The Lantern Vol. 60, No. 1, December 1992

• Bacon and Incense • The Rubix Cube • Recovery • Untitled • Star Six Nine • Breakfast Talk • Life as a Worker Bee • Cabal • One Cold Sunday Morning With Eggs • By the End of February • Eight Years and Five Minutes Away • Distance • Stuart\u27s Gift • Solitary Remembrance • The Gene Thing • Addictionhttps://digitalcommons.ursinus.edu/lantern/1139/thumbnail.jp

The values and benefits of environmental elements on housing rents

© 2016 Elsevier Ltd. The value provided by availability of environmental elements on human quality of urban life is difficult to assess and incorporate into urban planning and development. Researchers worldwide have seldom objectively factored these attributes into property pricing and associated decisions. This study contends that a better understanding of the effect of environmental elements requires systematic study of the relationship between objective and subjective measures of environmental phenomena and human responses. This paper summarizes the outcomes from applying Hedonic Pricing (HP) and Life Satisfaction (LS) methods - providing valuation in an increasingly expanding and privatized property Iranian market. A survey was carried out from 400 households that are more likely to make location choices and pay rent and property expenses in the city of Shiraz. The findings indicates that Shiraz neighbourhoods are likely to be characterized by deep environmental segregation. This study informs the decisions of policy makers and property developers regarding sales and purchases conversion, property development, urban nature conservation, and design of ecological green-space networks

Vertical Zoning in Marine Protected Areas: Ecological Considerations for Balancing Pelagic Fishing with Conservation of Benthic Communities

Marine protected areas (MPAs), ideally, manage human uses that threaten ecosystems, or components of ecosystems. During several recent MPA designation processes, concerns have arisen over the scientific justification for no-take MPAs, particularly those that restrict recreational fishing for pelagic species. An important question is: under what conditions might recreational pelagic fishing be compatible with the conservation goals of an MPA that is primarily focused on benthic Communities? In 2005, an expert workshop of fisheries biologists, marine ecologists, MPA managers, and recreational fishermen was convened by NOAAs National MPA Center to evaluate the limited empirical data on benthic-pelagic coupling and to help provide practical advice on this topic. The participants (i) proposed a preliminary conceptual framework for addressing vertical zoning, (ii) developed preliminary guidelines to consider when evaluating whether to allow or restrict pelagic fishing in an MPA, and (iii) identified future research priorities for understanding benthic-pelagic Coupling. A Suite of ecological conditions where recreational pelagic fishing may not be compatible with benthic conservation were identified: (1) high relief habitats, (2) depths shallower than 50-100 m (depending upon the specific location), (3) major topographic and oceanographic features, and (4) spawning areas. Similarly, pelagic fishing is not likely to affect benthic communities adversely in many circumstances. Until further scientific study can shed more light on the issue of how benthic-pelagic linkages affect specific conservation targets, the proposed framework in this manuscript provides practical, easily-applied guidance for using vertical zoning to manage fishing in multiple use MPAs that focus on benthic conservation.Areas Marinas Protegidas (AMP) idealmente, administran el uso humano que amenaza los ecosistemas o sus componentes. Durante el actual proceso de declaracion de AMP, han surgido algunas preocupaciones acerca de la justificacion cientifica para establecer areas de no pesca, particularmente aquellas que restringen la pesca recreativa de especies pelagicas. Una pregunta importante es QQQ ?bajo que condiciones la pesca pelagica recreativa es compatible con los objetivos de conservacion de un AMP que se enfoca principalmente en comunidades bentonicas? En 2005, un taller de expertos en biologia pesquera, ecologfa marina, manejo de AMP y Pescadores recreativos fue convocado por el Centra Nacional de AMP de la NOAA para evaluar los pocos datos empiricos del acoplamiento entre los sistemas pelagico y bentonico, y ofrecer asesoria practica sobre el tema. Los participantes (i) propusieron un marco conceptual preliminar para abordar el tema de la zonacion vertical, (ii) desarrollar directrices preliminares para que cuando se haga una evaluation si se permite o restringe la pesca pelagica dentro de la AMP, y (iii) identificar futuras lineas de investigation para comprender mejor el acoplamiento entre el bentos y el sistema pelagico. Se identifico una serie de condiciones ecologicas en las que la pesca recreativa pelagica puede no ser compatible con la conservacion del bentos: (1) habitat de alto relieve, (2) profundidades menores a 50 m-100 m (dependiendo de la zona), (3) caracteristicas oceanograficas y topograficas sobresalientes, y (4) areas de desove. De igual forma, bajo varias circunstancias, la pesca pelagica puede no afectar las comunidades bentonicas. Hasta que los estudios cientificos brinden mas information acerca de como las relaciones entre el bentos y el ambiente pelagico afectan los objetivos especificos de la conservacion, el contexto propuesto en este trabajo provee una guia practica y de facil aplicacion para utilizar la zonacion vertical en el manejo pesquero en varios aspectos de las AMP que se enfocan en la conservacion del bentos.Keywords: Trophic level, Marine protected areas, Pelagic fisheries, Conservatio

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Research highlights

Briefs on recent articles on grafted tomatoes, avocado ripening, fresh produce in low-income neighborhoods, a dystopic novel and more

Ensure Quality &amp; Unlock Energy Savings in Small Buildings Kensok et al: Ensure Quality and Unlock Energy Savings in Small Buildings 2 Figure A: Demographics of Existing Buildings

Synopsis New markets are forming around improving the energy efficiency of smaller buildings. The current focus of the commissioning industry on new construction fails to address the larger opportunities -both the revenue opportunity for the commissioning industry, as well as the opportunity for reduction in energy consumption -in the existing building market. On average there are about 2,000 existing buildings for every new building built; 1 98% are less than 100,000 square feet, comprising nearly two-thirds of the total floor area, and consuming nearly 60% of all the energy used by buildings in the U.S. Only about 10% of these buildings have a building automation system. 2 The sheer number of small and medium sized buildings, combined with poor access to data from these buildings, makes traditional processes for selling and executing commissioning difficult. Capitalizing on the existing building market will require new skills and technologies in order to sell the concept of commissioning and to cost effectively execute the jobs. The winners will be the firms that can see the coming market opportunityand plan for it by building processes, developing resources, and enabling scale. Will you be ready? About the Authors Tim Kensok is the Vice President of Market Development for AirAdvice, Inc., a Portland, Oregon-based provider of building performance diagnostic equipment and services. His expertise in this field focuses on HVAC markets and systems, sustainability, and indoor environmental controls. He has conducted extensive research into the performance of commercial buildings and the entire value chain from manufacturers through building owners to tenants. Jim Crowder, AirAdvice President and CEO, has spearheaded business development and successful technology startups within both established and emerging companies. During his 25-year career, he has created dynamic new divisions within several Fortune 500 companies and led key turnaround efforts in smaller corporations. With AirAdvice, he now brings his history of leadership in growth and innovation to drive sustainability and energy management in homes and commercial buildings

The Catalyst Vol. 1 No. 12

"The Catalyst" is comprised of 16 pages of student written articles, editorials, satires and political statements. This issue covered topics such as The Catalyst's printing difficulties due to the Lubbock Tornado and local presses refusing to print the underground paper; arrests and house searchers of staff members of The Catalyst; the breaking of the arm of Los Terulianos's president Billy Aquero by a Lubbock officer; Ralph Yarborough's loss in the elections to Lloyd Bentsen; death of civil rights protesters; underground newspapers; Nixon's administration invading Cambodia and the slayings at Kent State University; arts protesting the U.S. government; and music. The issue is the first summer edition, 1970, and sold for 25 cents.Billy Aquero is most likely Bidal Aguero. "Billy" was his nickname