The care of the dependent classes in Columbia, Missouri

It would seem at first thought that Columbia would have no serious charity problem, that it is so advantageously situated that poverty and dependency would be reduced to a minimum. The city has a population of 13,122, most of whom are native born. There are no large factories to employ any great number of laborers, hence the foreign population is very small. Columbia's boast is that it is a city whose cief business is education; it is the seat of the state university and has besides the great state school two junior colleges for girls. The city is situation in one of the best agricultural districts of the state. However, notwithstanding all of these advantages there is found here, in minature, many of the conditions that obtain in the poorer districts of the larger cities, bad housing bad sanitation, and unemployment. The purpose of the study here undertaken were four fold: 1. To discovr as accurately as possible the size and nature of the charity problem of the city. 2. To find out what was being done for the different dependent groups. 3. To investigate the work of the different agencies offering relief so as to ascertain how well they were meeting the situation. 2. To make some suggestions that might improve the efficiency of the different agencies studied

The changing role of the missionary to the Philippines

https://place.asburyseminary.edu/ecommonsatsdissertations/2328/thumbnail.jp

Anaphylaxis and sensitisation: with special reference to the skin and its diseases

The object of this Thesis is to describe and dîscuss the phenomena of anaphylaxis and sensitisation in so far as they affect the skin. Before taking up each section separately, it will be well to give a short general description of our present knowledge of these phenomena and an explanation of the numerous terms which will he used throughout this work.Anaphylaxis was the term introduced by RICHET to describe the series of phenomena which occur on reinjection into animals, after an interval of several days, of certain substances which were harmless on first injection. As the animal had been rendered more susceptible to the substance injected, RICHET thought the condition was the opposite of Prophylaxis or Immunity, and gave it the name Anaphylaxis,

Economic case statement: Chronic Obstructive Pulmonary Disease (COPD)

© Australian Lung FoundationAlan J. Crockett, Josephine M. Cranston and John R. Mos

Models of chronic disease management in primary care for patients with mild to moderate asthma or COPD

The research reported in this paper is a project of the Australian Primary Health Care Research Institute, which is supported by a grant from the Australian Government Department of Health and Ageing under the Primary Health Care Research, Evaluation and Development Strategy

High performance structural laminate composite material for use to 1000.degree. F. and above, apparatus for and method of manufacturing same, and articles made with same

A novel materials technology has been developed and demonstrated for providing a high modulus composite material for use to 1000.degree. F. and above. This material can be produced at 5-20% of the cost of refractory materials, and has higher structural properties. This technology successfully resolves the problem of thermal shock or ply lift, which limits traditional high temperature laminates (such as graphite/polyimide and graphite/phenolic) to temperatures of 550-650.degree. F. in thicker (0.25 and above) laminates. The technology disclosed herein is an enabling technology for the nose for the External Tank (ET) of the Space Shuttle, and has been shown to be capable of withstanding the severe environments encountered by the nose cone through wind tunnel testing, high temperature subcomponent testing, and full scale structural, dynamic, acoustic, and damage tolerance testing

Structural Variations in Hybrid All-Nanoparticle Gibbsite Nanoplatelet/Cellulose Nanocrystal Multilayered Films

Cellulose nanocrystals (CNCs) are promising bio-sourced building blocks for the production of high performance materials. In the last ten years, CNCs have been used in conjunction with polymers for the design of multilayered thin films via the layer-by-layer assembly technique. Herein, polymer chains have been replaced with positively charged inorganic gibbsite nanoplatelets (GN) to form hybrid “nanoparticle-only” composite films. A combination of atomic force microscopy and neutron reflectivity experiments was exploited to investigate the growth and structure of the films. Data show that the growth and density of GN/CNC films can be tuned over a wide range during preparation by varying the ionic strength in the CNC suspension and the film drying protocol. Specifically, thin and dense multilayered films or very thick, more porous mixed slabs, as well as intermediate internal structures could be obtained in a predictable manner. The influence of key physicochemical parameters on the multilayer film build up was elucidated and the film architecture was linked to the dominating interaction forces between components. The degree of structural control over these hybrid nanoparticle-only films is much higher than that reported for CNC/polymer films, which offers new properties and potential applications as separation membranes or flame retardant coatings

Impact-based forecasting for convective rainfall: a new approach combining rainfall ensembles and hazard impacts

•PREDICTOR (PREDICTing flooding impacts from cOnvective Rainfall) has been developed to improve the approach to forecasting the impacts of surface water flooding. PREDICTOR is a next generation decision-support tool that utilises the latest Met Office convective precipitation ensemble forecasting capabilities and Scotland’s National Flood Risk Assessment (NFRA) flood maps. •The Impact-based Forecasting (IbF) approach of PREDICTOR combines the likelihood ("the chance") of flood-producing rainfall (from the Met Office ensemble forecasts) and the potential impact (from NFRA) to produce "Flood Risk" forecasts. The precipitation forecast product used is the Best Short Range (BSR) ensemble from the Met Office (MOGREPS-UK). 15-minute precipitation accumulations are available, extending out to ~32 hours and issued 4 times a day with 24 ensemble members. The NFRA surface water flooding maps have been generated using design rainfall inputs from the Flood Estimation Handbook (FEH) plus outputs from a number of different flood modelling studies, and used to consider property and road impacts. •Neighbourhood or ‘in-vicinity’ post processing of precipitation forecasts is performed to calculate exceedance probability (or ensemble confidence) of the forecast rainfall that would lead to surface water flooding impacts. This is calculated on a 10km grid basis across Scotland to provide individual gridded risk assessments of the likelihood and impact of flooding. The web-based system has been successfully used by SEPA forecasters during 2023 and in partnership with Transport Scotland to assess the value of predicting the risk on the trunk road network

The PARP inhibitor AZD2461 provides insights into the role of PARP3 inhibition for both synthetic lethality and tolerability with chemotherapy in preclinical models

The PARP inhibitor AZD2461 was developed as a next-generation agent following olaparib, the first PARP inhibitor approved for cancer therapy. In BRCA1-deficient mouse models, olaparib resistance predominantly involves overexpression of P-glycoprotein,so AZD2461 was developed as a poor substrate for drug transporters. Here we demonstrate the efficacy of this compound against olaparib-resistant tumors that overexpress P-glycoprotein. In addition, AZD2461 was better tolerated in combination with chemotherapy than olaparib in mice, which suggests that AZD2461 could have significant advantages over olaparib in the clinic. However, this superior toxicity profile did not extend to rats. Investigations of this difference revealed a differential PARP3 inhibitory activity for each compound and a higher level of PARP3 expression in bone marrow cells from mice as compared with rats and humans. Our findings have implications for the use of mouse models to assess bone marrow toxicity for DNA-damaging agents and inhibitors of the DNA damage response. Finally, structural modeling of the PARP3-active site with different PARP inhibitors also highlights the potential to develop compounds with different PARP family member specificity profiles for optimal antitumor activity and tolerability