Detrital zircon geochronology of Paleoproterozoic sedimentary rocks from the upper Huronian Supergroup, Canada

The Huronian Supergroup is a well-known succession of primarily sedimentary rocks exposed north of Lake Huron. Deposition of the succession is constrained between 2450 and 2220 Ma (million years), which corresponds with Earth’s rise of atmospheric oxygen, however the depositional timing of the uppermost formations cannot be refined further due to a lack of interbedded volcanic rocks. A geochronological study of detrital zircon grains from sandstone and claystone beds from the two youngest Huronian formations, the Gordon Lake and Bar River formations, was completed in order to confine the maximum age of deposition. Zircon is a mineral that commonly forms in trace amounts in felsic igneous rocks and records the age of lava or magma crystallization. Over time, weathering of the parent rock leads to erosion of zircon grains, which frequently become incorporated into sedimentary deposits. Detrital zircons can therefore provide a maximum depositional age for sedimentary rocks. Uranium-lead age data was collected using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS). Data from the youngest zircon grains indicate that deposition occurred sometime after 2315 ± 5 Ma, but prior to emplacement of igneous intrusions approximately 95 million years later. These results are consistent with reported U-Pb zircon ages from purported tuff beds in the Gordon Lake Formation, however our results support a detrital origin of the zircon grains, as opposed to a period of volcanic activity. Determining the depositional age of sedimentary successions is critical for reconstructing ancient environments and provides important information on the tectonic processes operating at the time of deposition

Sources and Sinks of Microplastics in Canadian Lake Ontario Nearshore, Tributary and Beach Sediments

Microplastics contamination of Lake Ontario sediments is investigated with the aim of identifying distribution patterns and hotspots in nearshore, tributary and beach depositional environments. Microplastics are concentrated in nearshore sediments in the vicinity of urban and industrial regions. InHumber Bay and Toronto Harbour microplastic concentrations were consistently greater than 500 particles per kg dry sediment. Maximum concentrations of ~28,000 particles per kg dry sediment were determined in Etobicoke Creek. The microplastic particles were primarily fibres and fragments less than 2 mm in size. Both low- and high-density plastics were identified using Raman spectroscopy. We provide a baseline for future monitoring and discuss potential sources of microplastics in terms of how and where to implement preventative measures to reduce the contaminant influx. Although the impacts of microplastics contamination on ecosystem health and functioning is uncertain, understanding, monitoring and preventing further microplastics contamination in Lake Ontario and the other Great Lakes is crucial

Climatic Cycles Recorded in Glacially Influenced Rhythmites of the Gowganda Formation, Huronian Supergroup

The Gowganda Formation of the 2.45–2.2 Ga Huronian Supergroup contains glacially-induced, varve-like rhythmites that potentially preserve a detailed record of climatic conditions during the Paleoproterozoic Era. Four rhythmic couplet thickness records were measured at two outcrops near Wharncliffe, Ontario for the purpose of time-series analysis. The couplets, which range from 1 to 32 mm thick, are composed of alternating layers of siltstone and claystone. Time-series analysis of the couplet thickness records using the MTM Toolkit of Mann and Lees (1996) consistently revealed periodicities in the range of 2.2–2.9 couplets per cycle, which is consistent with climatic cycles such as the quasi-biennial oscillation (QBO) and the El Niño Southern Oscillation (ENSO) observed in modern times. This periodicity suggests that the rhythmic couplets represent annual deposits (i.e. varves). Evidence for the presence of cycles at 3.0– 4.9 couplets, 6.6–6.9 couplets, 8.8–9.2 couplets, 22.8 couplets, and 30.1–31.0 couplets were also observed in some couplet thickness records; however, the presence of these longer term cycles was inconsistent from site to site

Positive lifestyle changes around the time of pregnancy:a cross-sectional study

OBJECTIVES: To examine the prevalence of positive lifestyle behaviours before and during pregnancy in Ireland. DESIGN: Cross-sectional study. SETTING: Population-based study in Ireland. PARTICIPANTS: A total of 718 women of predominantly Caucasian origin from the Pregnancy Risk Assessment Monitoring System (PRAMS), Ireland, were included. PRIMARY AND SECONDARY OUTCOME MEASURES Positive lifestyle behaviour changes before and during pregnancy in Ireland on alcohol consumption, smoking, folate use and nutrition. RESULTS: Of 1212 women surveyed, 718 (59%) responded. 26% were adherent to all three recommendations on alcohol consumption, smoking and folate use before pregnancy. This increased to 39% for the same three behaviours during pregnancy, with greater increases in adherence observed among women with the lowest adherence before pregnancy. Age, education and ethnicity gaps in adherence before pregnancy appeared to narrow during pregnancy. Adherence to all seven food pyramid guidelines was less than 1% overall, and less than 1% of participants met all four micronutrient guidelines on vitamin D, folate, calcium and iron intake around the time of pregnancy. CONCLUSIONS: Low levels of healthy lifestyle behaviours before pregnancy and low levels of positive lifestyle behaviours during pregnancy demonstrate an urgent need for increased clinical and public health efforts to target deleterious health behaviours before, during and after pregnancy

The geological cycle of plastics and their use as a stratigraphic indicator of the Anthropocene

The rise of plastics since the mid-20th century, both as a material element of modern life and as a growing environmental pollutant, has been widely described. Their distribution in both the terrestrial and marine realms suggests that they are a key geological indicator of the Anthropocene, as a distinctive stratal component. Most immediately evident in terrestrial deposits, they are clearly becoming widespread in marine sedimentary deposits in both shallow- and deep-water settings. They are abundant and widespread as macroscopic fragments and virtually ubiquitous as microplastic particles; these are dispersed by both physical and biological processes, not least via the food chain and the ‘faecal express’ route from surface to sea floor. Plastics are already widely dispersed in sedimentary deposits, and their amount seems likely to grow several-fold over the next few decades. They will continue to be input into the sedimentary cycle over coming millennia as temporary stores – landfill sites – are eroded. Plastics already enable fine time resolution within Anthropocene deposits via the development of their different types and via the artefacts (‘technofossils’) they are moulded into, and many of these may have long-term preservation potential when buried in strata

Urban agriculture, civil interfaces and moving beyond difference: the experiences of plot holders in Dublin and Belfast

Recent literature suggests that a “shared politics of place” attained through joint activities fosters social integration and provides people with a means to practise co-operation [Baumann, G., 1996. Contesting culture: discourses of identity in multi-ethnic London. Cambridge: Cambridge University Press; Sanjek, R., 1998. The future of us all: race & neighbourhood policies in New York City. Ithaca, NY: Cornell University Press; Sennett, R., 2012. Together: the rituals, pleasures and politics of cooperation. UK: Penguin]. Such a “shared politics of place” is most likely to occur in the context of public space conceptualised broadly as “the setting for everyday spatial behaviour of individuals and communities, emphasizing ordinary activities of citizens” [Lownsbrough, H. and Beunderman, J., 2007. Equally spaced? Public space and interaction between diverse communities. London: Demos, p. 8]. Here we explore one element of such public space – urban agriculture sites – with a view to identifying the extent to which a “shared politics of place” can be created and nurtured among the cultivating citizenry. The paper draws on data collected on allotment gardening sites in two urban contexts: Dublin (Ireland) and Belfast (Northern Ireland) over the period 2009–2013. We demonstrate the centrality of allotment cultivation to the generation of solidarity, mutuality and trust among participating citizens. Individuals engaging in allotment gardening in both Dublin and Belfast create and sustain civil interfaces – dismantling barriers, exchanging knowledge, challenging stereotypes, generating empathy and getting on with the business of simply getting on with their lives. The modus operandi of allotment gardening is predicated on a willingness to disregard social and ethno-national categorisations while on site. This is not to deny that such differences exist and persist, but allotments offer a “space of potential” where those differences are, at least for a time, rendered less salient

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment