Participatory design of a thematic questionnaire in the field of victimization studies

The paper introduces the results of a two-step process that led to the design of a new questionnaire in the field of victimization studies. A desk-based review of national Crime and Victimization Surveys from five EU countries was performed and resulted in identifying opportunities to improve the consistency among these surveys as well as the need to include more independent variables in order to measure fear of crime and its correlation with sociological variables. Then 12 experts in survey-based measures of crime-related issues were involved in a Delphi panel with the objective of enhancing a participatory design of a new questionnaire addressing individual and space-based determinants of the perception of insecurity, which has been poorly explored to date

On the construction of model Hamiltonians for adiabatic quantum computation and its application to finding low energy conformations of lattice protein models

In this report, we explore the use of a quantum optimization algorithm for obtaining low energy conformations of protein models. We discuss mappings between protein models and optimization variables, which are in turn mapped to a system of coupled quantum bits. General strategies are given for constructing Hamiltonians to be used to solve optimization problems of physical/chemical/biological interest via quantum computation by adiabatic evolution. As an example, we implement the Hamiltonian corresponding to the Hydrophobic-Polar (HP) model for protein folding. Furthermore, we present an approach to reduce the resulting Hamiltonian to two-body terms gearing towards an experimental realization.Comment: 35 pages, 8 figure

vandetanib improves anti tumor effects of l19mtnfα in xenograft models of esophageal cancer

Purpose: Targeting the tumor vasculature by vascular disrupting agents (VDAs) has shown therapeutic activity in mouse models. In most cases, however, VDA efficacy is substantially compromised by the inability of these drugs to completely kill tumor cells located at the periphery of the tumor mass. In this study, we investigated anti-tumor effects of L19mTNFα, a fusion protein composed of L19 (scFv), specific for the angiogenesis-associated ED-B containing fibronectin isoform, and murine TNFα, in xenograft models of esophageal cancer. Experimental design: We evaluated ED-B expression in esophageal cancer samples. Subsequently, we generated subcutaneous xenografts from primary tumors, treated them with the L19mTNFα scFv, and determined effects on tumor vasculature, viability and proliferation, and VEGF expression and infiltration by hematopoietic cells. To overcome tumor resistance, L19mTNFα scFv was combined with vandetanib, a tyrosine kinase inhibitor of VEGF receptor, epidermal growth factor receptor, and RET signaling. Results: ED-B was broadly expressed by esophageal cancer cell lines, as well as xenografts and primary surgical samples of esophageal cancer. Administration of L19mTNFα acutely damaged tumor vasculature and increased necrosis, indicating a VDA-like activity of this immunoconjugate. This event was followed, however, by rapid tumor growth recovery associated with increased expression of VEGF and recruitment of CD11b+Gr1+ myeloid cells into tumors. Combination of L19mTNFα with vandetanib severely impaired vascular functions in tumors, leading to a reduction of cell proliferation and increased necrosis, without apparent signs of toxicity. Conclusion: These findings indicate that a combination of vascular damaging agents with anti-angiogenic drugs could represent a promising therapeutic strategy for esophageal cancer. Clin Cancer Res; 17(3); 447–58. ©2010 AACR

Nonlinear multimode fiber optics: recent advances

We start by providing an overview of the emerging field of nonlinear optics in multimode optical fibers [1]. These fibers provide a simple testbed for observing complex wave propagation dynamics, in analogy with other fields of physics ranging from two-dimensional hydrodynamic turbulence and Bose-Einstein condensation. In addition, nonlinear multimode optical fibers enable new methods for achieving the ultrafast, light-activated control of temporal, spatial and spectral degrees of freedom of intense, pulsed light beams, for a range of different technological applications

The 2017 Regional Election in Catalonia: An attempt to understand the pro-independence vote

This paper tries to unveil the main factors behind the triumph of the proindependence vote in the 2017 Regional Election in Catalonia. The empirical analysis, which is carried out at the county level and by using a spatial econometric model, reveals that geographical location matters. The estimation results also suggest that the pro-independence vote is mainly linked to the birthplace of individuals. More specifically, it shows that the independence feeling is weaker the higher the share of citizens born outside Catalonia. On the other side, young and highly educated people are more prone to independence. Additionally, it is shown that people working in the public sector are more likely to vote for a political party in favor of Catalonia remaining in Spain, while the opposite happens for those voters working in construction. Finally, the results seem to dispel some myths associated with the role played by the county’s size and level of income on the proindependence vote

From an experimental paper to a playful screen : How the essence of materiality modulates the process of creation

The article seeks to develop a better understanding of the contribution of materiality in a discourse between a creator (content producer) and an interface, dealing with analogue and digital artefacts. Focus is in the materiality of the two different art-creation learning processes, acrylic painting and digital painting. The objective of this paper is to consider especially the affect and meaning of these two different content creation modalities and intra-action within that. Through reflective autoethnographic consideration, the purpose is to consider the essences of materials manifesting and modulating the processes of content creation as a posthumanist phenomenon. It will be shown that the creation processes with paper are more experimental whereas the processes with digital screen are more playful. There is a growing need to deeper understand the cultural change of material cultures and the people's intra-action with the materials also enabling arts creation. This paper will widen our limited understanding and deepen our theoretical perspectives of the essence of materials which then avails confronting analogue and digital when developing teaching and learning in the posthuman era especially in early education. Practitioner Notes What is already known about this topic There is a growing interest in the new materialism and posthuman thinking amongst educational technology research and development. Reading analogue versus digital is well-documented. What this paper adds New materialist thinking offers a useful perspective in education for looking at the essence of analogue and digital materiality modulating content creation. Characterising the nuances in analogue and digital production can help in evaluating their educational potential. Implications for practice and/or policy As practitioners we should critically question the political vision of education digitalisation especially concerning early childhood education. There is a need to move beyond debates about analogue versus digital to look at more specific examples of their advantages (and disadvantages) in developing posthumanist education and intra-active pedagogy especially for young children.Peer reviewe

On Second-Order Monadic Monoidal and Groupoidal Quantifiers

We study logics defined in terms of second-order monadic monoidal and groupoidal quantifiers. These are generalized quantifiers defined by monoid and groupoid word-problems, equivalently, by regular and context-free languages. We give a computational classification of the expressive power of these logics over strings with varying built-in predicates. In particular, we show that ATIME(n) can be logically characterized in terms of second-order monadic monoidal quantifiers