Multiple thermochronometers applied to the quantitative analysis of compressive systems: The southern sub-Andean fold and thrust belt of Bolivia: From source rock to trap

The evolution of fold and thrust belts requires time data restrictions to determine the rates related to the interaction of surface and subsurface processes and to quantify the time relationship between the components of the petroleum system: reservoir, seal, source rock and trap. The sub-Andean fold-and-thrust belt in the Bolivian territory in general, and the regional transect that links the structures of Curuyuqui-Carohuaicho-Tatarenda-Borebigua-Charagua and Mandeyapecua in particular, constitutes a complex multi-variable system in which the definition of time-Temperature (t-T) trajectories has led to new suitable structural and stratigraphic conclusions. The integration of multiple thermochronological-geochronological systems (Apatite Fission Track, Apatite (U-Th-Sm)/He and UPb SHRIMP on zircon) and the existing surface and subsurface geological constraints made it possible to develop a chrono-kinematic characterization of fault-related anticlines, defining their formation chronology, structural growth rate and link between them in the study area. Furthermore, it was also possible to perform a quantitative analysis of the subsidence-burial and exhumation-erosion phenomena that occurred from the deposition of Silurian-Devonian source rocks to the present time, providing relevant determinations to the modeling of the Oil & Gas system.Fil: Hernandez, Juan I.. Geomap S.a.; ArgentinaFil: Hernández, Roberto M.. Geomap S.a.; ArgentinaFil: Dalenz Farjat, Alejandra. Geomap S.a.; ArgentinaFil: Cristallini, Ernesto Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología. Laboratorio de Modelado Geológico; ArgentinaFil: Alvarez, Luis A.. Geomap S.a.; ArgentinaFil: Dellmans, Luis M.. Geomap S.a.; ArgentinaFil: Costilla, Marcos Roberto. Geomap S.a.; ArgentinaFil: Alvarez, Andres F.. Geomap S.a.; ArgentinaFil: Becchio, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Bordese, Sofia. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Arzadún, Guadalupe. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guibaldo, Cristina. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Glasmacher, Ulrich A.. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Tomezzoli, Renata Nela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Stockli, Daniel F.. University of Texas; Estados UnidosFil: Fuentes, Facundo. YPF - Tecnología; ArgentinaFil: Soria Galvarro, Jaime. YPF - Tecnología; ArgentinaFil: Rosales, Adolfo. YPF - Tecnología; ArgentinaFil: Dzelalija, Francisco. YPF - Tecnología; ArgentinaFil: Haring, Claudio. YPF - Tecnología; Argentin

Both moderate and severe exacerbations accelerate physical activity decline in COPD patients

Physical activity (PA) is a relevant outcome measure in chronic obstructive pulmonary disease (COPD). Low PA is prevalent and drives prognosis [1]. Unfortunately, the determinants of PA and its change over time are poorly understood [1]. The fact that the PA progressively declines over time along with worsening of lung function and health status [2] suggests that the PA decline could be due to the progression of the disease and specifically to acute exacerbations [3]. An acute reduction in PA at the onset has been reported both in severe exacerbations requiring a hospitalisation [4] and in ambulatory treated exacerbations [5, 6]. A sustained PA reduction has been shown 1 month after hospital discharge [4] whereas PA almost returns to stable levels after community-treated exacerbations [6]. One study found faster PA decline in patients with a history of two or more exacerbations in the 12 months prior to the study [5]. This analysis did not adjust for confounders of the association (e.g. airflow obstruction, symptom burden) or external variables influencing PA (e.g. climate). It could also be argued that the greater decline in PA was due to lower health status at baseline. Although PA is an important outcome for COPD patients, little is known about the role of exacerbations in patients' experience of PA. Importantly, both the amount of activity and difficulties experienced during activity are integral to the concept of PA limitation [7]. The aim of the present analysis was to assess the association between the number and severity of exacerbations and changes in PA and PA experience