Socio-ecological roots of cultures of honor

Social psychological research on honour has been growing rapidly in the last decade and increasing our understanding of cross-cultural differences in a variety of psychological processes. This growing interest in honor has stimulated research designed to examine the origins of honor cultures which is increasingly adopting creative methodologies to tackle the difficulty associated with studying causes of cultural syndromes that are rooted macro-level structures such as politics, economics, and religion. In this review, we briefly summarize this research as inspiring examples that can be adopted to examine socio-ecological roots of other cultural dimensions commonly used to explain cultural differences in psychological processes

The social and cultural psychology of honour: What have we learned from researching honour in Turkey?

A growing literature in social and cultural psychology has examined cultures of honour primarily focusing on southern states in the US and on Mediterranean countries of southern Europe. In this article, we review a programme of research that has extended theories of cultures of honour to an under-researched context: Turkey. We first describe research that assessed lay reports of the situations that enhance or attack a person’s honour and lay prototypes of honour. Next, we review research that built on this foundation and examined emotional implications, actual retaliatory responses, and preferences for different types of actions (e.g., attack vs. withdrawal) in the face of honour threats. We then briefly comment on our current research focused on the ways that honour threats can impede goal pursuit, on the distinction between different types of honour threats, and on acculturation processes in immigrant groups from cultures of honour. We conclude by highlighting the contributions of this programme of research to the literature on cultures of honour and discuss future directions. (167 words

Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

We examined uptake of the model therapeutic agent, minoxidil, into appendages, stratum corneum (SC), and through human skin, under the influence of different vehicles. Quantitative estimation of therapeutic drug deposition into all three areas has not previously been reported. Finite doses of minoxidil (2%, w/v) in formulations containing varying amounts of ethanol, propylene glycol (PG), and water (60:20:20, 80:20:0, and 0:80:20 by volume, respectively) were used. Minoxidil in SC (by tape stripping), appendages (by cyanoacrylate casting), and receptor fluid was determined by liquid scintillation counting. At early times (30 min, 2 h), ethanol-containing formulations (60:20:20 and 80:20:0) caused significantly greater minoxidil retention in SC and appendages, compared to the formulation lacking ethanol (0:80:20). A significant increase in minoxidil receptor penetration occurred with the PG-rich 0:80:20 formulation after 12 h. We showed that deposition of minoxidil into appendages, SC, and skin penetration into receptor fluid were similar in magnitude. Transport by the appendageal route is likely to be a key determinant of hair growth promotion by minoxidil. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:712–718, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64562/1/21856_ftp.pd

A price to pay: Turkish and American retaliation for threats to personal and family honor

Two studies investigated retaliatory responses to actual honor threats among members of an honor culture (Turkey) and a dignity culture (northern U.S.). The honor threat in these studies was based on previous research which has shown that honesty is a key element of the conception of honor and that accusations of dishonesty are threatening to one’s honor. In both studies, participants wrote an essay describing the role of honesty in their lives and received feedback on their essay accusing them of being dishonest (vs. neutral feedback). Turkish participants retaliated more strongly than did northern U.S. participants against the person who challenged their honesty by assigning him/her to solve more difficult tangrams over easy ones (Study 1) and by choosing sensory tasks of a higher level of intensity to complete (Study 2). Study 2 added a relational honor condition, in which participants wrote about honesty in their parents’ lives and examined the role of individual differences in honor values in retaliation. Endorsement of honor values predicted retaliation among Turkish participants in both the personal and relational honor conditions, but not among northern U.S. participants

Evaluating Three Active Thermal Architectures for Exploration Missions

Mass and cost are typically the two biggest challenges facing space craft designers. Active thermal control systems for crewed space-craft are typically among the more massive and costly systems on the vehicle. A study was completed evaluating three different thermal control system architectures to evaluate overall performance, mass and cost for a typical exploration mission profile. The architectures that were evaluated were 1 - a two-loop system using an internal liquid loop interfacing with an external liquid loop and flow loop with flow through radiators; 2 - a-single loop architecture with flow through radiators utilizing a regenerative heat exchanger and heater; and 3 - a single-loop architecture with heat pipe radiators. Environmental conditions, calculated for a given lunar exploration mission, and mission heat load profiles, generated based on previous Orion time lines, were evalauated through the phases of the on orbit mission. Performance for each of the architectures was evaluated along with the resultant mass of each system. Recommendations include adding a thermal topping system to lunar missions due to the extreme hot environments encountered in near-lunar approaches

Cultures of honor

Cultures of honor developed in contexts in which a person’s livelihood was easily stolen (such as a herd of animals) and the rule of law was weak. In such contexts, men were required to develop a reputation for toughness and willingness to retaliate quickly and aggressively when threatened, so that others would not consider stealing their property. Consequently, cultures of honor have developed ideologies, norms, and practices that reinforce the importance of maintaining social respect through aggressive means if necessary. In this chapter, we first briefly review the initial work by anthropologists, sociologists and historians that described cultures of honor in the Mediterranean region and southern US states. This early work formed the foundation of research by Nisbett, Cohen, and their colleagues, who carefully articulated a psychological theory of how concerns for honor may explain higher rates of aggression and violence in southern US states compared to northern states. We then summarize research on components of honor, behavioral and psychological consequences of honor, and socialization practices that maintain cultures of honor. We finish by discussing possible future directions and methodological considerations in research on cultures of honor. This research has extended the scope of cultural psychology by going beyond the more common east-west comparisons; it has the potential to help explain behavior of groups that have not been widely studied by social psychologists

The role of culture in appraisals, emotions, and helplessness in response to threats

In honour cultures such as Turkey, reputation management is emphasized, whereas in dignity cultures such as northern US, self-respect and personal achievements are central. Turkey is also a collectivistic culture, where relationship harmony is as important as reputation management. When Turkish people’s reputation is threatened, they may experience an internal conflict between these two motives and display helplessness. In this study, we predicted and found that Turkish participants anticipated stronger anger, shame, and helplessness in response to reputation threat than self-respect threat situations, whereas these differences were non-existent or smaller in northern US. Moreover, shame was a mediator between appraisal and helplessness for reputation threats in Turkey (shame positively predicted helplessness), whereas anger was a mediator between appraisal and helplessness for self-respect threats in northern US (anger negatively predicted helplessness). These results are novel in their inclusion of helplessness and appraisal theory of emotions when examining honour and dignity cultures

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

The 5'-cap-structures of higher eukaryote mRNAs are ribose 2'-O-methylated. Likewise, a number of viruses replicating in the cytoplasm of eukayotes have evolved 2'-O-methyltransferases to modify autonomously their mRNAs. However, a defined biological role of mRNA 2'-O-methylation remains elusive. Here we show that viral mRNA 2'-O-methylation is critically involved in subversion of type-I-interferon (IFN-I) induction. We demonstrate that human and murine coronavirus 2'-O-methyltransferase mutants induce increased IFN-I expression, and are highly IFN-I sensitive. Importantly, IFN-I induction by 2'-O-methyltransferase-deficient viruses is dependent on the cytoplasmic RNA sensor melanoma differentiation-associated gene 5 (MDA5). This link between MDA5-mediated sensing of viral RNA and mRNA 2'-O-methylation suggests that RNA modifications, such as 2'-O-methylation, provide a molecular signature for the discrimination of self and non-self mRNA

Molecular pedigree reconstruction and estimation of evolutionary parameters in a wild Atlantic salmon river system with incomplete sampling:A power analysis

Background: Pedigree reconstruction using genetic analysis provides a useful means to estimate fundamental population biology parameters relating to population demography, trait heritability and individual fitness when combined with other sources of data. However, there remain limitations to pedigree reconstruction in wild populations, particularly in systems where parent-offspring relationships cannot be directly observed, there is incomplete sampling of individuals, or molecular parentage inference relies on low quality DNA from archived material. While much can still be inferred from incomplete or sparse pedigrees, it is crucial to evaluate the quality and power of available genetic information a priori to testing specific biological hypotheses. Here, we used microsatellite markers to reconstruct a multi-generation pedigree of wild Atlantic salmon (Salmo salar L.) using archived scale samples collected with a total trapping system within a river over a 10 year period. Using a simulation-based approach, we determined the optimal microsatellite marker number for accurate parentage assignment, and evaluated the power of the resulting partial pedigree to investigate important evolutionary and quantitative genetic characteristics of salmon in the system. Results: We show that at least 20 microsatellites (ave. 12 alleles/locus) are required to maximise parentage assignment and to improve the power to estimate reproductive success and heritability in this study system. We also show that 1.5 fold differences can be detected between groups simulated to have differing reproductive success, and that it is possible to detect moderate heritability values for continuous traits (h2 ~ 0.40) with more than 80% power when using 28 moderately to highly polymorphic markers. Conclusion: The methodologies and work flow described provide a robust approach for evaluating archived samples for pedigree-based research, even where only a proportion of the total population is sampled. The results demonstrate the feasibility of pedigree-based studies to address challenging ecological and evolutionary questions in free-living populations, where genealogies can be traced only using molecular tools, and that significant increases in pedigree assignment power can be achieved by using higher numbers of markers

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.

Identifying the underlying genetic drivers of the heritability of breast cancer prognosis remains elusive. We adapt a network-based approach to handle underpowered complex datasets to provide new insights into the potential function of germline variants in breast cancer prognosis. This network-based analysis studies ~7.3 million variants in 84,457 breast cancer patients in relation to breast cancer survival and confirms the results on 12,381 independent patients. Aggregating the prognostic effects of genetic variants across multiple genes, we identify four gene modules associated with survival in estrogen receptor (ER)-negative and one in ER-positive disease. The modules show biological enrichment for cancer-related processes such as G-alpha signaling, circadian clock, angiogenesis, and Rho-GTPases in apoptosis