Book review of Trauma-Sensitive Schools: The Importance of Instilling Grit, Determination, and Resilience

This paper is a review of Colleen Lelli’s book “Trauma-sensitive schools: The importance of instilling grit, determination, and resilience”. With her career and lived experience as her reference, Lelli provides a practical and informational guide for educators working with children and youth who have experienced trauma. Drawing on many foundational theorists, this book provides insight into trauma-sensitive schools, the benefits, and how teachers can implement these practices within their classrooms. This book is sure to be valuable to educators at any stage in their careers

Book review of Trauma-Sensitive Schools: The Importance of Instilling Grit, Determination, and Resilience

This paper is a review of Colleen Lelli’s book “Trauma-sensitive schools: The importance of instilling grit, determination, and resilience”. With her career and lived experience as her reference, Lelli provides a practical and informational guide for educators working with children and youth who have experienced trauma. Drawing on many foundational theorists, this book provides insight into trauma-sensitive schools, the benefits, and how teachers can implement these practices within their classrooms. This book is sure to be valuable to educators at any stage in their careers

Exploiting the antiparasitic activity of naphthalimides derivatives

A set of 1,8-naphtalimides derivatives were synthesized and tested against three protozoans that cause important human diseases: Leishmaniainfantum, Trypanosomabrucei and Trypanosomacruzi. Additionally, toxicity was determined by growth inhibition of THP-1 derived macrophages. The results suggest that chemical modifications in the carbon chain linking the naphthalimide and the substituting groups have different effects in the parasites. This work should provide new insights new insights for the design and optimization of more potent and directed naphthalimide derivatives against these organisms.The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreements No.602773 (Project KINDRED). L.G. was supported by the Fundaçãopara a Ciência e Tecnologia through grant SFRH/BD/81604/2011.The research leading to these results has received funding from the European Community’s Seventh Framework Programme under grant agreements No.602773 (Project KINDRED). Thanks are due also to the NMR Portuguese network (PTNMR, BrukerAvance III 400Univ. Minho), and FCT and FEDER for financial support to CQ/UM.info:eu-repo/semantics/publishedVersio

Effect of starvation and subsequent feeding on glycogen concentration, behavior and mortality in the golden mussel Limnoperna Fortunei (Dunker, 1857) (Bivalvia: Mytilidae)

The success of Limnoperna fortunei as an invasive species is related to its physiological plasticity that allows them to endure adverse environmental conditions. Starvation tolerance is considered to be an important trait associated with bivalve invasiveness. In natural ecosystems, food resources can vary during the year, exposing mussels to variable periods of starvation or limited food availability. Thus, mussels have developed physiological strategies to tolerate fluctuations in food availability. Glycogen concentration has been used in different monitoring studies as an indicator of the nutritional condition of bivalves. The aim of this study was to investigate the physiological responses of L. fortunei based on the glycogen concentrations of specimens under four treatments, comprising differentcombinations of feeding and starvation, during 125 days. The experiment was carried out in two phases. In the phase I, mussels were divided in two treatments: starvation (S) and feeding (F). After 100 days, tissue samples were collected to quantify glycogen concentrations and, each phase I group was divided in two subgroups: starvation (S) and feeding (F), resulting in four treatments. In the phase II, that lasted 25 days, starvation specimens (S) from phase I were allowed to feed (starvation-feeding treatment, or S-F), or continued to undergo starvation (starvation-starvation treatment, or S-S) and the feeding specimens (F) continued feeding (feeding-feeding group, or F-F), or were subjected to starvation (feeding-starvation treatment, or F-S). Behavior (valve-closing) and mortality were recorded in 24 h intervals. After the 25 days (phase II) all specimens were killed, and thei r soft tissue was removed to quantify glycogen concentrations. The glycogen concentration of the S-F treatment was lower than that of the F-S treatment, which was initially allowed to feed (phase I) and then subjected to starvation (phase II). Stability in the glycogen concentrations was observed when the phase II feeding conditions were maintained during the experiments, as observed in the S-S (continued starvation) and F-F (continued feeding) treatments. Based on our glycogen concentrations results, the golden mussel shows a higher tolerance to starvation (125 days) than has previously been published, which suggests that its tolerance strongly influences its invasive behavior.Facultad de Ciencias Naturales y Muse

Effect of starvation and subsequent feeding on glycogen concentration, behavior and mortality in the golden mussel Limnoperna Fortunei (Dunker, 1857) (Bivalvia: Mytilidae)

The success of Limnoperna fortunei as an invasive species is related to its physiological plasticity that allows them to endure adverse environmental conditions. Starvation tolerance is considered to be an important trait associated with bivalve invasiveness. In natural ecosystems, food resources can vary during the year, exposing mussels to variable periods of starvation or limited food availability. Thus, mussels have developed physiological strategies to tolerate fluctuations in food availability. Glycogen concentration has been used in different monitoring studies as an indicator of the nutritional condition of bivalves. The aim of this study was to investigate the physiological responses of L. fortunei based on the glycogen concentrations of specimens under four treatments, comprising differentcombinations of feeding and starvation, during 125 days. The experiment was carried out in two phases. In the phase I, mussels were divided in two treatments: starvation (S) and feeding (F). After 100 days, tissue samples were collected to quantify glycogen concentrations and, each phase I group was divided in two subgroups: starvation (S) and feeding (F), resulting in four treatments. In the phase II, that lasted 25 days, starvation specimens (S) from phase I were allowed to feed (starvation-feeding treatment, or S-F), or continued to undergo starvation (starvation-starvation treatment, or S-S) and the feeding specimens (F) continued feeding (feeding-feeding group, or F-F), or were subjected to starvation (feeding-starvation treatment, or F-S). Behavior (valve-closing) and mortality were recorded in 24 h intervals. After the 25 days (phase II) all specimens were killed, and thei r soft tissue was removed to quantify glycogen concentrations. The glycogen concentration of the S-F treatment was lower than that of the F-S treatment, which was initially allowed to feed (phase I) and then subjected to starvation (phase II). Stability in the glycogen concentrations was observed when the phase II feeding conditions were maintained during the experiments, as observed in the S-S (continued starvation) and F-F (continued feeding) treatments. Based on our glycogen concentrations results, the golden mussel shows a higher tolerance to starvation (125 days) than has previously been published, which suggests that its tolerance strongly influences its invasive behavior.Facultad de Ciencias Naturales y Muse

Effect of starvation and subsequent feeding on glycogen concentration, behavior and mortality in the golden mussel Limnoperna Fortunei (Dunker, 1857) (Bivalvia: Mytilidae)

The success of Limnoperna fortunei as an invasive species is related to its physiological plasticity that allows them to endure adverse environmental conditions. Starvation tolerance is considered to be an important trait associated with bivalve invasiveness. In natural ecosystems, food resources can vary during the year, exposing mussels to variable periods of starvation or limited food availability. Thus, mussels have developed physiological strategies to tolerate fluctuations in food availability. Glycogen concentration has been used in different monitoring studies as an indicator of the nutritional condition of bivalves. The aim of this study was to investigate the physiological responses of L. fortunei based on the glycogen concentrations of specimens under four treatments, comprising differentcombinations of feeding and starvation, during 125 days. The experiment was carried out in two phases. In the phase I, mussels were divided in two treatments: starvation (S) and feeding (F). After 100 days, tissue samples were collected to quantify glycogen concentrations and, each phase I group was divided in two subgroups: starvation (S) and feeding (F), resulting in four treatments. In the phase II, that lasted 25 days, starvation specimens (S) from phase I were allowed to feed (starvation-feeding treatment, or S-F), or continued to undergo starvation (starvation-starvation treatment, or S-S) and the feeding specimens (F) continued feeding (feeding-feeding group, or F-F), or were subjected to starvation (feeding-starvation treatment, or F-S). Behavior (valve-closing) and mortality were recorded in 24 h intervals. After the 25 days (phase II) all specimens were killed, and thei r soft tissue was removed to quantify glycogen concentrations. The glycogen concentration of the S-F treatment was lower than that of the F-S treatment, which was initially allowed to feed (phase I) and then subjected to starvation (phase II). Stability in the glycogen concentrations was observed when the phase II feeding conditions were maintained during the experiments, as observed in the S-S (continued starvation) and F-F (continued feeding) treatments. Based on our glycogen concentrations results, the golden mussel shows a higher tolerance to starvation (125 days) than has previously been published, which suggests that its tolerance strongly influences its invasive behavior.Fil: Cordeiro, Nelmara I. S.. Universidade Federal de Minas Gerais; BrasilFil: Andrade, Jennifer T. M.. Universidade Federal de Minas Gerais; BrasilFil: Montresor, Lângia C.. Fundación Oswaldo Cruz; BrasilFil: Luz, Dalva M. R.. Universidade Federal de Minas Gerais; BrasilFil: Martinez, Carlos B.. Universidade Federal de Minas Gerais; BrasilFil: Darrigran, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Naturales y Museo. División Zoología Invertebrados; ArgentinaFil: Pinheiro, Jairo. Universidade Federal Rural Do Rio de Janeiro;Fil: Vidigal, Teofânia H. D. A.. Universidade Federal de Minas Gerais; Brasi

Treatment of Advanced Glaucoma Study:a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma-study protocol

Funding Nottingham University Hospitals NHS Trust sponsors the trial and provides the necessary trial insurance. The trial is funded by a grant awarded by the Health Technology Assessment (NIHR HTA) programme (project number 12/35/38).Peer reviewedPublisher PD

Gangrena de fournier decorrente de acidente automobilístico: um relato de caso

A Gangrena de Fournier é uma infecção bacteriana grave, de moderada mortalidade, mesmo com tratamento ideal. Neste presente relato de caso, objetiva-se discorrer sobre a importância do diagnóstico e do tratamento precoces em um caso de Gangrena de Fournier, visando evitar complicações graves ao paciente.  Apresentação do caso: Paciente masculino, 33 anos, vítima de acidente automobilístico com lesão vesical e uretral, sendo realizada rafia das lesões no mesmo dia do trauma. No 13º dia pós-operatório, o paciente evolui com sinais flogísticos região escrotal, associados a dor intensa. Foi aventado diagnóstico de Gangrena de Fournier e foi realizada abordagem cirúrgica do períneo. Conclusões: Por conta da suspeição clínica precoce, o tratamento cirúrgico foi possível de ser realizado em tempo hábil, de modo que ocorresse controle da infecção. Dessa maneira, o paciente teve ótima evolução clínica, sem consequências a longo prazo da gangrena

Politrauma grave por tentativa de suicídio: um relato de caso

Introdução: Sabe-se que o trauma é uma das principais causas de mortalidade no Brasil. Também, sabe-se que algumas formas de suicídio podem se enqudrar como politraumas graves: tal como a queda de grandes alturas, por mais que o suicídio entre crianças de 13 anos seja incomum, quando avaliados dados nacionais. Objetivo: Por meio de um relato de caso, de revisão de prontuário e de revisão bibliográfica, objetiva-se discorrer sobre a importância do atendimento pré hospitalar adequado associado às condutas cirúrgicas subsequentes para o melhor manejo possível do paciente traumatizado. Relato de caso: Paciente feminina, 13 anos, encaminhada pelo pré hospitalar, após queda de quatro andares por tentativa de suicídio. Foi submetida à laparotomia exploradora, na qual não foi fechada a aponeurose, devido ao aumento da pressão intra-abdominal e aos parâmetros ventilatórios ruins. Paciente evolui bem; porém, foi decretada morte encefálica no quarto dia após o trauma. Discussão: Sabe-se que quedas acima de 3 metros e trauma que resulte em Glasgow ≤12 são mecanismos traumáticos associados a politrauma grave, em crianças. Dessa forma, sabe-se que, por mais que o trauma autoprovocado pela paciente resultasse em prognóstico reservado, todas as condutas abordadas foram as mais adequadas possível