Impact-Melt Populations in Apollo Drive-Tubes

No abstract availabl

Alien Registration- Curran, Anna B. (Bangor, Penobscot County)

https://digitalmaine.com/alien_docs/14139/thumbnail.jp

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life

Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years. This study therefore aimed to determine if withdrawing from BZDs leads to changes in patients' cognitive function, quality of life, mood and sleep. Method: One hundred and ninety-two long-term users of BZD hypnotics, aged [gt-or-equal, slanted]65 years, were identified in 25 general practices. One hundred and four who wished to withdraw were randomly allocated to one of two groups under double-blind, placebo controlled conditions: group A's BZD dose was tapered from week 1 of the trial; group B were given their usual dose for 12 weeks and then it was tapered. An additional group (C) of 35 patients who did not wish to withdraw from BZDs participated as ‘continuers’. All patients were assessed at 0, 12 and 24 weeks and 50% were re-assessed at 52 weeks. Results: Sixty per cent of patients had taken BZDs continuously for >10 years; 27% for >20 years. Of all patients beginning the trial, 80% had successfully withdrawn 6 months later. There was little difference between groups A and B, but these groups differed from continuers (C) in that the performance of the withdrawers on several cognitive/psychomotor tasks showed relative improvements at 24 or 52 weeks. Withdrawers and continuers did not differ in sleep or BZD withdrawal symptoms. Conclusions: These results have clear implications for clinical practice. Withdrawal from BZDs produces some subtle cognitive advantages for older people, yet little in the way of withdrawal symptoms or emergent sleep difficulties. These findings also suggest that, taken long-term, BZDs do not aid sleep

Encoding of Marginal Utility across Time in the Human Brain

Marginal utility theory prescribes the relationship between the objective property of the magnitude of rewards and their subjective value. Despite its pervasive influence, however, there is remarkably little direct empirical evidence for such a theory of value, let alone of its neurobiological basis. We show that human preferences in an intertemporal choice task are best described by a model that integrates marginally diminishing utility with temporal discounting. Using functional magnetic resonance imaging, we show that activity in the dorsal striatum encodes both the marginal utility of rewards, over and above that which can be described by their magnitude alone, and the discounting associated with increasing time. In addition, our data show that dorsal striatum may be involved in integrating subjective valuation systems inherent to time and magnitude, thereby providing an overall metric of value used to guide choice behavior. Furthermore, during choice, we show that anterior cingulate activity correlates with the degree of difficulty associated with dissonance between value and time. Our data support an integrative architecture for decision making, revealing the neural representation of distinct subcomponents of value that may contribute to impulsivity and decisiveness

The connection between metallicity and metal-line kinematics in (sub-)damped Lyman-alpha systems

A correlation between the metallicity, [M/H], and rest-frame MgII equivalent width, EW, is found from 49 DLAs and strong sub-DLAs drawn from the literature over the redshift range 0.2<z_abs<2.6. The correlation is significant at 4.2 sigma and improves to 4.7 sigma when the mild evolution of [M/H] with redshift is taken into account. Even when including only the 26 DLAs (i.e. excluding sub-DLAs) which have Zn metallicities and EW>0.7A, the correlation remains at >3 sigma significance. Since the MgII2796 transition is predominantly saturated in DLAs (which always have EW greater than 0.3A), EW is far more sensitive to the kinematic spread of the metal velocity components across the absorption profile than it is to [M/H]. Thus, the observed [M/H]--EW correlation points to a strong link between the absorber metallicity and the mechanism for producing and dispersing the velocity components. We also note that approximately half of the 13 known molecular hydrogen absorbers have very high EW and very broad velocity structures which show characteristics usually associated with outflows. Follow-up ultraviolet- and blue-sensitive high-resolution spectra of high-EW systems, initially identified in low-resolution spectra, may therefore yield a large number of new H_2 discoveries.Comment: 9 pages, 2 figures (3 EPS files). Accepted by MNRA

Observed Faraday Effects in Damped Lyman-Alpha Absorbers and Lyman Limit Systems: The Magnetised Environment of Galactic Building Blocks at Redshift=2

Protogalactic environments are typically identified using quasar absorption lines, and these galactic building blocks can manifest as Damped Lyman-Alpha Absorbers (DLAs) and Lyman Limit Systems (LLSs). We use radio observations of Faraday effects to test whether DLAs and LLSs host a magnetised medium, by combining DLA and LLS detections throughout the literature with 1.4 GHz polarization data from the NRAO VLA Sky Survey (NVSS). We obtain a control, a DLA, and a LLS sample consisting of 114, 19, and 27 lines-of-sight respectively - all of which are polarized at $\ge8\sigma$ to ensure Rician bias is negligible. Using a Bayesian framework, we are unable to detect either coherent or random magnetic fields in DLAs: the regular coherent magnetic fields within the DLAs must be $\le2.8$ $\mu$G, and the lack of depolarization is consistent with the weakly magnetised gas in DLAs being non-turbulent and quiescent. However, we find mild suggestive evidence that LLSs have coherent magnetic fields: after controlling for the redshift-distribution of our data, we find a 71.5% probability that LLSs have a higher RM than a control sample. We also find strong evidence that LLSs host random magnetic fields, with a 95.5% probability that LLS lines-of-sight have lower polarized fractions than a control sample. The regular coherent magnetic fields within the LLSs must be $\le2.4$ $\mu$G, and the magnetised gas must be highly turbulent with a typical scale on the order of $\approx5$-20 pc, which is similar to that of the Milky Way. This is consistent with the standard dynamo pedagogy, whereby magnetic fields in protogalaxies increase in coherence and strength as a function of cosmic time. Our results are consistent with a hierarchical galaxy formation scenario, with the DLAs, LLSs, and strong magnesium II (MgII) systems exploring three different stages of magnetic field evolution in galaxies.Comment: Submitted to Ap

Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability

Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved in evolution, but their role in longevity has not previously been assessed. We screened 2,700 genes essential for Caenorhabditis elegans development and identified 64 genes that extend lifespan when inactivated postdevelopmentally. These candidate lifespan regulators are highly conserved from yeast to humans. Classification of the candidate lifespan regulators into functional groups identified the expected insulin and metabolic pathways but also revealed enrichment for translation, RNA, and chromatin factors. Many of these essential gene inactivations extend lifespan as much as the strongest known regulators of aging. Early gene inactivations of these essential genes caused growth arrest at larval stages, and some of these arrested animals live much longer than wild-type adults. daf-16 is required for the enhanced survival of arrested larvae, suggesting that the increased longevity is a physiological response to the essential gene inactivation. These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life

The role of proton precipitation in Jovian aurora: Theory and observation

It was proposed that the Jovian auroral emissions observed by Voyager spacecraft could be explained by energetic protons precipitating into the upper atmosphere of Jupiter. Such precipitation of energetic protons results in Doppler-shifted Lyman alpha emission that can be quantitatively analyzed to determine the energy flux and energy distribution of the incoming particle beam. Modeling of the expected emission from a reasonably chosen Voyager energetic proton spectrum can be used in conjunction with International Ultraviolet Explorer (IUE) observations, which show a relative lack of red-shifted Lyman alpha emission, to set upper limits on the amount of proton precipitation taking place in the Jovian aurora. Such calculations indicate that less than 10 percent of the ultraviolet auroral emissions at Jupiter can be explained by proton precipitation