Les-Eyzies-de-Tayac-Sireuil – Laugerie-Basse, abri des Marseilles

L’opération archéologique réalisée sur l’abri des Marseilles, à Laugerie-Basse, fait partie d’un projet plus large, financé par le gouvernement australien : Fortytwo degrees of latitude: Comparative archaeologies of southwest Tasmania and southwest France during the last Ice Age. Son objectif est d’étudier les stratégies de comportement et d’adaptation de chasseurs-cueilleurs du Paléolithique, lors de variations climatiques extrêmes, par la comparaison de deux contextes parfaitement séparés. ..

Population size does not explain past changes in cultural complexity

Acknowledgments We thank three anonymous reviewers and our PNAS editor, James O'Connell, for their generous feedback on earlier versions of this manuscript. K.V. acknowledges support from The Netherlands Organisation for Scientific Research (VIDI Grant 016.144312). M.C. is supported by the Social Sciences and Humanities Research of Canada, the Canada Research Chairs Program, the Canada Foundation for Innovation, the British Columbia Knowledge Development Fund, and Simon Fraser University. R.C. and W.R. acknowledge support from the Australian Research Council (Discovery Grant DP120100580).Peer reviewedPublisher PD

Managing Water under Uncertainty and Risk: The United Nations World Water Development Report 4

This report introduces new aspects of water issues: 1) it reintroduces the 12 challenge area reports that provided the foundation for the first two World Water Development Reports (WWDR); 2) 4 new reports on water quality, groundwater, gender, and desertification, land degradation and drought; 3) in recognition that the global challenges of water can vary considerably across countries and regions, a series of 5 regional reports have been included; 4) a deeper analysis of the main external forces of freshwater resources and possibilities for their future evolution; 5) managing water under uncertainty and risk

Recent Decisions

Comments on recent decisions by Edward J. Flattery, John E. Cosgrove, Thomas Broden, Richard H. Keen, and Ralph L. Fenderson, Jr

“An Institution Can Have Good Intentions and Still Be Atrocious : Transgender and Gender Expansive Experiences in Social Work Education

Educational settings have been found to be challenging arenas for transgender and gender expansive (TGE) youth and young adults due to misgendering, lack of affirming bathrooms, systemic exclusion (e.g., legal names and lack of inclusive gender identity demographic options), and frequent silence or avoidance related to TGE issues. Though studies of TGE adult experiences in higher education are emerging, most explore disaffirming experiences. Social work education focuses on diversity, equity, and inclusion, along with how to promote social justice, which suggests more affirming environments for TGE individuals. However, little is known about the experiences of TGE students and even less about faculty in social work education. To help fill this gap, the researchers interviewed 23 TGE social work students and faculty to explore their experiences of gender-related affirmation and challenges in social work educational programs. The findings from a thematic analysis identified examples of affirming and disaffirming experiences and recommendations for improving gender affirmation and inclusion in social work programs. Social work is in a strategic position to serve the needs and impact the social welfare of TGE individuals, starting with educational settings

T-Lymphocyte Activation is Not Affected by the Mobilization of Senescent T-Cells into the Peripheral Blood Following an Acute Bout of Exercise

It is well recognized that individuals are at an increased risk of illness following an arduous exercise regime. Exercise may affect activation status of cells and play a pivotal role in defense against pathogenic invasion. CD69 is the earliest known expressed cell surface antigen of T-cell activation and is a reliable marker of cell activation status (Green et al. Med. Sci. Sports Exerc. 35, 582-588: 2003). Exercise is known to alter the frequency of senescent cells in the blood expressing the cell surface glycoprotein killer cell lectin-like receptor G1 (KLRG1), and are antigen-experienced and unable to clonally expand upon further antigenic stimulation (Simpson et al. J. Appl. Phys. 103, 396-401:2007), PURPOSE: To examine the contribution of senescent T-cells mobilized by exercise on the overall activation status of the peripheral blood T-cell pool following an acute bout of exercise. METHODS: Ten moderately trained males (age: 24.6 ± 4.8; height: 183.1 ± 6.7cm; mass: 72.8 ± 7.9kg; ; 61.3 ± 5.9 ml.kg-1.min-1) ran at speeds corresponding to 80% until volitional exhaustion (time: 36.1 ± 5.8 minutes). Blood lymphocytes isolated before (PRE), immediately after (POST) and 1 hour after (1HrPOST) exercise were stimulated for 4 hours in culture with and without the mitogen PMA and assessed for KLRG1 and CD69 expression and co-expression on CD3+, CD3+/CD4+ (CD4+) and CD3+/CD8+ (CD8+) lymphocyte subsets using 4-colour flow cytometry. RESULTS: No changes in CD69 GMFI were observed on total CD3+, CD4+ and CD8+ T-cells POST or 1HrPOST exercise. The proportions of KLRG1+ cells among the total CD3+, CD4+ and CD8+ T-cell populations increased by 172%, 107% and 169% respectively POST exercise and fell below baseline values 1h later (p\u3c0.05). At all sample time points, CD69 GMFI was greater on stimulated KLRG1+ T-cells compared to KLRG1- cells (p\u3c0.05). CONCLUSION: We conclude that exercise does not affect the activation status of the total T-cell pool. Instead, the number of senescent cells expressing CD69 is greater than those that are not senescent at all times. This suggests that upon pathogenic invasion post-exercise

Health and Economic Impact of Surgical Site Infections Diagnosed after Hospital Discharge

Although surgical site infections (SSIs) are known to cause substantial illness and costs during the index hospitalization, little information exists about the impact of infections diagnosed after discharge, which constitute the majority of SSIs. In this study, using patient questionnaire and administrative databases, we assessed the clinical outcomes and resource utilization in the 8-week postoperative period associated with SSIs recognized after discharge. SSI recognized after discharge was confirmed in 89 (1.9%) of 4,571 procedures from May 1997 to October 1998. Patients with SSI, but not controls, had a significant decline in SF-12 (Medical Outcomes Study 12-Item Short-Form Health Survey) mental health component scores after surgery (p=0.004). Patients required significantly more outpatient visits, emergency room visits, radiology services, readmissions, and home health aide services than did controls. Average total costs during the 8 weeks after discharge were US$5,155 for patients with SSI and$1,773 for controls (p<0.001)