Role of endothelial permeability hotspots and endothelial mitosis in determining age-related patterns of macromolecule uptake by the rabbit aortic wall near branch points

AbstractBackground and aimsTransport of macromolecules between plasma and the arterial wall plays a key role in atherogenesis. Scattered hotspots of elevated endothelial permeability to macromolecules occur in the aorta; a fraction of them are associated with dividing cells. Hotspots occur particularly frequently downstream of branch points, where lesions develop in young rabbits and children. However, the pattern of lesions varies with age, and can be explained by similar variation in the pattern of macromolecule uptake. We investigated whether patterns of hotspots and mitosis also change with age.MethodsEvans’ Blue dye-labeled albumin was injected intravenously into immature or mature rabbits and its subsequent distribution in the aortic wall around intercostal branch ostia examined by confocal microscopy and automated image analysis. Mitosis was detected by immunofluorescence after adding 5-bromo-2-deoxiuridine to drinking water.ResultsHotspots were most frequent downstream of branches in immature rabbits, but a novel distribution was observed in mature rabbits. Neither pattern was explained by mitosis. Hotspot uptake correlated spatially with the much greater non-hotspot uptake (p < 0.05), and the same pattern was seen when only the largest hotspots were considered.ConclusionsThe pattern of hotspots changes with age. The data are consistent with there being a continuum of local permeabilities rather than two distinct mechanisms. The distribution of the dye, which binds to elastin and collagen, was similar to that of non-binding tracers and to lesions apart from a paucity at the lateral margins of branches that can be explained by lower levels of fibrous proteins in those regions

An in Situ Technique for Elemental Analysis of Lunar Surfaces

An in situ analytical technique that can remotely determine the elemental constituents of solids has been demonstrated. Laser-Induced Breakdown Spectroscopy (LIBS) is a form of atomic emission spectroscopy in which a powerful laser pulse is focused on a solid to generate a laser spark, or microplasma. Material in the plasma is vaporized, and the resulting atoms are excited to emit light. The light is spectrally resolved to identify the emitting species. LIBS is a simple technique that can be automated for inclusion aboard a remotely operated vehicle. Since only optical access to a sample is required, areas inaccessible to a rover can be analyzed remotely. A single laser spark both vaporizes and excites the sample so that near real-time analysis (a few minutes) is possible. This technique provides simultaneous multielement detection and has good sensitivity for many elements. LIBS also eliminates the need for sample retrieval and preparation preventing possible sample contamination. These qualities make the LIBS technique uniquely suited for use in the lunar environment

CEO Centrality

We investigate the relationship between CEO centrality -- the relative importance of the CEO within the top executive team in terms of ability, contribution, or power -- and the value and behavior of public firms. Our proxy for CEO centrality is the fraction of the top-five compensation captured by the CEO. We find that CEO centrality is negatively associated with firm value (as measured by industry-adjusted Tobin's Q). Greater CEO centrality is also correlated with (i) lower (industry-adjusted) accounting profitability, (ii) lower stock returns accompanying acquisitions announced by the firm and higher likelihood of a negative stock return accompanying such announcements, (iii) higher odds of the CEO’s receiving a “lucky” option grant at the lowest price of the month, (iv) greater tendency to reward the CEO for luck in the form of positive industry-wide shocks, (v) lower likelihood of CEO turnover controlling for performance, and (vi) lower firm-specific variability of stock returns over time. Overall, our results indicate that differences in CEO centrality are an aspect of firm management and governance that deserves the attention of researchers.

Exploring Human Vision Driven Features for Pedestrian Detection

Motivated by the center-surround mechanism in the human visual attention system, we propose to use average contrast maps for the challenge of pedestrian detection in street scenes due to the observation that pedestrians indeed exhibit discriminative contrast texture. Our main contributions are first to design a local, statistical multi-channel descriptorin order to incorporate both color and gradient information. Second, we introduce a multi-direction and multi-scale contrast scheme based on grid-cells in order to integrate expressive local variations. Contributing to the issue of selecting most discriminative features for assessing and classification, we perform extensive comparisons w.r.t. statistical descriptors, contrast measurements, and scale structures. This way, we obtain reasonable results under various configurations. Empirical findings from applying our optimized detector on the INRIA and Caltech pedestrian datasets show that our features yield state-of-the-art performance in pedestrian detection.Comment: Accepted for publication in IEEE Transactions on Circuits and Systems for Video Technology (TCSVT

Non-Rigid Puzzles

Shape correspondence is a fundamental problem in computer graphics and vision, with applications in various problems including animation, texture mapping, robotic vision, medical imaging, archaeology and many more. In settings where the shapes are allowed to undergo non-rigid deformations and only partial views are available, the problem becomes very challenging. To this end, we present a non-rigid multi-part shape matching algorithm. We assume to be given a reference shape and its multiple parts undergoing a non-rigid deformation. Each of these query parts can be additionally contaminated by clutter, may overlap with other parts, and there might be missing parts or redundant ones. Our method simultaneously solves for the segmentation of the reference model, and for a dense correspondence to (subsets of) the parts. Experimental results on synthetic as well as real scans demonstrate the effectiveness of our method in dealing with this challenging matching scenario

SHREC'16: partial matching of deformable shapes

Matching deformable 3D shapes under partiality transformations is a challenging problem that has received limited focus in the computer vision and graphics communities. With this benchmark, we explore and thoroughly investigate the robustness of existing matching methods in this challenging task. Participants are asked to provide a point-to-point correspondence (either sparse or dense) between deformable shapes undergoing different kinds of partiality transformations, resulting in a total of 400 matching problems to be solved for each method - making this benchmark the biggest and most challenging of its kind. Five matching algorithms were evaluated in the contest; this paper presents the details of the dataset, the adopted evaluation measures, and shows thorough comparisons among all competing methods

A reduced semantics for deciding trace equivalence using constraint systems

Many privacy-type properties of security protocols can be modelled using trace equivalence properties in suitable process algebras. It has been shown that such properties can be decided for interesting classes of finite processes (i.e., without replication) by means of symbolic execution and constraint solving. However, this does not suffice to obtain practical tools. Current prototypes suffer from a classical combinatorial explosion problem caused by the exploration of many interleavings in the behaviour of processes. M\"odersheim et al. have tackled this problem for reachability properties using partial order reduction techniques. We revisit their work, generalize it and adapt it for equivalence checking. We obtain an optimization in the form of a reduced symbolic semantics that eliminates redundant interleavings on the fly.Comment: Accepted for publication at POST'1