Lighting as a Circadian Rhythm-Entraining and Alertness-Enhancing Stimulus in the Submarine Environment

The human brain can only accommodate a circadian rhythm that closely follows 24 hours. Thus, for a work schedule to meet the brain’s hard-wired requirement, it must employ a 24 hour-based program. However, the 6 hours on, 12 hours off (6/12) submarine watchstanding schedule creates an 18-hour “day” that Submariners must follow. Clearly, the 6/12 schedule categorically fails to meet the brain’s operational design, and no schedule other than one tuned to the brain’s 24 hour rhythm can optimize performance. Providing Submariners with a 24 hour-based watchstanding schedule—combined with effective circadian entrainment techniques using carefully-timed exposure to light—would allow crewmembers to work at the peak of their daily performance cycle and acquire more restorative sleep. In the submarine environment, where access to natural light is absent, electric lighting can play an important role in actively entraining—and closely maintaining—circadian regulation. Another area that is likely to have particular importance in the submarine environment is the potential effect of light to help restore or maintain alertness

MicroRNA miR-155 Is Necessary for Efficient Gammaherpesvirus Reactivation from Latency, but Not for Establishment of Latency

MicroRNA-155 (miR-155) has been shown to play significant roles in the immune response, including in the formation of germinal centers (GC) and the development and maturation of T follicular helper (Tfh) cells. There is in vitro evidence to support a critical role for cellular miR-155 and viral miR-155 homologs in the establishment of gammaherpesvirus latency in B cells. We sought to determine the contribution of miR-155 to the establishment and maintenance of latency in vivousing murine gammaherpesvirus (MHV-68) infection. MHV-68-infected mice deficient in miR-155 exhibited decreases in GC B cells and Tfh cells. However, the frequencies of spleen cells harboring latent MHV-68 genomes were the same in both miR-155-deficient and wild-type (WT) mice. Similar latent loads were also observed in mixed bone marrow chimeric mice, where B cell-extrinsic effects of miR-155 deficiency were normalized. Interestingly, we observed markedly lower efficiency of reactivation from latency in miR-155-deficient cells, indicating an important role for miR-155 in this process. These in vivo data complement previous in vitro studies and lead to the conclusion that miR-155 is not necessary for the establishment or maintenance of gammaherpesvirus latency but that it does affect reactivation efficiency

Effect of intensive melt shearing on the formation of Fe-containing intermetallics in LM24 Al-alloy

Fe is one of the inevitable and detrimental impurities in aluminium alloys that degrade the mechanical performance of castings. In the present work, intensive melt shearing has been demonstrated to modify the morphology of Fe-containing intermetallic compounds by promoting the formation of compact α-Al(Fe,Mn)Si at the expense of needle-shaped β-AlFeSi, leading to an improved mechanical properties of LM24 alloy processed by MC-HPDC process. The promotion of the formation of α -Al(Fe, Mn)Si phase is resulted from the enhanced nucleation on the well dispersed MgAl 2O 4 particles in the melt. The Fe tolerance of LM24 alloy can be effectively improved by combining Mn alloying and intensive melt shearing

Viability of Pushrod Dilatometry Techniques for High Temperature In-Pile Measurements

To evaluate the performance of new fuel, cladding, and structural materials for use in advanced and existing nuclear reactors, robust instrumentation is needed. Changes in material deformation are typically evaluated out-of-pile, where properties of materials are measured after samples were irradiated for a specified length of time. To address this problem, a series of tests were performed to examine the viability of using pushrod dilatometer techniques for in-pile instrumentation to measure deformation. The tests were performed in three phases. First, familiarity was gained in the use and accuracy of this system by testing samples with well defined thermal elongation characteristics. Second, high temperature data for steels, specifically SA533 Grade B, Class 1 (SA533B1) Low Alloy Steel and Stainless Steel 304 (SS304), found in Light Water Reactor (LWR) vessels, were aquired. Finally, data were obtained from a short pushrod in a horizontal geometry to data obtained from a longer pushrod in a vertical geometry, the configuration likely to be used for in-situ measurements. Results of testing show that previously accepted data for the structural steels tested, SA533B1 and SS304, are inaccurate at high temperatures (above 500 oC) due to extrpolation of high temperature data. This is especially true for SA533B1, as previous data do not account for the phase transformation of the material between 730 oC and 830 oC. Also, comparison of results for horizontal and vertical configurations show a maximum percent difference of 2.02% for high temperature data

HTIR-TC Compensating Extension Wire Evaluations

In an effort to reduce production costs for the doped molybdenum/niobium alloy High Temperature Irradiation Resistant Thermocouples (HTIR-TCs) recently developed by the Idaho National Laboratory, a series of evaluations were completed to identify an optimum compensating extension cable. As documented in this report, results indicate that of those combinations tested, two inexpensive, commercially-available copper nickel alloy wires approximate the low temperature (0 to 500 °C) thermoelectric output of KW-Mo (molybdenum doped with tungsten and potassium silicate) versus Nb-1%Zr in HTIR-TCs. For lower temperatures (0 to 150 °C), which is the region where soft extension cable is most often located, results indicate that the thermocouple emf is best replicated by the Cu-3.5%Ni versus Cu-5%Ni combination (measured emfs were within 4% at 100 and 150 °C). At higher temperatures (300 to 500 °C), data suggest that the Cu-5%Ni versus Cu-10%Ni combination may yield data closer to that obtained with KWMo versus Nb-1%Zr wires (measured emfs were within 8%)

Effects of ethical leadership on emotional exhaustion in high moral intensity situations

© 2015 Elsevier Inc. Emotional exhaustion is a threat to standard operations, particularly in organizations in which physical safety is at risk. High moral intensity is inherent in such organizations due to the magnitude of consequences associated with ethical/unethical conduct. The authors proposed a psychological process in which ethical leadership affects emotional exhaustion directly and indirectly through team cohesion. As military operational contexts typically are (or frequently have the potential to become) high moral intensity situations, the authors tested their model among 338 military personnel deployed in combat zones. They found that: (1) team cohesion partially mediated the relationship between ethical leadership and emotional exhaustion, and (2) this psychological process of direct and indirect effects of ethical leadership did not hold among individuals approaching the low end of conscientiousness

Enhancements to High Temperature In-Pile Thermocouple Performance

A joint University of Idaho (UI) and Idaho National Laboratory (INL) University Nuclear Research Initiative (UNERI) was to initiated to extend initial INL efforts to develop doped molybdenum/niobium alloy High Temperature Irradiation Resistant Thermocouples (HTIR-TCs). The overall objective of this UNERI was to develop recommendations for an optimized thermocouple design for high temperature, long duration, in-pile testing by expanding upon results from initial INL efforts. Tasks to quantify the impact of candidate enhancements, such as alternate alloys, alternate geometries, and alternate thermocouple fabrication techniques, on thermocouple performance were completed at INL's High Temperature Test Laboratory (HTTL), a state of the art facility equipped with specialized equipment and trained staff in the area of high temperature instrumentation development and evaluation. Key results of these evaluations, which are documented in this report, are as follows. The doped molybdenum and Nb-1%Zr, which were proposed in the initial INL HTIR-TC design, were found to retain ductility better than the developmental molybdenum-low niobium alloys and the niobium-low molybdenum alloys evaluated. Hence, the performance and lower cost of the commercially available KW-Mo makes a thermocouple containing KW-Mo and Nb-1%Zr the best option at this time. HTIR-TCs containing larger diameter wires offer the potential to increase HTIR-TC stability and reliability at higher temperatures. HTIR-TC heat treatment temperatures and times should be limited to not more than 100 C above the proposed operating temperatures and to durations of at least 4 to 5 hours. Preliminary investigations suggest that the performance of swaged and loose assembly HTIR-TC designs is similar. However, the swaged designs are less expensive and easier to construct. In addition to optimizing HTIR-TC performance, This UNERI project provided unique opportunities to several University of Idaho students, allowing them to become familiar with the techniques and equipment used for specialized high temperature instrumentation fabrication and evaluation and to author/coauthor several key conference papers and journal articles

Options to Extend the Applicability of High Temperature Irradiation Resistant Thermocouples

Several options have been identified that could further enhance the reliability and increase the applicability of recently developed Idaho National Laboratory (INL) High Temperature Irradiation Resistant thermocouples (HTIR-TCs) for in-pile testing, allowing their use in higher temperature applications (up to at least 1700 °C). INL and the University of Idaho (UI) are investigating these options with the ultimate objective of providing recommendations for alternate thermocouple designs that are optimized for various applications. This paper reports the status of INL/UI investigations. Results are reported from tests completed to evaluate the ductility, resolution, transient response, and stability of thermocouples made from specially formulated alloys of molybdenum and niobium. In addition, this paper reports preliminary insights gained by comparing the performance of thermocouples fabricated with various heat treatments and alternate geometries

Physical activity to improve cognition in older adults: can physical activity programs enriched with cognitive challenges enhance the effects? A systematic review and meta-analysis

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