Localized Plasma Measurement During Instability Modes In a Hall Thruster

Hall thrusters are a key technology for current and future unmanned satellites, striking a balance between thrust and fuel economy suitable for many mission profiles of interest. Despite their extensive flight heritage and a large body of research, many phenomena occurring in the plasma discharge of Hall thrusters are not well understood. A combination of intrusive and non-intrusive measurement techniques were used to investigate the properties of the exhaust plume of two Hall thrusters and correlate optical characteristics of oscillating modes with the plasma potential and azimuthal current distribution during those modes. A strong trend was found associating the optical emission of spokes with a local increase in plasma potential as measured by an emissive probe, indicating a spoke structure with visible and non-visible regions. Additionally, a consistent phase delay was observed between oscillations in discharge current and Hall current during the breathing mode. A similar delay was not observed between discharge current and optical emission or plasma potential oscillations during the breathing mode. These trends were used to infer a possible plasma structure during breathing and spoke modes

The Three or Four Approaches to Financial Regulation: A Cautionary Analysis Against Exuberance in Crisis Response

Unprecedented interest in financial regulation reform accompanies the nearly-unprecedented scale of financial calamity facing the world. Dozens of elaborate reform proposals are in circulation, most determined to revolutionize financial regulation. No doubt, the crisis makes reevaluation essential, but we contribute a cautionary analysis amid the exuberant atmosphere. Reforms should not discount the value of traditional financial regulation, overlook the functional regulatory reform that has already occurred, or overstate ultimate differences between contending reform proposals. Despite proliferation of dozens of reform proposals, our analysis leads us to conclude that there are ultimately only three or four principal alternatives: (1) the traditional fragmented model that divides power and presided over the generation of substantial wealth, yet signally failed to prevent the crisis of 2008; (2) the on-the-fly reforms effected by Treasury and Fed’s massive and unorthodox intervention into and extensive renovation of all financial services industries; and (3) seemingly radical proposals, one by Republicans at the onset of crisis (Treasury Secretary Paulson’s Blueprint), the other by Democrats after financial markets imploded (former Fed Chair Volcker’s Group of Thirty reports). These three or four alternative approaches pose tests of our relative commitments to markets, organization, globalization and political control. Although each was developed in different circumstances by architects with different purposes, they cannot co-exist. One of them will provide the approach we take into the next crisis - and perhaps to pull us out of the current one. We provide a framework to consider each alternative and evaluate their respective advantages and disadvantages. Our analysis leads us to conclude that limited reform is best, recognizing the quasi-centralization that has occurred and the need to add protective regulation to particular areas that manifestly contributed to the global economic crisis that began in 2008

Steady and unsteady transonic small disturbance analysis of realistic aircraft configurations

A transonic unsteady aerodynamic and aeroelastic code called CAP-TSD (Computational Aeroelasticity Program - Transonic Small Disturbance) was developed for application to realistic aircraft configurations. It permits the calculation of steady and unsteady flows about complete aircraft configurations for aeroelastic analysis of the flutter critical transonic speed range. The CAP-TSD code uses a time accurate approximate factorization algorithm for solution of the unsteady transonic small disturbance potential equation. An overview is given of the CAP-TSD code development effort along with recent algorithm modifications which are listed and discussed. Calculations are presented for several configurations including the General Dynamics 1/9th scale F-16C aircraft model to evaluate the algorithm and hence the reliability of the CAP-TSD code in general. Calculations are also presented for a flutter analysis of a 45 deg sweptback wing which agree well with the experimental data. Descriptions are presented of the CAP-TSD code and algorithm details along with results and comparisons which demonstrate the stability, accuracy, efficiency, and utility of CAP-TSD

Selective nitrogen adsorption via backbonding in a metal-organic framework with exposed vanadium sites.

Industrial processes prominently feature π-acidic gases, and an adsorbent capable of selectively interacting with these molecules could enable important chemical separations1-4. Biological systems use accessible, reducing metal centres to bind and activate weakly π-acidic species, such as N2, through backbonding interactions5-7, and incorporating analogous moieties into a porous material should give rise to a similar adsorption mechanism for these gaseous substrates8. Here, we report a metal-organic framework featuring exposed vanadium(II) centres capable of back-donating electron density to weak π acids to successfully target π acidity for separation applications. This adsorption mechanism, together with a high concentration of available adsorption sites, results in record N2 capacities and selectivities for the removal of N2 from mixtures with CH4, while further enabling olefin/paraffin separations at elevated temperatures. Ultimately, incorporating such π-basic metal centres into porous materials offers a handle for capturing and activating key molecular species within next-generation adsorbents

A Randomized Controlled Trial of a Personalized Feedback Intervention for Problem Gamblers

<div><h3>Background</h3><p>Personalized feedback is a promising self-help for problem gamblers. Such interventions have shown consistently positive results with other addictive behaviours, and our own pilot test of personalized normative feedback materials for gamblers yielded positive findings. The current randomized controlled trial evaluated the effectiveness, and the sustained efficacy, of the personalized feedback intervention materials for problem gamblers.</p> <h3>Methodology/Principal Findings</h3><p>Respondents recruited by a general population telephone screener of Ontario adults included gamblers with moderate and severe gambling problems. Those who agreed to participate were randomly assigned to receive: 1) the full personalized normative feedback intervention; 2) a partial feedback that contained all the feedback information provided to those in condition 1 but without the normative feedback content (i.e., no comparisons provided to general population gambling norms); or 3) a waiting list control condition. The primary hypothesis was that problem gamblers who received the personalized normative feedback intervention would reduce their gambling more than problem gamblers who did not receive any intervention (waiting list control condition) by the six-month follow-up.</p> <h3>Conclusions/Significance</h3><p>The study found no evidence for the impact of normative personalized feedback. However, participants who received, the partial feedback (without norms) reduced the number of days they gambled compared to participants who did not receive the intervention. We concluded that personalized feedback interventions were well received and the materials may be helpful at reducing gambling. Realistically, it can be expected that the personalized feedback intervention may have a limited, short term impact on the severity of participants' problem gambling because the intervention is just a brief screener. An Internet-based version of the personalized feedback intervention tool, however, may offer an easy to access and non-threatening portal that can be used to motivate participants to seek further help online or in person.</p> <h3>Trial Registration</h3><p><a href="http://ClinicalTrials.gov">ClinicalTrials.gov</a><a href="http://www.clinicaltrials.gov/ct2/show/NCT00578357">NCT00578357</a></p> </div

The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis

Hsp90, a dimeric ATP‐dependent molecular chaperone, is required for the folding and activation of numerous essential substrate “client” proteins including nuclear receptors, cell cycle kinases, and telomerase. Fundamental to its mechanism is an ensemble of dramatically different conformational states that result from nucleotide binding and hydrolysis and distinct sets of interdomain interactions. Previous structural and biochemical work identified a conserved arginine residue (R380 in yeast) in the Hsp90 middle domain (MD) that is required for wild type hydrolysis activity in yeast, and hence proposed to be a catalytic residue. As part of our investigations on the origins of species‐specific differences in Hsp90 conformational dynamics we probed the role of this MD arginine in bacterial, yeast, and human Hsp90s using a combination of structural and functional approaches. While the R380A mutation compromised ATPase activity in all three homologs, the impact on ATPase activity was both variable and much more modest (2–7 fold) than the mutation of an active site glutamate (40 fold) known to be required for hydrolysis. Single particle electron microscopy and small‐angle X‐ray scattering revealed that, for all Hsp90s, mutation of this arginine abrogated the ability to form the closed “ATP” conformational state in response to AMPPNP binding. Taken together with previous mutagenesis data exploring intra‐ and intermonomer interactions, these new data suggest that R380 does not directly participate in the hydrolysis reaction as a catalytic residue, but instead acts as an ATP‐sensor to stabilize an NTD‐MD conformation required for efficient ATP hydrolysis.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92411/1/2103_ftp.pd

Atlantic Meridional Overturning Circulation

• The AMOC is key to maintaining the mild climate of the UK. • The AMOC is predicted to decline in the 21st century in response to a changing climate. • Past abrupt changes in the AMOC have had dramatic climate consequences. • There is growing evidence that the AMOC has been declining for at least a decade, pushing the Atlantic Multidecadal Variability into a cool phase. • Short term fluctuations in the AMOC have proved to have unexpected impacts, including being linked with severe winters and abrupt sea-level rise