4 research outputs found
Health tourism: an opportunity for sustainable development
In February 2017, the “Programma
Mattone Internazionale Salute” (ProMis), that is the
Italian Program for Internationalization of Regional
Health Systems of the Ministry of Health (MoH),
presented the first version of its Position Paper on
Health Tourism, which embeds a first shared
approach to the recommendations expressed by the
European Committee of Regions (CoR) on "AgeFriendly" tourism. The CoR stresses the importance
of local and regional authorities in the coordination
of multi-sectoral policies such as healthcare, social
assistance, transport, urban planning and rural
development in relation to the promotion of mobility,
security, accessibility of services, including health
care and social services.
"Age-friendly" tourism is an example of an
innovative tourist offer that strives to meet the health
needs of the entire "traveling" population, with an
integrated and cross-sector approach that involves
various organizations operating in sectors such as
healthcare, accessibility and transport.
The aim of the workshop was to explore the
interest of the stakeholders to participate in a
systemic action in the field of "health" tourism, and
to identify priority implementation areas that offer
opportunities to take advantage of validated,
innovative experiences that strengthen the
accessibility to health and social services in regional,
national and international contexts.
This effort provides the opportunity to take
advantage of aligning the European Structural and
Investment Funds (ESIF) to the development of
tourism, coherently with the needs and resources of
local and regional health authorities
E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells
Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response
Filamentous bacteriophage fd particles delivering antigenic determinants via DEC-205 (fdsc-αDEC) represent a powerful delivery system that induces CD8(+) T-cell responses even when administered in the absence of adjuvants or maturation stimuli for dendritic cells. In order to investigate the mechanisms of this activity, RNA-Sequencing of fd-pulsed dendritic cells was performed. A significant differential expression of genes involved in innate immunity, co-stimulation and cytokine production was observed. In agreement with these findings, we demonstrate that induction of proinflammatory cytokines and type I interferon by fdsc-αDEC was MYD88 mediated and TLR9 dependent. We also found that fdsc-αDEC is delivered into LAMP-1-positive compartments and co-localizes with TLR9. Thus, phage particles containing a single-strand DNA genome rich in CpG motifs delivered via DEC-205 are able to intercept and trigger the active TLR9 innate immune receptor into late endosome/lysosomes and to enhance the immunogenicity of the displayed antigenic determinants. These findings make fd bacteriophage a valuable tool for immunization without administering exogenous adjuvants