9 research outputs found
Nigellissima: A Study of Glamour, Performativity and Embodiment
- Author
- Benedetta Cappellini
- Borgerson J. E.
- Brown J.
- Buckley R.
- Butler J.
- Castle T.
- Comolli J.
- Craft-Fairchild C.
- Davis K.
- De Vault M. L.
- Dyhouse C.
- Ewen S.
- Gilly Smith
- Grosz E. A.
- Gundle S.
- Hewer P.
- Lawson N.
- Lorna Stevens
- Magee R. M.
- McRobbie A.
- Parker A.
- Postrel V.
- Radner H.
- Riviere J.
- Skeggs B.
- Smith G.
- Thornham S.
- Tripp D.
- Warde A.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2015
- Field of study
Get PDFThis is a study of glamour, its complexities and its relationship with and role within celebrity culture. We explore glamour in the context of Nigella, the London-born TV cook, food writer and self-proclaimed âdomestic goddessâ of British culinary culture. In our study we consider the interconnections between glamour, specifically Italian-style retro-glamour, and performativity in Nigellaâs career. We also address the role of embodiment and authenticity in the masquerade of femininity. Our analysis focuses on Nigellaâs glamour over time, considering its creation, enactment and reaffirmation following scandal. We conclude by speculating on glamourâs complex and ambivalent relationship with celebrity culture, and the role of vulnerability in creating authentic and enduring glamour in contemporary consumer society
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aaltonen L.
- Aaltonen V.
- Aarsland Dag
- Aavikko M.
- Abalos M.S.
- Abdelnour Carla
- Abner E.
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- Adams P.M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A.D.
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Ahmad S.
- Akinyemi R.O.
- Al-Chalabi A.
- AlarcĂłn-MartĂn Emilio
- Albert M.S.
- Albin R.L.
- Alcolea Daniel
- Alegret Montserrat
- Ali M.
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Get PDFCharacterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
The Law of the Father: Inchbaldâs A Simple Story
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
No full textRecommended from our members
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel A Meta-analysis
- Author
- Abner  Erin
- Adams  L.D
- Adams  Perrie, M
- Albert  Marilyn S
- Albin  Roger, L
- Apostolova  Liana, G
- Arnold  Steven, E
- Asthana  Sanjay
- Atwood  Craig, S
- Ayodele  Temitope
- Baldwin  Clinton, T
- Barber  Robert, C
- Barnes  Lisa L
- Barral  Sandra
- Beach  Thomas, G
- Becker  James, T
- Beecham  Gary, W
- Bennett  David A
- Bigio  Eileen, H
- Bird  Thomas, D
- Blacker  Deborah
- Boeve  Bradley, F
- Bowen  James, D
- Boxer  Adam
- Brewer  James B
- Burke  James, R
- Burns  Jeffrey, M
- Buxbaum  Joe D
- Byrd  Goldie S
- Cairns  Nigel, J
- Cantwell  Laura B
- Cao  Chuanhai
- Carlsson  Cynthia, M
- Carney  Regina, M
- Carrasquillo  Minerva, M
- Chui  Helena C
- Chung  Jaeyoon
- Craft  Suzanne
- Crane  Paul K
- Cribbs  David, H
- Cruchaga  Carlos
- Cuccaro  Michael L
- De Jager  Phil L
- DeCarli  Charles
- Dick  Malcom
- Dickson  Dennis, W
- Doody  Rachelle S
- Duara  Ranjan
- Ertekin-Taner  Nilufer
- Evans  Denis A
- Faber  Kelley, M
- Fairchild  Thomas, J
- Fallin  M. Daniele
- Fallon  Kenneth, B
- Fardo  David, W
- Farlow  Martin, R
- Farrer  Lindsay A
- Ferris  Steven
- Foroud  Tatiana M
- Frosch  Matthew, P
- Galasko  Douglas, R
- Gearing  Marla
- Geschwind  Daniel, H
- Ghetti  Bernardino
- Gilbert  John, R
- Go  Rodney C. P
- Goate  Alison M
- Golde  Todd E
- Grabowski  Thomas J
- Graff-Radford  Neill R
- Green  Robert, C
- Growdon  John, H
- Haines  Jonathan L
- Hakonarson  Hakon
- Hall  Kathleen S
- Hamilton  Ronald, L
- Hamilton-Nelson  Kara L
- Hardy  John
- Harrell  Lindy, E
- Henderson  Victor W
- Hendrie  Hugh C
- Honig  Lawrence, S
- Huebinger  Ryan, M
- Huentelman  Matthew, J
- Hulette  Christine, M
- Hyman  Bradley T
- Jarvik  Gail, P
- Jean-Francois  Melissa
- Jin  Lee-Way
- Jun  Gyungah R
- Kamboh  M. Ilyas
- Karydas  Anna
- Katz  Mindy, J
- Kauwe  John, S.K
- Kaye  Jeffrey A
- Keene  C. Dirk
- Kim  Ronald
- Klein  Hans-Ulrich
- Kowall  Neil W
- Kramer  Joel, H
- Kukull  Walter A
- Kunkle  Brian W
- Kuzma  Amanda B
- LaFerla  Frank M
- Lah  James, J
- Larson  Eric B
- Leung  Yuk Ye
- Leverenz  James B
- Levey  Allan I
- Li  Ge
- Lieberman  Andrew, P
- Lipton  Richard, B
- Logue  Mark W
- Lopez  Oscar L
- Lunetta  Kathryn L
- Lyketsos  Constantine, G
- Malamon  John
- Manly  Jennifer J
- Marson  Daniel, C
- Martin  Eden R
- Martinez  Izri
- Martiniuk  Frank
- Masliah  Eliezer
- Mayeux  Richard
- McCormick  Wayne, C
- McCurry  Susan, M
- McDavid  Andrew, N
- McDonough  Stefan
- McKee  Ann, C
- Mesulam  Marsel
- Mez  Jesse
- Miller  Bruce L
- Miller  Bruce, L
- Miller  Carol, A
- Montine  Thomas, J
- Morris  John C
- Mukherjee  Shubhabrata
- Myers  Amanda, J
- Naj  Adam C
- Obisesan  Thomas O
- Olichney  John, M
- OâBryant  Sid, E
- Parisi  Joseph, E
- Paulson  Henry L
- Pericak-Vance  Margaret A
- Peskind  Elaine
- Petersen  Ronald C
- Pierce  Aimee
- Poon  Wayne, W
- Potter  Huntington
- Qu  Liming
- Quinn  Joseph, F
- Raj  Ashok
- Raskind  Murray
- Reiman  Eric M
- Reisberg  Barry
- Reisch  Joan, S
- Reitz  Christiane
- Ringman  John, M
- Roberson  Erik, D
- Rogaeva  Ekaterina
- Rosen  Howard, J
- Rosenberg  Roger N
- Royall  Donald, R
- Sager  Mark, A
- Sano  Mary
- Saykin  Andrew J
- Schellenberg  Gerard D
- Schmidt  Michael
- Schneider  Julie, A
- Schneider  Lon, S
- Seeley  William, W
- Small  Scott
- Small  Scott A
- Sonnen  Joshua, A
- Spina  Salvatore
- St George-Hyslop  Peter
- Starks  Takiyah D
- Stern  Robert, A
- Strittmatter  Stephen M
- Swerdlow  Russell H
- Tanzi  Rudolph, E
- Trojanowski  John Q
- Troncoso  Juan, C
- Tsuang  Debby, W
- Valladares  Otto
- Van Deerlin  Vivianna, M
- Van Eldik  Linda J
- Vance  Jeffery M
- Vardarajan  Badri, N
- Vassar  Robert
- Vinters  Harry, V
- Vonsattel  Jean Paul
- Wang  Li-San
- Weintraub  Sandra
- Welsh-Bohmer  Kathleen, A
- Wilhelmsen  Kirk, C
- Williamson  Jennifer
- Wingo  Thomas, S
- Wisniewski  Thomas
- Woltjer  Randall, L
- Wu  Chuang-Kuo
- Younkin  Steven, G
- Yu  Chang-En
- Yu  Lei
- Zhao  Yi
- Publication venue
- Publication date
- 01/01/2021
- Field of study
No full textRecommended from our members
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimerâs disease: the Alzheimerâs Disease Genetics Consortium
- Author
- Abner  Erin
- Adams  Perrie M.
- Aguirre  Alyssa
- Albert  Marilyn S.
- Albin  Roger L.
- Allen  Mariet
- Alvarez  Lisa
- Apostolova  Liana G.
- Arnold  Steven E.
- Asthana  Sanjay
- Atwood  Craig S.
- Ayres  Gayle
- Baldwin  Clinton T.
- Barber  Robert C.
- Barnes  Lisa L.
- Barral  Sandra
- Bazemore  Katrina
- Beach  Thomas G.
- Becker  James T.
- Beecham  Gary W.
- Beekly  Duane
- Benchek  Penelope
- Benitez  Bruno A.
- Bennett  David
- Bertelson  John
- Bird  Thomas D.
- Blacker  Deborah
- Boeve  Bradley F.
- Bowen  James D.
- Boxer  Adam
- Brewer  James
- Burke  James R.
- Burns  Jeffrey M.
- Bush  William S.
- Buxbaum  Joseph D.
- Cairns  Nigel J.
- Cantwell  Laura B.
- Cao  Chuanhai
- Carlson  Christopher S.
- Carlsson  Cynthia M.
- Carney  Regina M.
- Carrasquillo  Minerva M.
- Chasse  Scott
- Chesselet  Marie-Francoise
- Chin  Nathaniel A.
- Chui  Helena C.
- Chung  Jaeyoon
- Craft  Suzanne
- Crane  Paul K.
- Cribbs  David H.
- Crocco  Elizabeth A.
- Cruchaga  Carlos
- Cuccaro  Michael L.
- Cullum  Munro
- Darby  Eveleen
- Davis  Barbara
- De Jager  Philip L.
- DeCarli  Charles
- DeToledo  John
- Dick  Malcolm
- Dickson  Dennis W.
- Dombroski  Beth A.
- Doody  Rachelle S.
- Duara  Ranjan
- Ertekin-Taner  NIlĂŒfer
- Evans  Denis A.
- Faber  Kelley M.
- Fairchild  Thomas J.
- Fallon  Kenneth B.
- Fardo  David W.
- Farlow  Martin R.
- Farrell  John J.
- Farrer  Lindsay A.
- Fernandez-Hernandez  Victoria
- Ferris  Steven
- Foroud  Tatiana M.
- Frosch  Matthew P.
- Fulton-Howard  Brian
- Galasko  Douglas R.
- Gamboa  Adriana
- Gearing  Marla
- Geschwind  Daniel H.
- Ghetti  Bernardino
- Gilbert  John R.
- Goate  Alison M.
- Grabowski  Thomas J.
- Graff-Radford  Neill R.
- Green  Robert C.
- Growdon  John H.
- Grunin  Michelle A.
- Haines  Jonathan L.
- Hakonarson  Hakon
- Hall  James
- Hamilton  Ronald L.
- Hamilton-Nelson  Kara L.
- Harari  Oscar
- Hardy  John
- Harrell  Lindy E.
- Haut  Jacob
- Head  Elizabeth
- Henderson  Victor W.
- Hernandez  Michelle
- Hohman  Timothy
- Honig  Lawrence S.
- Huebinger  Ryan M.
- Huentelman  Matthew J.
- Hulette  Christine M.
- Hyman  Bradley T.
- Hynan  Linda S.
- Ibanez  Laura
- Iqbal  Taha
- Jarvik  Gail P.
- Jayadev  Suman
- Jin  Lee-Way
- Johnson  Kim
- Johnson  Leigh
- Jun  Gyungah R.
- Kamboh  M. Ilyas
- Karydas  Anna M.
- Katz  Mindy J.
- Kauwe  John S.
- Kaye  Jeffrey A.
- Keene  C. Dirk
- Khaleeq  Aisha
- Kim  Ronald
- Knebl  Janice
- Kowall  Neil W.
- Kramer  Joel H.
- Kuksa  Pavel P.
- Kukull  Walter A.
- Kunkle  Brian W.
- Kushch  Nicholas
- Kuzma  Amanda B.
- LaFerla  Frank M.
- Lah  James J.
- Larson  Eric B.
- Lee  Wan-Ping
- Lerner  Alan
- Leung  Yuk Yee
- Leverenz  James B.
- Levey  Allan I.
- Li  Donghe
- Lieberman  Andrew P.
- Lipton  Richard B.
- Logue  Mark
- Lopez  Oscar L.
- Lucio da Fonseca  Eder
- Lunetta  Kathryn L.
- Lyketsos  Constantine G.
- Mains  Douglas
- Margaret  Flanagan E.
- Marson  Daniel C.
- Martin  Eden R R.
- Martiniuk  Frank
- Mash  Deborah C.
- Masliah  Eliezer
- Massman  Paul
- Masurkar  Arjun
- Mayeux  Richard
- McCormick  Wayne C.
- McCurry  Susan M.
- McDavid  Andrew N.
- McDonough  Stefan
- McKee  Ann C.
- Mesulam  Marsel
- Mez  Jesse B.
- Miller  Bruce L.
- Miller  Carol A.
- Miller  Joshua W.
- Montine  Thomas J.
- Monuki  Edwin S.
- Morris  John C.
- Mukherjee  Shubhabrata
- Myers  Amanda J.
- Naj  Adam C.
- Nguyen  Trung
- Olichney  John M.
- Ory  Marcia
- OâBryant  Sid
- Palmer  Ellen L.
- Palmer  Raymond
- Parisi  Joseph E.
- Pathak  Omkar
- Paulson  Henry L.
- Pavlik  Valory
- Paydarfar  David
- Perez  Victoria
- Pericak-Vance  Margaret A.
- Peskind  Elaine
- Petersen  Ronald C.
- Pierce  Aimee
- Pillai  Jagan
- Polk  Marsha
- Poon  Wayne W.
- Potter  Huntington
- Qu  Liming
- Quiceno  Mary
- Quinn  Joseph F.
- Raj  Ashok
- Rajabli  Farid
- Raskind  Murray
- Reiman  Eric M.
- Reisberg  Barry
- Reisch  Joan S.
- Reitz  Christiane
- Ringman  John M.
- Roberson  Erik D.
- Rodriguear  Monica
- Rogaeva  Ekaterina
- Rosen  Howard J.
- Rosenberg  Roger N.
- Royall  Donald R.
- Sager  Mark A.
- Sano  Mary
- Saykin  Andrew J.
- Schellenberg  Gerard D.
- Schneider  Julie A.
- Schneider  Lon S.
- Seeley  William W.
- Sha  Jin
- Sherva  Richard M.
- Slifer  Susan H.
- Small  Scott
- Smith  Amanda G.
- Smith  Janet P.
- Song  Yeunjoo E.
- Sonnen  Joshua A.
- Spina  Salvatore
- St George-Hyslop  Peter
- Stern  Robert A.
- Stevens  Alan B.
- Strittmatter  Stephen M.
- Sultzer  David
- Swerdlow  Russell H.
- Tanzi  Rudolph E.
- Tilson  Jeffrey L.
- Tosto  Giuseppe
- Trojanowski  John Q.
- Troncoso  Juan C.
- Tsuang  Debby W.
- Valladares  Otto
- Van Deerlin  Vivianna M.
- van Eldik  Linda J.
- Vance  Jeffery M.
- Vardarajan  Badri N.
- Vassar  Robert
- Vinters  Harry V.
- Vonsattel  Jean-Paul
- Wang  Li-San
- Weintraub  Sandra
- Welsh-Bohmer  Kathleen A.
- Wheeler  Nicholas R.
- Whitehead  Patrice L.
- Wijsman  Ellen M.
- Wilhelmsen  Kirk C.
- Williams  Benjamin
- Williamson  Jennifer
- Wilms  Henrik
- Wingo  Thomas S.
- Wisniewski  Thomas
- Woltjer  Randall L.
- Woon  Martin
- Wright  Clinton B.
- Wu  Chuang-Kuo
- Younkin  Steven G.
- Yu  Chang-En
- Yu  Lei
- Zhang  Xiaoling
- Zhao  Yi
- Zhu  Congcong
- Zhu  Xiongwei
- Publication venue
- Cold Spring Harbor Laboratory
- Publication date
- 08/07/2023
- Field of study
No full textLimited ancestral diversity has impaired our ability to detect risk variants more prevalent in non-European ancestry groups in genome-wide association studies (GWAS). We constructed and analyzed a multi-ancestry GWAS dataset in the Alzheimerâs Disease (AD) Genetics Consortium (ADGC) to test for novel shared and ancestry-specific AD susceptibility loci and evaluate underlying genetic architecture in 37,382 non-Hispanic White (NHW), 6,728 African American, 8,899 Hispanic (HIS), and 3,232 East Asian individuals, performing within-ancestry fixed-effects meta-analysis followed by a cross-ancestry random-effects meta-analysis. We identified 13 loci with cross-ancestry associations including known loci at/near
CR1
,
BIN1
,
TREM2
,
CD2AP
,
PTK2B
,
CLU
,
SHARPIN
,
MS4A6A
,
PICALM
,
ABCA7
,
APOE
and two novel loci not previously reported at 11p12 (
LRRC4C
) and 12q24.13 (
LHX5-AS1
). Reflecting the power of diverse ancestry in GWAS, we observed the
SHARPIN
locus using 7.1% the sample size of the original discovering single-ancestry GWAS (n=788,989). We additionally identified three GWS ancestry-specific loci at/near (
PTPRK
(
P
=2.4Ă10
-8
) and
GRB14
(
P
=1.7Ă10
-8
) in HIS), and
KIAA0825
(
P
=2.9Ă10
-8
in NHW). Pathway analysis implicated multiple amyloid regulation pathways (strongest with
P
adjusted
=1.6Ă10
-4
) and the classical complement pathway (
P
adjusted
=1.3Ă10
-3
). Genes at/near our novel loci have known roles in neuronal development (
LRRC4C, LHX5-AS1
, and
PTPRK
) and insulin receptor activity regulation (
GRB14
). These findings provide compelling support for using traditionally-underrepresented populations for gene discovery, even with smaller sample sizes
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-GĂłmez
- Adam Boxer
- Adam Ziemann
- Adams H.
- Adams P. M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
- Al-Chalabi A.
- Alan B Stevens
- Alan Lerner
- AlarcĂłn-MartĂn E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
- Alcolea D.
- Aldo Saenz
- Alegret M.
- Alessandra Chesi
- Alessandro Vacca
- Alexander Teumer
- Alexis Brice
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- Alisa Manning
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
No full textCharacterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele. © 2022, The Author(s)
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-GĂłmez Ad
- Adarmes-GĂłmez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- AlarcĂłn-MartĂn Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso MarĂa Dolores
- Alonso MarĂa Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- AntĂșnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
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- Mohammed Elhaj
- Mol Merel
- Molina-Porcel Laura
- Montes Angel MartĂn
- Montine Thomas J.
- Montrreal Laura
- Monuki Edwin S.
- Morales Atahualpa Castillo
- Morelli Laura
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- Moreno Mariona
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- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Mummery Catherine
- Muslin Anthony
- Myers Amanda J.
- MÀkelÀ Johanna
- MÀkelÀ Tomi
- MÀnnikkö Lotta
- MÀntylÀ PÀivi
- Nacmias Benedetta
- Naj Adam C.
- Nash William
- Natunen Teemu
- Ngandu Tiia
- Nguyen Trung
- Nicolas Gael
- Nielsen Sune Fallgaard
- Niemi Mari E.
- Nieminen Pekka
- Niiranen Teemu
- Nordestgaard BĂžrge G.
- Novack Gisela
- Nuñez-Llaves RaĂșl
- Nyquist Paul
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- Oh Danny
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- Pancho Ana
- Paolo Caffarra
- Papenberg Goran
- Parisi Joseph E.
- Parkkinen Jaakko
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- Parveen Kayenat
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- Passmore Peter
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- Pastor Alfonso Arias
- Pastor Ana Belén
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- Patel Yash
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- Paulson Henry L.
- Paus Tomas
- Pausova Zdenka
- Pavlik Valory
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- PelejĂ Esther
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- Pelkonen Margit
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- Peltola Jukka
- Peltonen Markku
- Peltonen Sirkku
- Pendergrass Sarah
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- Pericard Pierre
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- Petrovski Slavé
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- Pickering-Brown Stuart
- Pierce Aimee
- PihlajamÀki Jussi
- Pijnenburg Yolande A. L.
- Pikkarainen Sampsa
- Pinchler Sabrina
- Pineda Juan A.
- Pineda-SĂĄnchez R.
- Pineda-SĂĄnchez RocĂo
- Piras Fabrizio
- Piras Federica
- PirilÀ Laura
- Pisanu Claudia
- PitkÀranta Anne
- Piñol-Ripoll Gerard
- Plenge Robert
- Podgornaia Anna
- Polak Thomas
- Politis Daniel G.
- Polk Marsha
- Poon Wayne W.
- Popovic Relja
- Popp Julius
- Posthuma Danielle
- Potter Huntington
- Powell John
- Powell John F.
- Preckler Silvia
- Prestia Federico Ariel
- Priller Josef
- Proitsi Petra
- Prokic Ivana
- Psaty Bruce M.
- Puerta Raquel
- Pulford David
- Pulkki Kari
- Pussinen Pirkko
- PylkÀs Katri
- PĂ€rn Kalle
- PĂ©rez-CordĂłn Alba
- PĂ©rez-Tur Jordi
- Qu Liming
- Quarless Danjuma
- Quenez Olivier
- Quiceno Mary
- Quinn Joseph F.
- Quintela Inés
- Rahimov Fedik
- Raikkonen-Talvitie Katri
- Rainero Innocenzo
- Raj Ashok
- Raj Towfique
- Rajabli Farid
- Rajpal Deepak
- Rajula Reddy
- Ramakers Inez
- Ramirez Alfredo
- Raskind Murray
- Rathinakannan Venkat Subramaniam
- Real de AsĂșa Diego
- Real Luis M.
- Reeve Mary Pat
- Reiman Eric M.
- Reinders Marcel J. T.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Remes Anne
- Reyes-Dumeyer Dolly
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- Riemenschneider Matthias
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- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
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- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Ălvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Get PDFCharacterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
