Early tumor response to intraarterial or intravenous administration of carboplatin to treat naturally occurring lower urinary tract carcinoma in dogs.

BackgroundSurvival times and tumor responses associated with malignant neoplasia of the lower urinary tract are poor despite the vast array of current treatments. Therefore, the evaluation of alternative treatments, such as intraarterial administration of chemotherapy (IAC) should be considered.ObjectiveTo describe a technique for superselective catheterization for IAC and to evaluate initial tumor response by ultrasonography after both IAC and intravenous administration of chemotherapy (IVC).AnimalsClient-owned dogs with lower urinary tract neoplasia treated with either IVC (n = 15) or IAC (n = 11).MethodsRetrospective study. An arterial approach via the carotid or femoral artery was utilized to obtain superselective access and administer chemotherapy in the IAC cases. Medical record review was performed, data were recorded, and recorded variables were evaluated statistically.ResultsIntraarterial chemotherapy was successfully administered in all cases. There was a significantly greater decrease in longest unidimensional measurement in the IAC group as compared to the IVC group (P = .013). The IAC group was also significantly more likely to have a tumor response as assessed by modified RECIST guidelines (P = .049). Dogs in the IAC group were significantly less likely to develop anemia (P = .001), lethargy (P = .010) and anorexia (P = .024).Conclusion and clinical importanceThis study demonstrated the feasibility and efficacy of performing IAC for lower urinary tract neoplasia. Further investigation is necessary as the follow-up time was short and the impact on long-term outcome and survival was not determined

Nurses\u27 Alumnae Association Bulletin, September 1958

Committee Reports Digest of Alumnae Meetings Graduation Awards - 1957 List of Wrong Addresses Marriages Necrology New Arrivals Physical Advances at Jefferson President\u27s Message School of Nursing Repor

Transesophageal echocardiographic evaluation of an intraoperative retrograde acute aortic dissection: case report

BACKGROUND: We report an intraoperative retrograde dissection of the aorta and its subsequent evaluation by transesophageal echocardiography (TEE). CASE PRESENTATION: A 78 year old woman with an ascending aortic aneurysm without dissection and coronary artery disease was brought to the operating room for aneurysm repair and coronary artery bypass grafting. After initiation of cardiopulmonary bypass through a femoral artery cannula, aortic dissection was noted and subsequently imaged by TEE. CONCLUSION: Retrograde aortic dissection through the femoral artery is life-threatening. Intraoperative TEE can be used to diagnose this uncommon event, and should be considered after initiation of bypass

Description and Comparison of the Results of the Proposed House: Habitat for Humanity at Frazier Court, Dallas, Texas, with the 2004 IECC Standard Reference House

The Energy Systems Laboratory was requested to calculate the emissions reductions associated with the Habitat for Humanity Housing Project at Frazier Court, Dallas Texas. This report presents the results of the required analysis, a set of houses was compared to a corresponding standard reference house as described in the 2004 International Energy Conservation Code (2004 IECC). The energy consumption calculations were carried out using DOE-2.1e input file RES3ST.inp (Version 4.01.07) and DDP (Version: 1.7.03). Based on this comparison, the % above/below code for the proposed house was determined. The resultant emissions calculations were carried out using eCALC software (ESL, 2006). This report also contains detailed information about the description of the proposed house in terms of its building parameters, resultant energy consumption and emission reductions. Calculations are carried out using TMY2 weather file for Tarrant County, TX which is in climate zone 3 of the IECC 2004 climate zone categories. For the 1285 sq. ft. houses, the energy consumption of the Habitat for Humanity houses is in the range of 10.3% - 11.7% above code and for the 843 sq. ft. houses, the energy consumption is in the range of 20.9% - 21.4% below code. The HERS ratings calculated by IC3 is in the range of 71.7– 74.2 for the 1285 sq. ft. houses and in the range of 79.4 – 80.6 for the 843 sq. ft. houses

The effects of voice and manual control mode on dual task performance

Two fundamental principles of human performance, compatibility and resource competition, are combined with two structural dichotomies in the human information processing system, manual versus voice output, and left versus right cerebral hemisphere, in order to predict the optimum combination of voice and manual control with either hand, for time-sharing performance of a dicrete and continuous task. Eight right handed male subjected performed a discrete first-order tracking task, time-shared with an auditorily presented Sternberg Memory Search Task. Each task could be controlled by voice, or by the left or right hand, in all possible combinations except for a dual voice mode. When performance was analyzed in terms of a dual-task decrement from single task control conditions, the following variables influenced time-sharing efficiency in diminishing order of magnitude, (1) the modality of control, (discrete manual control of tracking was superior to discrete voice control of tracking and the converse was true with the memory search task), (2) response competition, (performance was degraded when both tasks were responded manually), (3) hemispheric competition, (performance degraded whenever two tasks were controlled by the left hemisphere) (i.e., voice or right handed control). The results confirm the value of predictive models invoice control implementation

Static Pressure Losses in 6, 8, and 10-inch Non-Metallic Flexible Ducts

This study measured airflow static pressure losses through non-metallic flexible ducts in compliance with ASHRAE Standard 120-1999, Methods of Testing to Determine Flow Resistance of HVAC Air Ducts and Fittings (ASHRAE 1999). Duct sizes of 6, 8, and 10 inches were tested in a positive pressure, blow-through configuration. An “as-built” test protocol expands the test configurations specified by Standard 120. Results of the current tests extend the existing ASHRAE/ACCA data for the flexible duct, which does not include pressure loss data for flexible ducts that are compressed beyond approximately 4%. The data from this study exhibit higher pressure losses than prior ACCA or ASHRAE data. Some configurations have over ten times the pressure loss found in rigid ducts or fully stretched flexible ducts of the same diameter. The experimental results were utilized to create a set of loss prediction equations for flexible ducts that did not previously exist

Introduction: resilience and the Anthropocene: the stakes of ‘renaturalising’ politics

The Anthropocene marks a new geological epoch in which human activity (and specifically Western production and consumption practices) has become a geological force. It also profoundly destabilizes the grounds of Western political philosophy. Visions of a dynamic earth system wholly indifferent to human survival liquefy modernity’s division between nature and politics. Critical thought has only begun to scratch the surface of the Anthropocene’s re-naturalization of politics. This special issue of Resilience: International Policies, Practices and Discourses explores the politics of resilience within the wider cultural and political moment of the Anthropocene. It is within the field of resilience thinking that the implications of the Anthropocene for forms of governance are beginning to be sketched out and experimental practices are undertaken. Foregrounding the Anthropocene imaginary’s re-naturalization of politics enables us to consider the political possibilities of resilience from a different angle, one that is irreducible to neoliberal post-political rule

Prediction of photoperiodic regulators from quantitative gene circuit models

Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm. Sufficient data are available to test this quantitatively in plants, though not yet in animals. In Arabidopsis, the clock-regulated genes CONSTANS (CO) and FLAVIN, KELCH, F-BOX (FKF1) and their lightsensitive proteins are thought to form an external coincidence sensor. We use 40 timeseries of molecular data to model the integration of light and timing information by CO, its target gene FLOWERING LOCUS T (FT), and the circadian clock. Among other predictions, the models show that FKF1 activates FT. We demonstrate experimentally that this effect is independent of the known activation of CO by FKF1, thus we locate a major, novel controller of photoperiodism. External coincidence is part of a complex photoperiod sensor: modelling makes this complexity explicit and may thus contribute to crop improvement