10,784 research outputs found
Hall current effects in dynamic magnetic reconnection solutions
The impact of Hall current contributions on flow driven planar magnetic merging solutions is discussed. The Hall current is important if the dimensionless Hall parameter (or normalized ion skin depth) satisfies cH>η where η is the inverse Lundquist number for the plasma. A dynamic analysis of the problem shows, however, that the Hall current initially manifests itself, not by modifying the planar reconnection field, but by inducing a non-reconnecting perpendicular "separator" component in the magnetic field. Only if the stronger condition c2/H > η is satisfied can Hall currents be expected to affect the planar merging. These analytic predictions are then tested by performing a series of numerical experiments in periodic geometry, using the full system of planar magnetohydrodynamic (MHD) equations. The numerical results confirm that the nature of the merging changes dramatically when the Hall coupling satisfies c2/H > η. In line with the analytic treatment of sheared reconnection, the coupling provided by the Hall term leads to the emergence of multiple current layers that can enhance the global Ohmic dissipation at the expense of the reconnection rate. However, the details of the dissipation depend critically on the symmetries of the simulation, and when the merging is "head-on" (i.e., comprises fourfold symmetry) the reconnection rate can be enhanced
The identification of histidine ligands to cytochrome a in cytochrome c oxidase
A histidine auxotroph of Saccharomyces cerevisiae has been used to metabolically incorporate [1,3-15N2] histidine into yeast cytochrome c oxidase. Electron nuclear double resonance (ENDOR) spectroscopy of cytochrome a in the [15N]histidine-substituted enzyme reveals an ENDOR signal which can be assigned to hyperfine coupling of a histidine 15N with the low-spin heme, thereby unambiguously identifying histidine as an axial ligand to this cytochrome. Comparison of this result with similar ENDOR data obtained on two 15N-substituted bisimidazole model compounds, metmyoglobin-[15N]imidazole and bis[15N]imidazole tetraphenyl porphyrin, provides strong evidence for bisimidazole coordination in cytochrome a
Analytic solutions of the magnetic annihilation and reconnection problems. I. Planar flow profiles
The phenomena of steady-state magnetic annihilation and reconnection in the vicinity of magnetic nulls are considered. It is shown that reconnective solutions can be derived by superposing the velocity and magnetic fields of simple magnetic annihilation models. These solutions contain most of the previous models for magnetic merging and reconnection, as well as introducing several new solutions. The various magnetic dissipation mechanisms are classified by examining the scaling of the Ohmic diffusion rate with plasma resistivity. Reconnection solutions generally allow more favorable "fast" dissipation scalings than annihilation models. In particular, reconnection models involving the advection of planar field components have the potential to satisfy the severe energy release requirements of the solar flare. The present paper is mainly concerned with magnetic fields embedded in strictly planar flows—a discussion of the more complicated three-dimensional flow patterns is presented in Part II [Phys. Plasmas 4, 110 (1997)]
Highly Efficient Modeling of Dynamic Coronal Loops
Observational and theoretical evidence suggests that coronal heating is
impulsive and occurs on very small cross-field spatial scales. A single coronal
loop could contain a hundred or more individual strands that are heated
quasi-independently by nanoflares. It is therefore an enormous undertaking to
model an entire active region or the global corona. Three-dimensional MHD codes
have inadequate spatial resolution, and 1D hydro codes are too slow to simulate
the many thousands of elemental strands that must be treated in a reasonable
representation. Fortunately, thermal conduction and flows tend to smooth out
plasma gradients along the magnetic field, so "0D models" are an acceptable
alternative. We have developed a highly efficient model called Enthalpy-Based
Thermal Evolution of Loops (EBTEL) that accurately describes the evolution of
the average temperature, pressure, and density along a coronal strand. It
improves significantly upon earlier models of this type--in accuracy,
flexibility, and capability. It treats both slowly varying and highly impulsive
coronal heating; it provides the differential emission measure distribution,
DEM(T), at the transition region footpoints; and there are options for heat
flux saturation and nonthermal electron beam heating. EBTEL gives excellent
agreement with far more sophisticated 1D hydro simulations despite using four
orders of magnitude less computing time. It promises to be a powerful new tool
for solar and stellar studies.Comment: 34 pages, 8 figures, accepted by Astrophysical Journal (minor
revisions of original submitted version
Bose-Einstein condensates with attractive 1/r interaction: The case of self-trapping
Amplifying on a proposal by O'Dell et al. for the realization of
Bose-Einstein condensates of neutral atoms with attractive interaction,
we point out that the instance of self-trapping of the condensate, without
external trap potential, is physically best understood by introducing
appropriate "atomic" units. This reveals a remarkable scaling property: the
physics of the condensate depends only on the two parameters and
, where is the particle number, the scattering length,
the "Bohr" radius and the trap frequency in atomic units. We
calculate accurate numerical results for self-trapping wave functions and
potentials, for energies, sizes and peak densities, and compare with previous
variational results. As a novel feature we point out the existence of a second
solution of the extended Gross-Pitaevskii equation for negative scattering
lengths, with and without trapping potential, which is born together with the
ground state in a tangent bifurcation. This indicates the existence of an
unstable collectively excited state of the condensate for negative scattering
lengths.Comment: 7 pages, 7 figures, to appear in Phys. Rev.
Translation research: from accurate diagnosis to appropriate treatment
This review article focuses on the various aspects of translational research, where research on human subjects can ultimately enhance the diagnosis and treatment of future patients. While we will use specific examples relating to the asbestos related cancer mesothelioma, it should be stressed that the general approach outlined throughout this review is readily applicable to other diseases with an underlying molecular basis. Through the integration of molecular-based technologies, systematic tissue procurement and medical informatics, we now have the ability to identify clinically applicable "genotype"-"phenotype" associations across cohorts of patients that can rapidly be translated into useful diagnostic and treatment strategies. This review will touch on the various steps in the translational pipeline, and highlight some of the most essential elements as well as possible roadblocks that can impact success of the program. Critical issues with regard to Institutional Review Board (IRB) and Health Insurance Portability and Accountability Act (HIPAA) compliance, data standardization, sample procurement, quality control (QC), quality assurance (QA), data analysis, preclinical models and clinical trials are addressed. The various facets of the translational pipeline have been incorporated into a fully integrated computational system, appropriately named Dx2Tx. This system readily allows for the identification of new diagnostic tests, the discovery of biomarkers and drugable targets, and prediction of optimal treatments based upon the underlying molecular basis of the disease
Ionisation and discharge in cloud-forming atmospheres of brown dwarfs and extrasolar planets
Brown dwarfs and giant gas extrasolar planets have cold atmospheres with rich chemical compositions from which mineral cloud particles form. Their properties, like particle sizes and material composition, vary with height, and the mineral cloud particles are charged due to triboelectric processes in such dynamic atmospheres. The dynamics of the atmospheric gas is driven by the irradiating host star and/or by the rotation of the objects that changes during its lifetime. Thermal gas ionisation in these ultra-cool but dense atmospheres allows electrostatic interactions and magnetic coupling of a substantial atmosphere volume. Combined with a strong magnetic field , a chromosphere and aurorae might form as suggested by radio and x-ray observations of brown dwarfs. Non-equilibrium processes like cosmic ray ionisation and discharge processes in clouds will increase the local pool of free electrons in the gas. Cosmic rays and lighting discharges also alter the composition of the local atmospheric gas such that tracer molecules might be identified. Cosmic rays affect the atmosphere through air showers in a certain volume which was modelled with a 3D Monte Carlo radiative transfer code to be able to visualise their spacial extent. Given a certain degree of thermal ionisation of the atmospheric gas, we suggest that electron attachment to charge mineral cloud particles is too inefficient to cause an electrostatic disruption of the cloud particles. Cloud particles will therefore not be destroyed by Coulomb explosion for the local temperature in the collisional dominated brown dwarf and giant gas planet atmospheres. However, the cloud particles are destroyed electrostatically in regions with strong gas ionisation. The potential size of such cloud holes would, however, be too small and might occur too far inside the cloud to mimic the effect of, e.g. magnetic field induced star spots
The nature of CuA in cytochrome c oxidase
The isolation and purification of yeast cytochrome c oxidase is described. Characterization of the purified protein indicates that it is spectroscopically identical with cytochrome c oxidase isolated from beef heart. Preparations of isotopically substituted yeast cytochrome c oxidase are obtained incorporating [1,3-15N2]histidine or [beta,beta- 2H2]cysteine. Electron paramagnetic resonance and electron nuclear double resonance spectra of the isotopically substituted proteins identify unambiguously at least 1 cysteine and 1 histidine as ligands to CuA and suggest that substantial spin density is delocalized onto a cysteine sulfur in the oxidized protein to render the site Cu(I)-S
Magnetic Flux Braiding: Force-Free Equilibria and Current Sheets
We use a numerical nonlinear multigrid magnetic relaxation technique to
investigate the generation of current sheets in three-dimensional magnetic flux
braiding experiments. We are able to catalogue the relaxed nonlinear force-free
equilibria resulting from the application of deformations to an initially
undisturbed region of plasma containing a uniform, vertical magnetic field. The
deformations are manifested by imposing motions on the bounding planes to which
the magnetic field is anchored. Once imposed the new distribution of magnetic
footpoints are then taken to be fixed, so that the rest of the plasma must then
relax to a new equilibrium configuration. For the class of footpoint motions we
have examined, we find that singular and nonsingular equilibria can be
generated. By singular we mean that within the limits imposed by numerical
resolution we find that there is no convergence to a well-defined equilibrium
as the number of grid points in the numerical domain is increased. These
singular equilibria contain current "sheets" of ever-increasing current
intensity and decreasing width; they occur when the footpoint motions exceed a
certain threshold, and must include both twist and shear to be effective. On
the basis of these results we contend that flux braiding will indeed result in
significant current generation. We discuss the implications of our results for
coronal heating.Comment: 13 pages, 12 figure
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