Performance comparison between signal digitizers and low-cost digital oscilloscopes: spectroscopic, pulse shape discrimination and timing capabilities for nuclear detectors

Signal digitizers revolutionized the approach to the electronics readout of radiation detectors in Nuclear Physics. These highly specialized pieces of equipment are designed to acquire the signals that are characteristic of the detectors in nuclear physics experiments. The functions of the several modules that were once needed for signal acquisition, can now be substituted by a single digitizer. As suggested by the name, with such readout modules, signals are first digitized (i.e. the signal waveform is sampled and converted to a digital representation) and then either stored or analyzed on-the-fly. The performances can be comparable or better than the traditional analog counterparts, in terms of energy, time resolution, and acquisition rate. In this work, we investigate the use of general-purpose digital oscilloscopes as signal digitizers for nuclear detectors. In order to have a proper comparison, we employ a distributed data acquisition system (DAQ), that standardizes the interface between the hardware and the on-line data analysis. The signals, from a set of typical radiation detectors, are digitized and analyzed with the very same algorithms in order to avoid biases due to different software analysis. We compare two traditional signal digitizers (CAEN DT5725 and CAEN DT5751) to two low-cost digital oscilloscopes (Digilent Analog Discovery 2, and Red Pitaya STEMLab 125-14), in terms of their capabilities for spectroscopy (energy resolution), time resolution, pulse shape discrimination, and maximum acquisition rate.Comment: 17 pages, 8 figures, 4 tables, Prepared for submission to JINS

a distributed data acquisition system for nuclear detectors

Nowadays, many examples of data acquisition (DAQ) software for experimental nuclear physics are monolithic processes that run on a computer attached to the DAQ hardware. In this article we present a distributed DAQ system developed for the C-BORD project. With our system, we propose a novel approach, in which each task related to the different DAQ parts (acquisition, pre-process, analysis, etc.) runs in a separate process. In particular, the system is composed of a set of servers that exchange information through dedicated communication sockets. Therefore, with this architecture, an important advantage is the possibility to run the processes on different computers to distribute the computational load. The initial tests of the system have been giving excellent results, both in terms of performance (i.e., maximum acquisition rates) and stability. The project entitled "Effective container inspection at BORDer control points" (C-BORD) is funded by the European H2020 programme. Its aim is to develop a comprehensive set of technologies for the generalized non-intrusive inspection (NII) of containers and large-volume freight at the European Union border

Impact of gastrointestinal side effects on patients’ reported quality of life trajectories after radiotherapy for prostate cancer: Data from the prospective, observational pros-it CNR study

Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects

Novel neutron detector assembly based on SiPM readout to be coupled with the Active Target for SPES

The Active Target ATS (Active Target for SPES) is a new time-projection chamber designed for reaction and decay studies with nuclei far from stability. The physics cases for the new-generation active target are related to the ongoing developments of facilities for radioactive ion beams. Thanks to its flexibility, this instrument will be capable of taking advantage of the most exotic beams which will become available at the SPES facility under construction at the Legnaro National Laboratories in Italy. Particular attention will be also paid to couple it with ancillary detectors, for both charged and neutral (gamma and neutrons) particles. In particular, in this work, we will focus the attention on the neutron ancillary detectors. The proposed prototype is a compact device able to discriminate, by performing pulse shape analysis, between neutrons and gamma. The device take advantage of recent improvements in silicon photomultiplier (SiPM) technology and the development of new plastic scintillators exhibiting neutron/gamma discrimination capability. Our work is focused on the read-out with silicon photomultipliers arrays of EJ-276 (and its old version EJ-299) and EJ-276G scintillators of several sizes (ranging from 20 mm to 50 mm diameter). Moreover, we will show the comparison of discrimination performances between SiPM and standard photomultiplier read-out configurations

Stopping power measurements with the Time-of-Flight (ToF) technique

A review of measurements of the stopping power of ions in matter is presented along with new measurements of the stopping powers of O, Si, Ti, and Au ions in self-supporting thin foils of SiO2, Nb2O5, and Ta2O5. A Time-of-Flight system at the Ion Beam Materials Laboratory at the University of Tennessee, Knoxville, was used in transmission geometry in order to reduce experimental uncertainties. The resulting stopping powers show good precision and accuracy and corroborate previously quoted values in the literature. New stopping data are determined

Poliovirus and Other Enteroviruses from Environmental Surveillance in Italy, 2009-2015

Within the initiatives for poliomyelitis eradication by WHO, Italy activated an environmental surveillance (ES) in 2005. ES complements clinical Acute Flaccid Paralysis (AFP) surveillance for possible polio cases, detects poliovirus circulation in environmental sewage, and is used to monitor transmission in communities. In addition to polioviruses, the analyses comprised: (i) the monitoring of the presence of non-polio enteroviruses in sewage samples and (ii) the temporal and geographical distribution of the detected viruses. From 2009 to 2015, 2880 sewage samples were collected from eight cities participating in the surveillance. Overall, 1479 samples resulted positive for enteroviruses. No wild-type polioviruses were found, although four Sabin-like polioviruses were detected. The low degree of mutation found in the genomes of these four isolates suggests that these viruses have had a limited circulation in the population. All non-polio enteroviruses belonged to species B and the most frequent serotype was CV-B5, followed by CV-B4, E-11, E-6, E-7, CV-B3, and CV-B2. Variations in the frequency of different serotypes were also observed in different seasons and/or Italian areas. Environmental surveillance in Italy, as part of the 'WHO global polio eradication program', is a powerful tool to augment the polio surveillance and to investigate the silent circulation or the re-emergence of enteroviruses in the population

Release of IFNγ by acute myeloid leukemia cells remodels bone marrow immune microenvironment by inducing regulatory T cells

Purpose: The stromal and immune bone marrow (BM) landscape is emerging as a crucial determinant for acute myeloid leukemia (AML). Regulatory T cells (Treg) are enriched in the AML microenvironment, but the underlying mechanisms are poorly elucidated. Here, we addressed the effect of IFNγ released by AML cells in BM Treg induction and its impact on AML prognosis. Experimental Design: BM aspirates from patients with AML were subdivided according to IFNG expression. Gene expression profiles in INFγhigh and IFNγlow samples were compared by microarray and NanoString analysis and used to compute a prognostic index. The IFNγ release effect on the BM microenvironment was investigated in mesenchymal stromal cell (MSC)/AML cell cocultures. In mice, AML cells silenced for ifng expression were injected intrabone. Results: IFNγhigh AML samples showed an upregulation of inflammatory genes, usually correlated with a good prognosis in cancer. In contrast, in patients with AML, high IFNG expression was associated with poor overall survival. Notably, IFNγ release by AML cells positively correlated with a higher BM suppressive Treg frequency. In coculture experiments, IFNγhigh AML cells modified MSC transcriptome by upregulating IFNγ-dependent genes related to Treg induction, including indoleamine 2,3-dioxygenase 1 (IDO1). IDO1 inhibitor abrogated the effect of IFNγ release by AML cells on MSC-derived Treg induction. In vivo, the genetic ablation of IFNγ production by AML cells reduced MSC IDO1 expression and Treg infiltration, hindering AML engraftment. Conclusions: IFNγ release by AML cells induces an immune-regulatory program in MSCs and remodels BM immunologic landscape toward Treg induction, contributing to an immunotolerant microenvironment