The Nature of the Peculiar Virgo Cluster Galaxies NGC 4064 and NGC 4424

We present a detailed study of the peculiar HI-deficient Virgo cluster spiral galaxies NGC 4064 and NGC 4424, using $^{12}$CO 1-0 interferometry, optical imaging and integral-field spectroscopic observations, in order to learn what type of environmental interactions have afected these galaxies. Optical imaging reveals that NGC 4424 has a strongly disturbed stellar disk, with banana-shaped isophotes and shells. NGC 4064, which lies in the cluster outskirts, possesses a relatively undisturbed outer stellar disk and a central bar. In both galaxies H-alpha emission is confined to the central kiloparsec. CO observations reveal bilobal molecular gas morphologies, with H-alpha emission peaking inside the CO lobes, implying a time sequence in the star formation process.Gas kinematics reveals strong bar-like non-circular motions in the molecular gas in both galaxies, suggesting that the material is radially infalling. In NGC 4064 the stellar kinematics reveal strong bar-like non-circular motions in the central 1 kpc. On the other hand, NGC 4424 has extremely modest stellar rotation velocities (Vmax ~ 30 km s-1), and stars are supported by random motions as far out as we can measure it. The observations suggest that the peculiarities of NGC 4424 are the result of an intermediate-mass merger plus ram pressure stripping. In the case of NGC 4064, the evidence suggests an already stripped "truncated/normal" galaxy that recently suffered a minor merger or tidal interaction with another galaxy. We propose that galaxies with "truncated/compact" H-alpha morphologies such as these are the result of the independent effects of ram pressure stripping, which removes gas from the outer disk, and gravitational interactions such as mergers, which heat stellar disks, drive gas to the central kpc and increase the central mass concentrations.Comment: 42 pages, 21 figure

Kinematics of a globular cluster with an extended profile: NGC5694

We present a study of the kinematics of the remote globular cluster NGC5694 based on GIRAFFE@VLT medium resolution spectra. A sample of 165 individual stars selected to lie on the Red Giant Branch in the cluster Color Magnitude Diagram was considered. Using radial velocity and metallicity from Calcium triplet, we were able to select 83 bona-fide cluster members. The addition of six previously known members leads to a total sample of 89 cluster giants with typical uncertainties <1.0 km/s in their radial velocity estimates. The sample covers a wide range of projected distances from the cluster center, from ~0.2 arcmin to 6.5 arcmin = 23 half-light radii (r_h). We find only very weak rotation, as typical of metal-poor globular clusters. The velocity dispersion gently declines from a central value of sigma=6.1 km/s to sigma = 2.5 km/s at ~2 arcmin = 7.1= r_h, then it remainins flat out to the next (and last) measured point of the dispersion profile, at ~4 arcmin = 14.0 r_h, at odds with the predictions of isotropic King models. We show that both isotropic single-mass non-collisional models and multi-mass anisotropic models can reproduce the observed surface brightness and velocity dispersion profiles.Comment: Accepted for publication by MNRAS. Pdflatex, 10 pages, 10 figure

Submillimetre dust polarisation and opacity in the HD163296 protoplanetary ring system

We present ALMA images of the sub-mm continuum polarisation and spectral index of the protoplanetary ringed disk HD163296. The polarisation fraction at 870{\mu}m is measured to be ~0.9% in the central core and generally increases with radius along the disk major axis. It peaks in the gaps between the dust rings, and the largest value (~4%) is found between rings 1 and 2. The polarisation vectors are aligned with the disk minor axis in the central core, but become more azimuthal in the gaps, twisting by up to +/-9degrees in the gap between rings 1 and 2. These general characteristics are consistent with a model of self-scattered radiation in the ringed structure, without requiring an additional dust alignment mechanism. The 870/1300{\mu}m dust spectral index exhibits minima in the centre and the inner rings, suggesting these regions have high optical depths. However, further refinement of the dust or the disk model at higher resolution is needed to reproduce simultaneously the observed degree of polarisation and the low spectral index.Comment: 5 pages +2 pages supplemental data. v2 - revised figures and final values; conclusions unchange

ALMA Science Verification Data: Millimeter Continuum Polarimetry of the Bright Radio Quasar 3C 286

We present full-polarization observations of the compact, steep-spectrum radio quasar 3C~286 made with the ALMA at 1.3~mm. These are the first full-polarization ALMA observations, which were obtained in the framework of Science Verification. A bright core and a south-west component are detected in the total intensity image, similar to previous centimeter images. Polarized emission is also detected toward both components. The fractional polarization of the core is about 17\%, this is higher than the fractional polarization at centimeter wavelengths, suggesting that the magnetic field is even more ordered in the millimeter radio core than it is further downstream in the jet. The observed polarization position angle (or EVPA) in the core is $\sim$\,$39^{\circ}$, which confirms the trend that the EVPA slowly increases from centimeter to millimeter wavelengths. With the aid of multi-frequency VLBI observations, we argue that this EVPA change is associated with the frequency-dependent core position. We also report a serendipitous detection of a sub-mJy source in the field of view, which is likely to be a submillimeter galaxy.Comment: 10 pages, 9 figures, Accepted for publication in the Ap

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia.

Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or resistance. While generally well tolerated, dasatinib has been associated with a higher risk for pleural effusions. Frequency, risk factors, and outcomes associated with pleural effusion were assessed in two phase 3 trials (DASISION and 034/Dose-optimization) and a pooled population of 11 trials that evaluated patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib (including DASISION and 034/Dose-optimization). In this largest assessment of patients across the dasatinib clinical trial program (N=2712), pleural effusion developed in 6-9% of patients at risk annually in DASISION, and in 5-15% of patients at risk annually in 034/Dose-optimization. With a minimum follow up of 5 and 7 years, drug-related pleural effusion occurred in 28% of patients in DASISION and in 33% of patients in 034/Dose-optimization, respectively. A significant risk factor identified for developing pleural effusion by a multivariate analysis was age. We found that overall responses to dasatinib, progression-free survival, and overall survival were similar in patients who developed pleural effusion and in patients who did not. clinicaltrials.gov identifier 00481247; 00123474

PADAMOT : project overview report

Background and relevance to radioactive waste management International consensus confirms that placing radioactive wastes and spent nuclear fuel deep underground in a geological repository is the generally preferred option for their long-term management and disposal. This strategy provides a number of advantages compared to leaving it on or near the Earth’s surface. These advantages come about because, for a well chosen site, the geosphere can provide: • a physical barrier that can negate or buffer against the effects of surface dominated natural disruptive processes such as deep weathering, glaciation, river and marine erosion or flooding, asteroid/comet impact and earthquake shaking etc. • long and slow groundwater return pathways from the facility to the biosphere along which retardation, dilution and dispersion processes may operate to reduce radionuclide concentration in the groundwater. • a stable, and benign geochemical environment to maximise the longevity of the engineered barriers such as the waste containers and backfill in the facility. • a natural radiation shield around the wastes. • a mechanically stable environment in which the facility can be constructed and will afterwards be protected. • an environment which reduces the likelihood of the repository being disturbed by inadvertent human intrusion such as land use changes, construction projects, drilling, quarrying and mining etc. • protection against the effects of deliberate human activities such as vandalism, terrorism and war etc. However, safety considerations for storing and disposing of long-lived radioactive wastes must take into account various scenarios that might affect the ability of the geosphere to provide the functionality listed above. Therefore, in order to provide confidence in the ability of a repository to perform within the deep geological setting at a particular site, a demonstration of geosphere “stability” needs to be made. Stability is defined here to be the capacity of a geological and hydrogeological system to minimise the impact of external influences on the repository environment, or at least to account for them in a manner that would allow their impacts to be evaluated and accounted for in any safety assessments. A repository should be sited where the deep geosphere is a stable host in which the engineered containment can continue to perform according to design and in which the surrounding hydrogeological, geomechanical and geochemical environment will continue to operate as a natural barrier to radionuclide movement towards the biosphere. However, over the long periods of time during which long-lived radioactive wastes will pose a hazard, environmental change at the surface has the potential to disrupt the stability of the geosphere and therefore the causes of environmental change and their potential consequences need to be evaluated. As noted above, environmental change can include processes such as deep weathering, glaciation, river and marine erosion. It can also lead to changes in groundwater boundary conditions through alternating recharge/discharge relationships. One of the key drivers for environmental change is climate variability. The question then arises, how can geosphere stability be assessed with respect to changes in climate? Key issues raised in connection with this are: • What evidence is there that 'going underground' eliminates the extreme conditions that storage on the surface would be subjected to in the long term? • How can the additional stability and safety of the deep geosphere be demonstrated with evidence from the natural system? As a corollary to this, the capacity of repository sites deep underground in stable rock masses to mitigate potential impacts of future climate change on groundwater conditions therefore needs to be tested and demonstrated. To date, generic scenarios for groundwater evolution relating to climate change are currently weakly constrained by data and process understanding. Hence, the possibility of site-specific changes of groundwater conditions in the future can only be assessed and demonstrated by studying groundwater evolution in the past. Stability of groundwater conditions in the past is an indication of future stability, though both the climatic and geological contexts must be taken into account in making such an assertion

J/psi Spin Asymmetries in the Colour-Octet Model

We investigate the pattern of asymmetries in the colour-octet model for inclusive production of charmonium with polarised initial state hadrons and photons. We find that singly polarised asymmetries vanish. The double polarised asymmetry for J/psi involves a new combination of long-distance matrix element. We also investigate the asymmetries for eta_c, chi_c and Upsilon production. The asymmetries distinguish well between different models of charmonium production.Comment: LaTeX source, 18 page

Dynactin-dependent cortical dynein and spherical spindle shape correlate temporally with meiotic spindle rotation in Caenorhabditis elegans.

Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the perpendicular orientation. To understand the mechanism of spindle rotation, we characterized events that correlated temporally with rotation, including shortening of the spindle in the pole-to pole axis, which resulted in a nearly spherical spindle at rotation. By analyzing large spindles of polyploid C. elegans and a related nematode species, we found that spindle rotation initiated at a defined spherical shape rather than at a defined spindle length. In addition, dynein accumulated on the cortex just before rotation, and microtubules grew from the spindle with plus ends outward during rotation. Dynactin depletion prevented accumulation of dynein on the cortex and prevented spindle rotation independently of effects on spindle shape. These results support a cortical pulling model in which spindle shape might facilitate rotation because a sphere can rotate without deforming the adjacent elastic cytoplasm. We also present evidence that activation of spindle rotation is promoted by dephosphorylation of the basic domain of p150 dynactin