Polyphase Laramide Structures and Possible Folded Tertiary(?) Sills at Dagger mountain, Big Bend National Park, Texas

Dagger Mountain, in Sierra del Carmen within Big Bend National Park, Texas, is a 5 km-long, doubly-plunging, southwest-vergent anticline adjacent to a doubly plunging syncline. Dagger Mountain lies near the eastern margins of the Cordilleran orogen and the Basin and Range province. Mapping at 1:12,000 scale reveals details about three phases of Laramide and Basin and Range structures. Mapping and descriptive structural analysis complement previous mapping at 1:12,000 – 1:75,000 scales (Poth, 1979; Moustafa, 1988; Cooper and others, 2011; Turner and others, 2011; Maxwell and others, 1967). Four distinctive formations of Cretaceous age crop out on Dagger Mountain: Santa Elena Limestone, Del Rio Clay, Buda Limestone, and Boquillas Formation. At least two phaneritic, mafic, feldpathoid-rich sills intrude the Boquillas Formation. A similar, possibly correlative sill south of Dagger Mountain is dated at 32.47 ± 0.41 Ma ( 40Ar/39 Ar on groundmass; Morgan and Shanks, 2008). One well-exposed Dagger Mountain sill can be traced from one map-scale fold limb, through the hinge, and into the other limb. The Dagger Mountain anticline is a first-phase (D1) fold. D1 map- and outcrop-scale folds contain subvertical NNW-striking axial planes and subhorizontal fold axes. Second-phase (D2) folds produced NNW and SSE plunges of the DM anticline. D2 map- and outcrop-scale folds display subvertical NE-striking axial planes and subhorizontal fold axes. Third-phase (D3) high-angle faults strike NNW and NW and cross-cut D1 folds and Tertiary sills. Drag during D3 faulting produced D3 folds. Dagger Mountain structures are significant because: a) few polyphase folds have been documented in the Big Bend region, b) the west-verging Dagger Mountain anticline and other D1 folds show fault-propagation fold characteristics, c) the apparently folded Tertiary(?) sill suggests that Laramide deformation at Dagger Mountain is post-32 Ma and unusually recent. Alternatively, the sill could be as old as Cretaceous, or the sill could have intruded both limbs and hinge of an existing fold

'Half-cut' science : a qualitative examination of alcohol industry actors' use of peer-reviewed evidence in policy submissions on Minimum Unit Pricing

Aim: To assess the extent to which alcohol industry actors cited evidence in submissions to the Scottish Parliament Health and Sport Committee’s 2011 call for written evidence on the Alcohol (Minimum Pricing) (Scotland) Bill and to compare any citations of peer-reviewed evidence to original sources. Methods: All submissions to the consultation (n=128) were manually searched to identify those written by alcohol industry actors (n=25). The reference lists of all the alcohol industry submissions were reviewed and peer-reviewed sources were retrieved, read and assessed against their in-text citation within the alcohol industry submissions. Results: Although most industry submissions cited evidence of some sort, only 7 (28%) cited peer-reviewed evidence. Comparing the total number of citations to peer-reviewed evidence (n=17) to original sources demonstrates that 82% were questionably cited. Conclusion: Our findings demonstrate that the majority of references to peer-reviewed evidence in this sample of alcohol industry policy submissions were misleading with examples of citations being presented as supportive of arguments that the original evidence source specifically argued against. This suggests that even the depiction of peer-reviewed evidence within alcohol industry policy submissions needs to be treated with caution

A Randomised Phase 2 Trial of Intensive Induction Chemotherapy (CBOP/BEP) and Standard BEP in Poor-prognosis Germ Cell Tumours (MRC TE23, CRUK 05/014, ISRCTN 53643604)

AbstractBackgroundStandard chemotherapy for poor-prognosis metastatic nonseminoma has remained bleomycin, etoposide, and cisplatin (BEP) for many years; more effective regimens are required.ObjectiveTo explore whether response rates with a new intensive chemotherapy regimen, CBOP/BEP (carboplatin, bleomycin, vincristine, cisplatin/BEP), versus those in concurrent patients treated with standard BEP justify a phase 3 trial.Design, setting, and participantsWe conducted a phase 2 open-label randomised trial in patients with germ cell tumours of any extracranial primary site and one or more International Germ Cell Cancer Collaborative Group poor-prognosis features. Patients were randomised between 2005 and 2009 at 16 UK centres.InterventionBEP (bleomycin 30 000 IU) was composed of four cycles over 12 wk. CBOP/BEP was composed of 2×CBOP, 2×BO, and 3×BEP (bleomycin 15 000 IU).Outcome measurements and statistical analysisPrimary end point was favourable response rate (FRR) comprising complete response or partial response and normal markers. Success required the lower two-sided 90% confidence limit to exclude FRRs <60%; 44 patients on CBOP/BEP gives 90% power to achieve this if the true FRR is ≥80%. Equal numbers were randomised to BEP to benchmark contemporary response rates.Results and limitationsA total of 89 patients were randomised (43 CBOP/BEP, 46 BEP); 40 and 41, respectively, completed treatment. CBOP/BEP toxicity, largely haematologic, was high (96% vs 63% on BEP had Common Terminology Criteria for Adverse Events v.3 grade ≥3). FRRs were 74% (90% confidence interval [CI], 61–85) with CBOP/BEP, 61% with BEP (90% CI, 48–73). After a median of 58-mo follow-up, 1-yr progression-free survival (PFS) was 65% and 43%, respectively (hazard ratio: 0.59; 95% CI, 0.33–1.06); 2-yr overall survival (OS) was 67% and 61%. Overall, 3 of 14 CBOP/BEP and 2 of 18 BEP deaths were attributed to toxicity, one after an overdose of bleomycin during CBOP/BEP. The trial was not powered to compare PFS.ConclusionsThe primary outcome was met, the CI for CBOP/BEP excluding FRRs <61%, but CBOP/BEP was more toxic. PFS and OS data are promising but require confirmation in an international phase 3 trial.Patient summaryIn this study we tested a new, more intensive way to deliver a combination of drugs often used to treat men with testicular cancer. We found that response rates were higher but that the CBOP/BEP regimen caused more short-term toxicity. Because most patients are diagnosed when their cancer is less advanced, it took twice as long to complete the trial as expected. Although we plan to carry out a larger trial, we will need international collaboration.Trial registrationISRCTN53643604; http://www.controlled-trials.com/ISRCTN53643604

From Chip to Cooling Tower Data Center Modeling:

The chiller cooled data center environment consists of many interlinked elements that are usually treated as individual components. This chain of components and their influences on each other must be considered in determining the benefits of any data center design and operational strategies seeking to improve efficiency, such as temperature controlled fan algorithms. Using the models previously developed by the authors, this paper extends the analysis to include the electronics within the rack through considering the processor heat sink temperature. This has allowed determination of the influence of various cooling strategies on the data center coefficient of performance. The strategy of increasing inlet aisle temperature is examined in some detail and found not to be a robust methodology for improving the overall energy performance of the data center, while tight temperature controls at the chip level consistently provide better performance, yielding more computing per watt of cooling power. These findings are of strong practical relevance for the design of fan control algorithms at the rack level and general operational strategies in data centers. Finally, the impact of heat sink thermal resistance is considered, and the potential data center efficiency gains from improved heat sink designs are discussed

A Study of the Sediments of Narragansett Bay, Volume 1: The Surface Sediments of Narragansett Bay

This report is divided into two volumes. The focus of Volume I is the surface sediments of Narragansett Bay. Volume I contains a study of the surface sediments of Narragansett Bay (Chapter 1), a study of suspended sediments in the northwestern section of the Narragansett Bay System (Chapter 2), a study of the relationship between contaminant concentrations in the surface sediments and soft tissues of the hard clam, Mercenaria mercenaria in Narragansett Bay (Chapter 3), and the results of a side-scan sonar survey of the Providence River dredged channel (Chapter 4). The focus of Volume II is a study of sediment cores from the Narragansett Bay System. Chapter 5 contains the results of geophysical (side-scan and sub-bottom sonar) that support the core studies. The results of studies of sediment cores from Narragansett Bay are contained in Chapter 6, and the results of sediment core studies from its freshwater tributaries (i.e., the Blackstone and Pawtuxet Rivers) are contained in Chapter 7. (Text taken from report preface

Planning energy interventions in buildings and tackling fuel poverty : Can two birds be fed with one scone?

Energy retrofitting and renovations are an inseparable part of decarbonisation strategies in the building sector. These measures are often tied up with several social factors that can potentially impact the wellbeing of households and the community if the end-user requirements are not carefully considered. Fuel poverty is one of these social factors that is an essential consideration for designing effective, just, and user-centred interventions, but it is often overlooked in engineering processes. Therefore, this article seeks to re-connect the notion of fuel poverty to practice by bringing it forward from the post-intervention assessments to the design and decision-making stages. To do so, a new indicator, Potential Fuel Poverty Index (PFPI), is developed to obtain the likelihood of fuel poverty that future interventions can pose to the households. The PFPI presents a more targeted analysis of fuel poverty by reflecting the socio-spatial characterisation of the households. Using the PFPI, fuel poverty can be observed as a design/decision factor at the early stages of sketching interventions, in conjunction with other economic, environmental, and technical factors. Finally, the utility of the developed method is demonstrated using a real case study in the UK, assessing the impact of heat decarbonisation through heat pumps on fuel poverty.publishedVersionPeer reviewe

Towards a just heat transition in the building sector: A study on social indicators of sustainability

Heating in UK buildings is dominated by fossil fuels as the main energy source, representing over 80% of the household energy consumption and 79% of the carbon emissions. Therefore, heat decarbonisation in this sector should be accelerated in order to achieve the 2050 net zero carbon targets. However, there is still a great deal of uncertainty regarding the social impacts of heat decarbonisation strategies on households and the communities. The multiplicity of social criteria and inconsistency of their measuring methods complicate the assessment of social sustainability in the energy systems, leading to less incorporation of the social factors in design and decision-making processes. Therefore, identifying a set of indicators that represent the social performance of energy systems is an essential for conducting a holistic sustainability assessment. In this research, a methodological process is established primarily aimed to identify, select, and prioritise a representative set of indicators that can reflect the social sustainability of the heating transition in the building industry. The research accounts for a qualitative survey and judgments of experts to determine the indicators and their importance weights thus reducing the subjectivity and uncertainties of the process. The result is a social sustainability assessment framework that will enable decision-makers to evaluate the transition pathways, select the best alternatives, and monitor their performance, by analysing social indicators in conjunction with other sustainability parameters.publishedVersionPeer reviewe

Spatial Distribution of Aphis glycines (Hemiptera: Aphididae): A Summary of the Suction Trap Network

The soybean aphid, Aphis glycines Matsumura (Hemiptera: Aphididae), is an economically important pest of soybean, Glycine max (L.) Merrill, in the United States. Phenological information ofA. glycines is limited; specifically, little is known about factors guiding migrating aphids and potential impacts of long distance flights on local population dynamics. Increasing our understanding of A. glycines population dynamics may improve predictions of A. glycines outbreaks and improve management efforts. In 2005 a suction trap network was established in seven Midwest states to monitor the occurrence of alates. By 2006, this network expanded to 10 states and consisted of 42 traps. The goal of the STN was to monitor movement of A. glycines from their overwintering hostRhamnus spp. to soybean in spring, movement among soybean fields during summer, and emigration from soybean to Rhamnus in fall. The objective of this study was to infer movement patterns ofA. glycines on a regional scale based on trap captures, and determine the suitability of certain statistical methods for future analyses. Overall, alates were not commonly collected in suction traps until June. The most alates were collected during a 3-wk period in the summer (late July to mid-August), followed by the fall, with a peak capture period during the last 2 wk of September. Alate captures were positively correlated with latitude, a pattern consistent with the distribution of Rhamnus in the United States, suggesting that more southern regions are infested by immigrants from the north