Detection of SiO emission from a massive dense cold core

We report the detection of the SiO (J = 2 - 1) transition from the massive cold dense core G333.125-0.562. The core remains undetected at wavelengths shorter than 70 micron and has compact 1.2 mm dust continuum. The SiO emission is localised to the core. The observations are part of a continuing multi-molecular line survey of the giant molecular cloud G333. Other detected molecules in the core include 13CO, C18O, CS, HCO+, HCN, HNC, CH3OH, N2H+, SO, HC3N, NH3, and some of their isotopes. In addition, from NH3 (1,1) and (2,2) inversion lines, we obtain a temperature of 13 K. From fitting to the spectral energy distribution we obtain a colour temperature of 18 K and a gas mass of 2 x 10^3 solar mass. We have also detected a 22 GHz water maser in the core, together with methanol maser emission, suggesting the core will host massive star formation. We hypothesise that the SiO emission arises from shocks associated with an outflow in the cold core.Comment: 6 pages, 4 figures, 1 table, to be published in MNRA

Chromosome 9p deletion in clear cell renal cell carcinoma predicts recurrence and survival following surgery

BACKGROUND: Wider clinical applications of 9p status in clear cell renal cell carcinoma (ccRCC) are limited owing to the lack of validation and consensus for interphase fluorescent in situ hybridisation (I-FISH) scoring technique. The aim of this study was to analytically validate the applicability of I-FISH in assessing 9p deletion in ccRCC and to clinically assess its long-term prognostic impact following surgical excision of ccRCC. METHODS: Tissue microarrays were constructed from 108 renal cell carcinoma (RCC) tumour paraffin blocks. Interphase fluorescent in situ hybridisation analysis was undertaken based on preset criteria by two independent observers to assess interobserver variability. 9p status in ccRCC tumours was determined and correlated to clinicopathological variables, recurrence-free survival and disease-specific survival. RESULTS: There were 80 ccRCCs with valid 9p scoring and a median follow-up of 95 months. Kappa statistic for interobserver variability was 0.71 (good agreement). 9p deletion was detected in 44% of ccRCCs. 9p loss was associated with higher stage, larger tumours, necrosis, microvascular and renal vein invasion, and higher SSIGN (stage, size, grade and necrosis) score. Patients with 9p-deleted ccRCC were at a higher risk of recurrence (P=0.008) and RCC-specific mortality (P=0.001). On multivariate analysis, 9p deletion was an independent predictor of recurrence (hazard ratio 4.323; P=0.021) and RCC-specific mortality (hazard ratio 4.603; P=0.007). The predictive accuracy of SSIGN score improved from 87.7% to 93.1% by integrating 9p status to the model (P=0.001). CONCLUSIONS: Loss of 9p is associated with aggressive ccRCC and worse prognosis in patients following surgery. Our findings independently confirm the findings of previous reports relying on I-FISH to detect 9p (CDKN2A) deletion

Insecticides Based on Differences in Metabolic Pathways

Insects have been major pests of humankind at least since the beginning of recorded history. To this day insects continue to cause problems in domestic, agricultural, and health situations. It is no wonder that people have continually sought new solutions to controlling insect pests. Even when new control methods are discovered and established, insects evolve into resistant species so that the method is only of real value for a few brief years. Modern science and technology are now enabling scientists to tear away the fabric that has so long masked physiological and biochemical events critical to insects. Armed with this new knowledge, researchers should be able to develop novel control strategies that focus on key physiological, biological, and biochemical events such that they can be altered, influenced, disrupted, and/or inhibited. Three promising areas that may lead or are currently leading to new insect control methods are the cuticle, prostaglandins, and steroids. We discuss each of these areas in regard to their biological significance, current research, metabolic inhibitors and their modes of action

The Intrinsic Dimensionality of Attractiveness: A Study in Face Profiles

The study of human attractiveness with pattern analysis techniques is an emerging research field. One still largely unresolved problem is which are the facial features relevant to attractiveness, how they combine together, and the number of independent parameters required for describing and identifying harmonious faces. In this paper, we present a first study about this problem, applied to face profiles. First, according to several empirical results, we hypothesize the existence of two well separated manifolds of attractive and unattractive face profiles. Then, we analyze with manifold learning techniques their intrinsic dimensionality. Finally, we show that the profile data can be reduced, with various techniques, to the intrinsic dimensions, largely without loosing their ability to discriminate between attractive and unattractive face

Jet Deflection via Cross winds: Laboratory Astrophysical Studies

We present new data from High Energy Density (HED) laboratory experiments designed to explore the interaction of a heavy hypersonic radiative jet with a cross wind. The jets are generated with the MAGPIE pulsed power machine where converging conical plasma flows are produced from a cylindrically symmetric array of inclined wires. Radiative hypersonic jets emerge from the convergence point. The cross wind is generated by ablation of a plastic foil via soft-X-rays from the plasma convergence region. Our experiments show that the jets are deflected by the action of the cross wind with the angle of deflection dependent on the proximity of the foil. Shocks within the jet beam are apparent in the data. Analysis of the data shows that the interaction of the jet and cross wind is collisional and therefore in the hydro-dynamic regime. MHD plasma code simulations of the experiments are able to recover the deflection behaviour seen in the experiments. We consider the astrophysical relevance of these experiments applying published models of jet deflection developed for AGN and YSOs. Fitting the observed jet deflections to quadratic trajectories predicted by these models allows us to recover a set of plasma parameters consistent with the data. We also present results of 3-D numerical simulations of jet deflection using a new astrophysical Adaptive Mesh Refinement code. These simulations show highly structured shocks occurring within the beam similar to what was observed in the experimentsComment: Submitted to ApJ. For a version with figures go to http://web.pas.rochester.edu/~afrank/labastro/CW/Jet-Wind-Frank.pd

Internet-Based Brief Intervention to Prevent Unhealthy Alcohol Use among Young Men: A Randomized Controlled Trial.

INTRODUCTION: Alcohol use is one of the leading modifiable morbidity and mortality risk factors among young adults. STUDY DESIGN: 2 parallel-group randomized controlled trial with follow-up at 1 and 6 months. SETTING/PARTICIPANTS: Internet based study in a general population sample of young men with low-risk drinking, recruited between June 2012 and February 2013. Intervention: Internet-based brief alcohol primary prevention intervention (IBI). The IBI aims at preventing an increase in alcohol use: it consists of normative feedback, feedback on consequences, calorific value alcohol, computed blood alcohol concentration, indication that the reported alcohol use is associated with no or limited risks for health. Intervention group participants received the IBI. Control group (CG) participants completed only an assessment. MAIN OUTCOME MEASURES: Alcohol use (number of drinks per week), binge drinking prevalence. Analyses were conducted in 2014-2015. RESULTS: Of 4365 men invited to participate, 1633 did so; 896 reported low-risk drinking and were randomized (IBI: n = 451; CG: n = 445). At baseline, 1 and 6 months, the mean (SD) number of drinks/week was 2.4(2.2), 2.3(2.6), 2.5(3.0) for IBI, and 2.4(2.3), 2.8(3.7), 2.7(3.9) for CG. Binge drinking, absent at baseline, was reported by 14.4% (IBI) and 19.0% (CG) at 1 month and by 13.3% (IBI) and 13.0% (CG) at 6 months. At 1 month, beneficial intervention effects were observed on the number of drinks/week (p = 0.05). No significant differences were observed at 6 months. CONCLUSION: We found protective short term effects of a primary prevention IBI. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN55991918

Internet-based brief intervention for young men with unhealthy alcohol use: a randomized controlled trial in a general population sample.

To test the efficacy of an internet-based brief intervention (IBI) in decreasing alcohol use among young Swiss men aged 21 years on average. Two parallel-group randomized controlled trial with a 1 : 1 allocation ratio containing follow-up assessments at 1 and 6 months post-randomization Internet-based study in a general population sample. Twenty-one-year-old men from Switzerland with unhealthy alcohol use (> 14 drinks/week or ≥ 6 drinks/occasion at least monthly or Alcohol Use Disorders Identification Test (AUDIT) scores ≥ 8) INTERVENTION: IBI consisting of (1) normative feedback, (2) feedback on consequences of alcohol use, (3) calorific value of reported consumption, (4) computed blood alcohol concentration for reported consumption, (5) indication of risk, (6) information on alcohol and health and (7) recommendations indicating low-risk drinking limits. Control condition: no intervention (assessment only). At 1 and 6 months: quantity/frequency questions on alcohol use (primary outcome: number of drinks/week) and binge drinking prevalence; at 6 months: AUDIT score, consequences of drinking (range = 0-12). Follow-up rates were 92% at 1 month and 91% at 6 months. At 6 months, participants in the intervention group (n = 367) reported greater reductions in the number of drinks/week than participants in the control group (n = 370) [treatment × time interaction, incidence rate ratio (RR) = 0.86, 95% confidence interval (CI) = 0.78; 0.96], but no significant differences were observed on binge drinking prevalence. There was a favourable intervention effect on AUDIT scores (IRR = 0.93, 95% CI = 0.88; 0.98), but not on the number of consequences (IRR = 0.93, 95% CI = 0.84; 1.03). An internet-based brief intervention directed at harmful alcohol use among young men led to a reduction in self-reported alcohol consumption and AUDIT scores compared with a no-intervention control condition (assessment only)

The Effects of Regular Yoga Practice on Psychophysiological Measures in College Students

PURPOSE: The purpose of this study was to test the hypothesis that 12 weeks of a regular yoga practice (150 minutes/week) would improve measures of cardiovascular and psychological health in college students. METHODS: Twenty-two college students (211.2 yrs; 21 female) participated in this study. Height, weight, waist/hip circumference, resting blood pressure and heart rate, fasting blood glucose and cholesterol, and psychological health (STAI form Y-1 and Y-2) were assessed prior to the end of the third week of the semester (PRE). Subjects participated in their Yoga I class throughout Fall semester. After the 12th week of class, participants reported to the laboratory for follow up testing (POST). RESULTS: A significant improvement in trait anxiety (Y-2), assessing participants’ disposition to develop anxiety as a part of their personality, was observed after 12 weeks of a regular yoga program (PRE: 392 vs POST: 341.8; p=0.002). There was no change in state anxiety (Y-1), assessing participants’ levels of anxiety “in the moment” (PRE: 341.7 vs POST: 331.9; p=0.96). There was also no change in weight, waist/hip circumference, resting heart rate, resting blood pressure, fasting blood glucose, or cholesterol measurements from PRE to POST testing. CONCLUSION: 12 weeks of regular attendance to a beginner yoga program improved measures of (personality) trait-anxiety in college students

A developmental evaluation to enhance stakeholder engagement in a wide-scale interactive project disseminating quality improvement data: Study protocol for a mixed-methods study

© 2017 Article author(s). All rights reserved. Introduction: Bringing together continuous quality improvement (CQI) data from multiple health services offers opportunities to identify common improvement priorities and to develop interventions at various system levels to achieve large-scale improvement in care. An important principle of CQI is practitioner participation in interpreting data and planning evidence-based change. This study will contribute knowledge about engaging diverse stakeholders in collaborative and theoretically informed processes to identify and address priority evidence-practice gaps in care delivery. This paper describes a developmental evaluation to support and refine a novel interactive dissemination project using aggregated CQI data from Aboriginal and Torres Strait Islander primary healthcare centres in Australia. The project aims to effect multilevel system improvement in Aboriginal and Torres Strait Islander primary healthcare. Methods and analysis: Data will be gathered using document analysis, online surveys, interviews with participants and iterative analytical processes with the research team. These methods will enable real-time feedback to guide refinements to the design, reports, tools and processes as the interactive dissemination project is implemented. Qualitative data from interviews and surveys will be analysed and interpreted to provide in-depth understanding of factors that influence engagement and stakeholder perspectives about use of the aggregated data and generated improvement strategies. Sources of data will be triangulated to build up a comprehensive, contextualised perspective and integrated understanding of the project's development, implementation and findings. Ethics and dissemination: The Human Research Ethics Committee (HREC) of the Northern Territory Department of Health and Menzies School of Health Research (Project 2015-2329), the Central Australian HREC (Project 15-288) and the Charles Darwin University HREC (Project H15030) approved the study. Dissemination will include articles in peer-reviewed journals, policy and research briefs. Results will be presented at conferences and quality improvement network meetings. Researchers, clinicians, policymakers and managers developing evidence-based system and policy interventions should benefit from this research