341 research outputs found

    The Limits of Intention in the Common Law

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    In criminal law, intention functions as the concept whereby human actions, and the reasons for them, are understood in relation to a criminal system. If there is no law, then there can be no punishment; but what if there is law, what then? How are the actions of the accused supposed to be understood in relation to the criminal law? One is very much aware that the criminal law, as it is presently conducted, generally pits the smallness of an individual against the corporate greatness and might of the state. What ought to serve to balance these competing interests? In any philosophical exploration one attempts to return to the source of the issue under scrutiny. In this exploration of intention the sources have been wide and varied and, at times, rare and difficult to obtain. There seem to be no clear and precise links from one moment of legal history to another. One is required to make educated guesses, thoughtful assumptions, and proffer what seem to be reasonable links from one epoch into the next. One reading of the sources suggests that intention is a volitive concept. Its beginnings as malice aforethought suggest that the accused had been moved to break the law (a law which was believed to have a moral foundation) because of his own disruption of character and moral disquietude. One did the deed, not thought the deed. However, the violation of a law which had a moral foundation leads one to ask further questions about both law and morals. Law and morals have distinct spheres. Is it possible that there is a common link between the ability to break a social law, and the ability to break a moral law? From history one will remember how both Bracton and Fleta admitted how both spheres could surround a human act. At times the spheres overlap, and at other times they are separate. Common, however, to each sphere is the ability and capacity of mankind to move within those spheres. This leads into the old and common effort to inquire into the nature of mankind. Without doubt, it is true that mankind possesses a nature. Whether that nature can be deciphered, decoded, and put into well defined, nonambiguous sets of linguistic propositions has been and is the rub. Historic modes of thought about human nature identified two broad differences: intellect and will. For centuries these broad conceptual differences seemed to take on concrete forms of their own. One\u27s will and intellect seemed to be reified in moral and theological writings, as if each were possessed of its own distinct identity, acting for its own distinct ends. Added to this reification of will and intellect, one further distinction was set forth that something about man\u27s nature put him into both a world of matter (mass and extension) and of spirit (energy and infinitude). Could any more contradictory sets of postulates have been integrated into a growing legal system

    Lentiviral shRNA knock-down of ADAMTS-5 and-9 restores matrix deposition in 3D chondrocyte culture

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    Aggrecan is one of the two major constituents of articular cartilage, and during diseases such as osteoarthritis (OA) it is subject to degradation by proteolytic enzymes. The primary proteases responsible for aggrecan cleavage are the aggrecanases, identified as members of the ADAMTS family of proteases, which are upregulated in response to inflammatory stimuli. It is uncertain which of the six aggrecanases (ADAMTS‐1, ‐4, ‐5, ‐8, ‐9 and ‐15) are primarily responsible for the degradation of aggrecan in human cartilage. Here we show that four of the six aggrecanases are expressed in immortalized chondrocyte cell‐lines and can be upregulated in response to inflammatory cytokines. Using RNA interference, we demonstrate robust knock‐down of ADAMTS‐5 and ‐9 expression in these cells and, by culturing them on three‐dimensional (3D) scaffolds, show that reduction in expression of ADAMTS‐5 enzyme results in an increase in matrix deposition. These data suggest that the quality of tissue‐engineered cartilage matrix might be improved by targeted depletion of aggrecanase expression. Moreover, this work also provides further evidence that ADAMTS‐5 may be a therapeutic target in the treatment of arthritic disease

    Influences on academics' approaches to development: voices from below

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    The purpose of this qualitative case study research was to explore faculty-based academics’ views on what influences their behaviours and attitudes towards their development. Informed by critical realist ontology, the data collection was carried out through narrative interviews with academics in two contrasting English Universities. Findings, or areas for reflection, have emerged about the constraints and enablements academics perceive in respect of their professional development. In particular, themes such as the significance of professional status; misaligned initiatives and priorities; the influence of supportive networks; and emergent personal, individual concerns have surfaced. The conclusion is drawn that the significance of agency raises the importance of responding to the ‘voices from below’

    Isotope Effect for the Penetration Depth in Superconductors

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    We show that various factors can lead to an isotopic dependence of the penetration depth δ\delta. Non-adiabaticity (Jahn-Teller crossing) leads to the isotope effect of the charge carrier concentration nn and, consequently, of δ\delta in doped superconductors such as the cuprates. A general equation relating the isotope coefficients of TcT_c and of δ\delta is presented for London superconductors. We further show that the presence of magnetic impurities or a proximity contact also lead to an isotopic dependence of δ\delta; the isotope coefficient turns out to be temperature dependent, β(T)\beta(T), in these cases. The existence of the isotope effect for the penetration depth is predicted for conventional as well as for high-temperature superconductors. Various experiments are proposed and/or discussed.Comment: 11 pages, 8 figures, accepted for publication in Phys. Rev.

    Melting as a String-Mediated Phase Transition

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    We present a theory of the melting of elemental solids as a dislocation-mediated phase transition. We model dislocations near melt as non-interacting closed strings on a lattice. In this framework we derive simple expressions for the melting temperature and latent heat of fusion that depend on the dislocation density at melt. We use experimental data for more than half the elements in the Periodic Table to determine the dislocation density from both relations. Melting temperatures yield a dislocation density of (0.61\pm 0.20) b^{-2}, in good agreement with the density obtained from latent heats, (0.66\pm 0.11) b^{-2}, where b is the length of the smallest perfect-dislocation Burgers vector. Melting corresponds to the situation where, on average, half of the atoms are within a dislocation core.Comment: 18 pages, LaTeX, 3 eps figures, to appear in Phys. Rev.

    Leptonic and Semileptonic Decays of Charm and Bottom Hadrons

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    We review the experimental measurements and theoretical descriptions of leptonic and semileptonic decays of particles containing a single heavy quark, either charm or bottom. Measurements of bottom semileptonic decays are used to determine the magnitudes of two fundamental parameters of the standard model, the Cabibbo-Kobayashi-Maskawa matrix elements VcbV_{cb} and VubV_{ub}. These parameters are connected with the physics of quark flavor and mass, and they have important implications for the breakdown of CP symmetry. To extract precise values of Vcb|V_{cb}| and Vub|V_{ub}| from measurements, however, requires a good understanding of the decay dynamics. Measurements of both charm and bottom decay distributions provide information on the interactions governing these processes. The underlying weak transition in each case is relatively simple, but the strong interactions that bind the quarks into hadrons introduce complications. We also discuss new theoretical approaches, especially heavy-quark effective theory and lattice QCD, which are providing insights and predictions now being tested by experiment. An international effort at many laboratories will rapidly advance knowledge of this physics during the next decade.Comment: This review article will be published in Reviews of Modern Physics in the fall, 1995. This file contains only the abstract and the table of contents. The full 168-page document including 47 figures is available at http://charm.physics.ucsb.edu/papers/slrevtex.p

    Volunteerism, social context and health impacts: a qualitative study of Glasgow Commonwealth Games event volunteers

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    Volunteer engagement is crucial to the effective delivery of mega-sporting events. While evidence points to reported motivations and wellbeing benefits for individual participants during and post event, there is less evidence on how this type of civic participation relates to the social context in which it occurs and the wider social determinants of health. This qualitative study sought to understand impacts on wellbeing and the determinants of health resulting from the experience of volunteering at the Glasgow 2014 Commonwealth Games. Focus groups and interviews were conducted one-year post-Games to gather the perspectives of 46 volunteers and 7 unsuccessful applicants on their experiences. Participants provided insight into the volunteer journey, contributions and associated outcomes. Wider social impacts were also reported including a renewed sense of pride in the city. The qualitative analysis suggested an important non-linear relationship between volunteer contributions, impacts and rewards, and the outcome of enhanced social connections. The emergent ‘people and place’ framework identifies some critical factors around city life and volunteer assets that planners could consider in developing and evaluating sustainable volunteering and its wider impacts beyond a mega-event

    Demonstration of the temporal matter-wave Talbot effect for trapped matter waves

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    We demonstrate the temporal Talbot effect for trapped matter waves using ultracold atoms in an optical lattice. We investigate the phase evolution of an array of essentially non-interacting matter waves and observe matter-wave collapse and revival in the form of a Talbot interference pattern. By using long expansion times, we image momentum space with sub-recoil resolution, allowing us to observe fractional Talbot fringes up to 10th order.Comment: 17 pages, 7 figure
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