266 research outputs found
A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori-Induced Metaplasia in the Stomach
Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gas-tric adenocarcinoma. To our knowledge, we are the
first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s2/i2 form of VacA colonized mice more efficiently than mutants null for VacA or producing more active forms of it, providing the
first evidence of a positive role for the minimally active s2/i2 toxin. Strains producing more active toxin forms induced more severe and extensive metaplasia and in flammation in the mouse stomach than strains producing weakly active (s2/i2) toxin. We also examined the association in humans, controlling for cag PAI status. In human gastric biopsy specimens, the vacA i1 allele was strongly associated with precancerous intestinal metaplasia, with almost complete absence of intestinal metaplasia in subjects infected with i2-type strains, even in a vacA s1, cagA+ background
Herschel-SPIRE-Fourier Transform Spectroscopy of the nearby spiral galaxy IC342
We present observations of the nearby spiral galaxy IC342 with the Herschel
Spectral and Photometric Imaging Receiver (SPIRE) Fourier Transform
Spectrometer. The spectral range afforded by SPIRE, 196-671 microns, allows us
to access a number of 12CO lines from J=4--3 to J=13--12 with the highest J
transitions observed for the first time. In addition we present measurements of
13CO, [CI] and [NII]. We use a radiative transfer code coupled with Bayesian
likelihood analysis to model and constrain the temperature, density and column
density of the gas. We find two 12CO components, one at 35 K and one at 400 K
with CO column densities of 6.3x10^{17} cm^{-2} and 0.4x10^{17} cm^{-2} and CO
gas masses of 1.26x10^{7} Msolar and 0.15x10^{7} Msolar, for the cold and warm
components, respectively. The inclusion of the high-J 12CO line observations,
indicate the existence of a much warmer gas component (~400 K) confirming
earlier findings from H_{2} rotational line analysis from ISO and Spitzer. The
mass of the warm gas is 10% of the cold gas, but it likely dominates the CO
luminosity. In addition, we detect strong emission from [NII] 205microns and
the {3}P_{1}->{3}P_{0} and {3}P_{2} ->{3}P_{1} [CI] lines at 370 and 608
microns, respectively. The measured 12CO line ratios can be explained by
Photon-dominated region (PDR) models although additional heating by e.g. cosmic
rays cannot be excluded. The measured [CI] line ratio together with the derived
[C] column density of 2.1x10^{17} cm^{-2} and the fact that [CI] is weaker than
CO emission in IC342 suggests that [CI] likely arises in a thin layer on the
outside of the CO emitting molecular clouds consistent with PDRs playing an
important role.Comment: 9 pages, 8 figures, accepted for publication in Monthly Notices of
the Royal Astronomical Society (MNRAS
Dissecting the origin of the submillimeter emission in nearby galaxies with Herschel and LABOCA
We model the infrared to submillimeter spectral energy distribution of 11
nearby galaxies of the KINGFISH sample using Spitzer and Herschel data and
compare model extrapolations at 870um (using different fitting techniques) with
LABOCA 870um observations. We investigate how the differences between
predictions and observations vary with model assumptions or environment. At
global scales, we find that modified blackbody models using realistic cold
emissivity indices (beta_c=2 or 1.5) are able to reproduce the 870um observed
emission within the uncertainties for most of the sample. Low values
(beta_c<1.3) would be required in NGC0337, NGC1512 and NGC7793. At local
scales, we observe a systematic 870um excess when using beta_=2.0. The
beta_c=1.5 or the Draine and Li (2007) models can reconcile predictions with
observations in part of the disks. Some of the remaining excesses occur towards
the centres and can be partly or fully accounted for by non-dust contributions
such as CO(3-2) or, to a lesser extent, free-free or synchrotron emission. In
three non-barred galaxies, the remaining excesses rather occur in the disk
outskirts. This could be a sign of a flattening of the submm slope (and
decrease of the effective emissivity index) with radius in these objects.Comment: 31 pages (including appendix), 7 figures, accepted for publication in
MNRA
Comparing [CII], HI, and CO dynamics of nearby galaxies
The HI and CO components of the interstellar medium (ISM) are usually used to
derive the dynamical mass M_dyn of nearby galaxies. Both components become too
faint to be used as a tracer in observations of high-redshift galaxies. In
those cases, the 158 m line of atomic carbon [CII] may be the only way to
derive M_dyn. As the distribution and kinematics of the ISM tracer affects the
determination of M_dyn, it is important to quantify the relative distributions
of HI, CO and [CII]. HI and CO are well-characterised observationally, however,
for [CII] only very few measurements exist. Here we compare observations of CO,
HI, and [CII] emission of a sample of nearby galaxies, drawn from the HERACLES,
THINGS and KINGFISH surveys. We find that within R_25, the average [CII]
exponential radial profile is slightly shallower than that of the CO, but much
steeper than the HI distribution. This is also reflected in the integrated
spectrum ("global profile"), where the [CII] spectrum looks more like that of
the CO than that of the HI. For one galaxy, a spectrally resolved comparison of
integrated spectra was possible; other comparisons were limited by the
intrinsic line-widths of the galaxies and the coarse velocity resolution of the
[CII] data. Using high-spectral-resolution SOFIA [CII] data of a number of star
forming regions in two nearby galaxies, we find that their [CII] linewidths
agree better with those of the CO than the HI. As the radial extent of a given
ISM tracer is a key input in deriving M_dyn from spatially unresolved data, we
conclude that the relevant length-scale to use in determining M_dyn based on
[CII] data, is that of the well-characterised CO distribution. This length
scale is similar to that of the optical disk.Comment: Accepted for publication in the Astronomical Journa
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Cool dust heating and temperature mixing in nearby star-forming galaxies
Physical conditions of the interstellar medium in galaxies are closely linked
to the ambient radiation field and the heating of dust grains. In order to
characterize dust properties in galaxies over a wide range of physical
conditions, we present here the radial surface brightness profiles of the
entire sample of 61 galaxies from Key Insights into Nearby Galaxies:
Far-Infrared Survey with Herschel (KINGFISH). The main goal of our work is the
characterization of the grain emissivities, dust temperatures, and interstellar
radiation fields responsible for heating the dust. After fitting the dust and
stellar radial profiles with exponential functions, we fit the far-infrared
spectral energy distribution (SED) in each annular region with
single-temperature modified black bodies using both variable (MBBV) and fixed
(MBBF) emissivity indices beta, as well as with physically motivated dust
models. Results show that while most SED parameters decrease with radius, the
emissivity index beta also decreases with radius in some galaxies, but in
others is increasing, or rising in the inner regions and falling in the outer
ones. Despite the fixed grain emissivity (average beta~ 2.1) of the
physically-motivated models, they are well able to accommodate flat spectral
slopes with beta<= 1. We find that flatter slopes (beta<= 1.5) are associated
with cooler temperatures, contrary to what would be expected from the usual
Tdust-beta degeneracy. This trend is related to variations in Umin since beta
and Umin are very closely linked over the entire range in Umin sampled by the
KINGFISH galaxies: low Umin is associated with flat beta<=1. Both these results
strongly suggest that the low apparent \beta values (flat slopes) in MBBV fits
are caused by temperature mixing along the line-of-sight, rather than by
intrinsic variations in grain properties. Abstract truncated for arXiv.Comment: 28 pages, 20 figures, accepted for publication in A&
A far-IR view of the starburst driven superwind in NGC 2146
NGC 2146, a nearby luminous infrared galaxy (LIRG), presents evidence for
outflows along the disk minor axis in all gas phases (ionized, neutral atomic
and molecular). We present an analysis of the multi-phase starburst driven
superwind in the central 5 kpc as traced in spatially resolved spectral line
observations, using far-IR Herschel PACS spectroscopy, to probe the effects on
the atomic and ionized gas, and optical integral field spectroscopy to examine
the ionized gas through diagnostic line ratios. We observe an increased ~250
km/s velocity dispersion in the [OI] 63 micron, [OIII] 88 micron, [NII] 122
micron and [CII] 158 micron fine-structure lines that is spatially coincident
with high excitation gas above and below the disk. We model this with a slow
~200 km/s shock and trace the superwind to the edge of our field of view 2.5
kpc above the disk. We present new SOFIA 37 micron observations to explore the
warm dust distribution, and detect no clear dust entrainment in the outflow.
The stellar kinematics appear decoupled from the regular disk rotation seen in
all gas phases, consistent with a recent merger event disrupting the system. We
consider the role of the superwind in the evolution of NGC 2146 and speculate
on the evolutionary future of the system. Our observations of NGC 2146 in the
far-IR allow an unobscured view of the wind, crucial for tracing the superwind
to the launching region at the disk center, and provide a local analog for
future ALMA observations of outflows in high redshift systems.Comment: 16 pages, 13 figures, accepted for publication in Ap
Anomalous Coulomb Drag in Electron-Hole Bilayers
We report Coulomb drag measurements on GaAs-AlGaAs electron-hole bilayers. The two layers are separated by a 10 or 25 nm barrier. Below T approximate to 1 K we find two features that a Fermi-liquid picture cannot explain. First, the drag on the hole layer shows an upturn, which may be followed by a downturn. Second, the effect is either absent or much weaker in the electron layer, even though the measurements are within the linear response regime. Correlated phases have been anticipated in these, but surprisingly, the experimental results appear to contradict Onsager's reciprocity theorem
A Study of Heating and Cooling of the ISM in NGC 1097 with Herschel-PACS and Spitzer-IRS
NGC 1097 is a nearby Seyfert 1 galaxy with a bright circumnuclear starburst
ring, a strong large-scale bar and an active nucleus. We present a detailed
study of the spatial variation of the far infrared (FIR) [CII]158um and
[OI]63um lines and mid-infrared H2 emission lines as tracers of gas cooling,
and of the polycyclic aromatic hydrocarbon (PAH) bands as tracers of the
photoelectric heating, using Herschel-PACS, and Spitzer-IRS infrared spectral
maps. We focus on the nucleus and the ring, and two star forming regions (Enuc
N and Enuc S). We estimated a photoelectric gas heating efficiency
([CII]158um+[OI]63um)/PAH in the ring about 50% lower than in Enuc N and S. The
average 11.3/7.7um PAH ratio is also lower in the ring, which may suggest a
larger fraction of ionized PAHs, but no clear correlation with
[CII]158{\mu}m/PAH(5.5 - 14um) is found. PAHs in the ring are responsible for a
factor of two more [CII]158um and [OI]63um emission per unit mass than PAHs in
the Enuc S. SED modeling indicates that at most 25% of the FIR power in the
ring and Enuc S can come from high intensity photodissociation regions (PDRs),
in which case G0 ~ 10^2.3 and nH ~ 10^3.5 cm^-3 in the ring. For these values
of G0 and nH PDR models cannot reproduce the observed H2 emission. Much of the
the H2 emission in the starburst ring could come from warm regions in the
diffuse ISM that are heated by turbulent dissipation or shocks.Comment: 17 pages, 14 figures, 5 tables; accepted for publication in Ap
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