MiR675-5p acts on HIF-1α to sustain hypoxic responses: A new therapeutic strategy for glioma

Hypoxia is a common feature in solid tumours. In glioma, it is considered the major driving force for tumour angiogenesis and correlates with enhanced resistance to conventional therapies, increased invasiveness and a poor prognosis for patients. Here we describe, for the first time, that miR675-5p, embedded in hypoxia-induced long non-coding RNA H19, plays a mandatory role in establishing a hypoxic response and in promoting hypoxia-mediated angiogenesis. We demonstrated, in vitro and in vivo, that miR675-5p over expression in normoxia is sufficient to induce a hypoxic moreover, miR675-5p depletion in low oxygen conditions, drastically abolishes hypoxic responses including angiogenesis. In addition, our data indicate an interaction of miR675-5p, HIF-1α mRNA and the RNA Binding Protein HuR in hypoxia-induced responses. We suggest the modulation of miR675-5p as a new therapeutic option to promote or abolish hypoxia induced angiogenesis

Application of Multifractal Measures to Tehran Price Index

We report an empirical study of Tehran Price Index (TEPIX). To analyze our data we use various methods like as, rescaled range analysis ($R/S$), modified rescaled range analysis (Lo's method), Detrended Fluctuation Analysis (DFA) and generalized Hurst exponents analysis. Based on numerical results, the scaling range of TEPIX returns is specified, long memory effect or long range correlation property in this market is investigated, characteristic exponent for probability distribution function of TEPIX returns is derived and finally the stage of development in Tehran Stock Exchange is determined.Comment: 19 pages, 6 figure

Effect of different stunning methods of pigs on subcutaneous veining defect and meat quality of raw ham

Trecentocinque suini pesanti sono stati sottoposti a stordimento elettrico (146 soggetti) o con CO2 (159 soggetti) per valutare l’effetto del metodo di stordimento sull’incidenza del difetto di venatura delle cosce, sul valore del pH, sul colore dei muscoli SM e BF e su alcuni parametri ematici. Nei suini sottoposti a stordimento con CO2 si è osservata una più alta percentuale di cosce con il difetto di venatura e valori più elevati di HCT, PT e PTT. I suini storditi mediante elettronarcosi hanno presentato un pH1 più basso e un colore più chiaro nel SM

First AUV and ROV investigation of seismogenic faults in the Alboran Sea (Western Meditarranean)

In May-June 2015 we carried out the SHAKE cruise on board the RV “Sarmiento de Gamboa” the first in situ investigation using state-of-the-art underwater vehicles, the AUVs “AsterX” and “IdefX” (IFREMER, France) and the ROV “Max Rover” (HCMR, Greece). Here we present how these vehicles helped us to achieve our main goals to survey active seismogenic faults and associated structures of the Eastern Alboran Sea (Western Mediterranean).Peer Reviewe

Forecasting for Network Management with Joint Statistical Modelling and Machine Learning

Forecasting is a task of ever increasing importance for the operation of mobile networks, where it supports anticipa tory decisions by network intelligence and enables emerging zero touch service and network management models. While current trends in forecasting for anticipatory networking lean towards the systematic adoption of models that are purely based on deep learning approaches, we pave the way for a different strategy to the design of predictors for mobile network environments. Specifically, following recent advances in time series prediction, we consider a hybrid approach that blends statistical modelling and machine learning by means of a joint training process of the two methods. By tailoring this mixed forecasting engine to the specific requirements of network traffic demands, we develop a Thresholded Exponential Smoothing and Recurrent Neural Network (TES-RNN) model. We experiment with TES RNN in two practical network management use cases, i.e., (i) anticipatory allocation of network resources, and (ii) mobile traffic anomaly prediction. Results obtained with extensive traffic workloads collected in an operational mobile network show that TES-RNN can yield substantial performance gains over current state-of-the-art predictors in both applications consideredThis work is partially supported by the European Union's Horizon 2020 research and innovation programme under grant agreement no.101017109 DAEMON. This work is partially supported by the Spanish Ministry of Economic Affairs and Digital Transformation and the European Union-NextGenerationEU through the UNICO 5G I+D 6GCLARION-OR and AEON-ZERO. The authors would like to thank Dario Bega for his contribution to developing the forecasting use case I, and Slawek Smyl for his feedback on the baseline ES-RNN model

The Spin-Statistics Connection in Quantum Gravity

It is well-known that is spite of sharing some properties with conventional particles, topological geons in general violate the spin-statistics theorem. On the other hand, it is generally believed that in quantum gravity theories allowing for topology change, using pair creation and annihilation of geons, one should be able to recover this theorem. In this paper, we take an alternative route, and use an algebraic formalism developed in previous work. We give a description of topological geons where an algebra of "observables" is identified and quantized. Different irreducible representations of this algebra correspond to different kinds of geons, and are labeled by a non-abelian "charge" and "magnetic flux". We then find that the usual spin-statistics theorem is indeed violated, but a new spin-statistics relation arises, when we assume that the fluxes are superselected. This assumption can be proved if all observables are local, as is generally the case in physical theories. Finally, we also show how our approach fits into conventional formulations of quantum gravity.Comment: LaTeX file, 31 pages, 5 figure

Anomalous behavior of the Debye temperature in Fe-rich Fe-Cr alloys

Debye temperature, $\Theta_D$, of Fe-rich Fe$_{100-x}$Cr$_x$ disordered alloys with $0\le x \le 22.3$ was determined from the temperature dependence of the central shift of M\"ossbauer spectra recorded in the temperature range of 60 -- 300 K. Its compositional dependence shows a maximum at $x \approx 5$ with a relative increase of $\sim 30$% compared to a pure iron. The composition at which the effect occurs correlates well with that at which several other quantities, e. g. the Curie temperature and the spin-wave stiffness coefficient, $D_0$, show their maxima, but the enhancement of $\Theta_D$ is significantly greater and comparable with the enhancement of the hyperfine field (spin-density of itinerant $s$-like electrons) in the studied system. The results suggest that the electron-phonon interaction is important in this alloy system