Does it matter where patent citations come from? Inventor versus examiner citations in European patents

patent, European, citations

The relative importance of home and host innovation systems in the internationalisation of MNE R&D: a patent citation analysis

host innovation systems, internationalisation, MNE, R&D

Managing Unsolicited Ideas for R&D

Existing academic and popular literature suggests that unsolicited ideas, the non-contractual and voluntary submission of innovation-related information from external sources to the firm, offer the promise of a bountiful and low-cost tool to sustain and extend firms' R&D efforts. Yet, in practice, many organizations find it difficult to deal with unsolicited ideas because of high quantity, low quality, and the need to transfer IP ownership. This article identifies a range of practices that allow organizations to meet these challenges and therefore realize some of the potential of unsolicited ideas for R&D

The elixir (or burden) of youth? Exploring differences in innovation between start-ups and established firms

Despite the widely acknowledged role of start-ups in economic development, little is known about their innovative activities compared with those of established firms. Drawing on a sample of 12,209 UK firms, we differentiate between services and manufacturing firms and, using a matching estimator approach, demonstrate that start-ups differ significantly from established firms in their innovation activities. We find that in services, being a start-up increases the likelihood of product innovations. However, in manufacturing, we find no significant differences in the likelihood of product innovation between start-ups and established firms. When examining the returns to innovation, we find that start-ups have a significant advantage both in services and in manufacturing. We explore the implications of these results for theory and policy

Quantum causal histories

Quantum causal histories are defined to be causal sets with Hilbert spaces attached to each event and local unitary evolution operators. The reflexivity, antisymmetry, and transitivity properties of a causal set are preserved in the quantum history as conditions on the evolution operators. A quantum causal history in which transitivity holds can be treated as ``directed'' topological quantum field theory. Two examples of such histories are described.Comment: 16 pages, epsfig latex. Some clarifications, minor corrections and references added. Version to appear in Classical and Quantum Gravit

TRATTAMENTO ASSOCIATO UVB-DITRANOLO IN PAZIENTI CON PSORIASI A PLACCHE

The purpose of this study was to determine whether the combination of ultraviolet B therapy and anthralin would result in a more rapid resolution of plaque-type psoriasis. Short-contact anthralin (0.5% in petrolatum) was used. Ultraviolet B irradiation was carried out 5 times a week with a bank of 8 Philips TL 40W/12 tubes (irradiance, 1 mW/cm2 30 cm). Out of the 14 patients studied, seven (group I) were given anthralin for 15 days before practicing UVB therapy and seven (group II) carried out phototherapy sessions for 15 days before the combination of both treatments. These results show both a more rapid clearance of psoriatic plaques and lower UVB total dose with anthralin pretreatment

Coping with Open Innovation: Responding to the Challenges of External Engagement in R&D

Open innovation often requires wholesale changes to the nature of R&D. However, academic research and managerial practice have paid little attention to the challenges that individuals face in the daily pursuit of open innovation. As a result, there is little understanding of how individuals cope with open innovation, and which organizational practices can support them in this role. Drawing on the experiences of R&D professionals, this article identifies four specific challenges and coping strategies of individuals engaged in open innovation. It proposes a range of open innovation practices that organizations can implement to better equip their staff to undertake effective external engagement

PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of parkinsonism.

We analyzed the PINK1 gene in 58 patients with early-onset Parkinsonism and detected the homozygous mutation W437X in 1 patient. The clinical phenotype was characterized by early onset (22 years of age), good re- sponse to levodopa, early fluctuations and dyskinesias, and psychiatric symptoms. The mother, heterozygote for W437X mutation, was affected by Parkinson’s disease and 3 further relatives were reported affected, according to an autosomal dominant transmission

A novel mutation in SACS gene in a family from southern Italy

A form of autosomal recessive spastic ataxia (ARSACS) has been described in the Charlevoix and Saguenay regions of Quebec. So far a frameshift and a nonsense mutation have been identified in the SACS gene. The authors report a new mutation (1859insC), leading to a frameshift with a premature termination of the gene product sacsin, in two sisters from consanguineous parents. The phenotype is similar to previously described patients with ARSACS

2+12+1 Covariant Lattice Theory and t'Hooft's Formulation

We show that 't Hooft's representation of (2+1)-dimensional gravity in terms of flat polygonal tiles is closely related to a gauge-fixed version of the covariant Hamiltonian lattice theory. 't Hooft's gauge is remarkable in that it leads to a Hamiltonian which is a linear sum of vertex Hamiltonians, each of which is defined modulo $2 \pi$. A cyclic Hamiltonian implies that ``time'' is quantized. However, it turns out that this Hamiltonian is {\it constrained}. If one chooses an internal time and solves this constraint for the ``physical Hamiltonian'', the result is not a cyclic function. Even if one quantizes {\it a la Dirac}, the ``internal time'' observable does not acquire a discrete spectrum. We also show that in Euclidean 3-d lattice gravity, ``space'' can be either discrete or continuous depending on the choice of quantization. Finally, we propose a generalization of 't Hooft's gauge for Hamiltonian lattice formulations of topological gravity dimension 4.Comment: 10 pages of text. One figure available from J.A. Zapata upon reques