8,692 research outputs found

    Early Social-Emotional Functioning and Public Health: The Relationship Between Kindergarten Social Competence and Future Wellness

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    A new 20-year study shows a link between children's social skills in kindergarten and their well-being in early adulthood.Researchers from Pennsylvania State and Duke Universities analyzed what happened to nearly 800 kindergarteners from four locations after their teachers measured their social competency skills in 1991. The children were evaluated on a range of social behaviors, such as whether they resolve peer problems, listen to others, share materials, cooperate, and are helpful. Each student then received a composite score representing his or her overall level of positive social skills/behavior, on a scale from ("not at all") to 4 ("very well"). The research team monitored these students and the positive and negative milestones each obtained until they turned 25.Using a variety of data sources, including official records; reports from parents; and self-reporting by the participants, researchers recorded whether the students obtained high school diplomas, college degrees, and full-time jobs. They also kept track of whether students developed a criminal record or substance abuse problems, among other negative outcomes

    An International Comparison of Work Sharing Programs

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    This article draws together primarily unpublished information that provides comparative information with respect to North American and Western European experiences with work sharing

    The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

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    This study was undertaken to determine the roles of individual alpha/beta 1 integrin heterodimers in promoting cellular interactions with the different attachment-promoting domains of laminin (LN). To do this, antibodies to the integrin beta 1 subunit or to specific integrin alpha subunits were tested for effects on cell attachment to LN, to elastase fragments E1-4 and E1, derived from the short arms and core of LN's cruciform structure, and to fragment E8 derived from the long arm of this structure. The human JAR choriocarcinoma cells used in this study attached to LN and to fragments E1 and E8. Attachment to E1-4 required a much higher substrate coating concentration, suggesting that it is a poor substrate for JAR cell attachment. The ability of cells to attach to different LN domains suggested the presence of more than one LN receptor. These multiple LN receptors were shown to be beta 1 integrin heterodimers because antibodies to the integrin beta 1 subunit inhibited attachment of JAR cells to LN and its three fragments. To identify the individual integrin alpha/beta 1 heterodimers that mediate interactions with these LN domains, mAbs specific for individual beta 1 heterodimers in human cells were used to study JAR cell interactions with LN and its fragments. An anti-alpha 6/beta 1-specific mAb, GoH3, virtually eliminated cell attachment to E8 and partially inhibited attachment to E1 and intact LN. Thus the major alpha 6/beta 1 attachment domain is present in fragment E8. An alpha 1/beta 1-specific mAb (S2G3) strongly inhibited cell attachment to collagen IV and partially inhibited JAR attachment to LN fragment E1. Thus, the alpha 1/beta 1 heterodimer is a dual receptor for collagen IV and LN, interacting with LN at a site in fragment E1. In combination, the anti-alpha 1- and anti-alpha 6-specific antibodies completely inhibited JAR cell attachment to LN and fragment E1. Thus, the alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers each function as LN receptors and act together to mediate the interactions of human JAR choriocarcinoma cells with LN

    Topological data analysis of Escherichia coli O157:H7 and non-O157 survival in soils.

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    Shiga toxin-producing E. coli O157:H7 and non-O157 have been implicated in many foodborne illnesses caused by the consumption of contaminated fresh produce. However, data on their persistence in soils are limited due to the complexity in datasets generated from different environmental variables and bacterial taxa. There is a continuing need to distinguish the various environmental variables and different bacterial groups to understand the relationships among these factors and the pathogen survival. Using an approach called Topological Data Analysis (TDA); we reconstructed the relationship structure of E. coli O157 and non-O157 survival in 32 soils (16 organic and 16 conventionally managed soils) from California (CA) and Arizona (AZ) with a multi-resolution output. In our study, we took a community approach based on total soil microbiome to study community level survival and examining the network of the community as a whole and the relationship between its topology and biological processes. TDA produces a geometric representation of complex data sets. Network analysis showed that Shiga toxin negative strain E. coli O157:H7 4554 survived significantly longer in comparison to E. coli O157:H7 EDL 933, while the survival time of E. coli O157:NM was comparable to that of E. coli O157:H7 EDL 933 in all of the tested soils. Two non-O157 strains, E. coli O26:H11 and E. coli O103:H2 survived much longer than E. coli O91:H21 and the three strains of E. coli O157. We show that there are complex interactions between E. coli strain survival, microbial community structures, and soil parameters

    Travelling waves in a drifting flux lattice

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    Starting from the time-dependent Ginzburg-Landau (TDGL) equations for a type II superconductor, we derive the equations of motion for the displacement field of a moving vortex lattice without inertia or pinning. We show that it is linearly stable and, surprisingly, that it supports wavelike long-wavelength excitations arising not from inertia or elasticity but from the strain-dependent mobility of the moving lattice. It should be possible to image these waves, whose speeds are a few \mu m/s, using fast scanning tunnelling microscopy.Comment: 4 pages, revtex, 2 .eps figures imbedded in paper, title shortened, minor textual change

    Enabling science with Gaia observations of naked-eye stars

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    ESA's Gaia space astrometry mission is performing an all-sky survey of stellar objects. At the beginning of the nominal mission in July 2014, an operation scheme was adopted that enabled Gaia to routinely acquire observations of all stars brighter than the original limit of G~6, i.e. the naked-eye stars. Here, we describe the current status and extent of those observations and their on-ground processing. We present an overview of the data products generated for G<6 stars and the potential scientific applications. Finally, we discuss how the Gaia survey could be enhanced by further exploiting the techniques we developed.Comment: 16 pages, 8 figures. Submitted for the proceedings of the 2016 SPIE Astronomical Instrumentation and Telescopes conference (SPIE 9904
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