997 research outputs found
Higher dimensional Calabi-Yau manifolds of Kummer type
Based on Cynk-Hulek method we construct complex Calabi-Yau varieties of
arbitrary dimensions using elliptic curves with automorphism of order 6. Also
we give formulas for Hodge numbers of varieties obtained from that
construction. We shall generalize result of Katsura and Sch\"utt to obtain
arbitrarily dimensional Calabi-Yau manifolds which are Zariski in any
characteristic Comment: 13 pages, 2 figure
Intensity of Brillouin light scattering from spin waves in magnetic multilayers with noncollinear spin configurations: Theory and experiment
The scattering of photons from spin waves (Brillouin light scattering -- BLS)
is a well-established technique for the study of layered magnetic systems. The
information about the magnetic state and properties of the sample is contained
in the frequency position, width, and intensity of the BLS peaks. Previously
[Phys. Rev. B 67, 184404 (2003)], we have shown that spin wave frequencies can
be conveniently calculated within the ultrathin film approach, treating the
intralayer exchange as an effective bilinear interlayer coupling between thin
virtual sheets of the ferromagnetic layers. Here we give the consequent
extension of this approach to the calculation of the Brillouin light scattering
(BLS) peak intensities. Given the very close relation of the BLS cross-section
to the magneto-optic Kerr effect (MOKE), the depth-resolved longitudinal and
polar MOKE coefficients calculated numerically via the usual magneto-optic
formalism can be employed in combination with the spin wave precessional
amplitudes to calculate full BLS spectra for a given magnetic system. This
approach allows an easy calculation of BLS intensities even for noncollinear
spin configurations including the exchange modes. The formalism is applied to a
Fe/Cr/Fe/Ag/Fe trilayer system with one antiferromagnetically coupling spacer
(Cr). Good agreement with the experimental spectra is found for a wide variety
of spin configurations.Comment: 19 pages, 5 figure
The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer
Regulation by hypoxia may underlie the expression of vascular endothelial growth factor in bladder cancer. We have compared the distribution of vascular endothelial growth factor mRNA with a hypoxia marker, carbonic anhydrase 9 (CA IX). vascular endothelial growth factor mRNA was analysed by in situ hybridisation and CA IX by immunochemistry in 22 cases of bladder cancer. The relationship of microvessels to the distribution of CA IX was determined. In a separate series of 49 superficial tumours, CA IX immunostaining was compared with clinico-pathological outcome. In superficial and invasive disease there was overlap in the expression of vascular endothelial growth factor and CA IX, CA IX being more widespread. Both were expressed predominantly on the luminal surface, and surrounding areas of necrosis (invasive tumours). Expression of both factors was greater in superficial disease. Expression was absent within ∼80 μm of microvessels. Unlike vascular endothelial growth factor, CA IX did not predict outcome in superficial disease. Differential responses to reoxygenation provide one explanation: vascular endothelial growth factor mRNA declined rapidly, while CA IX expression was sustained for >72 h. Expression of vascular endothelial growth factor mRNA in bladder tumours is consistent with hypoxic regulation and suggests differential regulation in superficial vs invasive disease. The expression of CA IX on the luminal surface justifies investigation of its utility as a therapeutic target/prognostic indicator
Time-resolved X-ray spectral modeling of an intermediate burst from SGR1900+14 observed by HETE-2/FREGATE and WXM
We present a detailed analysis of a 3.5 s long burst from SGR 1900+14 that occurred on 2001 July 2. The 2-150 keV time-integrated energy spectrum is well described by the sum of two blackbodies whose temperatures are approximately 4.3 and 9.8 keV. The time-resolved energy spectra are similarly well fitted by the sum of two blackbodies. The higher temperature blackbody evolves with time in a manner consistent with a shrinking emitting surface. The interpretation of these results in the context of the magnetar model suggests that the two-blackbody fit is an approximation of an absorbed, multitemperature spectrum expected on theoretical grounds rather than a physical description of the emission. If this is indeed the case, our data provide further evidence for a strong magnetic field and indicate that the entire neutron star was radiating during most of the burst duration
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Small, Low-energy, Dispersive Solar Energetic Particle Events Observed by Parker Solar Probe
The Energetic Particle Instrument–Low Energy (EPI-Lo) experiment has detected several weak, low-energy (~30–300 keV nucleon⁻¹) solar energetic particle (SEP) events during its first two closest approaches to the Sun, providing a unique opportunity to explore the sources of low-energy particle acceleration. As part of the Parker Solar Probe (PSP) Integrated Science Investigation of the Sun (IS⊙IS) suite, EPI-Lo was designed to investigate the physics of energetic particles; however, in the special lowest-energy "time-of-flight only" product used in this study, it also responds to solar photons in a subset of approximately sunward-looking apertures lacking special light-attenuating foils. During the first three perihelia, in a frame rotating with the Sun, PSP undergoes retrograde motion, covering a 17° heliographic longitudinal range three times during the course of the ~11-day perihelion passes, permitting a unique spatial and temporal study into the location, correlation, and persistence of previously unmeasurable SEPs. We examine the signatures of these SEPs (during the first PSP perihelion pass only) and the connection to possible solar sources using remote observations from the Solar Dynamics Observatory (SDO), the Solar TErrestrial RElations Observatory (STEREO), and the ground-based Global Oscillation Network Group (GONG). The orientation of the Sun relative to STEREO, SDO, and GONG makes such identifications challenging, but we do have several candidates, including an equatorial coronal hole at a Carrington longitude of ~335°. To analyze observations from EPI-Lo, which is a new type of particle instrument, we examine instrumental effects and provide a preliminary separation of the ion signal from the photon background
HETE Observations of the Gamma-Ray Burst GRB030329: Evidence for an Underlying Soft X-ray Component
An exceptionally intense gamma-ray burst, GRB030329, was detected and
localized by the instruments on board the High Energy Transient Explorer
satellite (HETE) at 11:37:14 UT on 29 March 2003. The burst consisted of two
\~10s pulses of roughly equal brightness and an X-ray tail lasting >100s. The
energy fluence in the 30-400 keV energy band was 1.08e-4 erg/cm2, making
GRB030329 one of the brightest GRBs ever detected. Communication of a 2 arcmin
error box 73 minutes after the burst allowed the rapid detection of a
counterpart in the optical, X-ray, radio and the ensuing discovery of a
supernova with most unusual characteristics. Analyses of the burst lightcurves
reveal the presence of a distinct, bright, soft X-ray component underlying the
main GRB: the 2-10 keV fluence of this component is ~7e-6 erg/cm2. The main
pulses of GRB030329 were preceded by two soft, faint, non-thermal bumps. We
present details of the HETE observations of GRB030329.Comment: 22 pages, 5 figures, to be published in ApJ 617, no. 2 (10 December
2004). Referee comments have been incorporated; results of improved spectral
analysis are include
Scientific Highlights of the HETE-2 Mission
The HETE-2 mission has been highly productive. It has observed more than 250
GRBs so far. It is currently localizing 25 - 30 GRBs per year, and has
localized 43 GRBs to date. Twenty-one of these localizations have led to the
detection of X-ray, optical, or radio afterglows, and as of now, 11 of the
bursts with afterglows have known redshifts. HETE-2 has confirmed the
connection between GRBs and Type Ic supernovae, a singular achievement and
certainly one of the scientific highlights of the mission so far. It has
provided evidence that the isotropic-equivalent energies and luminosities of
GRBs are correlated with redshift, implying that GRBs and their progenitors
evolve strongly with redshift. Both of these results have profound implications
for the nature of GRB progenitors and for the use of GRBs as a probe of
cosmology and the early universe. HETE-2 has placed severe constraints on any
X-ray or optical afterglow of a short GRB. It is also solving the mystery of
"optically dark' GRBs, and revealing the nature of X-ray flashes.Comment: 10 pages, 9 figures, to appear in proc. "The Restless High-Energy
Universe", Royal Tropical Institute, Amsterdam; revised text, added ref
Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma
Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. This was an open-labelled, nonrandomised dose-escalation phase I study. In all, 12 patients with a history of recurrent superficial bladder cancer were grouped into four dose levels (10–150 mg ml−1 in 60 ml saline). Six catheter instillations at weekly intervals were used. Cystoscopy and biopsy were performed before and 3 months after the start of treatment. Suramin was assayed using high-performance liquid chromatography, vascular endothelial growth factor (VEGF) using ELISA (enzyme-linked immunosorbent assay), and urinary protein profile using surface-enhanced laser desorption ionisation mass spectroscopy (SELDI). Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml−1. Urinary VEGF was affected by Suramin at doses above 50 mg ml−1, corresponding to the estimated threshold of saturation of Suramin binding to urine albumin. SELDI showed a specific disappearance of urinary protein peaks during treatment. Intravesical Suramin shows lack of toxicity and low systemic absorption. The results of this phase I trial support expanded clinical trials of efficacy at a dose of 100 mg ml−1 intravesically
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