Normalizacion del sistema de gestion para planificacion de mantenimiento

145 p.El trabajo que se describe a continuación, corresponde a la memoria presentada por el autor, para poder optar al título de Ingeniero Civil Industrial. Se genera en Andes Service S.A, empresa dedicada a la prestación de servicios de embalaje de fruta, tanto para los huertos propios de la Empresa, como para terceros. Se decidió mejorar el proceso productivo, donde el área de mantenimiento es de vital importancia al momento de querer realizar una mejora. Por ello que se decide trabaja en la gestión del mantenimiento. Se llevaron a cabo visitas a terreno, con el fin de observar tanto en las etapas de proceso productivo como en la etapa de detención; como se comportaba el área de mantenimiento. Con el fin de poder conocer las instalaciones, los proceso productivo, la documentación de control y los diferentes registros que se almacenan en cuanto a detenciones y paradas. En las etapas iniciales para entender en forma más clara los problemas posibles se aplicó una auditoria de mantenimiento, donde la información obtenida, en su conjunto, ayudaron a formar parte de la descripción y diagnostico de la situación actual de la empresa. El propósito de la auditoría fue poder detectar las principales debilidades yfortalezas que estaba presentando el departamento. Una vez obtenidas las debilidades, se procedió a la búsqueda de una solución, mediante la aplicación de distintas técnicas asociadas al análisis de datos, se procedió a la elaboración de mejoras, mediante modelos de trabajo. Esto se llevo a cabo a través de la utilización de distintos elementos, entre los que podemos encontrar: Análisis de modos de fallos y efectos críticos, Diagramas Causa – Efecto y Diseño del Sistema de Información. Se desarrolló un sistema de información estructurado, de diseño ordenado y claro, en donde las personas involucradas podrán de forma rápida llamar y almacenar información obtenida por el departamento, esto hará más evidente la detección de las fallas, mejoras en los tiempos de reacción y principalmente poder disminuir los costos relacionados a las detenciones y reparaciones no programadas

Economic assessment of investment in automatic feeding systems for sea bass grow-out farms of different sizes

The aim of this work was to run an economic assessment of investment in automatic feeding systems for grow-out farms of different sizes producing European sea bass in the Mediterranean Sea. For this, we have used an economic model to simulate the annual income statement of a typical farm with different production volumes: a small-sized farm with a production of 413 tons/year, a medium-sized farm of 1122 tons/year, and a large-sized farm of 2539 tons/year. With the values obtained in the simulation, we have carried out partial budget and investment analyses to estimate the economic value of this investment decision. To complement our economic assessment, a sensitivity analysis has also been run to include risk in the investment decision. Our findings show that the implementation of automatic feeding systems in sea bass grow-out farms would be a good economic decision, regardless of the farm size, since there are technological options suitable for different farm sizes and capital investment capacities. Consequently, innovation and investment in feeding management should not be impeded or limited by the farm size.info:eu-repo/semantics/publishedVersio

Efecto alelopático de la invasora Acacia dealbata Link (Fabaceae) en dos especies de plantas nativas del centro-sur de Chile

Plant species that growth close to or under the canopy of Acacia dealbata Link (Fabaceae, subfamily: Mimosoideae) withinits non-native range, survive with difficulty or not at all, especially if they are native. This phenomenon has been attributedto allelopathy; one of the strategies used by A. dealbata to trigger an invasion process. Native species Quillaja saponariaMolina (tree) and Helenium aromaticum (Hook.) H.L. Bailey (herb), share A. dealbata’s range in South-central Chile. Thisstudy was performed on the Mediterranean Biobío Region of Chile. We evaluated the effect of leaves, flowers, pods andseeds of A. dealbata on the germination and early growth of these native species. Biological assays were carried out underlaboratory conditions, based on aqueous extracts and the direct effect of plant material. Leaf litter prevented the germinationof both species and seeds of the invasive species impeded the germination of Q. saponaria. Other plant parts from A.dealbata also induced reductions of hypocotyl and radicle lengths in the native species, reaching over 50 % in some treatmentvalues. All plant parts caused radicle necrosis, preventing the formation of root hairs and, consequently, jeopardizing thesurvival possibility of the recipient species. The results show that A. dealbata can interfere with the establishment of pioneerherbaceous species in ecological succession and can also affect trees if they are reached by the invasion front.Las plantas que crecen cerca o bajo el dosel de Acacia dealbata Link (Fabaceae, subfamilia: Mimosoideae), cuando esta seencuentra en el rango no nativo, sobreviven con dificultad o no lo logran, especialmente si son nativas. Este fenómeno se haatribuido a la alelopatía; una de las estrategias utilizadas por A. dealbata para promover su proceso de invasión. Las especiesnativas Quillaja saponaria Molina (arbórea) y Helenium aromaticum (Hook.) H.L. Bailey (herbácea) comparten el rango dedistribución de A. dealbata en el centro-sur de Chile. El presente trabajo se realizó en la Región del Biobío y se evaluaronlos efectos de hojas, flores, vainas y semillas de A. dealbata en la germinación y crecimiento temprano de las especiesnativas mencionadas. Los ensayos biológicos se llevaron a cabo en condiciones de laboratorio, basados en extractos acuososy efectos directos del material vegetal. Nuestros resultados indicaron que las hojas impidieron la germinación de ambasespecies nativas, pero las semillas impidieron sólo la germinación de Q. saponaria. Otras partes de la planta de A. dealbatatambién indujeron fuertes reducciones de las longitudes del hipocótilo y radícula en las especies nativas, superándose el50% en algunos tratamientos. Todas las partes de la planta causaron necrosis en la radícula, evitando la formación de pelosradicales y, por consiguiente, comprometiendo la posibilidad de supervivencia de las especies receptoras. Estos resultadosmuestran que A. dealbata puede interferir en el establecimiento de especies herbáceas pioneras en la sucesión ecológica ytambién puede afectar especies arbóreas secundarias si son alcanzadas por el frente de invasión

Modelling physical activity profiles in COPD patients: a fully functional approach to variable domain functional regression models

Physical activity plays a significant role in the well-being of individuals with Chronic obstructive Pulmonary Disease (COPD). Specifically, it has been directly associated with changes in hospitalization rates for these patients. However, previous investigations have primarily been conducted in a cross-sectional or longitudinal manner and have not considered a continuous perspective. Using the telEPOC program we use telemonitoring data to analyze the impact of physical activity adopting a functional data approach. However, Traditional functional data methods, including functional regression models, typically assume a consistent data domain. However, the data in the telEPOC program exhibits variable domains, presenting a challenge since the majority of functional data methods, are based on the fact that data are observed in the same domain. To address this challenge, we introduce a novel fully functional methodology tailored to variable domain functional data, eliminating the need for data alignment, which can be computationally taxing. Although models designed for variable domain data are relatively scarce and may have inherent limitations in their estimation methods, our approach circumvents these issues. We substantiate the effectiveness of our methodology through a simulation study, comparing our results with those obtained using established methodologies. Finally, we apply our methodology to analyze the impact of physical activity in COPD patients using the telEPOC program's data. Software for our method is available in the form of R code on request at \url{https://github.com/Pavel-Hernadez-Amaro/V.D.F.R.M-new-estimation-approach.git}

Stratus 13 thirteenth setting of the Stratus Ocean Reference Station cruise on board RV Ron Brown February 25 - March 15, 2014 Valparaiso, Chile - Arica, Chile

The Ocean Reference Station at 20°S, 85°W under the stratus clouds west of northern Chile is being maintained to provide ongoing climate-quality records of surface meteorology, air-sea fluxes of heat, freshwater, and momentum, and of upper ocean temperature, salinity, and velocity variability. The Stratus Ocean Reference Station (ORS Stratus) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Climate Observation Program. It is recovered and redeployed annually, with past cruises that have come between October and January. This cruise was conducted on the NOAA vessel Ron Brown. During the 2014 cruise on the Ron Brown to the ORS Stratus site, the primary activities were the recovery of the previous (Stratus 12) WHOI surface mooring, which was adrift since January 25 2014 and drifting northwest, deployment of the new Stratus 13 WHOI surface mooring, in-situ calibration of the buoy meteorological sensors by comparison with instrumentation installed on the ship, CTD casts near the moorings. Surface drifters and subsurface floats were also launched along the track.Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA09OAR4320129 and the Cooperative Institute for the North Atlantic Region (CINAR)

A Production Calendar Based on Water Temperature, Spat Size, and Husbandry Practices Reduce OsHV-1 μvar Impact on Cultured Pacific Oyster Crassostrea gigas in the Ebro Delta (Catalonia), Mediterranean Coast of Spain

Since 2006, the production of Pacific oyster Crassostrea gigas in the Ebro Delta area has dramatically declined from around 800 metric tons (MT) per year to 138 MT in 2011. This decline in production has had a significant socio-economic impact in a region where the shellfish sector is a traditional economic activity for many families. The identified agent responsible for this reduction in C. gigas production was Ostreid Herpesvirus microvar (OsHV-1 μvar), which has been associated with C. gigas spat mortalities in France, and in many other countries. In Spain the episodes of mortality became critical for the regional shellfish production between 2008 until 2014, with mortality percentage up to 100%. In this study, local hatchery C. gigas spat was used as sentinel animals for epidemiological studies and management tests carried out with the aim of reducing oyster mortality in the Ebro Delta area. A production calendar mainly based on water temperature dynamics was designed around an optimal schedule for spat immersion. The mmersion calendar included two optimal periods for spat immersion, in summer when temperatures are ≥25◦C and at the end of autumn and beginning of winter when they are ≤13◦C. Such production planning has reduced mortalities from 80% (in 2014 and previous years) to 2–7.5% in 2015 in cemented oysters. Furthermore, other recommendations related to spat immersion size, culture density and methodology, and cementing calendar, which helped to achieve the results presented, were also recorded and transferred to local producers. This work presents a successfully tested management strategy reducing OsHV-1 μvar impact by designing new field management practices mainly focused on the handling and timing of spat immersion. This approach could be used as a management model in areas presenting similar production practices and environmental characteristics.info:eu-repo/semantics/publishedVersio

The clinical and molecular cardiometabolic fingerprint of an exploratory psoriatic arthritis cohort is associated with the disease activity and differentially modulated by methotrexate and apremilast

Objectives: (1) To evaluate clinical and molecular cardiovascular disease (CVD) signs and their relationship with psoriatic arthritis (PsA) features and (2) to identify a clinical patient profile susceptible to benefit from methotrexate (MTX) and/or apremilast regarding CVD risk. Methods: This cross-sectional study included 100 patients with PsA and 100 age-matched healthy donors. In addition, an exploratory cohort of 45 biologically naïve patients treated for 6 months with apremilast, MTX or combined therapy according to routine clinical practice was recruited. Extensive clinical and metabolic profiles were obtained. Ninety-nine surrogate CVD-related molecules were analysed in plasma and peripheral blood mononuclear cells (PBMCs). Hard cluster analysis was performed to identify the clinical and molecular phenotypes. Mechanistic studies were performed on adipocytes. Results: Cardiometabolic comorbidities were associated with disease activity and long-term inflammatory status. Thirty-five CVD-related proteins were altered in the plasma and PBMCs of PsA patients and were associated with the key clinical features of the disease. Plasma levels of some of the CVD-related molecules might distinguish insulin-resistant patients (MMP-3, CD163, FABP-4), high disease activity (GAL-3 and FABP-4) and poor therapy outcomes (CD-163, LTBR and CNTN-1). Hard cluster analysis identified two phenotypes of patients according to the rates of cardiometabolic comorbidities with distinctive clinical and molecular responses to each treatment. Conclusions: (1) Novel CVD-related proteins associated with clinical features could be emerging therapeutic targets in the context of PsA and (2) the pleiotropic action of apremilast could make it an excellent choice for the management of PsA patients with high CVD risk, targeting metabolic alterations and CVD-related molecules