Mass Density of Individual Cobalt Nanowires

The mass density of nanowires is determined using in-situ resonance frequency experiments combined with quasi-static nanotensile tests. Our results reveal a mass density of 7.36 g/cm3 on average which is below the theoretical density of bulk cobalt. Also the density of electrodeposited cobalt nanowires is found to decrease with the aspect ratio. The results are discussed in terms of the measurement accuracy and the microstructure of the nanowires.Comment: 3 Figure

Erlen : Une interface tangible pour la réduction de la consommation énergétique sur le poste de travail

International audienceIn this demonstration paper, we present the Erlen environment. A set of tangible interfaces dedicated to raising awareness of employees and the workplace’s energy consumption reduction.Dans cette article de démonstration, nous présentons l’environne- ment Erlen. Un ensemble d’interfaces tangibles dédiées à la prise de conscience des employés et à la réduction de la consommation énergétique d’un poste de travail

Erlen : Une interface tangible pour la réduction de la consommation énergétique sur le poste de travail

International audienceIn this demonstration paper, we present the Erlen environment. A set of tangible interfaces dedicated to raising awareness of employees and the workplace’s energy consumption reduction.Dans cette article de démonstration, nous présentons l’environne- ment Erlen. Un ensemble d’interfaces tangibles dédiées à la prise de conscience des employés et à la réduction de la consommation énergétique d’un poste de travail

Formulación de estrategias para competitividad ganadera en el contexto de la revolución industrial 4.0 : estudio de caso Villa del Rosario

La ganadería de doble propósito que se practica en Colombia presenta dificultades en la productividad debido a la poca inversión estatal y a la escasa implementación de tecnologías de punta que ayuden a dejar atrás la explotación artesanal en los hatos ganaderos. En aras a ayudar en estas dificultades se efectuó está investigación, en donde se desarrollaron estrategias utilizando tecnologías de la revolución industrial 4.0 las cuales ayudan a aumentar la competitividad de un negocio ganadero. El éxito de este trabajo parte de mostrarle al ganadero como es que se descubre la estructura de su negocio y en qué actividades se puede implementar tecnologías de la industria 4.0. que maximicen la competitividad de su negocio. Este trabajo puede ser utilizado como un manual para implementar tecnologías de la industria 4.0 en una finca ganadera, que involucra las variables, actividades, modelos y tecnologías que deberían estar presentes para desarrollar competitivamente un negocio ganadero.The double purpose livestock that is practiced in Colombia presents difficulties in productivity due to the limited state investment and the insufficient implementation of advanced technologies that help to leave behind the traditional exploitation in the livestock farms. to address these difficulties, this research developed strategies using technologies of the industrial revolution 4.0. industrial revolution helped to increase the competitiveness of a livestock business. The success of this research is in showing the farmer how to discover the structure of his business and in which activities he can implement technologies of the 4.0 industry to maximize the competitiveness of his business. This research can be used by farmers to implement 4.0 industry technologies in a livestock farming, which includes the variables, activities, models and technologies that should be present to develop a competitive livestock business.Magíster en Administración MBAMaestrí

Incidence, risk factors, and CT characteristics of radiation recall pneumonitis induced by immune checkpoint inhibitor in lung cancer.

BACKGROUND AND PURPOSE: Radiation recall pneumonitis (RRP) is a delayed radiation-induced lung toxicity triggered by systemic agents, typically anticancer drugs. Immune checkpoint inhibitors (ICIs) have recently been identified as potential causal agents of RRP but its real incidence and potential risk factors remain unknown. MATERIALS AND METHODS: Medical records and CTs of patients treated with programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitors for advanced lung cancer between 2014 and 2019 at our tertiary center, and who had a previous history of lung irradiation were retrospectively analyzed. We identified RRP as lung CT modifications occurring in the irradiation field >6 months after conventionally fractionated radiotherapy completion and >1 year after stereotactic body radiation therapy. Clinical and dosimetric data were analyzed to identify potential risk factors for RRP. RESULTS: Among 348 patients treated with ICIs, data from 80 eligible patients were analyzed (median age, 69 years [interquartile range, 11]; 45 men). Fifteen patients (18.8%) presented with RRP. Median time between end of radiotherapy and RRP was 450 days (range, 231-1859). No risk factor was significantly associated with RRP. ICI-related pneumonitis was associated with RRP in 33.3% of cases (p = 0.0021), developing either concomitantly or after RRP. Incidence of grade ≥ 3 pneumonitis in the RRP population was 13.3 %. CONCLUSION: We demonstrated a high incidence of RRP (18.8%) in our population of previously irradiated patients treated with ICIs for lung cancer. We identified no risk factors for RRP, but an association was noted between RRP and ICI-related pneumonitis.Peer reviewe

The project ENDORSE: exploiting EO data to develop pre-market services in renewable energy

International audienceThe ENDORSE project is co-funded by the FP7 programme of the European Commission, from 2011 to 2013. It exploits the atmosphere service MACC of the European GMES programme (Global Monitoring for Environment and Security) together with other Earth Observation (EO) data and modelling. It aims at providing public authorities and private investors with accurate evaluation and forecasts of renewable resources. The focus is on the devel-opment of downstream services that create added-value information. We present here the achievements of the first period. A very accurate though fast algorithm describing the position of the sun in the sky has been developed. A series of recommendations for quality control of meteorological data have been issued. All algorithms are available as code sources and are being implemented as Web processing services (WPS). Support vector machine techniques prove successful to map the air temperature at 2-m height from satellite images and a few measurements at ground level. The next development of ENDORSE is a portfolio of pre-market downstream services, serving as precursors and examples of best practices for similar services. The resulting services will be described using the INSPIRE metadata and declared in an existing Catalog Service for the Web (CSW) dedicated to energy. Finally, we discuss the mutual benefits between GEOSS (Global Earth Observation System of Systems) and ENDORSE

Adult Stromal Cells Derived from Human Adipose Tissue Provoke Pancreatic Cancer Cell Death both In Vitro and In Vivo

1932-6203 (Electronic) Journal Article Research Support, Non-U.S. Gov'tBACKGROUND: Normal tissue homeostasis is maintained by dynamic interactions between epithelial cells and their microenvironment. Disrupting this homeostasis can induce aberrant cell proliferation, adhesion, function and migration that might promote malignant behavior. Indeed, aberrant stromal-epithelial interactions contribute to pancreatic ductal adenocarcinoma (PDAC) spread and metastasis, and this raises the possibility that novel stroma-targeted therapies represent additional approaches for combating this malignant disease. The aim of the present study was to determine the effect of human stromal cells derived from adipose tissue (ADSC) on pancreatic tumor cell proliferation. PRINCIPAL FINDINGS: Co-culturing pancreatic tumor cells with ADSC and ADSC-conditioned medium sampled from different donors inhibited cancer cell viability and proliferation. ADSC-mediated inhibitory effect was further extended to other epithelial cancer-derived cell lines (liver, colon, prostate). ADSC conditioned medium induced cancer cell necrosis following G1-phase arrest, without evidence of apoptosis. In vivo, a single intra-tumoral injection of ADSC in a model of pancreatic adenocarcinoma induced a strong and long-lasting inhibition of tumor growth. CONCLUSION: These data indicate that ADSC strongly inhibit PDAC proliferation, both in vitro and in vivo and induce tumor cell death by altering cell cycle progression. Therefore, ADSC may constitute a potential cell-based therapeutic alternative for the treatment of PDAC for which no effective cure is available

Randomized phase 2 trial of intravenous oncolytic virus JX-594 combined with low-dose cyclophosphamide in patients with advanced soft-tissue sarcoma

JX-594 is an oncolytic vaccinia virus genetically modified to replicate selectively in tumor cells. Metronomic chemotherapy has shown preclinical synergy with oncolytic viruses. We report here the results of the METROMAJX which is a randomized phase II clinical trial investigating the combination of JX-594 combined with metronomic cyclophosphamide (arm 1) or metronomic cyclophosphamide (arm 2) in patients with advanced STS. A two-stage Simon design was used. JX-594 was administered intra-venously at the dose 1.109 every 2 weeks for the first 3 injections and then every 3 weeks. Cyclophosphamide was given orally at the dose of 50 mg BID 1 week on 1 week off. The primary endpoint was the 6-month non progression rate. 20 patients were included (arm 1:15, arm 2:5). The two most frequent toxicities were grade 1 fatigue and fever and grade 2 fatigue and grade 2 lymphopenia in arms 1 and 2, respectively. In arm 1, 12 patients were assessable for the efficacy analysis. None of them were progression-free at 6 months indicating that the first stage of the Simon's design was not satisfied. One patient out 4 assessable for efficacy was progression-free at 6 months in arm 2. High throughput analysis of sequential plasma samples revealed an upregulation of protein biomarkers reflecting immune induction such as CXCL10 and soluble CD8 antigen in arm 1. Systemic treatment with JX-594 is safe in patients with advanced STS. Further investigations are needed to improve immune response to oncolytic viruses and define their therapeutic potential in patients with STS