How Sensitive is the CMB to a Single Lens?

We study the imprints of a single lens, that breaks statistical isotropy, on the CMB and calculate the signal to noise ratio (S/N) for its detection. We emphasize the role of non-Gaussianities induced by LCDM weak lensing in this calculation and show that typically the S/N is much smaller than expected. In particular we find that the hypothesis that a void (texture) is responsible for the WMAP cold spot can barely (cannot) be tested via weak lensing of the CMB.Comment: Accepted for publication in JCAP, 24 pages, 5 figure

A Laser Frequency Comb System for Absolute Calibration of the VTT Echelle Spectrograph

A wavelength calibration system based on a laser frequency comb (LFC) was developed in a co-operation between the Kiepenheuer-Institut f\"ur Sonnenphysik, Freiburg, Germany and the Max-Planck-Institut f\"ur Quantenoptik, Garching, Germany for permanent installation at the German Vacuum Tower Telescope (VTT) on Tenerife, Canary Islands. The system was installed successfully in October 2011. By simultaneously recording the spectra from the Sun and the LFC, for each exposure a calibration curve can be derived from the known frequencies of the comb modes that is suitable for absolute calibration at the meters per second level. We briefly summarize some topics in solar physics that benefit from absolute spectroscopy and point out the advantages of LFC compared to traditional calibration techniques. We also sketch the basic setup of the VTT calibration system and its integration with the existing echelle spectrograph.Comment: 9 pages, 2 figures; Solar Physics 277 (2012

Discrete molecular dynamics simulations of peptide aggregation

We study the aggregation of peptides using the discrete molecular dynamics simulations. At temperatures above the alpha-helix melting temperature of a single peptide, the model peptides aggregate into a multi-layer parallel beta-sheet structure. This structure has an inter-strand distance of 0.48 nm and an inter-sheet distance of 1.0 nm, which agree with experimental observations. In this model, the hydrogen bond interactions give rise to the inter-strand spacing in beta-sheets, while the Go interactions among side chains make beta-strands parallel to each other and allow beta-sheets to pack into layers. The aggregates also contain free edges which may allow for further aggregation of model peptides to form elongated fibrils.Comment: 15 pages, 8 figure

Local Void vs Dark Energy: Confrontation with WMAP and Type Ia Supernovae

It is now a known fact that if we happen to be living in the middle of a large underdense region, then we will observe an "apparent acceleration", even when any form of dark energy is absent. In this paper, we present a "Minimal Void" scenario, i.e. a "void" with minimal underdensity contrast (of about -0.4) and radius (~ 200-250 Mpc/h) that can, not only explain the supernovae data, but also be consistent with the 3-yr WMAP data. We also discuss consistency of our model with various other measurements such as Big Bang Nucleosynthesis, Baryon Acoustic Oscillations and local measurements of the Hubble parameter, and also point out possible observable signatures.Comment: Minor numerical errors and typos corrected, references adde

Apoptosis in human liver carcinoma caused by gold nanoparticles in combination with carvedilol is mediated via modulation of MAPK/Akt/mTOR pathway and EGFR/FAAD proteins

Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas

Overcoming seed dormancy in visgueiro-of-the-igapó (Parkia discolor)

This study aimed to evaluate the effects of pregerminative mechanical scarification treatments, as well as heat pre-treatments on the germination of visgueiro-of-the-igapó (Parkia discolor Spruce ex Benth.) seeds. The first experiment, with a completely randomized design and four repetitions, evaluated these pre-treatments: control (without pre-treatment); clipping at the distal portion; clipping at the proximal portion (hilum); clipping at the proximal and distal portions; scraping at the distal portion; scraping at the proximal portion; scraping at the proximal and distal portions; perforation of the husk with a soldering-iron; and perforation by pyrography. In the second experiment, with a completely randomized design and factorial 2 (heat: dry and wet) x 4 (temperature: 40ºC, 50ºC, 60ºC and 70ºC) x 5 (period of conditioning: 6, 16, 24, 30 and 48 hours), with three repetitions. The clipping or scraping of the seeds in the proximal portion and proximal and distal portions allowed faster imbibition of the seeds (143-163% in three days and half), and consequently, better germination (98-100% in four days), germination speed rate (1,351-1,460) and average time of germination (3 days). The pre-treatment with heat (wet and dry), under different temperatures and different conditioning periods did not overcome the dormancy of P. discolor seeds.O presente trabalho teve como objetivo avaliar os efeitos da aplicação de tratamentos pré-germinativos de escarificação mecânica, bem como pré-tratamentos com calor, sobre a germinação de sementes de visgueiro-do-igapó (Parkia discolor Spruce ex Benth.). No primeiro experimento, sob delineamento inteiramente ao acaso, com quatro repetições, foram avaliados os pré-tratamentostestemunha (sem pré-tratamento); desponte no lado distal; desponte no lado proximal; desponte nos lados distal e proximal; lixamento no lado distal; lixamento no lado proximal; lixamento nos lados distal e proximal; perfuração do tegumento com ferro-de-solda; e perfuração com pirógrafo. No segundo experimento, foi adotado o delineamento inteiramente casualizado, em esquema fatorial 2 (calorseco e úmido) x 4 (temperatura40ºC, 50ºC, 60ºC e 70ºC) x 5 (período de condicionamento6, 16, 24, 30 e 48 horas), com três repetições. O desponte ou lixamento das sementes na porção proximal e porções proximal e distal possibilitaram uma embebição mais rápida (143-163%, aos três dias e meio) e, conseqüentemente, melhores resultados de germinação (98-100%, aos quatro dias), do índice de velocidade de germinação (1,351-1,460) e do tempo médio de germinação (3 dias). Os pré-tratamentos com calor (úmido e seco), sob diferentes temperaturas, e por vários períodos de condicionamento não superaram a dormência de sementes de P. discolor