Cancer rétroviraux : relation petits ruminants-homme

Abstract

National audienceHuman bronchiolo-alveolar carcinoma (BAC) presents similar clinical, histological and radiological characteristics with sheep pulmonary adenocarcinoma (SPA) associated with Jaagsiekte Sheep Retrovirus (JSRV) infection. However, neither serologic nor molecular approaches allowed to find evidence for viral infection in patients with BAC.The objective was to determine if ovine/caprine exposition is an independent risk factor of BAC in human. A hospital national multicentric (n=23) case-control study was implemented from May 2005. Cases were patients with BAC according the 1999 WHO criteria. Control patients had pulmonary adenocarcinoma (TG1) or another type of lung cancer (TG2) and were matched on hospital and date of diagnosis. Standardised questionnaire was used. A descriptive analysis was performed for intermediate results of the 36 (9 cases, 9 TG1 and 18 TG2) included until March 2006. In agreement with the most recent data, we observed that cases were more often women and smoked less, and that there was no difference according to their age. Three hundred and fifty-six items related to the frequency and type of contact with animals, either professional or during leisure, as well as the age period at which they occurred are going to be explored when large enough samples would become available. This very preliminary study suggest the existence of another risk factor for BAC among cases