1,008 research outputs found

    SmartPark

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    Language and Cultural Learning Through Student-Generated Photography

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    This paper discusses the need for including a strong cultural awareness and instruction component in the curriculum of Communication classes for Japanese students at university. Important training in cultural awareness skills is sometimes lacking in classes or only lightly covered with short reading sections on selected cultural topics. Paying inadequate attention to this essential element of language learning can greatly hinder students in their desire for effective communication with native speakers. This paper presents a brief synopsis and explanation of a course taught in the English 1 Communication Course at Kansai University. The aim of this course is to develop linguistic competence in conjunction with cultural competence through the use of student-generated photographs of their own culture

    Long-term trends in modal share for urban passenger travel

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    Institute of Transport and Logistics Studies. Faculty of Economics and Business. The University of Sydne

    Language and Cultural Learning Through Student Generated Photography

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    This paper examines and discusses the unique teaching context and the inherent problems faced by foreign English teachers in the Japanese University System. It contains a personal account of the process the author went through to develop a new and interesting curriculum to overcome these problems. This curriculum is based on student-generated photographs of their lives and is an effective method of both language learning and culture learning. Included in the paper is a step-by-step course description of twenty-four lesson plans based on the photographs

    Long-term patterns of Australian public transport use

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    The last few years have seen substantial rises in passenger numbers across many Australian public transit systems, partially due to periods of higher than average fuel prices and to various infrastructure expansions. To properly assess the likely scope for any future changes in patronage levels, across the various urban passenger modes, a sound knowledge of what has happened over time, in urban transport patterns, can be of significant value. This paper presents long-term time-series for the usage patterns of Urban Public Transport (UPT) – compiled for each of the Australian capital cities, and covering a period of more than a century (1900 to 2010). Such long-term historical estimates demonstrate how radically the share of total urban travel due to UPT has changed over time – with public transit dominant through the early part of last century, and still accounting for more than half of total urban passenger-kilometres up till around 1950, before gradually losing market share with the growing popularity of private car travel (resulting in close to 90 per cent of current urban travel being done in light motor vehicles and about 10 per cent by rail, bus and ferry). Long-term trends in patronage levels (both total and per capita) are given for the various UPT modes, along with aggregate modal share patterns across the Australian capital cities

    Stationkeeping of the First Earth-Moon Libration Orbiters: The ARTEMIS Mission

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    Libration point orbits near collinear locations are inherently unstable and must be controlled. For Acceleration Reconnection and Turbulence and Electrodynamics of the Moon's Interaction with the Sun (ARTEMIS) Earth-Moon Lissajous orbit operations, stationkeeping is challenging because of short time scales, large orbital eccentricity of the secondary, and solar gravitational and radiation pressure perturbations. ARTEMIS is the first NASA mission continuously controlled at both Earth-Moon L1 and L2 locations and uses a balance of optimization, spacecraft implementation and constraints, and multi-body dynamics. Stationkeeping results are compared to pre-mission research including mode directions

    Improving Simulated Soil Moisture Fields Through Assimilation of AMSR-E Soil Moisture Retrievals with an Ensemble Kalman Filter and a Mass Conservation Constraint

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    Model simulated soil moisture fields are often biased due to errors in input parameters and deficiencies in model physics. Satellite derived soil moisture estimates, if retrieved appropriately, represent the spatial mean of soil moisture in a footprint area, and can be used to reduce model bias (at locations near the surface) through data assimilation techniques. While assimilating the retrievals can reduce model bias, it can also destroy the mass balance enforced by the model governing equation because water is removed from or added to the soil by the assimilation algorithm. In addition, studies have shown that assimilation of surface observations can adversely impact soil moisture estimates in the lower soil layers due to imperfect model physics, even though the bias near the surface is decreased. In this study, an ensemble Kalman filter (EnKF) with a mass conservation updating scheme was developed to assimilate the actual value of Advanced Microwave Scanning Radiometer (AMSR-E) soil moisture retrievals to improve the mean of simulated soil moisture fields by the Noah land surface model. Assimilation results using the conventional and the mass conservation updating scheme in the Little Washita watershed of Oklahoma showed that, while both updating schemes reduced the bias in the shallow root zone, the mass conservation scheme provided better estimates in the deeper profile. The mass conservation scheme also yielded physically consistent estimates of fluxes and maintained the water budget. Impacts of model physics on the assimilation results are discussed

    Accelerated return to sport after osteochondral autograft plug transfer

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    Background:Previous studies have reported varying return-to-sport protocols after knee cartilage restoration procedures.Purpose:To (1) evaluate the time for return to sport in athletes with an isolated chondral injury who underwent an accelerated return-to-sport protocol after osteochondral autograft plug transfer (OAT) and (2) evaluate clinical outcomes to assess for any consequences from the accelerated return to sport.Study Design:Case series; Level of evidence, 4.Methods:An institutional cohort of 152 OAT procedures was reviewed, of which 20 competitive athletes met inclusion and exclusion criteria. All patients underwent a physician-directed accelerated rehabilitation program after their procedure. Return to sport was determined for all athletes. Clinical outcomes were assessed using International Knee Documentation Committee (IKDC) and Tegner scores as well as assessment of level of participation on return to sport.Results:Return-to-sport data were available for all 20 athletes; 13 of 20 athletes (65%) were available for clinical evaluation at a mean 4.4-year follow-up. The mean time for return to sport for all 20 athletes was 82.9 ± 25 days (range, 38-134 days). All athletes were able to return to sport at their previous level and reported that they were satisfied or very satisfied with their surgical outcome and ability to return to sport. The mean postoperative IKDC score was 84.5 ± 9.5. The mean Tegner score prior to injury was 8.9 ± 1.7; it was 7.7 ± 1.9 at final follow-up.Conclusion:Competitive athletes with traumatic chondral defects treated with OAT managed using this protocol had reduced time to preinjury activity levels compared with what is currently reported, with excellent clinical outcomes and no serious long-term sequelae.</jats:sec

    Combined Remote Sensing and Field Investigations of Hydrocarbon Trap Analogue Structures: Examples from the Zagros Simply Folded Belt, Iran and the Sawtooth Range, Montana [ABSTRACT]

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    First paragraph of abstract: Structures that outcrop at the surface in fold-thrust belts are frequently good analogues for hydrocarbon traps in compressional environments. Along-strike changes in structure and geometry have important implications for connectivity and fluid flow throughout the petroleum system, e.g. in the Zagros Simply Folded Belt, Iran, and in a surface reservoir analogue in the Sawtooth Range, Montana

    Quantitative analysis of cytokine-induced hepatocellular death in the context of hepatotoxic therapeutics

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    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2009."February 2009." Cataloged from PDF version of thesis.Includes bibliographical references (p. 161-178).Numerous therapeutics, such as viral gene therapy vectors, have unintended toxicity in part due to interactions with inflammatory cytokine signaling to elicit hepatocyte death, thus limiting their clinical use. Although much is known about how cytokines and certain therapeutics individually induce hepatotoxicity, there is little understanding of how they jointly regulate the complex cellular signaling network governing hepatocellular death. In this thesis, we explored the signaling mechanisms governing the cytokine-induced hepatocellular death in the context of adenoviral vector (Adv) infection and pharmaceutical compounds with idiosyncratic hepatotoxicity. Initially, we examined the role of autocrine and intracellular signaling pathways in governing the synergistic induction of hepatocyte apoptosis by the cytokine tumor necrosis factor-a (TNF) in the presence of Adv infection in a primary rat hepatocyte cell culture model. We demonstrated that Adv/TNF-induced hepatocyte apoptosis is regulated by a coupled and self-antagonizing autocrine signaling cascade involving the sequential release of anti-apoptotic transforming growth factor-a (TGF-a), pro-apoptotic interleukin- 1 a/p (IL-l a/), and anti-apoptotic IL- 1 receptor antagonist (IL- Ira). This three-part autocrine cascade regulates multiple intracellular signal pathways, including ERK and JNK, that serve to integrate TNF- and Adv-induced signals and govern the resultant hepatocellular death response. Following this, we demonstrated that numerous idiosyncratic hepatotoxins, whose hepatotoxicities are not evident in standard cell preclinical screening models, elicit synergistic induction of hepatocellular death upon multi-cytokine co-stimulation in primary rat and human hepatocyte cell culture models. We showed that this drugcytokine co-treatment model could be usefully scaled to the high-throughput demands of pharmaceutical screening while maintaining idiosyncratic hepatotoxicity prediction accuracy. To identify the signaling mechanisms regulating these drug/cytokine hepatocellular death synergies, we collected multi-pathway signal-response data compendia from two human hepatocyte donors. Through the use of partial least-squares regression modeling, we showed that hepatocytes integrate signals from four pathways -- ERK, Akt, mTOR, and p38 -- to specify their cell death responses to toxic drug/cytokine conditions and that accurate prediction of hepatocellular death responses can be made across human hepatocyte donors. Together, these findings demonstrate that cytokine-induced hepatocellular death in the context of hepatotoxic therapeutics is governed by integrated network activity of multiple autocrine and intracellular signaling pathways.by Benjamin D. Cosgrove.Ph.D
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