Pharmacological and neurophysiological aspects of space/motion sickness

A motorized motion testing device modeled after a Ferris wheel was constructed to perform motion sickness tests on cats. Details of the testing are presented, and some of the topics covered include the following: xylazine-induced emesis; analysis of the constituents of the cerebrospinal fluid (CSF) during motion sickness; evaluation of serotonin-1A (5-HT sub 1A) agonists; other 5HT receptors; antimuscarinic mechanisms; and antihistaminergic mechanisms. The ability of the following drugs to reduce motion sickness in the cats was examined: amphetamines, adenosinergic drugs, opioid antagonists, peptides, cannabinoids, cognitive enhancers (nootropics), dextromethorphan/sigma ligands, scopolamine, and diphenhydramine

Path Conditions and Principal Matching: A New Approach to Access Control

Traditional authorization policies are user-centric, in the sense that authorization is defined, ultimately, in terms of user identities. We believe that this user-centric approach is inappropriate for many applications, and that what should determine authorization is the relationships that exist between entities in the system. While recent research has considered the possibility of specifying authorization policies based on the relationships that exist between peers in social networks, we are not aware of the application of these ideas to general computing systems. We develop a formal access control model that makes use of ideas from relationship-based access control and a two-stage method for evaluating policies. Our policies are defined using path conditions, which are similar to regular expressions. We define semantics for path conditions, which we use to develop a rigorous method for evaluating policies. We describe the algorithm required to evaluate policies and establish its complexity. Finally, we illustrate the advantages of our model using an example and describe a preliminary implementation of our algorithm.Comment: Accepted for publication at SACMAT 201

Stimulation of serotonin-1A receptors in mammals to alleviate motion sickness and emesis induced by chemical agents

A method for the alleviation of both motion sickness and chemically-induced emesis is provided which includes the administration of a nontoxic, therapeutically effective amount of a composition which stimulates serotonin-1A receptors in a mammal in need of such treatment. The preferred compounds for use are buspirone and 8-hydroxy-2(di-n-propylamino)-tetralin (8-OH-DPAT)