101 research outputs found
Food intake regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
Background
Neuropeptide Y (NPY), agouti related peptide (AgRP), cocaine and amphetamine-regulated transcript (CART) and melanocortins, the products of the proopiomelanocortin (POMC), are hypothalamic peptides involved in feeding regulation and energy homeostasis. Recent evidence has demonstrated their expression in rat and human placenta.
Methods
In the current study, we have investigated the expression of those neuropeptides in the rat placenta by real-time PCR using a model of maternal food restriction.
Results
Our results showed that placental-derived neuropeptides were regulated through pregnancy and following food restriction.
Conclusion
These data could indicate that placental-derived neuropeptides represent a local regulatory circuit that may fine-tune control of energy balance during pregnancyThis work has been supported by grants from Xunta de Galicia (ML: GRC2006/66), Fondo Investigationes Sanitarias (ML: PI061700), Ministerio de Educacion y Ciencia (CD: BFU2005), Mútua Madrileña (CD and ML) and European Union (CD: LSHM-CT-2003-503041)S
Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure
This is a pre-copyedited, author-produced version of an article accepted for publication in "Nephrology Dialysis Trasnplantation" following peer review. The version of the record is avaliable online at Oxford Academic website.Instituto de Salud Carlos III, PI051024Instituto de Salud Carlos III, PI070413Xunta de Galicia, PS07/12Xunta de Galicia, 2006/2
Fasting and postprandial plasma ghrelin levels are decreased in patients with liver failure previous to liver transplantation
[Abstract] Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Concentrations of ghrelin are controversial in liver cirrhosis. Our aim was to study fasting ghrelin and their response to an oral glucose tolerance test (OGTT) in liver failure patients and normal subjects. Methods We included 16 patients with severe liver failure prior to liver transplantation. As a control group we included 10 age- and BMI-matched healthy subjects. After an overnight fast, 75 g of oral glucose were administered; glucose, insulin, and ghrelin were obtained at baseline and at times 30, 60, 90, and 120 min, respectively. Results Fasting ghrelin (median and range) were statistically significantly lower for patients compared to the controls, 527 (377–971) pg/ml vs. 643 (523–2163) pg/ml, P = 0.045, for patients and controls, respectively. The area under the curve for total ghrelin post-OGTT were lower in end-stage liver failure patients than in the control group, 58815 (44730–87420) pg/ml min vs. 76560 (56160–206385) pg/ml min, for patients and controls, respectively, P = 0.027. Conclusions Ghrelin levels are significantly decreased both fasting and post-OGTT in patients with liver failure candidates for transplantation. Decreased ghrelin levels could contribute to anorexia in patients with cirrhosis.Instituto de Salud Carlos III; PI051024Instituto de Salud Carlos III; PI070413Xunta de Galicia; PS07/12Xunta de Galicia; PGIDT05PXIC91605PNXunta de Galicia; INCITE08ENA916110E
Survivors of childhood acute lymphoblastic leukaemia, with radiation-induced GH deficiency, exhibit hyperleptinaemia and impaired insulin sensitivity, unaffected by 12 months of GH treatment
Marked GH secretion after ghrelin alone or combined with GH-releasing hormone (GHRH) in obese patients
Modelo colisional para la penetración de proyectiles sobre un plano semi–infinito
Revista Ingeniería UC, Vol 20, No 1Se formula un modelo teórico de la colisión de un proyectil sobre un medio semi-infinito, abordando el problema de la penetración como un choque perfectamente inelástico y el comportamiento del material blanco como un fluido elástico para el cálculo de la longitud de penetración. El modelo fue corroborado experimentalmente en el laboratorio Balístico de la Compañía Anónima de Venezuela de Industria Militar (CAVIM). Los resultados concuerdan satisfactoriamente con el modelo, según el cual la longitud de penetración depende primordialmente de la longitud y la densidad del proyectil. Adicionalmente se discuten aplicaciones en: Tecnología Militar, la
determinación de la presión máxima de materiales y la colisión del navío Deep Impact sobre el cometa Temple 1.
Palabras clave: Modelo colisional, Proyectiles de Barrena, Longitud de Penetración, Misión Impacto Profundo
Comparison between insulin tolerance test, growth hormone (GH)-releasing hormone (GHRH), GHRH plus acipimox and GHRH plus GH-releasing peptide-6 for the diagnosis of adult GH deficiency in normal subjects, obese and hypopituitary patients
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