Synthesis and characterization of CdSe and Au-CdSe hybrid nanoparticles

Tesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Física Aplicada. Fecha de lectura: 10-02-201

Erratun: G-force induced giant efficiency of nanoparticles internalization into living cells

The original version of this Article contained a typographical error in the spelling of the author Jose Luis F. Cuñado, which was incorrectly given as Jose Luis, F. Cuñad

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Thermal ligand desorption in CdSe quantum dots by correlated XPS and STM

Pyramidal CdSe NCs self-assembled on highly oriented pyrolytic graphite (HOPG) substrates were characterized, both by STM and synchrotron XPS measurements, upon annealing treatments at different temperatures. By STM, shape modifications at different temperatures was observed. In particular the NCs experience a shape relaxation via an intra-particle ripening or physical coagulation after exposing the sample at 200°C, while a mass transfer via inter-particle ripening (Ostwald ripening) is activated at 400°C. Synchrotron XPS data allow establishing a clear differentiation between the desorption behavior of long octadecylphosphonic acid-related ligands and short chloride ionic ligands.B.H.J. thanks for funding under the frame of the following projects: S2013/MIT‐2740 from Comunidad de Madrid, FIS2012‐33011, FIS2015‐67367‐C2‐1‐P, and MAT2013‐47395‐C4‐3‐R, from the Spanish Ministry of Economy and Competitiveness. R.O. thanks for FIS2012‐33011 and FIS2015‐67367‐C2‐1‐P.Peer Reviewe

Conocimiento y práctica del uso de equipos de protección personal en el contexto Covid 19 en el personal de salud del servicio de UCI del Hospital El Carmen Huancayo 2020

Objective: To determine the relationship between knowledge and practice of the use of personal protective equipment in the context of COVID 19 in the health personnel of the ICU service of the hospital el Carmen Huancayo 2020. The area of study corresponds to medical and health sciences. Material and methods: The method of this research will be scientific which consists of a research method mainly used. The research design is correlational, non-experimental and cross-sectional, the type of research, according to the purpose will be basic, the level of research will be descriptive - correlational. Results: The results show that 56% of the ICU personnel of Hospital El Carmen have an average knowledge of the use of PPE and 68% comply moderately with the use of PPE in the Covid - 19 context. Conclusion: We conclude that there is a significant relationship between the level of knowledge and the application of the measures of the ICU personnel of Hospital El Carmen,2020. (p value=0.001<0.05).Objetivo: Determinar la relación entre el conocimiento y la práctica del uso de equipos de protección personal en el contexto COVID 19 en el personal de salud del servicio de UCI del hospital el Carmen Huancayo 2020. El área de estudio corresponde a las Ciencias médicas y de salud. Material y métodos: El método de esta investigación será el científico que consiste en un método de investigación usado principalmente. El diseño de investigación es correlacional, no experimental y de corte transversal, el tipo de investigación, de acuerdo a la finalidad realizada será básica, el nivel de Investigación será descriptivo – correlacional. Resultados: Los resultados muestran que el 56% del personal de UCI del Hospital El Carmen tiene un conocimiento medio del uso de EPP y el 68% cumple medianamente con el uso de EPP en el contexto Covid – 19. Conclusiones: Concluyendo que existe relación significativa entre el nivel de conocimiento y la aplicación de las medidas de del personal de UCI del Hospital El Carmen, 2020. (p valor=0,001<0,05)

Factores de comorbilidad y secuelas de covid 19 en trabajadores de un hospital nacional de Huancayo 2021

Objective: To determine the relationship of Covid 19 Comorbidity Factors and Sequelae in workers of a National Hospital of Huancayo 2021. Material and Methods: The method of this research was scientific, basic type, descriptive correlational level, non-experimental design, cross-sectional. The study sample calculated probabilistically was 137 workers. Results: the majority professionals in 52.6%, most of them had COVID-19, mild (51.8%) and severe 14.6%, 81.8% had contact with patients and believe that it was infected in the hospital in 58.4% and 43.8% received care at home and in a hospital overall 29.9%. The majority were between 31 and 40 years old (35.8%) followed by 41 and 50 years (30.7), they were male (60.6%). Among the comorbidity factors they had: 65% overweight, 8% diabetes, 0% HIV, 3% heart disease, 10.2% asthma, and 1.5% kidney disease. Most did not have respiratory system sequelae (40.9%), nor cardiovascular (86.9%), nor psychological (89.1%) nor dermatological (47.4%) sequelae. In relation to neuropsychiatric sequelae, it is observed that 4.4% had loss of smell, headache 50.4%; mood swings 15.3%; neuromuscular dysfunction 0.7%; Difficulty thinking or concentrating 8.8%; depression 40.9%; anxiety 9.5%; muscle pain 10.2%. Conclusion: There is a relationship between Comorbidity and sequelae factors related to Covid 19 in workers of a National Hospital of Huancayo 2021 (p value = 0.007 <0.05).Objetivo: Determinar la relación de los Factores de Comorbilidad y Secuelas de Covid 19 en trabajadores de un Hospital Nacional de Huancayo 2021. Material y Métodos: El método de esta investigación fue científico, de tipo básico, nivel descriptivo correlacional, diseño no experimental, de corte transversal. La muestra de estudio calculada probabilísticamente fue de 137 trabajadores. Resultados: El 52,6% de los pacientes tuvieron COVID-19, la mayoría leve (51,8%), y severo el 14,6%, el 81,8%  tuvieron contacto con los pacientes,  el 58,4% cree que se contagió en el hospital, recibió atención en su casa el 43,8% y en un hospital general el 29,9%. La mayoría tenía entre 31 y 40 años (35,8%) seguido de 41 y 50 años (30,7), fueron de sexo masculino (60,6%). Entre los factores de comorbilidad tenían: sobrepeso el 65%, diabetes el 8%, VIH 0%, cardiopatías el 3% asma al 10,2%, y enfermedades renales el 1,5%. La mayoría no tenía secuelas del aparato respiratorio (40,9%), tampoco cardiovasculares (86,9%), ni secuelas psicológicas (89,1%) tampoco dermatológicas (47,4%). En relación a las secuelas neuropsiquiátricas se observa que tuvieron pérdida de olfato el 4,4%, cefalea el 50,4%; cambios de humor 15,3%; disfunción neuromuscular 0,7%; dificultad para pensar o concentrarse el 8.8%; depresión 40,9%; ansiedad 9,5%; dolor muscular 10,2%. Conclusiones: Existe relación entre los factores de Comorbilidad y secuelas relacionados con el Covid 19 en trabajadores de un Hospital Nacional de Huancayo 2021 (p valor=0,007<0,05)

Determinantes sociales de salud y anemia en estudiantes del 5° año de secundaria de la I.E. Virgen de Fátima. Huancayo

Objetivos: Determinar la relación de los determinantes sociales de salud y anemia en los estudiantes del 5° año de secundaria de la I.E. “Virgen de Fátima”. Material y Métodos: La investigación tuvo como método el científico, el tipo es básico, el nivel correlacional y el diseño es no experimental y de corte transversal. La muestra de estudio fue de 84 estudiantes de la Institución Educativa en estudio. Resultados: Los resultados muestran que el 83,3% no tiene anemia, 8,3% tiene anemia grado leve, un 8,3% anemia grado moderado y anemia grado severo 0%. Conclusiones: No existe relación significativa entre los determinantes sociales de salud y anemia en los estudiantes del 5° año de secundaria de la I.E. “Virgen de Fátima” 2019. (p valor >0,05)

Aggregation effects on the magnetic properties of iron oxide colloids

Magnetic nanoparticles (MNPs), and in particular iron oxide nanoparticles (mainly magnetite and maghemite), are being widely used in the form of aqueous colloids for biomedical applications. In such colloids, nanoparticles tend to form assemblies, either aggregates, if the union is permanent, or agglomerates, if it is reversible. These clustering processes have a strong impact on the MNPs' properties that are often not well understood. In this review, the causes and consequences of MNPs aggregation/agglomeration are reviewed and discussed. Special attention has been paid to the impact of the MNPs aggregation/agglomeration on their magnetic properties and heating properties, when exposed to an alternating magnetic field in the frame of magnetic hyperthermia. In addition, a model system with MNPs of two different sizes coated with three different molecules oleic acid, meso-2, 3-dimercaptosuccinic acid and poly(maleic anhydride-alt-1-octadecene) has been characterized and the results used to support the ideas reviewed.This work was supported by Fondo Social de la DGA (grupos DGA, BIONANOSURF), Ministerio de la Economía y Competitividad del Gobierno de España for the public funding of Proyectos I+D+I—Programa Estatal de Investigación, Desarrollo e Innovación Orientada a los Retos de la Sociedad (projects MAT2017-88148-R, MAT2015-71806-R and SAF2014-54763-C2-2-R), Comunidad de Madrid (Project NANOFRONTMAG-CM, S2013/MIT-2850), and ERCStarting Grant 239931-NANOPUZZLE. IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686). LG acknowledges financial support from the Ramón y Cajal subprogram (RYC-2014-15512).Peer reviewe

BSA-coated magnetic nanoparticles for improved therapeutic properties

In recent years, magnetic nanoparticles have been widely investigated due to their potential in biomedical applications. For successful in vivo applications, magnetic nanoparticles must satisfy several requirements such as biocompatibility, invisibility to the immune system, high colloidal stability in biological fluids, and long blood circulation times. In this study, we have developed a formulation in which the magnetic nanoparticles are coated with bovine serum albumin to provide enhanced colloidal stability in biological fluids preserving their magnetic properties. In addition, the nanoparticles carry a chemotherapeutic drug, showing their potential as drug delivery systems. Our results reveal the influence of protein adsorption on the colloidal stability and the dynamical magnetic response of functionalized magnetic nanoparticles. Moreover, cellular internalization and in vitro cytotoxic activity in Panc-1 pancreatic cancer cells reveal enhanced cellular internalization, successful intracellular drug delivery, and efficient anticancer activity

Influence of coating and size of magnetic nanoparticles on cellular uptake for in vitro MRI

Iron oxide nanoparticles (IONPs) are suitable materials for contrast enhancement in magnetic resonance imaging (MRI). Their potential clinical applications range from diagnosis to therapy and follow-up treatments. However, a deeper understanding of the interaction between IONPs, culture media and cells is necessary for expanding the application of this technology to different types of cancer therapies. To achieve new insights of these interactions, a set of IONPs were prepared with the same inorganic core and five distinct coatings, to study their aggregation and interactions in different physiological media, as well as their cell labelling efficiency. Then, a second set of IONPs, with six different core sizes and the same coating, were used to study how the core size affects cell labelling and MRI in vitro. Here, IONPs suspended in biological media experience a partial removal of the coating and adhesion of molecules. The FBS concentration alters the labelling of all types of IONPs and hydrodynamic sizes & GE; 300 nm provide the greatest labelling using the centrifugation-mediated internalization (CMI). The best contrast for MRI results requires a core size range between 12-14 nm coated with dimercaptosuccinic acid (DMSA) producing R_2^* values of 393.7 s_(-1) and 428.3 s_(-1), respectively. These findings will help to bring IONPs as negative contrast agents into clinical settings