The space simulation facilities at IAL SPACE

The thermal vacuum facilities of IAL SPACE were tailored for testing of the ESA payloads. They were progressively upgraded for cryogenic payloads including 4 K (liquid helium temperature) experiments. A detailed review of the three vacuum chambers, ranging from 1.5 to 5 m diameter, is presented including the corresponding capabilities in the vacuum, thermal, and optical fields. The various aspects of cleanliness, product assurance, and quality control are also presented

Effectiveness of lurasidone in schizophrenia or schizoaffective patients switched from other antipsychotics: a 6-month, open-label, extension study

Objective. To evaluate the long-term safety and tolerability of lurasidone in schizophrenia and schizoaffective disorder patients switched to lurasidone. Method. Patients in this multicenter, 6-month open-label, flexible-dose, extension study had completed a core 6-week randomized trial in which clinically stable, but symptomatic, outpatients with schizophrenia or schizoaffective disorder were switched to lurasidone. Patients started the extension study on treatment with the same dose of lurasidone taken at study endpoint of the 6-week core study; following this, lurasidone was flexibly dosed (40-120 mg/day), if clinically indicated, starting on Day 7 of the extension study. The primary safety endpoints were the proportion of patients with treatment emergent adverse events (AEs), serious AEs, or who discontinued due to AEs. Secondary endpoints included metabolic variables and measures of extrapyramidal symptoms and akathisia, as well as the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impressions-Severity (CGI-S), and the Calgary Depression Scale for Schizophrenia (CDSS). The study was conducted from August 2010 to November 2011. Results. Of the 198 patients who completed the 6-week core study, 149 (75.3%) entered the extension study and 148 received study medication. A total of 98 patients (65.8%) completed the 6-month extension study. Lurasidone 40, 80, and 120 mg were the modal daily doses for 19 (12.8%), 65 (43.9%), and 64 (43.2%) of patients, respectively. Overall mean (SD) daily lurasidone dose was 102.0 mg (77.1). The most commonly reported AEs were insomnia (13 patients [8.8%]), nausea (13 patients [8.8%]), akathisia (12 patients [8.1%]), and anxiety (9 patients [6.1%]). A total of 16 patients (10.8%) had at least one AE leading to discontinuation from the study. Consistent with prior studies of lurasidone, there was no signal for clinically relevant adverse changes in body weight, lipids, glucose, insulin, or prolactin. Movement disorder rating scales did not demonstrate meaningful changes. Treatment failure (defined as any occurrence of discontinuation due to insufficient clinical response, exacerbation of underlying disease, or AE) was observed for 19 patients (12.8% of patients entering) and median time to treatment failure was 58 days (95% CI 22-86). The discontinuation rate due to any cause was 50/148 (33.8%), and median time to discontinuation was 62 days (95% CI 30-75). The mean PANSS total score, mean CGI-S score, and mean CDSS score decreased consistently from core study baseline across extension visits, indicating an improvement in overall condition. Conclusions. In this 6-month, open-label extension study, treatment with lurasidone was generally well-tolerated with sustained improvement in efficacy measures observed in outpatients with schizophrenia or schizoaffective disorder who had switched to lurasidone from a broad range of antipsychotic agents

IAL SPACE: A test laboratory for the ISO cryogenic payload

The ESA Infrared Space Observatory (ISO) satellite is a 3 axes pointed platform designed to make accurate pointed observations of astronomical objects and sources in the wavelength range between 2.5 and 200 microns. ISO is composed of a service module and a payload module which is a large cylindrical vacuum vessel. The vessel is in fact a cryostat (capacity of 2250 l of liquid He II) which contains the telescope and the four focal scientific instruments. The latter being cooled up to a temperature less than 4 K. The qualification of the payload requires the measurement respectively of: the image quality of the telescope through wave front error (WFE) measurements; and the optical alignment of the scientific instruments with respect to the telescope axis and the telescope focus, and this under cryogenic conditions. Consequently, since 1988, the FOCAL 5 IAL Space facility has been upgraded in order to perform the cryogenic optical tests of the ISO optical subsystems

Analyzing topographic changes through LiDAR and SfM techniques: assessing the deposition-erosion patterns and estimation of debris-flow volume in the eastern Italian Alps

On 4 August 2015, a very high intensity storm, 31.5 mm in 20 min (94.5 mm/h), hit the massif of Mount Antelao on the Venetian Dolomites (eastern Italian Alps) triggering stony debris flow characterized by high magnitude. It routed along the Ru Secco Creek and progressively reached the resort area and the village of San Vito di Cadore, causing fatalities and damages. The aim of the present research is the study of this debris-flow event by means of pre and post-event topographic data derived by LiDAR (Light Detection and Ranging) and Structure-from-Motion (SfM) photogrammetry technique associated to its occurrence. This study analyzes the Digital Terrain Models (DTMs) derived from LiDAR survey carried out in July 2015 and UAV-SfM data obtained in September 2019. The most important step to compare these multi-temporal surveys was the co-registration process, fundamental to guarantee the coherence among the two different surveys. The post-event SfM-DTM of the area routed by debris flow subtracted to the pre-event LiDAR-DTM, provided a DoD (DTM of Difference) that was useful to assess the deposition-erosion patterns and estimate debris-flow volume. Multi-temporal topographical data are important to analyze the phenomenon and its characteristics. This allowed us to more in depth analyzed the debris-flow effects and provide valuable information for the planning of risk prevention measures

On the nature of the Be star HR 7409 (7 Vul)

HR 7409 (7 Vul) is a newly identified Be star possibly part of the Gould Belt and is the massive component of a 69-day spectroscopic binary. The binary parameters and properties of the Be star measured using high-dispersion spectra obtained at Ondrejov Observatory and at Rozhen Observatory imply the presence of a low mass companion (~ 0.5-0.8 M_sun). If the pair is relatively young (<50-80 Myr), then the companion is a K V star, but, following another, older evolutionary scenario, the companion is a horizontal-branch star or possibly a white dwarf star. In the latter scenario, a past episode of mass transfer from an evolved star onto a less massive dwarf star would be responsible for the peculiar nature of the present-day, fast-rotating Be star.Comment: Accepted for publication in MNRA

Volume estimation of soil stored in agricultural terrace systems : a geomorphometric approach

High-resolution topographic (HRT) techniques allow the mapping and characterization of geomorphological features with wide-ranging perspectives at multiple scales. We can exploit geomorphometric information in the study of the most extensive and common landforms that humans have ever produced: agricultural terraces. We can only develop an understanding of these historical landform through in-depth knowledge of their origin, evolution and current state in the landscape. These factors can ultimately assist in the future preservation of such landforms in a world increasingly affected by anthropogenic activities. From HRT surveys, it is possible to produce high-resolution Digital Terrain Models (DTMs) from which important geomorphometric parameters such as topographic curvature, to identify terrace edges can be extracted, even if abandoned or covered by uncontrolled vegetation. By using riser bases as well as terrace edges (riser tops) and through the computation of minimum curvature, it is possible to obtain environmentally useful information on these agricultural systems such as terrace soil thickness and volumes. The quantification of terrace volumes can provide new benchmarks for soil erosion models, new perspectives to stakeholders for terrace management in terms of natural hazard and offer a measure of the effect of these agricultural systems on soil organic carbon sequestration. This paper presents the realization and testing of an innovative and rapid methodological workflow to estimate the anthropogenic reworked and moved soil of terrace systems in different landscapes. We start with remote terrace mapping at large scale and then utilize more detailed HRT surveys to extract geomorphological features, from which the original theoretical slope-surface of terrace systems were derived. These last elements were compared with sub-surface information obtained from the excavations across the study sites that confirm the reliability of the methodology used. The results of this work have produced accurate DTMs of Difference (DoD) for three terrace sites in central Europe in Italy and Belgium. Differences between actual and theoretical terraces from DTM and excavation evidence have been used to estimate the soil volumes and masses used to remould slopes. The utilization of terrace and lynchet volumetric data, enriched by geomorphometric analysis through indices such as sediment conductivity provides a unique and efficient methodology for the greater understanding of these globally important landforms, in a period of increasing land pressure

Ending the Cinderella Status of Terraces and Lynchets in Europe : The Geomorphology of Agricultural Terraces and Implications for Ecosystem Services and Climate Adaptation

Terraces and lynchets are ubiquitous worldwide and can provide increasingly important Ecosystem Services (ESs), which may be able to mitigate aspects of climate change. They are also a major cause of non-linearity between climate and erosion rates in agricultural systems as noted from alluvial and colluvial studies. New research in the ‘critical zone’ has shown that we must now treat soil production as an ecologically sensitive variable with implications for soil carbon sequestration. In this review and synthesis paper we present a modified classification of agricultural terraces, review the theoretical background of both terraces and lynchets, and show how new techniques are transforming the study of these widespread and often ancient anthropogenic landforms. The problems of dating terraces and the time-consuming nature of costly surveys has held back the geomorphological and geoarchaeological study of terraces until now. The suite of techniques now available, and reviewed here,includes Digital Elevation Models (DEMs) - Structure from Motion (SfM) photogrammetry, Airborne and Terrestrial Laser Scanning (ALS-TLS); optically stimulated luminescence (OSL and pOSL), portable x-ray fluorescence (pXRF), Fourier-transform infra-red analysis (FTIR), phytoliths from plants, and potentially environmental DNA. Three process-related geomorphological questions arise from using this suite of methods; a) can they provide both a chronology of formation and use history, b) can we identify the sources of all the soil components? c) can terrace soil formation and ecosystem services be modelled at the slope to catchment scale? The answers to these questions can also inform the management of the large areas of abandoned and under-used terraces that are resulting from both the economics of farming and rural population changes. Where possible, examples are drawn from a recently started ERC project (TerrACE; ERC-2018-2023; https://www.terrace.no/) that is working at over 15 sites in Europe ranging from Norway to Greece

When the Transmission of Culture Is Child's Play

Background: Humans frequently engage in arbitrary, conventional behavior whose primary purpose is to identify with cultural in-groups. The propensity for doing so is established early in human ontogeny as children become progressively enmeshed in their own cultural milieu. This is exemplified by their habitual replication of causally redundant actions shown to them by adults. Yet children seemingly ignore such actions shown to them by peers. How then does culture get transmitted intra-generationally? Here we suggest the answer might be 'in play'. Principal Findings: Using a diffusion chain design preschoolers first watched an adult retrieve a toy from a novel apparatus using a series of actions, some of which were obviously redundant. These children could then show another child how to open the apparatus, who in turn could show a third child. When the adult modeled the actions in a playful manner they were retained down to the third child at higher rates than when the adult seeded them in a functionally oriented way. Conclusions: Our results draw attention to the possibility that play might serve a critical function in the transmission of human culture by providing a mechanism for arbitrary ideas to spread between children