Expert Finding by Capturing Organisational Knowledge from Legacy Documents

Organisations capitalise on their best knowledge through the improvement of shared expertise which leads to a higher level of productivity and competency. The recognition of the need to foster the sharing of expertise has led to the development of expert finder systems that hold pointers to experts who posses specific knowledge in organisations. This paper discusses an approach to locating an expert through the application of information retrieval and analysis processes to an organization’s existing information resources, with specific reference to the engineering design domain. The approach taken was realised through an expert finder system framework. It enables the relationships of heterogeneous information sources with experts to be factored in modelling individuals’ expertise. These valuable relationships are typically ignored by existing expert finder systems, which only focus on how documents relate to their content. The developed framework also provides an architecture that can be easily adapted to different organisational environments. In addition, it also allows users to access the expertise recognition logic, giving them greater trust in the systems implemented using this framework. The framework were applied to real world application and evaluated within a major engineering company

Measurement of Parity Violation in the Early Universe using Gravitational-wave Detectors

A stochastic gravitational-wave background (SGWB) is expected to arise from the superposition of many independent and unresolved gravitational-wave signals, of either cosmological or astrophysical origin. Some cosmological models (characterized, for instance, by a pseudo-scalar inflaton, or by some modification of gravity) break parity, leading to a polarized SGWB. We present a new technique to measure this parity violation, which we then apply to the recent results from LIGO to produce the first upper limit on parity violation in the SGWB, assuming a generic power-law SGWB spectrum across the LIGO sensitive frequency region. We also estimate sensitivity to parity violation of the future generations of gravitational-wave detectors, both for a power-law spectrum and for a model of axion inflation. This technique offers a new way of differentiating between the cosmological and astrophysical sources of the isotropic SGWB, as astrophysical sources are not expected to produce a polarized SGWB.Comment: 5 pages, 2 figures, 1 tabl

Data Mining to Support Engineering Design Decision

The design and maintenance of an aero-engine generates a significant amount of documentation. When designing new engines, engineers must obtain knowledge gained from maintenance of existing engines to identify possible areas of concern. Firstly, this paper investigate the use of advanced business intelligence tenchniques to solve the problem of knowledge transfer from maintenance to design of aeroengines. Based on data availability and quality, various models were deployed. An association model was used to uncover hidden trends among parts involved in maintenance events. Classification techniques comprising of various algorithms was employed to determine severity of events. Causes of high severity events that lead to major financial loss was traced with the help of summarization techniques. Secondly this paper compares and evaluates the business intelligence approach to solve the problem of knowledge transfer with solutions available from the Semantic Web. The results obtained provide a compelling need to have data mining support on RDF/OWL-based warehoused data

Structural Studies on a Mitochondrial Glyoxalase II

Glyoxalase 2 is a β-lactamase fold-containing enzyme that appears to be involved with cellular chemical detoxification. Although the cytoplasmic isozyme has been characterized from several organisms, essentially nothing is known about the mitochondrial proteins. As a first step in understanding the structure and function of mitochondrial glyoxalase 2 enzymes, a mitochondrial isozyme (GLX2-5) from Arabidopsis thaliana was cloned, overexpressed, purified, and characterized using metal analyses, EPR and 1H NMR spectroscopies, and x-ray crystallography. The recombinant enzyme was shown to bind 1.04 ± 0.15 eq of iron and 1.31 ± 0.05 eq of Zn(II) and to exhibit kcat and Km values of 129 ± 10 s-1 and 391 ± 48 μm, respectively, when using S-d-lactoylglutathione as the substrate. EPR spectra revealed that recombinant GLX2-5 contains multiple metal centers, including a predominant Fe(III)Z-n(II) center and an anti-ferromagnetically coupled Fe(III)Fe(II) center. Unlike cytosolic glyoxalase 2 from A. thaliana, GLX2-5 does not appear to specifically bind manganese. 1H NMR spectra revealed the presence of at least eight paramagnetically shifted resonances that arise from protons in close proximity to a Fe(III)Fe(II) center. Five of these resonances arose from solvent-exchangeable protons, and four of these have been assigned to NH protons on metal-bound histidines. A 1.74-Å resolution crystal structure of the enzyme revealed that although GLX2-5 shares a number of structural features with human GLX2, several important differences exist. These data demonstrate that mitochondrial glyoxalase 2 can accommodate a number of different metal centers and that the predominant metal center is Fe(III)Zn(II)

A method for exploratory repeated-measures analysis applied to a breast-cancer screening study

When a model may be fitted separately to each individual statistical unit, inspection of the point estimates may help the statistician to understand between-individual variability and to identify possible relationships. However, some information will be lost in such an approach because estimation uncertainty is disregarded. We present a comparative method for exploratory repeated-measures analysis to complement the point estimates that was motivated by and is demonstrated by analysis of data from the CADET II breast-cancer screening study. The approach helped to flag up some unusual reader behavior, to assess differences in performance, and to identify potential random-effects models for further analysis.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS481 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

LAB-SCALE DEMONSTRATION OF PLUTONIUM PURIFICATION BY ANION EXCHANGE, PLUTONIUM (IV) OXALATE PRECIPITATION, AND CALCINATION TO PLUTONIUM OXIDE TO SUPPORT THE MOX FEED MISSION

H-Canyon and HB-Line are tasked with the production of PuO{sub 2} from a feed of plutonium metal. The PuO{sub 2} will provide feed material for the MOX Fuel Fabrication Facility. After dissolution of the Pu metal in H-Canyon, the solution will be transferred to HB-Line for purification by anion exchange. Subsequent unit operations include Pu(IV) oxalate precipitation, filtration and calcination to form PuO{sub 2}. This report details the results from SRNL anion exchange, precipitation, filtration, calcination, and characterization tests, as requested by HB-Line1 and described in the task plan. This study involved an 80-g batch of Pu and employed test conditions prototypical of HB-Line conditions, wherever feasible. In addition, this study integrated lessons learned from earlier anion exchange and precipitation and calcination studies. H-Area Engineering selected direct strike Pu(IV) oxalate precipitation to produce a more dense PuO{sub 2} product than expected from Pu(III) oxalate precipitation. One benefit of the Pu(IV) approach is that it eliminates the need for reduction by ascorbic acid. The proposed HB-Line precipitation process involves a digestion time of 5 minutes after the time (44 min) required for oxalic acid addition. These were the conditions during HB-line production of neptunium oxide (NpO{sub 2}). In addition, a series of small Pu(IV) oxalate precipitation tests with different digestion times were conducted to better understand the effect of digestion time on particle size, filtration efficiency and other factors. To test the recommended process conditions, researchers performed two nearly-identical larger-scale precipitation and calcination tests. The calcined batches of PuO{sub 2} were characterized for density, specific surface area (SSA), particle size, moisture content, and impurities. Because the 3013 Standard requires that the calcination (or stabilization) process eliminate organics, characterization of PuO{sub 2} batches monitored the presence of oxalate by thermogravimetric analysis-mass spectrometry (TGA-MS). To use the TGA-MS for carbon or oxalate content, some method development will be required. However, the TGA-MS is already used for moisture measurements. Therefore, SRNL initiated method development for the TGA-MS to allow quantification of oxalate or total carbon. That work continues at this time and is not yet ready for use in this study. However, the collected test data can be reviewed later as those analysis tools are available

Arctic and subarctic environmental analyses utilizing ERTS-1 imagery

The author has identified the following significant results. ERTS-1 imagery provides a means of distinguishing and monitoring estuarine surface water circulation patterns and changes in the relative sediment load of discharging rivers on a regional basis. Physical boundaries mapped from ERTS-1 imagery in combination with ground truth obtained from existing small scale maps and other sources resulted in improved and more detailed maps of permafrost terrain and vegetation for the same area. Snowpack cover within a research watershed has been analyzed and compared to ground data. Large river icings along the proposed Alaska pipeline route from Prudhoe Bay to the Brooks Range have been monitored. Sea ice deformation and drift northeast of Point Barrow, Alaska have been measured during a four day period in March and shore-fast ice accumulation and ablation along the west coast of Alaska have been mapped for the spring and early summer seasons

Structure and Metal Binding Properties of ZnuA, a Periplasmic Zinc Transporter from \u3cem\u3eEscherichia coli\u3c/em\u3e

ZnuA is the periplasmic Zn2+-binding protein associated with the high-affinity ATP-binding cassette ZnuABC transporter from Escherichia coli. Although several structures of ZnuA and its homologs have been determined, details regarding metal ion stoichiometry, affinity, and specificity as well as the mechanism of metal uptake and transfer remain unclear. The crystal structures of E. coli ZnuA (Eco-ZnuA) in the apo, Zn2+-bound, and Co2+-bound forms have been determined. ZnZnuA binds at least two metal ions. The first, observed previously in other structures, is coordinated tetrahedrally by Glu59, His60, His143, and His207. Replacement of Zn2+ with Co2+ results in almost identical coordination geometry at this site. The second metal binding site involves His224 and several yet to be identified residues from the His-rich loop that is unique to Zn2+ periplasmic metal binding receptors. Electron paramagnetic resonance and X-ray absorption spectroscopic data on CoZnuA provide additional insight into possible residues involved in this second site. The second site is also detected by metal analysis and circular dichroism (CD) titrations. Eco-ZnuA binds Zn2+ (estimated K d \u3c 20 nM), Co2+, Ni2+, Cu2+, Cu+, and Cd2+, but not Mn2+. Finally, conformational changes upon metal binding observed in the crystal structures together with fluorescence and CD data indicate that only Zn2+ substantially stabilizes ZnuA and might facilitate recognition of ZnuB and subsequent metal transfer

Observed Limits on Charge Exchange Contributions to the Diffuse X-ray Background

We present a high resolution spectrum of the diffuse X-ray background from 0.1 to 1 keV for a ~1 region of the sky centered at l=90, b=+60 using a 36-pixel array of microcalorimeters flown on a sounding rocket. With an energy resolution of 11 eV FWHM below 1 keV, the spectrum's observed line ratios help separate charge exchange contributions originating within the heliosphere from thermal emission of hot gas in the interstellar medium. The X-ray sensitivity below 1 keV was reduced by about a factor of four from contamination that occurred early in the flight, limiting the significance of the results. The observed centroid of helium-like O VII is 568+2-3 eV at 90% confidence. Since the centroid expected for thermal emission is 568.4 eV while for charge exchange is 564.2 eV, thermal emission appears to dominate for this line complex, consistent with much of the high-latitude O VII emission originating in 2-3 x 10^6 K gas in the Galactic halo. On the other hand, the observed ratio of C VI Ly gamma to Ly alpha is 0.3+-0.2. The expected ratios are 0.04 for thermal emission and 0.24 for charge exchange, indicating that charge exchange must contribute strongly to this line and therefore potentially to the rest of the ROSAT R12 band usually associated with 10^6 K emission from the Local Hot Bubble. The limited statistics of this experiment and systematic uncertainties due to the contamination require only >32% thermal emission for O VII and >20% from charge exchange for C VI at the 90% confidence level. An experimental gold coating on the silicon substrate of the array greatly reduced extraneous signals induced on nearby pixels from cosmic rays passing through the substrate, reducing the triggered event rate by a factor of 15 from a previous flight of the instrument.Comment: 14 pages, 7 figures, to be published in Ap

The Southern Zagros Collisional Orogen: New Insights From Transdimensional Trees Inversion of Seismic Noise

Imaging and resolving the lateral continuity of 3-D crustal structures enhances our ability to interpret seismicity, and to understand how orogens are created. We apply a Bayesian, hierarchical inversion approach based on a transdimensional trees-structured wavelet parameterisation to recover phase-velocity maps at 2-40 second periods. We then invert phase-velocity dispersion to constrain a 3-D shear-velocity model of the crust beneath south-central Iran. Together with accurate earthquake centroid depths and focal mechanisms, the pattern of 3-D velocity variations supports recent suggestions that most large earthquakes in the Zagros occur within the lower sedimentary cover, or close to the sediment-basement interface. Furthermore, we fi nd evidence for Arabian basement underthrusting beneath central Iran, although only in one location does it appear to generate earthquakes. Our new 3-D tomographic model clarifi es and throws new light on the crustal structure of the SE Zagros and its relation to seismicity and active faulting.NERC Horizon 2020 Petroleum Institute Research Centr