Accuracy of the QUAD4 thick shell element

The accuracy of the relatively new QUAD4 thick shell element is assessed via comparison with a theoretical solution for thick homogeneous and honeycomb flat simply supported plates under the action of a uniform pressure load. The theoretical thick plate solution is based on the theory developed by Reissner and includes the effects of transverse shear flexibility which are not included in the thin plate solutions based on Kirchoff plate theory. In addition, the QUAD4 is assessed using a set of finite element test problems developed by the MacNeal-Schwendler Corp. (MSC). Comparison of the COSMIC QUAD4 element as well as those from MSC and Universal Analytics, Inc. (UAI) for these test problems is presented. The current COSMIC QUAD4 element is shown to have excellent comparison with both the theoretical solutions and also those from the two commercial versions of NASTRAN that it was compared to

'Pest' and resource: A legal history of Australia's kangaroos

This paper presents an investigation into the legal history of Australias kangaroos. It aims to provide a detailed analysis of how the law and policy governing the killing of kangaroos has evolved over time in response to changing public perceptions. This history begins with the pre-European period and traces the impact of European colonisation, early growth of the commercial kangaroo industry, and the increased role of science and regulation upon kangaroos. The paper critiques the historical designation of kangaroos as `pests that need to be `managed and argues that such an approach is inconsistent with current scientific understanding. As this `pest status has fallen in importance there has been a shift in regulatory goals from damage mitigation to resource utilisation, although government planning and policy continue to cite damage mitigation alongside objectives to maintain viable populations and a sustainable and commercially viable industry. While the kangaroo industrys current focus is upon the `sustainable use of wildlife, the history of attitudes towards kangaroos as `pests is so deeply and widely entrenched that it is impossible for the industry to meet welfare standards. The article concludes that the commercial kangaroo industry does not have any clearly defined policy benefit and should be reassessed to take greater account of the impact it has on ecosystems and kangaroo welfar

Regular consumption of black tea increases circulating kynurenine concentrations: A randomized controlled trial

AbstractBackgroundCirculating neopterin and the ratio of kynurenine to tryptophan (KYN/TRP) concentrations are biomarkers of immune activation that have been linked to cardiovascular and total mortality. Several in vitro studies indicated that tea flavonoids and other antioxidants can modulate tryptophan breakdown rates and neopterin production in immune cells. We aimed to assess the effects of regular black tea consumption on tryptophan and neopterin metabolisms in vivo.MethodsParticipants were healthy individuals, with no major illnesses and having normal to mildly elevated systolic blood pressure. They were randomly assigned to consume 3cups/day of either powdered black tea solids (tea; n=45) or a flavonoid-free caffeine-matched beverage (control; n=49). Serum concentrations of tryptophan, kynurenine and neopterin were assessed at baseline and again at 3 and 6months after daily ingestion of the respective beverage.ResultsRegular consumption of tea over 6months, compared to control, did not significantly alter neopterin (p=0.13) or tryptophan (p=0.85) concentrations, but did result in significantly higher kynurenine (p=0.016) and KYN/TRP (p=0.012). Relative to the control group, in the tea group kynurenine and KYN/TRP increased during the treatment period by 0.28μmol/L (95% CI: −0.04, 0.60) and 3.2μmol/mmol (95% CI: −1.6, 8.0), respectively at 3months, and by 0.48μmol/L (95% CI: 0.16, 0.80) and 7.5μmol/mmol (95% CI: 2.5, 12.5), respectively at 6months.ConclusionsIncreased circulation of kynurenine and KYN/TRP following regular black tea consumption may indicate enhanced tryptophan breakdown, possibly due to immune activation-induced tryptophan degrading enzyme indoleamine 2,3-dioxygenase.General significanceThe influence of black tea consumption on biomarkers of immune system activation could relate to its general health benefits. Data suggests that the net effect strongly depends on the individual immune state, being stimulatory in healthy individuals, while acting more immune dampening in situations with an inflammatory background

The Reactome BioMart

Reactome is an open source, expert-authored, manually curated and peer-reviewed database of reactions, pathways and biological processes. We provide an intuitive web-based user interface to pathway knowledge and a suite of data analysis tools. The Reactome BioMart provides biologists and bioinformaticians with a single web interface for performing simple or elaborate queries of the Reactome database, aggregating data from different sources and providing an opportunity to integrate experimental and computational results with information relating to biological pathways. Database URL: http://www.reactome.org

Protoclusters associated with z > 2 radio galaxies. I. Characteristics of high redshift protoclusters

[Abridged] We present the results of a large program conducted with the Very Large Telescope and Keck telescope to search for forming clusters of galaxies near powerful radio galaxies at 2.0 < z < 5.2. We obtained narrow- and broad-band images of nine radio galaxies and their surroundings. The imaging was used to select candidate Lyman alpha emitting galaxies in ~3x3 Mpc^2 areas near the radio galaxies. A total of 337 candidate emitters were found with a rest-frame Lyman alpha equivalent width of EW_0 > 15 A and Sigma = EW_0/Delta EW_0 > 3. Follow-up spectroscopy confirmed 168 Lyman alpha emitters near eight radio galaxies. The success rate of our selection procedure is 91%. At least six of our eight fields are overdense in Lyman alpha emitters by a factor 3-5. Also, the emitters show significant clustering in velocity space. In the overdense fields, the width of the velocity distributions of the emitters is a factor 2-5 smaller than the width of the narrow-band filters. Taken together, we conclude that we have discovered six forming clusters of galaxies (protoclusters). We estimate that roughly 75% of powerful (L_2.7GHz > 10^33 erg/s/Hz/sr) high redshift radio galaxies reside in a protocluster, with a sizes of at least 1.75 Mpc. We estimate that the protoclusters have masses in the range 2-9 x 10^14 Msun and they are likely to be progenitors of present-day (massive) clusters of galaxies. For the first time, we have been able to estimate the velocity dispersion of cluster progenitors from z~5 to ~2. The velocity dispersion of the emitters increases with cosmic time, in agreement with the dark matter velocity dispersion in numerical simulations of forming massive clusters.Comment: 30 pages, 20 figures. Published in A&A. The article with high resolution figures is available at http://www.ast.cam.ac.uk/~venemans/research/datapaper/index.htm

Discovery of Extreme Examples of Superclustering in Aquarius

We report the discovery of two highly extended filaments and one extremely high density knot within the region of Aquarius. The supercluster candidates were chosen via percolation analysis of the Abell and ACO catalogs and include only the richest clusters (R >= 1). The region examined is a 10x45 degree strip and is now 87% complete in cluster redshift measurements to mag_10 = 18.3. In all, we report 737 galaxy redshifts in 46 cluster fields. One of the superclusters, dubbed Aquarius, is comprised of 14 Abell/ACO clusters and extends 110h^-1Mpc in length only 7 degrees off the line-of-sight. On the near-end of the Aquarius filament, another supercluster, dubbed Aquarius-Cetus, extends for 75h^-1Mpc perpendicular to the line-of-sight. After fitting ellipsoids to both Aquarius and Aquarius-Cetus, we find axis ratios (long-to- midlength axis) of 4.3 for Aquarius and 3.0 for Aquarius-Cetus. We fit ellipsoids to all N>=5 clumps of clusters in the Abell/ACO measured-z cluster sample. The frequency of filaments with axis ratios >=3.0 (~20%) is nearly identical with that found among `superclusters' in Monte Carlo simulations of random and random- clumped clusters, however, so the rich Abell/ACO clusters have no particular tendency toward filamentation. The Aquarius filament also contains a `knot' of 6 clusters at Z ~0.11, with five of the clusters near enough togeteher to represent an apparent overdensity of 150. There are three other R >= 1 cluster density enhancements similar to this knot at lower redshifts: Corona Borealis, the Shapely Concentration, and another grouping of seven clusters in Microscopium. All four of these dense superclusters appear near the point of breaking away from the Hubble Flow, and some may now be in collapse, but there is little evidence of any being virialized.Comment: 45 pages (+ e-tables), 7 figures, AASTeX Accepted for Publication in Ap

Recovering the Primordial Density Fluctuations: A comparison of methods

We present a comparative study of six different methods for reversing the gravitational evolution of a cosmological density field to recover the primordial fluctuations: linear theory, the Gaussianization mapping scheme, two different quasi-linear dynamical schemes based on the Zel'dovich approximation, a Hybrid dynamical-Gaussianization method and the Path Interchange Zel'dovich Approximation (PIZA). The final evolved density field from an N-body simulation constitutes our test case. We use a variety of statistical measures to compare the initial density field recovered from it to the true initial density field, using each of the six different schemes. These include point-by-point comparisons of the density fields in real space, the individual modes in Fourier space, as well as global statistical properties such as the genus, the PDF of the density, and the distribution of peak heights and their shapes. We find linear theory to be the most inaccurate of all the schemes. The Gaussianization scheme is the least accurate after linear theory. The two quasi-linear dynamical schemes are more accurate than Gaussianization, although they break down quite drastically when used outside their range of validity - the quasi-linear regime. The complementary beneficial aspects of the dynamical and the Gaussianization schemes are combined in the Hybrid method. We find this Hybrid scheme to be more accurate and robust than either Gaussianization or the dynamical method alone. The PIZA scheme performs substantially better than the others in all point-by-point comparisons. However, it produces an oversmoothed initial density field, with a smaller number of peaks than expected, but recovers the PDF of the initial density with impressive accuracy on scales as small as 3Mpc/h.Comment: 39 pages, including 13 Figures, submitted to Ap

Cosmological Limits on the Neutrino Mass from the Lya Forest

The Lya forest in quasar spectra probes scales where massive neutrinos can strongly suppress the growth of mass fluctuations. Using hydrodynamic simulations with massive neutrinos, we successfully test techniques developed to measure the mass power spectrum from the forest. A recent observational measurement in conjunction with a conservative implementation of other cosmological constraints places upper limits on the neutrino mass: m_nu < 5.5 eV for all values of Omega_m, and m_nu < 2.4 (Omega_m/0.17 -1) eV, if 0.2 < Omega_m <0.5 as currently observationally favored (both 95 % C.L.).Comment: 4 pages, 2 ps figures, REVTex, submitted to Phys. Rev. Let

Medial Axis Isoperimetric Profiles

Recently proposed as a stable means of evaluating geometric compactness, the isoperimetric profile of a planar domain measures the minimum perimeter needed to inscribe a shape with prescribed area varying from 0 to the area of the domain. While this profile has proven valuable for evaluating properties of geographic partitions, existing algorithms for its computation rely on aggressive approximations and are still computationally expensive. In this paper, we propose a practical means of approximating the isoperimetric profile and show that for domains satisfying a "thick neck" condition, our approximation is exact. For more general domains, we show that our bound is still exact within a conservative regime and is otherwise an upper bound. Our method is based on a traversal of the medial axis which produces efficient and robust results. We compare our technique with the state-of-the-art approximation to the isoperimetric profile on a variety of domains and show significantly tighter bounds than were previously achievable.Comment: Code and supplemental available here: https://github.com/pzpzpzp1/isoperimetric_profil