Biallelic BIRC3 inactivation in chronic lymphocytic leukaemia patients with 11q deletion identifies a subgroup with very aggressive disease.

Not availabl

RNAi-mediated silencing of the myo-inositol-1-phosphate synthase gene (GmMIPS1) in transgenic soybean inhibited seed development and reduced phytate content.

Made available in DSpace on 2018-05-31T00:34:36Z (GMT). No. of bitstreams: 1 ID273951.pdf: 364152 bytes, checksum: c18c2d707c0c7df8f411b9f94605a2c3 (MD5) Previous issue date: 2006-10-1

A cross validation of Consumer-Based Brand Equity (CBBE) with Private Labels in Spain

Molinillo,S., Ekinci, Y., Japutra, A. (2014)'A cross validation of Consumer-Based Brand Equity (CBBE) with Private Labels in Spain'. in Martínez-López, Gázquez-Abad, J.C. and Sethuraman, R. J.A. (eds.) Advances in National Brand and Private Label Marketing. Second International Conference, 2015. Springer Proceedings in Business and Economics, pp. 113-125In recent years a number of Consumer-Based Brand Equity (CBBE) models and measurement scales have been introduced in the branding literature. However, examinations of brand equity in Private Labels (PL) are rather limited. This study aims to compare the validity of the two prominent CBBE models those introduced by Yoo and Donthu (2001) and Nam et al. (2011). In order to test the models and make this comparison, the study collected data from 236 respondents who rated private labels in Spain. A list of 30 different fashion and sportswear PL was introduced to respondents. These brands do not make any reference to the retail store in which they are sold. Research findings suggest that the extended CBBE model introduced by Nam et al. (2011) and Ciftci et al. (2014) is more reliable and valid than Yoo and Donthu’s model for assessing PL. Theoretical contributions and managerial implications are discussed.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Posición del hueso hiodes en relación al volumen de la vía aérea en los diferentes patrones esqueletales

Objective: Determine the position of the hyoid bone in relation to the volume of the airway oropharynx in the different skeletal patterns using cone beam volumetric tomography. Materials and methods: Thirty-nine tomographic volumes of patients who met the inclusion criteria of the Radiology Service of the Dental Center of the University of San Martín de Porres from 2014 to 2017, the skeletal class was determined by the angle ANB, the analysis of the volume of the airway oropharynx was carried out performed with the tools of the software explorer Romexis 4.4 (Helsinki, Finland) and the antero-posterior position of the hyoid bone, was determined by the measurement of the C3-H plane. Once the numerical values were obtained, the Pearson correlation test was applied. Results: the correlation between the volume of the airway oropharynx and the position of the hyoid bone in class I patients is 0.651, class II 0.173 and class III 0.187 which indicates that there is no correlation. However, in the determination of the volume of the airway in the different skeletal patterns, marked differences were found between each group. Conclusions: there is not enough evidence to state that there is a statistically significant correlation between the anteroposterior position of the hyoid bone and the volume of the airway oropharynx in the different skeletal patterns .Objetivo: determinar la posición del hueso hioides en relación al volumen de la vía aérea orofaríngea en los diferentes patrones esqueletales utilizando la tomografía volumétrica de haz cónico. Materiales y métodos: Se evaluaron 39 volúmenes tomográficos de pacientes del servicio de Radiología del Centro Odontológico de la Universidad de San Martín de Porres del año 2014 a 2017, la clase esqueletal fue determinada por el ángulo ANB, el análisis del volumen de la vía aérea orofaríngea se llevó a cabo con las herramientas del explorador del software Romexis 4.4 (Helsinki, Finlandia) y la posición antero-posterior del hueso hioides, se determinó por la medición del plano C3-H. Una vez obtenidos los valores numéricos, se aplicó la prueba de correlación de Pearson. Resultados: No se encontró correlación estadísticamente significativa entre el volumen de la vía aérea orofaríngea y la posición del hueso hioides con ninguna clase esqueletal (Valor p en Clase I, II y III = 0.651, p=0.173 y p=0.187 respectivamente). Sin embargo, en la determinación del volumen de la vía aérea en los diferentes patrones esqueletales se encontraron diferencias marcadas entre cada grupo. Conclusiónes: no existe suficiente evidencia para afirmar que existe correlación estadísticamente significativa entre la posición anteroposterior del hueso hioides con el volumen de l a vía aérea orofaríngea en los diferentes patrones esqueletales

NEMO: A Project for a km3^3 Underwater Detector for Astrophysical Neutrinos in the Mediterranean Sea

The status of the project is described: the activity on long term characterization of water optical and oceanographic parameters at the Capo Passero site candidate for the Mediterranean km$^3$ neutrino telescope; the feasibility study; the physics performances and underwater technology for the km$^3$; the activity on NEMO Phase 1, a technological demonstrator that has been deployed at 2000 m depth 25 km offshore Catania; the realization of an underwater infrastructure at 3500 m depth at the candidate site (NEMO Phase 2).Comment: Proceeding of ISCRA 2006, Erice 20-27 June 200

Significant reduction of the hybrid BCR/ABL transcripts after induction and consolidation therapy is a powerful predictor of treatment response in adult Philadelphia-positive acute lymphoblastic leukemia.

in pres

Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement

Platelet-derived growth factor receptor B (PDGFRB) gene rearrangements define a unique subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and characterized by high sensitivity to tyrosine kinase inhibition. To date, various PDGFRB/5q32 rearrangements, involving at least 40 fusion partners, have been reported. However, information on genomic and clinical features accompanying rearrangements of PDGFRB is still scarce. Here, we characterized a series of 14 cases with a myeloid neoplasm using cytogenetic, single nucleotide polymorphism array, and next-generation sequencing. We identified nine PDGFRB translocation partners, including the KAZN gene at 1p36.21 as a novel partner in a previously undescribed t(1;5)(p36;q33) chromosome change. In all cases, the PDGFRB recombination was the sole cytogenetic abnormality underlying the phenotype. Acquired somatic variants were mainly found in clinically aggressive diseases and involved epigenetic genes (TET2, DNMT3A, ASXL1), transcription factors (RUNX1 and CEBPA), and signaling modulators (HRAS). By using both cytogenetic and nested PCR monitoring to evaluate response to imatinib, we found that, in non-AML cases, a low dosage (100–200 mg) is sufficient to induce and maintain longstanding hematological, cytogenetic, and molecular remissions

Characteristics of Global Health Careers among Graduates of a Global Health Equity Residency Training Program in the United States

Background: The number of global health (GH) physician training programs in the United States has increased in the past decade. Few studies have explored the demographics of individuals in these programs, the impact of global health training on career development, and specific factors associated with whether graduates achieve a career in global health. Objectives: We aimed to describe characteristics of program graduates and quantify which previously identified factors were associated with achieving a self-defined career in GH among a cohort of graduates from one GH post-graduate training program in a highly resourced academic medical center in the United States between 2003 and 2018. Methods: We conducted a cross-sectional survey and analyzed differences between participants who self-identified as having a career in GH compared to those who did not. Findings: Among 59 individuals invited to participate, 53 (89.9%) responded to the survey. Having a GH mentor was associated with having a career in GH (OR 10.3; p = 0.004). Those who had a GH career were more likely to have a clearly-defined career path (p = 0.03), have institutional support in their current job (p = 0.00006), be able to manage the split between their GH and non-GH work (p = 0.0001), find funding to achieve their objectives in GH (p = 0.01), invest in their personal and family life (p = 0.05), and split work abroad and domestically with few challenges (p = 0.01). Conclusions: We present sociodemographic and career characteristics for graduates from a GH training program in a highly resourced academic medical center in the United States. Mentorship, institutional support, funding, ability to balance GH with non-GH work, and time spent domestically or abroad are key factors associated with successful careers in GH. If institutional funding is allocated to strengthen these aspects of GH training, we anticipate more sustained GH career development