear on its resolution. We distinguish between merely influencing people’s opinions and providing genuine learning, where the latter requires that the source of the change in opinion should be reliable. Other important ideas here are the extent to which authors of fiction may be considered to provide testimony, or something like it, and the possibility of recognizing an unstated purpose in the project of the fictional work. We ask whether fictions can furnish us not merely with ideas but with reasons for believing them, perhaps by constituting thought experiments. We consider whether the focus should be on understanding rather than on knowledge, and whether fictions can inform us about the qualities of another’s experiences. We briefly describe some experimental work of recent decades and suggest that the evidence for learning from fiction is currently meagre

Cognitive Effects and Correlates of Reading Fiction: Two Pre-Registered Multi-Level Meta-Analyses

Despite significantly increasing research efforts, the psychological effects of reading fiction remain under debate. We present two pre-registered meta-analyses synthesizing cognitive effects and correlates of reading fiction. In meta-analysis 1 (371 effect sizes/70 experiments), reading fiction led to significant small-sized cognitive benefits, g = 0.14, 95% CI [0.06, 0.21]. This effect of fiction reading was moderated by comparison group (effects were greater when reading fiction was compared with watching fiction or reading nothing than when reading fiction was compared with reading nonfiction) and outcome variable (significant effects emerged for empathy and mentalizing only). In meta-analysis 2 (559 effect sizes/114 studies reporting correlations), lifetime exposure to print fiction was linked with significant small-sized cognitive benefits, r = .16, 95% CI [.13, .19]. This effect was moderated by outcome variable (effects were greatest for verbal abilities, followed by general cognitive abilities and empathy/mentalizing/outgroup judgments), fictionality of the print material (greater effects were found for fiction than nonfiction), publication status (published work exhibited greater effects than unpublished work), type of assessment measure (larger effects emerged when neither the outcome nor print exposure were assessed via self-report, than when either the outcome or print exposure were assessed via self-report), participant group (community samples showed greater effects than student samples), study design (greater effects were found for correlational than for experimental designs), and percentage of female participants (via a negative relationship with cognitive benefits). Together, these meta-analyses provide robust evidence for a small-sized positive relationship between reading fiction and cognitive benefits

Varroa destructor economic injury levels and pathogens associated with colony losses in Western Canada

IntroductionThe honey bee parasitic mite, Varroa destructor, is considered the main factor associated with winter colony losses. To control this mite, beekeepers must implement Integrated Pest Management (IPM) strategies. An effective IPM strategy is based on timely monitoring of mite levels to treat the colonies when the mites reach an economic threshold and before they grow to damaging levels (economic injury level). Additionally, concerns have been raised about the possible interaction between V. destructor and other stressors; stressors acting additively or synergistically may lead to high colony mortality.MethodologyVarroa destructor levels were recorded in colonies from five regions of British Columbia, Canada: Lower Mainland, Kootenay, Okanagan, Cariboo, and Peace. Mite levels were analyzed for associations with colony strength and mortality, as well as with other pathogens that were identified using total RNA sequencing.ResultsThe Kootenay and Lower Mainland regions had the highest V. destructor levels in the fall (3.38±0.65 and 2.51±0.57, respectively) followed by the Okanagan (1.54±0.36), Cariboo (1.31±0.39), and Peace (0.66±0.25) regions. The Peace region had a significantly lower proportion of dead colonies than the other regions. Varroa destructor levels in the fall significantly predicted odds of colony mortality in the spring. Colonies with ≥ 1% mite infestation in the fall (August) had a significantly higher mortality rate (p=0.005) compared to colonies with <1% mite levels. Therefore, treatment is recommended above that threshold. Also, deformed wing virus-B levels were 8.4 times higher than those of deformed wing virus-A variant in all the regions and were highest in the Kootenay region, which also had the highest rate of colony losses. Lastly, Malpighamoeba mellificae and Nosema (Vairimorpha) apis transcripts were identified along with other pathogens that deserve further investigation, including Apis mellifera filamentous virus, Apis rhabdovirus, Lake Sinai virus, Varroa tymo-like, and Apis mellifera solinvivirus 1.DiscussionThe dynamic nature of host-pathogen interactions requires frequent pathogen surveillance to determine the prevalence and levels of parasitic mites and associated infectious diseases, and their impact on honey bee health, not only in the regions of this study, but globally. Nevertheless, more studies are needed to determine the nature of the type of interaction between the identified pathogens and V. destructor. Also, more research is needed to evaluate their potential impact on colony survival, to provide accurate mite and disease control recommendations to beekeepers

Developing a National Implementation Strategy to accelerate Uptake of Evidence-Based Family Caregiver Support in Us Cancer Centers

OBJECTIVE: Characterize key factors and training needs of U.S. cancer centers in implementing family caregiver support services. METHODS: Sequential explanatory mixed methods design consisting of: (1) a national survey of clinicians and administrators from Commission-on-Cancer-accredited cancer centers (N = 238) on factors and training needed for establishing new caregiver programs and (2) qualitative interviews with a subsample of survey respondents (N = 30) to elicit feedback on survey findings and the outline of an implementation strategy to facilitate implementation of evidence-based family caregiver support (the Caregiver Support Accelerator). Survey data was tabulated using descriptive statistics and transcribed interviews were analyzed using thematic analysis. RESULTS: top factors for developing new caregiver programs were that the program be: consistent with the cancer center\u27s mission and strategic plan (87%), supported by clinic leadership (86.5%) and providers and staff (85.7%), and low cost or cost effective (84.9%). top training needs were how to: train staff to implement programs (72.3%), obtain program materials (63.0%), and evaluate program outcomes (62.6%). Only 3.8% reported that no training was needed. Qualitative interviews yielded four main themes: (1) gaining leadership, clinician, and staff buy-in and support is essential; (2) cost and clinician burden are major factors to program implementation; (3) training should help with adapting and marketing programs to local context and culture; and (4) the Accelerator strategy is comprehensive and would benefit from key organizational partnerships and policy standards. CONCLUSION: Findings will be used to inform and refine the Accelerator implementation strategy to facilitate the adoption and growth of evidence-based cancer caregiver support in U.S. cancer centers

Prevalence and Epidemiology of Non-O157 Escherichia coli Serogroups O26, O103, O111, and O145 and Shiga Toxin Gene Carriage in Scottish Cattle, 2014-2015

International audienceCattle are reservoirs for Shiga toxin Escherichia coli (STEC), bacteria shed in animal feces. Humans are infected through consumption of contaminated food or water and by direct contact, causing serious disease and kidney failure in the most vulnerable