886 research outputs found

    Estimating Brand Level Demand Elasticities and Measuring Market Power for Regular Carbonated Soft Drinks

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    This paper reports econometric estimation of brand level demand (AIDS) elasticities for regular carbonated soft drinks using Information Resources, Inc. panel data. Own and cross price elasticities are used to measure actual and hypothetical market power that would arise from potential mergers or collusive pricing arrangements.Demand and Price Analysis, Marketing,

    DNAReplication: a database of information and resources for the eukaryotic DNA replication community

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    DNAReplication (at http://www.dnareplication.net) has been set up as a freely available single resource to facilitate access to information on eukaryotic DNA replication. This database summarizes organism-sorted data on replication proteins in the categories of nomenclature, biochemical properties, motifs, interactions, modifications, structure, cell localization and expression, and general comments. Replication concepts are defined and a general model of the steps in DNA replication is presented. Links to relevant websites and homepages of replication labs are provided. The site also has an interactive section where links to recent replication papers are posted and readers are provided with the facility to post comments about each paper. The interactive and links pages are modified weekly and the whole site is updated annually

    Towards the development of the psychosocial impact of assistive devices scale for continence (C-PIADS)

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    BACKGROUND: Current outcome measures for continence management devices do not adequately address psychosocial impact. The PIADS is an assessment tool that has been shown to reliably predict the adoption and use of assistive technology devices, but it is not widely used for continence devices. OBJECTIVE: To explore whether the PIADS requires modification to address the particular needs of continence device users and to inform any subsequent item development. METHODS: The study used interpretive methods in which qualitative information from semi-structured interviews was combined with the findings from cognitive interviews for questionnaire pre-testing. A total of 40 participants in UK and Canada were interviewed. RESULTS: Few participants had difficulty in understanding or relating to the majority of PIADS items. Several items were not considered relevant to continence and some areas for potential new items were uncovered. Embarrassment and concealment of urinary incontinence from others were common topics. CONCLUSIONS: The PIADS appears to fundamentally address many, but not all, of the important psychosocial concerns of adults who have continence difficulties. A version for continence, the C-PIADS, will require modification of the PIADS and is likely to contain some new items

    Barriers and facilitators to overcoming mental block in springboard and highboard diving

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    Mental block can be a significant psychological challenge for many springboard and highboard divers. Consequently, this study investigated the barriers and facilitators to overcoming mental block in these performers. Three former elite divers engaged in reflective interviews to discuss their experiences of mental block. Four barriers (emotions, loss of control, poor coaching and physical sensations) and four facilitators (preparatory skills, team mates, good coaching and cognitive skills) emerged from analysed transcripts. Findings from the current study suggest a link to self-efficacy theory as a potential mediator of mental block in diving

    Melting as a String-Mediated Phase Transition

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    We present a theory of the melting of elemental solids as a dislocation-mediated phase transition. We model dislocations near melt as non-interacting closed strings on a lattice. In this framework we derive simple expressions for the melting temperature and latent heat of fusion that depend on the dislocation density at melt. We use experimental data for more than half the elements in the Periodic Table to determine the dislocation density from both relations. Melting temperatures yield a dislocation density of (0.61\pm 0.20) b^{-2}, in good agreement with the density obtained from latent heats, (0.66\pm 0.11) b^{-2}, where b is the length of the smallest perfect-dislocation Burgers vector. Melting corresponds to the situation where, on average, half of the atoms are within a dislocation core.Comment: 18 pages, LaTeX, 3 eps figures, to appear in Phys. Rev.

    A modified monomolecular film test for micro-quantities of lipids in foods

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    This bulletin is a report on Department of Poultry Husbandry research project 17, Egg Utilization--P. [3].Digitized 2007 AES.Includes bibliographical references (page 30)

    The effects of arthritis gloves on hand pain in people with rheumatoid or inflammatory arthritis : a randomised controlled trial (A-GLOVES TRIAL)

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    Background: Arthritis (compression) gloves are commonly provided to people with rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (IA) in the UK health service. These apply pressure and warmth to relieve hand pain, stiffness and improve hand function. A systematic review identified little evidence to support their use.[1] Objectives: This randomised controlled trial tested effectiveness and cost-effectiveness of mid-finger length compression (intervention) gloves (20% Lycra: commonest glove model provided) with control gloves (i.e. oedema gloves: 11% Lycra: fitted at least one size too big) in people with RA and IA. Methods: Both gloves, which had similar thermal qualities although the control gloves did not provide compression, were provided by rheumatology occupational therapists, following training.[2] Participants were also given brief advice on hand exercise and joint protection. Adults with RA/IA and persistent hand pain were randomised 1:1 to the two glove types, stratified by disease modifying anti-rheumatic drug (DMARD) change in previous 12 weeks. The primary outcome was dominant hand pain on activity Visual Analogue Scale (VAS:0–10); other outcomes included night hand pain, hand stiffness (both 0–10 VAS); Measure of Activity Performance Hand (MAP-HAND: 0–3). Multiple linear regression was undertaken to estimate the effect of group allocation on hand pain during activity, adjusting for the stratification variable and baseline values. Cost-effectiveness used individual patient level costs (intervention plus healthcare utilisation) and health benefit data (EQ-5D) to calculate costs and QALYs. Results: 206 participants were randomised (103 to each glove type): median age 59 years [IQR 51,67]; women:166 (81%); mean disease duration: 8.2 (SD 9.5) years; employed:76 (37%); right hand dominant:185 (90%). Of these, 163 (79%) completed 12 week follow-up questionnaires. Both groups reported similar adherence to glove wear (mean 5.2 days/week). At 12 w, hand pain scores in both groups similarly improved: the between-groups mean difference of 0.1 was not statistically significant (95% CI: −0.47 to 0.67; p=0.72). There were no significant differences between groups on any measures, with both groups improving similarly between baseline and 12 w. 73% in both groups considered gloves beneficial. Intervention gloves had higher costs (£552 (SD £464); control £391 (SD £543) but comparable benefits to control gloves. Intervention gloves would cost £83 700 to gain one QALY and were not likely to be cost-effective. Conclusions: Compression (intervention) and loose-fitting arthritis (control) gloves had similar effects on hand pain, stiffness and function. Therefore, compression is not the ‘active ingredient’ in arthritis gloves. Loose fitting gloves providing warmth were perceived as equally effective by participants. We do not know if the therapist effect is important or whether ordinary gloves providing warmth would provide similar results. References: Hammond, et al. Clin Rehabil 2016 30:213–24. Prior, et al. Rheumatology 2017. www.abstractsonline.com/pp8/#!/4205 Acknowledgements: This project was funded by the NIHR Research for Patient Benefit Programme (PB-PG-0214–33010). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health

    Left High and Dry: Deglaciation of Dogger Bank, North Sea, Recorded in Proglacial Lake Evolution

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    Reconstructions of palaeo-ice sheet retreat in response to climate warming using offshore archives can provide vital analogs for future ice-sheet behavior. At the Last Glacial Maximum, Dogger Bank, in the southern North Sea, was covered by the Eurasian Ice Sheet. However, the maximum extent and behavior of the ice sheet in the North Sea basin is poorly constrained. We reveal ice-marginal dynamics and maximum ice extent at Dogger Bank through sedimentological and stratigraphic investigation of glacial and proglacial lake sediments. We use a large, integrated subsurface dataset of shallow seismic reflection and geotechnical data collected during windfarm site investigation. For the first time, an ice stream is identified at Dogger Bank, based on preserved subglacial bedforms, eskers and meltwater channels. During ice-sheet advance, a terminal thrust-block moraine complex formed, whose crest runs approximately north-northeast to south-southwest. Subsequent ice stream shutdown caused stagnation of ice, and rapid retreat of the ice-sheet margin. The moraine complex, and outwash head from an adjacent ice-sheet lobe to the west, dammed a large (approximately 750 km2) proglacial lake. Subsequent sedimentation infilled the lake with 30 m of glacial outwash sediments. A lobate subaqueous fan formed at the ice-sheet margin, which thins toward the southeast with iceberg scours and ice-rafted debris at the base, and is onlapped by lake sediments calibrated to core as alternating clay and silt laminae, interpreted to be varves. The lake became isolated from the retreating ice-sheet margin, and ice-sheet retreat slowed. Sediment-laden meltwater was supplied to the ice-distal proglacial lake for c. 1500–2000 years. Subsequent ice-sheet retreat off Dogger Bank was more rapid due to the negative subglacial slope. The stepped retreat of rapid downwasting, slow retreat, and a final rapid phase off Dogger Bank occurred after the LGM at around 27 ka and before formation of a ribbon lake, dated previously to 23 ka and approximately 60 m lower in elevation, formed to the north of Dogger Bank. The complicated stratigraphic architecture revealed through these data improves forecasting of ground conditions for turbine footings at Dogger Bank, an important step in the provision of clean, sustainable energy
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