Spontaneous Parity Violation

We disprove the Vafa-Witten theorem on the impossibility of spontaneously breaking parity in vector-like gauge field theories, identifying a mechanism driven by quantum fluctuations. With the introduction of a meromorphic Lattice formulation, defined over 5 dimensions, we demonstrate that the minima of the free energy can be distinct from the maxima of the partition function : identifying and evaluating a suitable contour for the partition function defined such that asymptotic behaviour of the complex action is non-oscillatory.Comment: 6 page

The Lattice β\beta-function of Quantum Spin Chains

We derive the lattice $\beta$-function for quantum spin chains, suitable for relating finite temperature Monte Carlo data to the zero temperature fixed points of the continuum nonlinear sigma model. Our main result is that the asymptotic freedom of this lattice $\beta$-function is responsible for the nonintegrable singularity in $\theta$, that prevents analytic continuation between $\theta=0$ and $\theta=\pi$.Comment: 10 page

Lorentz Covariance and the Dimensional Crossover of 2d-Antiferromagnets

We derive a lattice $\beta$-function for the 2d-Antiferromagnetic Heisenberg model, which allows the lattice interaction couplings of the nonperturbative Quantum Monte Carlo vacuum to be related directly to the zero-temperature fixed points of the nonlinear sigma model in the presence of strong interplanar and spin anisotropies. In addition to the usual renormalization of the gapful disordered state in the vicinity of the quantum critical point, we show that this leads to a chiral doubling of the spectra of excited states

Exact Nonperturbative Renormalization

We propose an exact renormalization group equation for Lattice Gauge Theories, that has no dependence on the lattice spacing. We instead relate the lattice spacing properties directly to the continuum convergence of the support of each local plaquette. Equivalently, this is formulated as a convergence prescription for a characteristic polynomial in the gauge coupling that allows the exact meromorphic continuation of a nonperturbative system arbitrarily close to the continuum limit.Comment: 12 page

Increased susceptibility of striatal mitochondria to calcium-induced permeability transition

Mitochondria were simultaneously isolated from striatum and cortex of adult rats and compared in functional assays for their sensitivity to calcium activation of the permeability transition. Striatal mitochondria showed an increased dose-dependent sensitivity to Ca2+compared with cortical mitochondria, as measured by mitochondrial depolarization, swelling, Ca2+uptake, reactive oxygen species production, and respiration. Ratios of ATP to ADP were lower in striatal mitochondria exposed to calcium despite equal amounts of ADP and ATP under respiring and nonrespiring conditions. The Ca2+-induced changes were inhibited by cyclosporin A or ADP. These responses are consistent with Ca2+activation of both low and high permeability pathways constituting the mitochondrial permeability transition. In addition to the striatal supersensitivity to induction of the permeability transition, cyclosporin A inhibition was less potent in striatal mitochondria. Immunoblots indicated that striatal mitochondria contained more cyclophilin D than cortical mitochondria. Thus striatal mitochondria may be selectively vulnerable to the permeability transition. Subsequent mitochondrial dysfunction could contribute to the initial toxicity of striatal neurons in Huntington's disease.</jats:p

A scanning drift tube apparatus for spatio-temporal mapping of electron swarms

A "scanning" drift tube apparatus, capable of mapping of the spatio-temporal evolution of electron swarms, developing between two plane electrodes under the effect of a homogeneous electric field, is presented. The electron swarms are initiated by photoelectron pulses and the temporal distributions of the electron flux are recorded while the electrode gap length (at a fixed electric field strength) is varied. Operation of the system is tested and verified with argon gas, the measured data are used for the evaluation of the electron bulk drift velocity. The experimental results for the space-time maps of the electron swarms - presented here for the first time - also allow clear observation of deviations from hydrodynamic transport. The swarm maps are also reproduced by particle simulations

On the possibility to supercool molecular hydrogen down to superfluid transition

Recent calculations by Vorobev and Malyshenko (JETP Letters, 71, 39, 2000) show that molecular hydrogen may stay liquid and superfluid in strong electric fields of the order of $4\times 10^7 V/cm$. I demonstrate that strong local electric fields of similar magnitude exist beneath a two-dimensional layer of electrons localized in the image potential above the surface of solid hydrogen. Even stronger local fields exist around charged particles (ions or electrons) if surface or bulk of a solid hydrogen crystal is statically charged. Measurements of the frequency shift of the $1 \to 2$ photoresonance transition in the spectrum of two-dimensional layer of electrons above positively or negatively charged solid hydrogen surface performed in the temperature range 7 - 13.8 K support the prediction of electric field induced surface melting. The range of surface charge density necessary to stabilize the liquid phase of molecular hydrogen at the temperature of superfluid transition is estimated.Comment: 5 pages, 2 figure

Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites

A highly effective vaccine that confers sterile protection to malaria is urgently needed. Immunization under chemoprophylaxis with sporozoites (CPS) consistently confers high levels of protection in the Controlled Human Malaria infection (CHMI) model. To provide a broad, unbiased assessment of the composition and kinetics of direct ex vivo human immune responses to CPS, we profiled whole-blood transcriptomes by RNA-seq before and during CPS immunization and following CHMI challenge. Differential expression of genes enriched in modules related to T cells, NK cells, protein synthesis, and mitochondrial processes were detected in fully protected individuals four weeks after the first immunization. Non-protected individuals demonstrated transcriptomic changes after the third immunization and the day of treatment, with upregulation of interferon and innate inflammatory genes and downregulation of B-cell signatures. Protected individuals demonstrated more significant interactions between blood transcription modules compared to non-protected individuals several weeks after the second and third immunizations. These data provide insight into the molecular and cellular basis of CPS-induced immune protection from P. falciparum infection

Evidence of distinct RELN and TGFB1 genetic associations in familial and non-familial otosclerosis in a British population

Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association study identified evidence that variants within RELN are associated with the condition. Other genes in which an association has been reported include BMP2, COL1A1, FGF2, PPP2R5B and TGFB1. However, follow up studies have often failed to replicate initial positive results. The aim of this study was to establish if an association exists between eight single nucleotide polymorphisms (SNPs) in these six previously implicated genes and otosclerosis in a British case-control cohort (n = 748). Evidence of an association between rs1800472 in TGFB1 and otosclerosis was found (p = 0.034), this association was strongest amongst non-familial cases (p = 0.011). No evidence of an association was detected with variants in COL1A1, FGF2, BMP2, and PPP2R5B. No association between variation in RELN and otosclerosis was observed in the whole cohort. However, a significant association (p = 0.0057) was detected between one RELN SNP (rs39399) and otosclerosis in familial patients. Additionally, we identify expression of one RELN transcript in 51 of 81 human stapes tested, clarifying previous conflicting data as to whether RELN is expressed in the affected tissue. Our findings strengthen the association of TGFB1 (rs1800472) with otosclerosis and support a relationship between RELN and familial otosclerosis only, which may explain previous variable replications