287 research outputs found
Technological Aspects of Scalable Processes for the Production of Functional Liposomes for Gene Therapy
Globular Clusters around Galaxies in Groups
We have obtained deep photometry of NGC 1199 (in HCG 22) and NGC 6868 (in the
Telescopium group). Both galaxies are the optically brightest galaxies of their
groups. Our analysis of B and R images taken with the Keck II and the VLT/ESO
telescopes, detected a population of globular clusters around both galaxies,
with total specific frequencies S_N=1.7\pm0.6 for NGC 1199 and S_N = 1.3\pm0.6
for NGC 6868. The color distributions of the globular cluster systems shows
bimodal peaks centered at (B-R)_0 = 1.13\pm0.10 and 1.42\pm0.10 (NGC 1199) and
(B-R)_0=1.12\pm0.10 and 1.42\pm0.10 (NGC 6868).Comment: 3 pages, 1 figure. To appear in the proceedings of IAU Symp. 207,
"Extragalactic Star Clusters", eds. E. Grebel, D. Geisler, D. Minnit
Evaluation of Acid Detergent Fibre, Sulphuric Acid Lignin and N-Alkanes as Markers for Estimating Ruminal Digestibility in Cattle
Most of the published studies on estimating organic matter (OM) rumen digestibility (OMRD) use research animals fitted with simple t-type cannulas and an external or inter-nal marker for estimating the duodenal digesta flow. Although there is not an ideal or standard marker, com-pared to external markers, internal markers have the advantage of occurring naturally in the diet and, conse-quently, they flow intimately associated with digesta (Titgemeyer 1997). In digestibility studies where total faec-es output is measured, duodenal digesta flow may be estimated based on both faeces output and the ratio of a marker concentration in faeces and in duodenal digesta. Sulphuric acid lignin (ADL) has been commonly used as an internal marker in this approach. However, its low concen-trations in duodenal digesta usually compromises estimate precision. The objective of this study was to evaluate acid detergent fibre (ADF) in comparison with ADL, as well as with n-alkanes, as a marker for estimating OMRD in cattle
Estudo da interação solo-estrutura em um edifício residencial na cidade de Itaperuna/RJ a partir do respectivo projeto estrutural / Study of soil-structure interaction in a residential building in the city of Itaperuna/RJ based on the respective structural project
O presente artigo explora a interação do solo e estrutura em um edifício residencial de 12 pavimentos projetado na cidade de Itaperuna-RJ por meio de seu respectivo projeto estrutural. Para análise foram utilizados laudos de sondagens fornecidos por empresa especializada, afim de julgar a relação da estrutura projetada com os solos disponíveis. É essencial que se obtenha os laudos de sondagem para posterior seleção da fundação a ser projetada e executada. A investigação qualitativa detalhada teve por início na apuração dos laudos de sondagem em distintos terrenos situados no município de Itaperuna-RJ, e posteriormente foi definido o projeto estrutural. A exploração se desenvolveu por intermédio da inserção das informações contidas nos laudos de sondagem e da mesclagem da mesma com a projeção estrutural, através do software de projeção estrutural, que demonstrou as interações gráficas, que a fundação definida teve com cada solo. Informações daí aferidas impulsionaram a análise comparativa da fundação para os diferentes solos. O programa utilizado para as representações estruturais e gráficas foi o Eberick em função dos laudos apresentados e trabalhados em planilha específica. Pode-se entender o laudo da região proveniente da menor capacidade de carga para a estaca, como modelo para a projeção da fundação profunda (estaca raiz) no software e aplicando assim a mesma linha de raciocínio para o estudo comparativo das demais regiões aplicadas a mesma fundação profunda. A interação foi considerada satisfatória, atendendo a resistência que cada pilar exerce em razão de cada capacidade de carga da estaca
Arachnidism, scorpionism and ophidism in Ouro Preto Municipality, Minas Gerais State, Brazil
Abstract: INTRODUCTION This retrospective study shows the profile of arachnidism, ophidism, and scorpionism in the Ouro Preto Municipality, Brazil, from January 2007 to December 2013. METHODS The data were gathered from forms of the Epidemiological Surveillance Sector of the town's Health's Municipal Secretary. RESULTS Of the 412 envenomations, 308 were caused by spiders, 78 by scorpions, and 26 by snakes. The highest number of incidents involved people aged 20-34 years. Females were more affected than males. There were no reports of death. CONCLUSIONS The results show that envenomations caused by spiders, scorpions and snakes have decreased in recent years
Typical Lung Carcinoids with Metastasis:Potential Role of MicroRNAs in the Regulation of Adaptive Immunity Associated with Disease: a Case Study
Proteomics-based identification of differentially abundant proteins reveals adaptation mechanisms of Xanthomonas citri subsp citri during Citrus sinensis infection
Background: Xanthomonas citri subsp. citri (Xac) is the causal agent of citrus canker. A proteomic analysis under in planta infectious and non-infectious conditions was conducted in order to increase our knowledge about the adaptive process of Xac during infection. Results: For that, a 2D-based proteomic analysis of Xac at 1, 3 and 5 days after inoculation, in comparison to Xac growth in NB media was carried out and followed by MALDI-TOF-TOF identification of 124 unique differentially abundant proteins. Among them, 79 correspond to up-regulated proteins in at least one of the three stages of infection. Our results indicate an important role of proteins related to biofilm synthesis, lipopolysaccharides biosynthesis, and iron uptake and metabolism as possible modulators of plant innate immunity, and revealed an intricate network of proteins involved in reactive oxygen species adaptation during Plants'Oxidative Burst response. We also identified proteins previously unknown to be involved in Xac-Citrus interaction, including the hypothetical protein XAC3981. A mutant strain for this gene has proved to be non-pathogenic in respect to classical symptoms of citrus canker induced in compatible plants. Conclusions: This is the first time that a protein repertoire is shown to be active and working in an integrated manner during the infection process in a compatible host, pointing to an elaborate mechanism for adaptation of Xac once inside the plant.Fundacao de Amparo a Pesquisa do Estado de Sao PauloFundacao de Amparo a Pesquisa do Estado de Minas GeraisBIGA grant-CAPESUniv Fed Ouro Preto, Inst Ciencias Exatas & Biol, Dept Ciencias Biol DECBI, Ouro Preto, MG, BrazilUniv Fed Ouro Preto, Nucleo Pesquisas Ciencias Biol NUPEB, Ouro Preto, MG, BrazilUniv Fed Rio de Janeiro, Inst Quim, Dept Bioquim DBq, Rio De Janeiro, RJ, BrazilUniv Estadual Paulista, UNESP, Dept Tecnol, Fac Ciencias Agr & Vet Jaboticabal, Jaboticabal, SP, BrazilUniv Estadual Campinas, UNICAMP, Inst Quim, Campinas, SP, BrazilUniv Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilVirginia Tech, Biocomplex Inst, Blacksburg, VA USAUniv Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Ciencias Biol, Diadema, SP, BrazilCAPESFAPESP: 04/02006-7Fundacao de Amparo a Pesquisa do Estado de Minas Gerais: CBB-APQ-04425-10BIGA grant-CAPES: 3385/2013Web of Scienc
Inducible Nitric Oxide Synthase in Heart Tissue and Nitric Oxide in Serum of Trypanosoma cruzi-Infected Rhesus Monkeys: Association with Heart Injury
Chagas disease, a neglected tropical disease caused by the protozoan Trypanosoma cruzi, afflicts from 8 to 15 million people in the Latin America. Chronic chagasic cardiomyopathy (CCC) is the most frequent manifestation of Chagas disease. Currently, patient management only mitigates CCC symptoms. The pathogenic factors leading to CCC remain unknown; therefore their comprehension may contribute to develop more efficient therapies. In patients, high nitric oxide (NO) levels have been associated with CCC severity. In T. cruzi-infected mice, NO, mainly produced via inducible nitric oxide synthase (iNOS/NOS2), is proposed to work in parasite control. However, the participation of iNOS/NOS2 and NO in T. cruzi control and heart injury has been questioned. Here, infected rhesus monkeys and iNOS/NOS2-deficient mice were used to explore the participation of iNOS/NOS2-derived NO in heart injury in T. cruzi infection. Chronically infected monkeys presented electrical abnormalities, myocarditis and fibrosis, resembling the spectrum of human CCC. Moreover, cardiomyocyte lesion correlated with iNOS/NOS2+ cells infiltrating the cardiac tissue. Our findings support that parasite-driven iNOS/NOS2+ cells accumulation in the cardiac tissue and NO overproduction contribute to cardiomyopathy severity, mainly disturbing the pathway involved in electrical synchrony in T. cruzi infection
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