Perception of epidemic's related anxiety in the General French Population: a cross-sectional study in the Rhône-Alpes region

International audienceBackgroundTo efficiently plan appropriate public health interventions during possible epidemics, governments must take into consideration the following factors about the general population: their knowledge of epidemics, their fears of and psychological responses to them, their level of compliance with government measures and their communities' trusted sources of information. However, such surveys among the French general population are rare.MethodsA cross-sectional study was conducted in 2006 in a representative sample of 600 subjects living in the Rhône-Alpes region (south-east France) to investigate self-reported knowledge about infectious diseases and anxiety generated by epidemic risk with particular reference to avian influenza. Data on reactions to potentially new epidemics and the confidence level in various sources of information were also collected.ResultsRespondents were most knowledgeable about AIDS, followed by avian influenza. Overall, 75% of respondents had adequate knowledge of avian influenza. The percentage was even higher (88%) among inhabitants of the Ain district, where an avian influenza epidemic had previously been reported. However, 39% expressed anxiety about this disease. In total, 20% of respondents with knowledge about avian influenza stated that they had changed their behaviours during the epizooty. Epidemics were perceived as a real threat by 27% of respondents. In the event of a highly contagious outbreak, the majority of respondents said they would follow the advice given by authorities. The study population expressed a high level of confidence in physicians and scientists, but had strong reservations about politicians, deputies and the media.ConclusionsAlthough the survey was conducted only four months after the avian influenza outbreak, epidemics were not perceived as a major threat by the study population. The results showed that in the event of a highly infectious disease, the population would comply with advice given by public authorities

Professional Exposure to Goats Increases the Risk of Pneumonic-Type Lung Adenocarcinoma: Results of the IFCT-0504-Epidemio Study

Pneumonic-type lung adenocarcinoma (P-ADC) represents a distinct subset of lung cancer with specific clinical, radiological, and pathological features. Given the weak association with tobacco-smoking and the striking similarities with jaagsiekte sheep retrovirus (JSRV)-induced ovine pulmonary adenocarcinoma, it has been suggested that a zoonotic viral agent infecting pulmonary cells may predispose to P-ADC in humans. Our objective was to explore whether exposure to domestic small ruminants may represent a risk factor for P-ADC. We performed a multicenter case-control study recruiting patients with P-ADC as cases and patients with non-P-ADC non-small cell lung cancer as controls. A dedicated 356-item questionnaire was built to evaluate exposure to livestock. A total of 44 cases and 132 controls were included. At multivariate analysis, P-ADC was significantly more associated with female gender (Odds-ratio (OR) = 3.23, 95% confidence interval (CI): 1.32–7.87, p = 0.010), never- smoker status (OR = 3.57, 95% CI: 1.27–10.00, p = 0.015), personal history of extra-thoracic cancer before P-ADC diagnosis (OR = 3.43, 95% CI: 1.10–10.72, p = 0.034), and professional exposure to goats (OR = 5.09, 95% CI: 1.05–24.69, p = 0.043), as compared to other subtypes of lung cancer. This case-control suggests a link between professional exposure to goats and P-ADC, and prompts for further epidemiological evaluation of potential environmental risk factors for P-ADC

Diabetes as a risk factor for herpes zoster in adults: A synthetic literature review

International audienc

Evaluation of adult dTPaP vaccination coverage in France: experience in Lyon city, 2010-2011.

International audienceBACKGROUND: Compliance with official recommendations can be assessed by evaluating vaccination coverage (VC) in populations. The main objective of our study was to assess VC of adults against diphtheria, tetanus, poliomyelitis and pertussis (dTPaP) according to age. The second objective was to explore if vaccination status could be confirmed by documentation. METHODS: A cross-sectional study was conducted in 680 adults consulting for biological examination in private laboratories in Lyon (France) to evaluate VC for diphtheria, tetanus, poliomyelitis and pertussis (dTPaP) and enabled reported vaccinations to be compared with documented, confirmed vaccinations. RESULTS: Verification of documented, confirmed vaccinations disclosed VC of 78.7% for tetanus, 63.6% for poliomyelitis, 57.8% for diphtheria and 10.7% for pertussis. Comparison of confirmed and self-reported vaccinations revealed that a large percentage of people who thought that they were vaccinated were not. VC significantly decreased with age for diphtheria and poliomyelitis and did not vary by gender. The VC rate for pertussis has increased since the 2008 recommendations were made. CONCLUSIONS: The main thrust of this study was to compare reported and confirmed data. A significant percentage of people wrongly believed that they were up to date with their vaccination

Cancer rétroviraux : relation petits ruminants-homme

National audienceHuman bronchiolo-alveolar carcinoma (BAC) presents similar clinical, histological and radiological characteristics with sheep pulmonary adenocarcinoma (SPA) associated with Jaagsiekte Sheep Retrovirus (JSRV) infection. However, neither serologic nor molecular approaches allowed to find evidence for viral infection in patients with BAC.The objective was to determine if ovine/caprine exposition is an independent risk factor of BAC in human. A hospital national multicentric (n=23) case-control study was implemented from May 2005. Cases were patients with BAC according the 1999 WHO criteria. Control patients had pulmonary adenocarcinoma (TG1) or another type of lung cancer (TG2) and were matched on hospital and date of diagnosis. Standardised questionnaire was used. A descriptive analysis was performed for intermediate results of the 36 (9 cases, 9 TG1 and 18 TG2) included until March 2006. In agreement with the most recent data, we observed that cases were more often women and smoked less, and that there was no difference according to their age. Three hundred and fifty-six items related to the frequency and type of contact with animals, either professional or during leisure, as well as the age period at which they occurred are going to be explored when large enough samples would become available. This very preliminary study suggest the existence of another risk factor for BAC among cases

Acceptability and perception of the herpes zoster vaccine in the 65 and over population: A French observational study

International audienceL’objectif de l’étude était d’évaluer l’acceptabilité et de décrire la perception de la vaccination contre l’herpès zoster (HZ) chez les patients ambulatoires et hospitalisés à Lyon, en France, âgés de 65 ans et plus. Une étude observationnelle était basée sur un questionnaire rempli lors d’une entrevue en personne de janvier 2018 à mars 2019. Les patients externes bénévoles qui ont fréquenté des laboratoires médicaux privés ou qui ont été hospitalisés dans le service de gériatrie, ou qui étaient à la clinique médicale ambulatoire pour une consultation ont été invités à participer. Au total, 907 personnes ont été interrogées, avec un âge moyen de 75,8 ans. Une grande majorité de 87,6 % (795) connaissaient le ZONA et 68,9 % (625) accepteraient d’être vaccinés contre l’AS S’ils présentaient des facteurs de risque. Les participants connaissaient le HZ en tant que maladie, mais la sensibilisation au vaccin fait encore défaut dans le grand public

Professional exposure to goats increases the risk of pneumonic-type lung adenocarcinoma. Results of the IFCT-0504-epidemio study

International audienc

Exposure to livestock in the study population.

<p>Case (P-ADC) and control (non-P-ADC) groups were compared using univariate analysis with the Chi-2 test.</p

Factors independently associated with pneumonic-type lung adenocarcinoma.

<p>Multivariate analysis was performed using log regression model including significant variables at univariate analysis with <i>p</i><0.15.</p><p>CI: Confidence Interval.</p