99 research outputs found
Studies relating to the synthesis, enzymatic reduction and cytotoxicity of a series of nitroaromatic prodrugs
Specific and enantioselective sulfoxidation of an aryl-trifluoromethylsulfide by rat liver cytochromes P-450
International audienc
Semisynthesis of (+)- and (?)-goniomitine from (?)- and (+)-vincadifformine
International audienc
Bis-macrocyclic diketal diamines, analogue of the anti-viral and anti-tumoral bicyclam AMD 3100
Poste
First-in-class combination therapy of a copper(II) metallo-phosphorus dendrimer with cytotoxic agents
International audienceThe metallo-phosphorus dendrimer 1G3-Cu (generation 3 dendrimer bearing 48 conjugated copper(II) on its surface) has antiproliferative activity related to its capacity to activate Bax translocation. In the present study, we evaluate the activity of an association of 1G3-Cu with 5 cytotoxic agents used in chemotherapy having different modes of action. Data show no additive effect with camptothecin and cisplatin, additivity with paclitaxel and MG132, and synergy with doxorubicin. Results suggest that the multivalent Cu-conjugated dendrimer 1G3-Cu (activator of Bax translocation) plays an important role in boosting the clinical impact of Bax accumulation stimulated by the proteasome inhibitor MG132, antimitotic taxanes, and the topo II inhibitor doxorubicin
Synthesis and anti-proliferative activity of novel quinolin-8-ol derivatives
International audienc
Send reprint r.qu.sts to: EFFECTS OF GENETIC OR CHEMICALLY INDUCED DIABETES ON IMIPRAMINE METABOLISM Respective Involvement of Flavin Monooxygenase and Cytochrome P450-dependent Monooxygenases
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