A Transactional Analysis of Interaction Free Measurements

The transactional interpretation of quantum mechanics is applied to the "interaction-free" measurement scenario of Elitzur and Vaidman and to the Quantum Zeno Effect version of the measurement scenario by Kwiat, et al. It is shown that the non-classical information provided by the measurement scheme is supplied by the probing of the intervening object by incomplete offer and confirmation waves that do not form complete transactions or lead to real interactions.Comment: Accepted for publication in Foundations of Physics Letter

Structural basis of TFIIH activation for nucleotide excision repair.

Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH). Here we report the cryo-EM structure of an NER intermediate containing TFIIH and the NER factor XPA. Compared to its transcription conformation, the TFIIH structure is rearranged such that its ATPase subunits XPB and XPD bind double- and single-stranded DNA, consistent with their translocase and helicase activities, respectively. XPA releases the inhibitory kinase module of TFIIH, displaces a 'plug' element from the DNA-binding pore in XPD, and together with the NER factor XPG stimulates XPD activity. Our results explain how TFIIH is switched from a transcription to a repair factor, and provide the basis for a mechanistic analysis of the NER pathway

Diagnostic criteria for grading the severity of acute motion sickness

Diagnostic criteria for grading severity of acute motion sicknes

Structure of glassy lithium sulfate films sputtered in nitrogen (LISON): Insight from Raman spectroscopy and ab initio calculations

Raman spectra of thin solid electrolyte films obtained by sputtering a lithium sulfate target in nitrogen plasma are measured and compared to ab initio electronic structure calculations for clusters composed of 28 atoms. Agreement between measured and calculated spectra is obtained when oxygen atoms are replaced by nitrogen atoms and when the nitrogen atoms form bonds with each other. This suggests that the incorporation of nitrogen during the sputtering process leads to structures in the film, which prevent crystallization of these thin film salt glasses.Comment: 5 pages, 4 figure

Quantum equilibration in finite time

It has recently been shown that small quantum subsystems generically equilibrate, in the sense that they spend most of the time close to a fixed equilibrium state. This relies on just two assumptions: that the state is spread over many different energies, and that the Hamiltonian has non-degenerate energy gaps. Given the same assumptions, it has also been shown that closed systems equilibrate with respect to realistic measurements. We extend these results in two important ways. First, we prove equilibration over a finite (rather than infinite) time-interval, allowing us to bound the equilibration time. Second, we weaken the non degenerate energy gaps condition, showing that equilibration occurs provided that no energy gap is hugely degenerate.Comment: 7 page

Parametric instabilities in magnetized multicomponent plasmas

This paper investigates the excitation of various natural modes in a magnetized bi-ion or dusty plasma. The excitation is provided by parametrically pumping the magnetic field. Here two ion-like species are allowed to be fully mobile. This generalizes our previous work where the second heavy species was taken to be stationary. Their collection of charge from the background neutral plasma modifies the dispersion properties of the pump and excited waves. The introduction of an extra mobile species adds extra modes to both these types of waves. We firstly investigate the pump wave in detail, in the case where the background magnetic field is perpendicular to the direction of propagation of the pump wave. Then we derive the dispersion equation relating the pump to the excited wave for modes propagating parallel to the background magnetic field. It is found that there are a total of twelve resonant interactions allowed, whose various growth rates are calculated and discussed.Comment: Published in May 2004; this is a late submission to the archive. 14 pages, 8 figure

Quantum criticality as a resource for quantum estimation

We address quantum critical systems as a resource in quantum estimation and derive the ultimate quantum limits to the precision of any estimator of the coupling parameters. In particular, if L denotes the size of a system and \lambda is the relevant coupling parameters driving a quantum phase transition, we show that a precision improvement of order 1/L may be achieved in the estimation of \lambda at the critical point compared to the non-critical case. We show that analogue results hold for temperature estimation in classical phase transitions. Results are illustrated by means of a specific example involving a fermion tight-binding model with pair creation (BCS model).Comment: 7 pages. Revised and extended version. Gained one author and a specific exampl

Structural basis of RNA processing by human mitochondrial RNase P

Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to liberate all RNA species. In contrast to nuclear or bacterial RNase P, mtRNase P is not a ribozyme but comprises three protein subunits that carry out RNA cleavage and methylation by unknown mechanisms. Here, we present the cryo-EM structure of human mtRNase P bound to precursor tRNA, which reveals a unique mechanism of substrate recognition and processing. Subunits TRMT10C and SDR5C1 form a subcomplex that binds conserved mitochondrial tRNA elements, including the anticodon loop, and positions the tRNA for methylation. The endonuclease PRORP is recruited and activated through interactions with its PPR and nuclease domains to ensure precise pre-tRNA cleavage. The structure provides the molecular basis for the first step of RNA processing in human mitochondria